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Author : Sara Elizabeth Perlaky
Publisher :
ISBN 13 :
Total Pages : 264 pages
Book Rating : 4.:/5 (399 download)
Download or read book Translational Control Mechanisms in Drosophila written by Sara Elizabeth Perlaky and published by . This book was released on 1998 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 008091196X
Total Pages : 437 pages
Book Rating : 4.0/5 (89 download)
Download or read book Translational Control in Health and Disease written by and published by Academic Press. This book was released on 2009-10-26 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology and translational science. It contains contributions from leaders in their fields and abundant references. This volume focuses on translational control in health and disease. - Contributions from leading scholars and industry experts - Reference guide for researchers involved in molecular biology and related fields
Author : J. Ilan
Publisher : Springer Science & Business Media
ISBN 13 : 1461528941
Total Pages : 508 pages
Book Rating : 4.4/5 (615 download)
Download or read book Translational Regulation of Gene Expression 2 written by J. Ilan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, which results from the dramatic increase in interest in the control mechanism employed in gene expression and the importance of the regulated proteins, presents new information not covered in Translational Regulation of Gene Expression, which was published in 1987. It is not a revision of the earlier book but, rather, an extension of that volume witl, special emphasis on mecha nIsm. As the reader will discover, there is enormous diversity in the systems employing genes for translational regulation in order to regulate the appearance of the final product-the protein. Thus, we find that important proteins such as protooncogenes, growth factors, stress proteins, cytokines, lymphokines, iron storage and iron-uptake proteins, and a panorama of prokaryotic proteins, as well as eukaryotic viral proteins, are translationally regulated. Since for some gene products the degree of control is greater by a few orders of magnitude than their transcription, we can state that for these genes, at least, the expression is translationall y controlled. Translational regulation of gene expression in eukaryotes has emerged in the last few years as a major research field. The present book describes mechanisms of translational regulation in bacteria, yeast, and eukaryotic viruses, as well as in eukaryotic genes. In this book we try to provide in-depth coverage by including important examples from each group rather than systematically including all additional systems not described in the previous volume.
Author : Matthew Peter Scott
Publisher :
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.:/5 (77 download)
Download or read book Translational Control of Protein Synthesis in Drosophila written by Matthew Peter Scott and published by . This book was released on 1980 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nahum Sonenberg
Publisher : CSHL Press
ISBN 13 : 9780879696184
Total Pages : 1034 pages
Book Rating : 4.6/5 (961 download)
Download or read book Translational Control of Gene Expression written by Nahum Sonenberg and published by CSHL Press. This book was released on 2001 with total page 1034 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the 1996 publication of Translational Control, there has been fresh interest in protein synthesis and recognition of the key role of translation control mechanisms in regulating gene expression. This new monograph updates and expands the scope of the earlier book but it also takes a fresh look at the field. In a new format, the first eight chapters provide broad overviews, while each of the additional twenty-eight has a focus on a research topic of more specific interest. The result is a thoroughly up-to-date account of initiation, elongation, and termination of translation, control mechanisms in development in response to extracellular stimuli, and the effects on the translation machinery of virus infection and disease. This book is essential reading for students entering the field and an invaluable resource for investigators of gene expression and its control.
Author : Joseph Ilan
Publisher : Springer
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.3/5 (91 download)
Download or read book Translational Regulation of Gene Expression written by Joseph Ilan and published by Springer. This book was released on 1987 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jonathan D. Dinman
Publisher : Springer Science & Business Media
ISBN 13 : 1461439906
Total Pages : 325 pages
Book Rating : 4.4/5 (614 download)
Download or read book Biophysical Approaches to Translational Control of Gene Expression written by Jonathan D. Dinman and published by Springer Science & Business Media. This book was released on 2012-07-27 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights major advances in researching a cell’s molecular machinery through analytical, computational, and imaging methods. It focuses on developing biophysical approaches to studying control of gene expression at the translational level.
Author : Michael Mathews
Publisher : CSHL Press
ISBN 13 : 0879697679
Total Pages : 932 pages
Book Rating : 4.8/5 (796 download)
Download or read book Translational Control in Biology and Medicine written by Michael Mathews and published by CSHL Press. This book was released on 2007 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this successful monograph has been both updated and broadened. Since the previous (second) edition was published in 2000, the structures of the bacterial and eukaryotic ribosomes have been published, advancing our basic understanding of translation and mechanisms involving protein and RNA regulators. In addition, as the title indicates, this edition has a new focus on the role of translational control in human development and disease. This book, with 30 chapters written by experts in the field, is essential reading for anyone interested in the process of translation, its regulation, and how its failure can be the cause of disease.
Author : Meryl Nelson
Publisher :
ISBN 13 : 9780494580615
Total Pages : 278 pages
Book Rating : 4.5/5 (86 download)
Download or read book Translational Regulation in the Early Drosophila Embryo written by Meryl Nelson and published by . This book was released on 2008 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational regulation is an important mechanism for regulating gene expression. Regulation of specific transcripts is often mediated by elements present in the 3' untranslated region (UTR) of the mRNA. In the Drosophila embryo, translational repression of nanos mRNA is mediated by Smaug protein bound to specific sequences present in the 3' UTR of the mRNA. Here I show that Smaug recruits Cup protein to the mRNA and that Cup in turn binds to the translation initiation factor eIF4E that is present at the 5'. The interaction between Cup and eIF4E prevents formation of a productive translation initiation complex on the mRNA. Therefore, Smaug-dependent translational repression functions at the initiation step via the indirect interaction of Smaug with eIF4E, which is mediated by Cup. In the second example of translational regulation presented here, I show that an element present in the 3' untranslated region of the Hsp83 mRNA mediates translational enhancement in the Drosophila embryo. I have identified three proteins, Hrp48, DDP1 and PABP that interact with this element and have demonstrated that Hrp48 and DDP1 function in translational enhancement.
Author : Eric Jan
Publisher : Biota Publishing
ISBN 13 : 1615046313
Total Pages : 106 pages
Book Rating : 4.6/5 (15 download)
Download or read book Protein Translation written by Eric Jan and published by Biota Publishing. This book was released on 2014-05-01 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein synthesis is a fundamental aspect of gene expression across kingdoms. The regulation of translation is important for many biological processes including cell fate determination, development, and growth and is especially crucial to maintain cellular homeostasis during cellular stress and virus infection. Misregulation of protein translation can contribute to diseases such as diabetes, cancer, and neurodegenerative diseases. In this chapter, we highlight the basic understanding of eukaryotic translation and the major regulations that control biological events. We focus on signaling pathways that regulate overall protein synthesis and also mechanisms that control translation of specific mRNAs such as cis-acting elements within the 5' and 3 untranslated regions (UTR). Understanding these mechanisms provide insights into the fundamental gene regulations that may provide new targets for combating disease and virus infections.
Author : Marshal Evan Lieberfarb
Publisher :
ISBN 13 :
Total Pages : 280 pages
Book Rating : 4.:/5 (372 download)
Download or read book Translational Control in Drosophila Development written by Marshal Evan Lieberfarb and published by . This book was released on 1996 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yingshi Peng
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.4/5 (64 download)
Download or read book Probing Translational Control During Drosophila Oogenesi written by Yingshi Peng and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational control provides a key mechanism for the spatial and temporal regulation of eukaryotic gene expression. It plays a particularly important role in early embryonic development in organisms that rely heavily on maternally supplied mRNAs. The Drosophila developing oocyte serves as a valuable model for studying translational control. The Drosophila posterior determinant, nanos (nos), is translationally repressed throughout the oocyte cytoplasm except at the posterior pole. A multi-functional RNA-binding protein Glorund (Glo), the homolog of the mammalian hnRNP F/H family of proteins, represses translation of nos during oogenesis by targeting both translation initiation and translation elongation. To elucidate the molecular mechanism by which Glo regulates nos, I identified dFMRP as a Glo-interacting protein. By biochemically dissecting repression of nos translation in vitro, I demonstrated that dFMRP specifically inhibits translation elongation. Furthermore, I combined mutational analysis and in vivo and in vitro binding assays to show that Glo's qRRM2 domain specifically and directly interacts with dFMRP, suggesting that Glo's RNA-binding domains can also function as protein-protein interaction interfaces critical for its regulatory functions. Additionally, I applied ribosome footprint profiling to the Drosophila ovary at different developmental stages to identify maternal transcripts regulated during the translation elongation phase. A footprint peak-finding tool has been developed to detect transcriptome-wide ribosome stalling sites. My preliminary results suggest that developmentally regulated ribosome stalling sites may be widely present on Drosophila maternal transcripts. An A-/P-site mapping algorithm is currently under development to facilitate mechanistic analysis of ribosome stalling during oogenesis.
Author : Christopher Carter Wreden
Publisher :
ISBN 13 :
Total Pages : 262 pages
Book Rating : 4.:/5 (388 download)
Download or read book Translational Regulation of Drosophila Maternal Messenger RNAs written by Christopher Carter Wreden and published by . This book was released on 1997 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael B. Mathews
Publisher :
ISBN 13 : 9781621821861
Total Pages : 499 pages
Book Rating : 4.8/5 (218 download)
Download or read book Translation Mechanisms and Control written by Michael B. Mathews and published by . This book was released on 2018-09-30 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: A subject collection from Cold Spring Harbor Perspectives in Biology.
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Author : Ramona L. (Ramona Leigh) Cooperstock
Publisher : National Library of Canada = Bibliothèque nationale du Canada
ISBN 13 : 9780612918771
Total Pages : 414 pages
Book Rating : 4.9/5 (187 download)
Download or read book Mechanisms of Transcript Regulation in the Early Drosophila Embryo [microform] : Degradation, Localization and Translational Regulation written by Ramona L. (Ramona Leigh) Cooperstock and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 2002 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yan Song
Publisher :
ISBN 13 : 9780549084921
Total Pages : 172 pages
Book Rating : 4.0/5 (849 download)
Download or read book Localization and Translational Regulation of Nanos MRNA in Drosophila Embryos written by Yan Song and published by . This book was released on 2006 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taken together, I propose that posterior anchoring of nos mRNA in the oocyte is dependent of Hsp90, LKB1 and the 798 gene products. Upon its localization, translation of nos is activated partially through a structural switch of its 3'UTR.
Author : Richard She
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)
Download or read book Post-translational Control of Twine Triggers the End of the Maternal Cell Cycle Program in Drosophila written by Richard She and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
