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Tumor Microenvironment And Cellular Stress
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Author :Constantinos Koumenis Publisher :Springer Science & Business Media ISBN 13 :146145915X Total Pages :293 pages Book Rating :4.4/5 (614 download)
Book Synopsis Tumor Microenvironment and Cellular Stress by : Constantinos Koumenis
Download or read book Tumor Microenvironment and Cellular Stress written by Constantinos Koumenis and published by Springer Science & Business Media. This book was released on 2013-11-23 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
Book Synopsis Tumor Microenvironment by : Constantinos Koumenis
Download or read book Tumor Microenvironment written by Constantinos Koumenis and published by Springer. This book was released on 2016-06-20 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the topics presented at the 3rd International Conference on Tumor Microenvironment and Cellular Stress by an international community of researchers. The conference brings together scientists to discuss different cellular and animal models of tumor microenvironment study and identify common pathways that are candidates for therapeutic intervention; stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology (e.g., HIF regulation) and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery; and critically evaluate novel targets for imaging or therapeutic intervention that would be of use to the tumor microenvironment community and pharmaceutical industry.
Book Synopsis The Heterogeneity of Cancer Metabolism by : Anne Le
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Book Synopsis Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions by : Debabrata Banerjee
Download or read book Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions written by Debabrata Banerjee and published by Springer Nature. This book was released on 2021-12-09 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor micronenvironment’s various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.
Book Synopsis Autophagy in tumor and tumor microenvironment by : Sujit Kumar Bhutia
Download or read book Autophagy in tumor and tumor microenvironment written by Sujit Kumar Bhutia and published by Springer Nature. This book was released on 2020-10-24 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the paradoxical role of autophagy in tumor suppression and tumor promotion in cancer cells. Autophagy plays opposing, context-dependent roles in tumors; accordingly, strategies based on inhibiting or stimulating autophagy could offer as potential cancer therapies. The book elucidates the physiological role of autophagy in modulating cancer metastasis, which is the primary cause of cancer-associated mortality. Further, it reviews its role in the differentiation, development, and activation of multiple immune cells, and its potential applications in tumor immunotherapy. In addition, it examines the effect of epigenetic modifications of autophagy-associated genes in regulating tumor growth and therapeutic response and summarizes autophagy’s role in the development of resistance to a variety of anti-cancer drugs in cancer cells. In closing, it assesses autophagy as a potential therapeutic target for cancer treatment. Given its scope, the book offers a valuable asset for all oncologists and researchers who wish to understand the potential role of autophagy in tumor biology.
Book Synopsis Tumor Microenvironment by : Dietmar W. Siemann
Download or read book Tumor Microenvironment written by Dietmar W. Siemann and published by John Wiley & Sons. This book was released on 2011-06-24 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The microenvironment in which a tumor originates plays a critical role in its initiation and progression. Tumor Microenvironment reviews the importance of tumor microenvironment in cancer management. Particular emphasis is placed on discussing how the unique characteristics of the tumor microenvironment not only impact disease progression and response to conventional anticancer therapies, but have also led to the identification of potential new therapeutic targets and treatment possibilities for cancer patients. Tumor Microenvironment also reviews the fundamental basis of target development, preclinical assessment, and the current clinical status of these therapies.
Book Synopsis Tumor Microenvironment by : Alexander Birbrair
Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-02-06 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including S1P, neuregulin, Notch, erythropoietin, Rho-ROCK, mTOR, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
Book Synopsis Tumor Microenvironment by : Alexander Birbrair
Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-02-06 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses recent research advances in cancer biology, focusing on the role of the tumor microenvironment. Taken alongside its companion volumes, Tumor Microenvironment: Recent Advances covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.
Book Synopsis Tumor Microenvironment by : Alexander Birbrair
Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2021-10-18 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.
Book Synopsis Tumor Microenvironment by : Alexander Birbrair
Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-06-25 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research in the field. A variety of topics are covered, including metabolism in the tumor microenvironment, stellate cells and endothelial progenitors in the tumor microenvironment, as well as the effects of HIV, viral hepatitis, and inflammation in the tumor microenvironment, and more. Taken alongside its companion volumes, Tumor Microenvironment: State of the Science updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
Book Synopsis Tumor Microenvironment by : Alexander Birbrair
Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-06-23 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including Cathepsin D, galectins, iron, oxygen, Phospholipase D1, leptin, extracellular vesicles, and more. Taken alongside its companion volumes, these books update us on what we know about the tumor microenvironment as well as future directions. Tumor Microenvironment: Molecular Players – Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
Book Synopsis The Tumor Microenvironment by : Rebecca G. Bagley
Download or read book The Tumor Microenvironment written by Rebecca G. Bagley and published by Springer Science & Business Media. This book was released on 2010-09-02 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fact that tumors are composed of both tumor cells and host cells has long been known. These tumor-associated cells include vascular endothelial cells and pe- cytes, as well as inflammatory cells such as neutrophils, monocytes, macrophages, mast cells and eosinophils, and lymphocytes. The tumor cells also interact with stromal cells and with elements of the tissue extracellular matrix. What has been less appreciated is the role that these cells could have in modulating the growth, invasion, and metastasis of the tumor. Early on, the elements of what we now call the tumor microenvironment were considered to be more or less innocent bysta- ers to the role of the tumor cells as they grew and invaded local sites. Today, there is an increased understanding of the critical role of the tumor microenvironment as dramatically influencing the course of tumor development and dissemination. This volume represents a superb compilation of the latest thoughts and data regarding the role of each essential component of the tumor microenvironment in cancer development and progression. Perhaps, the earliest recognition of the role of nonmalignant cells as cancer re- lators was the recognition that lymphocytes can participate in what was termed “immune surveillance” in the 1960s. Our understanding of tumor immunity has improved markedly since then, and there are now successful clinical studies sh- ing the potential use of immune-based therapies in cancer treatment.
Book Synopsis Tumor Microenvironment by : Alexander Birbrair
Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-04-07 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on the extracellular matrix components of the tumor during cancer development. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include heparan sulphate, hyaluronan, fibronectin, perlecan, glypican, matrix metalloproteinases, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Extracellular Matrix Components – Part A updates us on what we know about the different aspects of the tumor microenvironment, as well as apprises us on the future advances in the field. For the newest generation of researchers, this volume serves as a useful introduction to the history of scientists’ focus on the tumor microenvironment, and explores how this knowledge is currently applied in cancer treatments. The book is an essential text for advanced cell biology and cancer biology students, as well as for scientists seeking an update on the developments in tumor microenvironment research. All of the chapter authors are renowned international experts in the field of cancer biology, and in the specific subfields that are the focus of their chapters.
Book Synopsis Systems Biology of Tumor Microenvironment by : Katarzyna A. Rejniak
Download or read book Systems Biology of Tumor Microenvironment written by Katarzyna A. Rejniak and published by Springer. This book was released on 2016-10-13 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume discusses the complexity of tumor microenvironments during cancer development, progression and treatment. Each chapter presents a different mathematical model designed to investigate the interactions between tumor cells and the surrounding stroma and stromal cells. The topics covered in this book include the quantitative image analysis of a tumor microenvironment, the microenvironmental barriers in oxygen and drug delivery to tumors, the development of tumor microenvironmental niches and sanctuaries, intravenous transport of the circulating tumor cells, the role of the tumor microenvironment in chemotherapeutic interventions, the interactions between tumor cells, the extracellular matrix, the interstitial fluid, and the immune and stromal cells. Mathematical models discussed here embrace both continuous and agent-based approaches, as well as mathematical frameworks of solid mechanics, fluid dynamics and optimal control theory. The topics in each chapter will be of interest to a biological community wishing to apply the mathematical methods to interpret their experimental data, and to a biomathematical audience interested in exploring how mathematical models can be used to address complex questions in cancer biology.
Book Synopsis The Extracellular Matrix and the Tumor Microenvironment by : Ilona Kovalszky
Download or read book The Extracellular Matrix and the Tumor Microenvironment written by Ilona Kovalszky and published by Springer Nature. This book was released on 2022-07-06 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces the most important and best studied extracellular and pericellular molecules of the tumor microenvironment. It gives a comprehensive overview of their role in tumor development and cancer progression. Twelve chapters deal with the biochemical and biophysical background of extracellular matrix (ECM) changes in the tumor stroma compared to the physiological state. The reader learns about the major ECM components that are deregulated during cancer development and how they are associated with cancer progression associated with survival, inflammation process, among others. These are followed by recent data about the cooperative activity of extracellular matrix in tumor metabolism, promoting cancer progression. Two chapters focus specifically on the critical role of the ECM in tumor angiogenesis, linking this process to cellular infiltration and metastatic behavior of tumors. The final part describes how the ECM influences the success of immuno- and chemotherapy in cancer patients, its potential as biomarkers for diagnosis, prognosis, and therapeutic target, as well as the mechanism of resistance-associated changes in the ECM. This book is an interesting read for anyone who want to know more about ECM and cancer biology. Early career scientists can use it as an introduction to the field, offering an excellent tool for studying ECM. Advanced researchers and clinicians can gain a broader overview of the subject, considering the role of ECM for influencing every cancer hallmark as well as in the response of cancer treatments. The work serves to inspire future research and shows that the ECM should be considered as an important factor in the development of cancer therapeutics. The series "Biology of Extracellular Matrix" is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
Book Synopsis Tumor Microenvironment by : Alexander Birbrair
Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-10-29 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include eosinophils, NK cells, γδ T cells, regulatory T Cells, Langerhans cells, hematopoietic stem cells, Mast cells, B cells and Microglia, and more. Taken alongside its companion volumes, Tumor Microenvironment: Hematopoietic Cells – Part B updates us on what we know about various aspects of the tumor microenvironment as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
Book Synopsis Tumor Microenvironment by : Alexander Birbrair
Download or read book Tumor Microenvironment written by Alexander Birbrair and published by Springer Nature. This book was released on 2020-10-29 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including Src, Neuregulin, Adenosine, TGFβ, Androgen, Wnt, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways – Part B is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.
