Type I Interferon In Human Autoimmunity

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Type I Interferon in Human Autoimmunity

Author : Timothy B. Niewold
Publisher : Frontiers Media SA
ISBN 13 : 2889193403
Total Pages : 88 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Type I Interferon in Human Autoimmunity by : Timothy B. Niewold

Download or read book Type I Interferon in Human Autoimmunity written by Timothy B. Niewold and published by Frontiers Media SA. This book was released on 2015-04-21 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: The type I interferon system plays a critical role in host defense in health, and a growing body of literature suggests that type I interferon is a critical mediator of human autoimmune disease. Type I interferons function as a bridge between the innate and adaptive immune systems, and as such play an important role in setting thresholds for response against self antigens. Many investigators have focused on the role type I interferons play in autoimmune disease. This fascinating and rapidly growing body of literature encompasses many different autoimmune diseases, including systemic lupus erythematosus, type I diabetes, multiple sclerosis, and others. In this Research Topic, we provide a comprehensive overview of the various roles type I interferons play in autoimmune diseases, with a focus on human immunology.

Type I Interferon in Autoimmune Diseases and Its Clinical Applications

Author : Yihong Yao
Publisher : Nova Science Publishers
ISBN 13 : 9781624173790
Total Pages : 0 pages
Book Rating : 4.1/5 (737 download)

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Book Synopsis Type I Interferon in Autoimmune Diseases and Its Clinical Applications by : Yihong Yao

Download or read book Type I Interferon in Autoimmune Diseases and Its Clinical Applications written by Yihong Yao and published by Nova Science Publishers. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Auto-immune diseases such as systemic lupus erythematosus (SLE), Sjögren's syndrome, psoriasis, scleroderma (SSc) and myositis are heterogeneous disorders that result from interactions between genetic and environmental factors. Type I interferons (IFNs), especially IFN-α/β, have multiple biological functions including anti-viral and anti-bacterial properties, immuno-modulation, anti-proliferation, and intensive studies over decades have also revealed important roles in auto-immunity and cancer. Sustained Type I IFN elevation has been implicated in immune responses against self-antigens and tissue damage, which has led to the hypothesis that type I IFN might play a critical role in the pathogenesis of some auto-immune and inflammatory diseases. This book provides an overview of many key topics surrounding type I IFNs, beginning with detailed discussion of the type I IFN signalling pathway, the interplay between components that regulate this pathway, its involvement in auto-immunity, and a detailed review of the roles of type I IFNs in a series of well characterised inflammatory and auto-immune diseases.

Autoimmunity and Autoimmune Disease

Author : David Evered
Publisher : John Wiley & Sons
ISBN 13 : 0470513497
Total Pages : 288 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis Autoimmunity and Autoimmune Disease by : David Evered

Download or read book Autoimmunity and Autoimmune Disease written by David Evered and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work focuses on the autoimmune processes that have now been proven to underlie a number of serious diseases, including diabetes mellitus, rheumatoid arthritis and multiple sclerosis. Papers explore the rapidly expanding developments in research on immune response and regulation, and their potential in the development of treatments for autoimmune diseases. The wide range of subjects covered here include: the nature of intracellular and cell surface-derived ``self'' antigens; competing theories of the generation of immune tolerance and their implications of current theories for research and treatment; possible links between autoimmunity and genetic complement deficiency; the contributions of interferons and class II HLA antigen expression to autoimmunity; and the potential of monoclonal antibodies and other biotechnological advances in treating human autoimmune conditions.

Type I Interferon Signaling and Emotional Behavior Regulation

Author : Hua Zhang
Publisher :
ISBN 13 :
Total Pages : 290 pages
Book Rating : 4.:/5 (768 download)

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Book Synopsis Type I Interferon Signaling and Emotional Behavior Regulation by : Hua Zhang

Download or read book Type I Interferon Signaling and Emotional Behavior Regulation written by Hua Zhang and published by . This book was released on 2010 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chronic administration of interferon-alpha (IFN-alpha, a type of I IFN) as an anti-viral or anti-cancer therapy in humans has frequently been found to result in severe psychiatric side effects, especially anxiety and depression. Type I IFN has also been implicated in neuropsychiatric dysfunction in systemic lupus erythematosus (SLE). Nevertheless, the role of type I IFN signaling in regulation of emotional behaviors is poorly defined because of limited access to the human brain. In this regard, behavioral impact of direct IFN-alpha treatment on animals remains highly controversial. The overall hypothesis tested is that the activation of type I IFN signaling directly contributes to emotional behavior dysfunction. First, behavioral evaluation in the mice with central nervous system (CNS)-targeted expression of IFN-alpha transgene revealed unaltered anxiety or depression profile. Second, using lupus-prone female NZBWF1 and NZB mice as animal models of human SLE, we demonstrated that (i) lupus-prone mice displayed anxiety-like behavior, and such behavioral dysfunction is correlated with their serum anti-nuclear autoantibody levels; (ii) repeated IFN-alpha treatment aggravated the anxiety-like behavior in lupus-prone NZBWF1 mice, but not that in the control NZW mice; and (iii) molecular dissection identified a significantly enhanced expression of interferon-stimulated genes in both brain and kidney in NZBWF1 mice compared with control NZW mice in response to repeated IFN-alpha treatment. Finally, ablation of type I IFN receptor did not reduce the anxiety-like behavior in autoimmune NZB female mice; however, such disruption of type I IFN signaling significantly attenuated the lupus-like kidney disease and splenomegaly in these mice. In conclusion, these findings indicated that up-regulated type I IFN signaling contribute to the behavioral dysfunction associated with autoimmune disease. However, activation of type I IFN signaling alone is not sufficient in inducing behavioral abnormality, suggesting that other factors are required for the development of IFN-alpha-triggered behavioral dysfunction in lupus-prone mice. The interactions between type I IFN and those uncharacterized contributing factors in the development of psychopathology following chronic INF-alpha treatment remain to be defined. Together, our studies demonstrate the complexity of type I IFN in behavioral regulation and provide new information regarding the CNS actions of type I IFN signaling.

Innate Immunity in Health and Disease

Author : Shailendra K. Saxena
Publisher : BoD – Books on Demand
ISBN 13 : 1838807659
Total Pages : 416 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Innate Immunity in Health and Disease by : Shailendra K. Saxena

Download or read book Innate Immunity in Health and Disease written by Shailendra K. Saxena and published by BoD – Books on Demand. This book was released on 2021-08-25 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.

Organ-specific Autoimmunity

Author : Pierluigi E. Bigazzi
Publisher :
ISBN 13 :
Total Pages : 416 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Organ-specific Autoimmunity by : Pierluigi E. Bigazzi

Download or read book Organ-specific Autoimmunity written by Pierluigi E. Bigazzi and published by . This book was released on 1990 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: An international group of scientists contribute 19 perspectives on the current state of organ-specific and tissue-specific autoimmunity, describing experimentally induced and spontaneously occurring animal models for autoimmune diseases as examples for the development and assessment of new therapeutic strategies, and detailing clinical studies on the autoimmune processes and responses in such disorders as rheumatoid arthritis, syphilis, schizophrenia, multiple sclerosis, thyroid disease and autoimmune thyroiditis, autoimmune myocarditis, diabetes mellitus and polyendocrine syndromes, and human male infertility. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com)

Idiotypes in Medicine: Autoimmunity, Infection and Cancer

Author : R.C. Kennedy
Publisher : Elsevier
ISBN 13 : 0080534430
Total Pages : 557 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Idiotypes in Medicine: Autoimmunity, Infection and Cancer by : R.C. Kennedy

Download or read book Idiotypes in Medicine: Autoimmunity, Infection and Cancer written by R.C. Kennedy and published by Elsevier. This book was released on 1997-11-19 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the most comprehensive review of the idiotypic network available. All the current knowledge of idiotypes of the various antibodies is incorporated in this volume. The pathogenic role of idiotypes in autoimmunity and cancer is reviewed in depth. The therapeutic part focusses on harnessing anti-idiotypes for treating autoimmunological disorders, and on the employment of idiotypes for vaccines in cancer and infectious diseases, as well as explaining the manipulation of the idiotypic network in autoimmunity and cancer idiotypes and vaccines.

Uveitis

Author : Robert B. Nussenblatt
Publisher :
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Uveitis by : Robert B. Nussenblatt

Download or read book Uveitis written by Robert B. Nussenblatt and published by . This book was released on 1996 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition expands on the diagnostic and therapeutic approaches to uveitis. New fluorescein angiograms and indocyanine angiograms are presented, and descriptive case studies provide examples relevant to the treatment of patients with uveitis. Now with 79 color photographs, the book is even more thorough in its coverage of the medical, pharmacological, and surgical treatment of uveitis. You will also find the most up-to-date information on other conditions associated with uveitis, including inflammatory complications of AIDS. A Brandon Hill Title

Innovative Medicine

Author : Kazuwa Nakao
Publisher : Springer
ISBN 13 : 4431556516
Total Pages : 330 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Innovative Medicine by : Kazuwa Nakao

Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Diagnostic Criteria in Autoimmune Diseases

Author : Yehuda Shoenfeld
Publisher : Springer Science & Business Media
ISBN 13 : 1603272852
Total Pages : 555 pages
Book Rating : 4.6/5 (32 download)

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Book Synopsis Diagnostic Criteria in Autoimmune Diseases by : Yehuda Shoenfeld

Download or read book Diagnostic Criteria in Autoimmune Diseases written by Yehuda Shoenfeld and published by Springer Science & Business Media. This book was released on 2010-06-08 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the Autoimmune Diseases Coordinating Committee (ADCC), between 14.7 and 23.5 million people in the USA – up to eight percent of the population are affected by autoimmune disease. Autoimmune diseases are a family of more than 100 chronic, and often disabling, illnesses that develop when underlying defects in the immune system lead the body to attack its own organs, tissues, and cells. In Handbook of Autoimmune Disease, the editors have gathered in a comprehensive handbook a critical review, by renowned experts, of more than 100 autoimmune diseases, divided into two main groups, namely systemic and organ-specific autoimmune diseases. A contemporary overview of these conditions with special emphasis on diagnosis is presented. Each chapter contains the essential information required by attending physicians as well as bench scientists to understand the definition of a specific autoimmune disease, the diagnostic criteria, and the treatment.

The Innate Immune Response to Noninfectious Stressors

Author : Massimo Amadori
Publisher : Academic Press
ISBN 13 : 0128019743
Total Pages : 278 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Innate Immune Response to Noninfectious Stressors by : Massimo Amadori

Download or read book The Innate Immune Response to Noninfectious Stressors written by Massimo Amadori and published by Academic Press. This book was released on 2016-02-23 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation. Provides insights into the fundamental homeostatic processes vis-à-vis stressors to help in investigation Illustrates the depicted tenets and how to offset them against established models of response to physical and psychotic stressors in both animals and humans Covers the crucial issue of the immune response to endocrine disruptors Includes immunological parameters as reporter system of environmental adaptation Provides many illustrative examples to foster reader understanding

Immunopathogenesis and Immune-based Therapy for Selected Autoimmune Disorders

Author : Mourad Aribi
Publisher : BoD – Books on Demand
ISBN 13 : 9535130218
Total Pages : 184 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Immunopathogenesis and Immune-based Therapy for Selected Autoimmune Disorders by : Mourad Aribi

Download or read book Immunopathogenesis and Immune-based Therapy for Selected Autoimmune Disorders written by Mourad Aribi and published by BoD – Books on Demand. This book was released on 2017-03-22 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book Immunopathogenesis and Immune-Based Therapy for Selected Autoimmune Disorders is a synthesis work that discusses two main aspects of autoimmunity: Immunopathogenesis and therapeutic approaches essentially based on the immunotherapies. This book deals with different topics on a number of autoimmune disorders, including type 1 diabetes, autoimmune cardiomyopathy, autoimmunity of gastrointestinal tract, systemic sclerosis, and myasthenia gravis. This book will be useful to clinicians, biologists, researchers, teachers, and students who are interested in immunology and immunopathology.

Virus Dynamics : Mathematical Principles of Immunology and Virology

Author : Martin Nowak
Publisher : Oxford University Press, UK
ISBN 13 : 0191588512
Total Pages : 253 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Virus Dynamics : Mathematical Principles of Immunology and Virology by : Martin Nowak

Download or read book Virus Dynamics : Mathematical Principles of Immunology and Virology written by Martin Nowak and published by Oxford University Press, UK. This book was released on 2000-11-23 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the examples of HIV/AIDS and hepatitis B, Nowak and May show how mathematical models can help researchers to understand the detailed dynamics of infection and the effects of antiviral therapy. Models are developed to describe the dynamics of drug resistance, immune responses, viral evolution and mutation, and to optimise the design of therapy and vaccines. - ;We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study. - ;... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host - Nature

Viral Gastroenteritis

Author : Shunzo Chiba
Publisher : Springer Science & Business Media
ISBN 13 : 3709165539
Total Pages : 301 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Viral Gastroenteritis by : Shunzo Chiba

Download or read book Viral Gastroenteritis written by Shunzo Chiba and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, rapid developments have occurred in the field of viral gastroenteritis. This book is an update of fundamental and practical aspects of viral gastroenteritis. Among the various agents that cause viral gastroenteritis, group A rotaviruses and caliciviruses are the focus of this volume because of their clinical impact and the significance of new findings about them.

Dubois' Lupus Erythematosus and Related Syndromes - E-Book

Author : Daniel Wallace
Publisher : Elsevier Health Sciences
ISBN 13 : 0323550649
Total Pages : 752 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Dubois' Lupus Erythematosus and Related Syndromes - E-Book by : Daniel Wallace

Download or read book Dubois' Lupus Erythematosus and Related Syndromes - E-Book written by Daniel Wallace and published by Elsevier Health Sciences. This book was released on 2018-08-16 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, Dubois’ Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It’s an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. Offers an increased focus on the clinical management of related disorders such as Sjogren’s syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.

Hepatotoxicity

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781719520
Total Pages : 848 pages
Book Rating : 4.7/5 (195 download)

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Book Synopsis Hepatotoxicity by : Hyman J. Zimmerman

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Mosaic of Autoimmunity

Author : Carlo Perricone
Publisher : Academic Press
ISBN 13 : 012814307X
Total Pages : 728 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Mosaic of Autoimmunity by : Carlo Perricone

Download or read book Mosaic of Autoimmunity written by Carlo Perricone and published by Academic Press. This book was released on 2019-02-15 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications