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Author : Ahmed Lasfar
Publisher : Frontiers Media SA
ISBN 13 : 2889632830
Total Pages : 148 pages
Book Rating : 4.8/5 (896 download)
Download or read book Tumor Microenvironment and Resistance to Current Therapies written by Ahmed Lasfar and published by Frontiers Media SA. This book was released on 2020-01-27 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Peter P. Lee
Publisher : Springer Nature
ISBN 13 : 303038862X
Total Pages : 326 pages
Book Rating : 4.0/5 (33 download)
Download or read book Tumor Microenvironment written by Peter P. Lee and published by Springer Nature. This book was released on 2020-03-25 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.
Author : Alexander Birbrair
Publisher : Springer Nature
ISBN 13 : 3030357279
Total Pages : 160 pages
Book Rating : 4.0/5 (33 download)
Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-02-06 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses recent research advances in cancer biology, focusing on the role of the tumor microenvironment. Taken alongside its companion volumes, Tumor Microenvironment: Recent Advances covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.
Author : Apostolos Zaravinos
Publisher : Frontiers Media SA
ISBN 13 : 2832527124
Total Pages : 218 pages
Book Rating : 4.8/5 (325 download)
Download or read book Tumor Microenvironment, Inflammation, and Resistance to Immunotherapies written by Apostolos Zaravinos and published by Frontiers Media SA. This book was released on 2023-06-29 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Myron R. Szewczuk
Publisher : Springer
ISBN 13 : 303021477X
Total Pages : 320 pages
Book Rating : 4.0/5 (32 download)
Download or read book Current Applications for Overcoming Resistance to Targeted Therapies written by Myron R. Szewczuk and published by Springer. This book was released on 2019-07-15 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted therapies were initially developed to exploit the upregulation and dependence on key oncogenic pathways critical to cancer progression. Additionally, they also presented as a method to overcome chemoresistance by supplementing conventional therapeutic regimens with targeted therapies. However, the development of resistance to these combinatorial approaches has led to the reassessment of currently available therapeutic options to overcome resistance to targeted therapy. This book aims to provide an update on the advancements in the therapeutic arms race between cancer, clinicians and scientists alike to overcome resistance to targeted therapies. Subject experts provide a comprehensive overview of the challenges and solutions to resistance to several conventional targeted therapies in addition to providing a discussion on broad topics including targeting components of the tumor microenvironment, emerging therapeutic options, and novel areas to be explored concerning nanotechnology and the epigenome.
Author : Shoaquan Zheng
Publisher : Frontiers Media SA
ISBN 13 : 2832536557
Total Pages : 537 pages
Book Rating : 4.8/5 (325 download)
Download or read book Tumor Microenvironment and Cancer Therapy written by Shoaquan Zheng and published by Frontiers Media SA. This book was released on 2023-10-17 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is well established that the tumor microenvironment(TME) plays a pivotal role in tumor initiation, progression and therapeutic resistance by creating a dynamic interaction with cancer cells. TME is comprised of extracellular matrix (ECM), growth factors, nutrients, blood and lymphatic vessels, and non-cancer stromal cells, which serve as a sustained niche for cancer cells to proliferate and metastasize. Notably, various cellular components in TME, including endothelial cells, fibroblasts, pericytes, adipocytes, immune cells, cancer stem cells, and vasculature, could promote tumor’s immune evasion and growth.
Author : Petranel T. Ferrao
Publisher : Frontiers Media SA
ISBN 13 : 288963115X
Total Pages : 186 pages
Book Rating : 4.8/5 (896 download)
Download or read book Cancer Plasticity and the Microenvironment: Implications for Immunity and Therapy Response written by Petranel T. Ferrao and published by Frontiers Media SA. This book was released on 2019-11-01 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer cells can change and adapt, especially within the host environment; a phenomenon known as cancer plasticity. Several factors, including the immune system can influence, and be influenced by, cancer plasticity which in turn can impact upon patient responses to treatment. As such, we currently face several challenges for implementing combination therapies as effective cancer treatment strategies. We have compiled a topic with a number of articles that emphasize the various aspects of cancer plasticity, describing in particular the important role of the tumor microenvironment. As we embark on a new era of precision medicine with multi-modal therapies for improving patient outcomes, this topic highlights some relevant points for consideration that are pertinent to the incorporation and effective use of new treatments as part of cancer treatment regimens, including immune-modulating drugs.
Author : Jian Huang
Publisher : Frontiers Media SA
ISBN 13 : 2889742555
Total Pages : 229 pages
Book Rating : 4.8/5 (897 download)
Download or read book Unveiling the Impact of Local or Systemic Therapeutic Strategies on the Tumor Microenvironment written by Jian Huang and published by Frontiers Media SA. This book was released on 2022-02-14 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sandra Orsulic
Publisher : Frontiers Media SA
ISBN 13 : 288971781X
Total Pages : 157 pages
Book Rating : 4.8/5 (897 download)
Download or read book The Tumor Microenvironment: Recent Advances and Novel Therapeutic Approaches written by Sandra Orsulic and published by Frontiers Media SA. This book was released on 2021-12-03 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Fumito Ito
Publisher : Elsevier Health Sciences
ISBN 13 : 0323549500
Total Pages : 271 pages
Book Rating : 4.3/5 (235 download)
Download or read book Immune Checkpoint Inhibitors in Cancer written by Fumito Ito and published by Elsevier Health Sciences. This book was released on 2018-09-03 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get a quick, expert overview of the latest clinical information and guidelines for cancer checkpoint inhibitors and their implications for specific types of cancers. This practical title by Drs. Fumito Ito and Marc Ernstoff synthesizes the most up-to-date research and clinical guidance available on immune checkpoint inhibitors and presents this information in a compact, easy-to-digest resource. It's an ideal concise reference for trainee and practicing medical oncologists, as well as those in research. - Discusses the current understanding of how to best harness the immune system against different types of cancer at various stages. - Helps you translate current research and literature into practical information for daily practice. - Presents information logically organized by disease site. - Covers tumor immunology and biology; toxicities associated with immune checkpoint inhibitors; and future outlooks. - Consolidates today's available information on this timely topic into one convenient resource.
Author : Andreas Pircher
Publisher : Frontiers Media SA
ISBN 13 : 2889768295
Total Pages : 254 pages
Book Rating : 4.8/5 (897 download)
Download or read book New Horizons in Tumor Microenvironment Biology and Therapy: Implications for New Therapies Vol. II written by Andreas Pircher and published by Frontiers Media SA. This book was released on 2022-08-19 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Salem Chouaib
Publisher : Frontiers Media SA
ISBN 13 : 2889638170
Total Pages : 196 pages
Book Rating : 4.8/5 (896 download)
Download or read book Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy written by Salem Chouaib and published by Frontiers Media SA. This book was released on 2020-07-02 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jacinta Serpa
Publisher : Springer Nature
ISBN 13 : 3030340252
Total Pages : 430 pages
Book Rating : 4.0/5 (33 download)
Download or read book Tumor Microenvironment written by Jacinta Serpa and published by Springer Nature. This book was released on 2020-03-04 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The way a cell undergoes malignant transformation should meet their capacity of surviving in the microenvironment of the organ where the cancer will develop. Metabolic adaptation is for sure one of the criteria that must be accomplished, driven by metabolic plasticity that allows the adaptation of cancer cells to the availability of energy and biomass sources that will sustain cell survival and proliferation. Each human organ has a particular microenvironment which depends on several cell types and in some cases also on symbiotic microorganisms. These biological partners are constantly sharing organic compounds and signaling molecules that will control mitogenesis, cell death and differentiation, accounting for the organ's function. Nevertheless, cancer cells are capable of taking advantage of this metabolic and signaling microenvironmental dynamics. In this book, we intend to present the different components of the microenvironment driving the metabolic fitness of cancer cells. The metabolic changes required for establishing a tumor in a given microenvironment and how these metabolic changes limit the response to drugs will generally be the major items addressed. It is important to mention not only aspects of the microenvironment that stimulate metabolic changes and that select better adapted tumor cells, but also how this regulation of cell plasticity is made. Thus, the signaling pathways that orchestrate and are orchestrated throughout this panoply of metabolic rearrangements will also be addressed in this book. The subjects will be presented from the conceptual point of view of the cross-cancer mechanisms and also particularizing some models that can be examples and enlightening within the different areas.
Author : Gianfranco Baronzio
Publisher : Springer Science & Business Media
ISBN 13 : 1402095767
Total Pages : 247 pages
Book Rating : 4.4/5 (2 download)
Download or read book Cancer Microenvironment and Therapeutic Implications written by Gianfranco Baronzio and published by Springer Science & Business Media. This book was released on 2009-04-10 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the post-genomic era, cancer is a genetic disease. However, cancer genotype does not always equal cancer phenotype. Cancers with the same genetic abnormalities don’t always behave the same. Understanding and eradicating cancers will require an appreciation for cancer’s ecology. This book is the first to comprehensively explore and critically appraise cancer microenvironments and host interactions with an eye towards exploiting our understanding for new treatments. The team of contributors share amongst them impressive experiences at the laboratory bench and in the clinic. These physician-scientists have dedicated themselves to the tension between the urgency for cures and the technical challenges of discovery. The target audience includes clinical oncologists, clinical hematologists, research oncologists, research hematologists, immunologists, stem cell researchers, oncology and hematology fellows (trainees), oncology educators (graduate and undergraduate levels), and course book for graduate students and undergraduate students.
Author : Peter P. Lee
Publisher :
ISBN 13 : 9783030388638
Total Pages : pages
Book Rating : 4.3/5 (886 download)
Download or read book Tumor Microenvironment written by Peter P. Lee and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.
Author : Shaoquan Zheng
Publisher : Frontiers Media SA
ISBN 13 : 2832534694
Total Pages : 156 pages
Book Rating : 4.8/5 (325 download)
Download or read book Tumor microenvironment, immunotherapy, and drug resistance in breast and gastrointestinal cancer written by Shaoquan Zheng and published by Frontiers Media SA. This book was released on 2023-09-29 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lucas Treps
Publisher : Frontiers Media SA
ISBN 13 : 2889749665
Total Pages : 287 pages
Book Rating : 4.8/5 (897 download)
Download or read book Tumor Vessels as Directors of the Tumor Microenvironment: New Findings, Current Challenges & Perspectives written by Lucas Treps and published by Frontiers Media SA. This book was released on 2022-04-22 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt:
