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Author : Ganes C. Sen
Publisher : R G Landes Company
ISBN 13 : 9781570595011
Total Pages : 174 pages
Book Rating : 4.5/5 (95 download)
Download or read book Transcriptional Regulation in the Interferon System written by Ganes C. Sen and published by R G Landes Company. This book was released on 1997-01-01 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hannah Anh-Quan Nguyen
Publisher :
ISBN 13 :
Total Pages : 460 pages
Book Rating : 4.:/5 (427 download)
Download or read book Regulation of Gene Expression and Cell Growth by Transcriptional Proteins of the Interferon System written by Hannah Anh-Quan Nguyen and published by . This book was released on 1998 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The Interferon Regulatory Factors (IRFs) are a family of interferon-inducible proteins which play distinct roles in diverse processes such as pathogen response, cytokine signalling, cell growth regulation and hematopoietic development. The objective of this research was to investigate the mechanisms by which IRF-1 and IRF-2 regulate gene expression and cell growth. Structure-function analyses of the IRF-2 protein demonstrate that transcriptional repression by IRF-2 is contained within the first 125 N-terminal amino acids and correlates directly with IRF-2 DNA binding. Overexpression of functional IRF-2 deletion mutant proteins in NIH3T3 cells results in oncogenic transformation and tumorigenesis, suggesting that IRF-2 oncogenicity correlates directly with transcriptional repression. Similar structure-function analyses localize IRF-1 transactivation to the C-terminus. Like IRF-1, hybrid constructs which fuse the DNA binding domain of IRF-1 and IRF-2 to the transactivation domain of NF-kappaB RelA(p65) are transcriptional activators. Inducible expression of IRF-1 and IRF/RelA in NIH3T3 cells results in reduced cellular growth and induction of apoptosis. Furthermore, expression of the PKR, STAT1(p91), and WAF1 growth regulatory proteins are elevated following induction of IRF-1 or IRF/RelA, correlating transactivation function and tumor suppressor activity of IRF-1 or IRF/RelA. By RNA fingerprinting, the secretory leukocyte protease inhibitor (SLPI) was identified as the first gene whose expression is downregulated by IRF-1 or IRF-1/RelA. A region in the SLPI promoter was identified that bound IRF-1, suggesting a direct mechanism for IRF-1 regulation of SLPI expression." --
Download or read book Regulation of Gene Expression and Cell Growth by Transcriptional Proteins of the Interferon System written by and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : E. M. DeMaeyer
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 472 pages
Book Rating : 4.3/5 (91 download)
Download or read book Interferons and Other Regulatory Cytokines written by E. M. DeMaeyer and published by Wiley-Interscience. This book was released on 1988 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a presentation of the state-of-knowledge of interferons (IFNs) providing a synthetic overview of the role and significance of IFNs in health and disease. Treatment is placed in a broad biological context including much up-to-date background information on the different systems (eg oncogenes or T cell function) that are under the influence of IFNs. This approach makes the book accessible to those not directly involved in IFN research. Coverage also includes other cytokines, such as tumor necrosis factor alpha and beta, and the various interleukins.
Author : Junming Yie
Publisher :
ISBN 13 :
Total Pages : 318 pages
Book Rating : 4.:/5 (449 download)
Download or read book Transcriptional Regulation of the Interferon-beta Gene written by Junming Yie and published by . This book was released on 1999 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 4 pages
Book Rating : 4.:/5 (474 download)
Download or read book Den rigtige Haandværker-Tidende written by and published by . This book was released on 1887 with total page 4 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nicholas J. MacDonald
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (181 download)
Download or read book Transcriptional Regulation of the Interferon Genes written by Nicholas J. MacDonald and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Daniel Solomon Kessler
Publisher :
ISBN 13 :
Total Pages : 260 pages
Book Rating : 4.:/5 (38 download)
Download or read book Signal Transduction and Transcriptional Regulation in the Response to Type I Interferon written by Daniel Solomon Kessler and published by . This book was released on 1990 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Athanasios Mavropoulos
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (499 download)
Download or read book Post-transcriptional Regulation of Interferon-β Gene Expression written by Athanasios Mavropoulos and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)
Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.
Author : Andrew T. Parsa
Publisher :
ISBN 13 :
Total Pages : 286 pages
Book Rating : 4.:/5 (351 download)
Download or read book Transcriptional Regulation of the Interferon Responsive Gene BS4 written by Andrew T. Parsa and published by . This book was released on 1995 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Karen Sue Gustafson
Publisher :
ISBN 13 :
Total Pages : 404 pages
Book Rating : 4.:/5 (352 download)
Download or read book Transcriptional Regulation of HLA-E Gene Expression by Interferon Gamma written by Karen Sue Gustafson and published by . This book was released on 1996 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Andreas Sailer
Publisher :
ISBN 13 :
Total Pages : 119 pages
Book Rating : 4.:/5 (165 download)
Download or read book Transcriptional Regulation of the Interferon Genes written by Andreas Sailer and published by . This book was released on 1992 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David Maxwell Barrett
Publisher :
ISBN 13 :
Total Pages : 258 pages
Book Rating : 4.:/5 (522 download)
Download or read book Transcriptional Regulation of HLA-E by Interferon-gamma written by David Maxwell Barrett and published by . This book was released on 2003 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Hongkang Xi
Publisher :
ISBN 13 :
Total Pages : 244 pages
Book Rating : 4.:/5 (48 download)
Download or read book Transcriptional Regulation of Class II Transactivator by Interferon Regulatory Factor-2 written by Hongkang Xi and published by . This book was released on 2001 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ken Ishii
Publisher : Academic Press
ISBN 13 : 0124051685
Total Pages : 369 pages
Book Rating : 4.1/5 (24 download)
Download or read book Biological DNA Sensor written by Ken Ishii and published by Academic Press. This book was released on 2013-10-30 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class experts Ideal source of information for those wanting to learn about DNA sensing Provides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them
Author : Christophe Heylbroeck
Publisher :
ISBN 13 :
Total Pages : 216 pages
Book Rating : 4.:/5 (974 download)
Download or read book Regulation of Cytokines Gene Activation in Virus Infected Cells by Interferon Regulatory Factor 3 written by Christophe Heylbroeck and published by . This book was released on 1999 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
