Toxicology Of Perfluorodecanoic Acid

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Toxicology of Perfluorodecanoic Acid

Author :
Publisher :
ISBN 13 :
Total Pages : 17 pages
Book Rating : 4.:/5 (227 download)

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Book Synopsis Toxicology of Perfluorodecanoic Acid by :

Download or read book Toxicology of Perfluorodecanoic Acid written by and published by . This book was released on 1990 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite hypothyroxinemia, PFDA-treated rats are not functionally hypothyroid. Furthermore, any alteration in functional thyroid status can be dissociated from the overt toxicity (i.e., severe hypophagia and body weight loss). PFDA exerts effects on neutral lipid metabolism in both liver and carcass of the rat. At 7 days following a single administration of PFDA, hepatic esterification of free fatty acid into TG and CE was increased yet the expected augmentation in the export of these neutral lipids from liver into plasma was absent. An efficient chemical method was developed for the purification of commercially available PFDA that contains contaminants of mono- and diprotio-substituted materials. PFDA of high specific activity has been synthesized with 14 C-labeling in the C-1 position. In vivo experiments indicate that perfluorinated acid derived radioactivity found in rat tissues behaves similarly to PFDA or PFOA added directly to frozen rat tissue. Hepatic oxidation of long-chain medium-chain and short-chain fatty acids was unaffected by pretreatment with PFDA or PFOA. Similarly, esterification was not affected.

The Toxicology of Perfluorodecanoic Acid in Rodents

Author : Carl T. Olson
Publisher :
ISBN 13 :
Total Pages : 17 pages
Book Rating : 4.:/5 (228 download)

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Book Synopsis The Toxicology of Perfluorodecanoic Acid in Rodents by : Carl T. Olson

Download or read book The Toxicology of Perfluorodecanoic Acid in Rodents written by Carl T. Olson and published by . This book was released on 1983 with total page 17 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perfluoro-n-decanoic acid or nonadecafluoro-n-decanoic acid (NDFDA) is a straight chain, perfluorinated, ten-carbon acid. Experiments were conducted to determine the LD50 and to evaluate survival times of rats after single intraperitoneal (IP) injections of NDFDA or of Fluorooctanoic acid (PFOA), the shorter-chain analog, dissolved in propylene glycol/water (1:1, v:v). Ten male Fischer 344 rats were used in each dose group and an additional 10 rats were used in each dose group and an additional 10 rats were given 2 mL/kg propylene glycol/water, the same dosing volume used with all experimental animals. With NDFDA, the LD50/14 days was 63.6 mg/kg, and the LD50/30 days was 41.4 mg/kg. With PFOA, there was no mortality after the 5th day following injection, and both the LD50/14 and LD50/30 were 188.7 mg/kg.

NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats

Download NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (115 download)

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Book Synopsis NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats by :

Download or read book NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats written by and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Revised)

Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (135 download)

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Download or read book NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage to Sprague Dawley (Hsd:Sprague Dawley SD) Rats (Revised) written by and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (115 download)

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Download or read book NTP Technical Report on the Toxicity Studies of Perfluoroalkyl Carboxylates (Perfluorohexanoic Acid, Perfluorooctanoic Acid, Perfluorononanoic Acid, and Perfluorodecanoic Acid) Administered by Gavage written by and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances

Author : Jamie C. DeWitt
Publisher : Humana Press
ISBN 13 : 3319155180
Total Pages : 500 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances by : Jamie C. DeWitt

Download or read book Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances written by Jamie C. DeWitt and published by Humana Press. This book was released on 2015-04-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as a timely and comprehensive overview of the latest science for perfluoroalkyl and polyfluoroalkyl substances (PFASs), covering the development of methods for assessing PFASs in biological fluids and tissues as well as the current knowledge regarding their toxicity to vertebrate organisms. This book includes chapters on human and wildlife exposure/body burdens, reviews of metabolism and toxicological effects by organ system/developmental stage and aspects of PFAS toxicity that are driving PFAS research and regulatory oversight. Toxicological Effects of Perfluoroalkyl and Polyfluoroalkyl Substances provide critical assessments of the most controversial topics surrounding toxicological evaluation of PFASs to give readers an expert perspective on the issues. Emphasis is placed on the integration of modes and mechanisms of action with functional endpoints that are relevant to human and wildlife health. This book will be a useful resource for toxicologists, environmental chemists, risk assessors and researchers with an interest in the class of compounds known as perfluoroalkyl and polyfluoroalkyl substances.

Environmental Forensics for Persistent Organic Pollutants

Author : Gwen O'Sullivan
Publisher : Newnes
ISBN 13 : 0444594515
Total Pages : 424 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Environmental Forensics for Persistent Organic Pollutants by : Gwen O'Sullivan

Download or read book Environmental Forensics for Persistent Organic Pollutants written by Gwen O'Sullivan and published by Newnes. This book was released on 2013-11-20 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Forensics for Persistent Organic Pollutants represents the state-of-the-art in environmental forensics in relation to persistent organic pollutants (POPs). The book is a complete reference for practitioners and students, covering a range of topics from new analytical techniques to regulatory and legal status in the global community. Through case studies from leading international experts, real-world issues — including the allocation of responsibility for release into the environment — are resolved through the application of advanced analytical and scientific techniques. This book introduces and assesses the development of new techniques and technologies to trace the source and fate of newly emerging and classic POPs (perfluoroalkyl substances, brominated flame retardants, organochlorine pesticides, perfluorinated chemicals, polycyclic aromatic hydrocarbons, and polychlorinated biphenyls) in environmental media, including atmospheric, marine, freshwater, and urban environments. Real-world case studies show the application of advanced analytical and scientific techniques Discussion of GC*GC provides an introduction and assessment of a novel technique from leaders in the field Introduces the development of new analytical techniques (such as 2-D GC*HC and LC*LC) to trace the source and fate Raises awareness about the health and environmental impact of persistent organic pollutants (POPs) Outlines the development of international measures to control POPs so that chemists can understand the legal issues

Hepatic Toxicity of Perfluorocarboxylic Acids

Author :
Publisher :
ISBN 13 :
Total Pages : 11 pages
Book Rating : 4.:/5 (227 download)

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Book Synopsis Hepatic Toxicity of Perfluorocarboxylic Acids by :

Download or read book Hepatic Toxicity of Perfluorocarboxylic Acids written by and published by . This book was released on 1996 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt: This AASERF grant has provided support for two graduate students in the Biomedical Sciences Ph. D. Program at Wright State University, Dayton, OH. A Ph. D. degree was conferred in 1994 to C. Goecke- Flora, while the other student, M. Adinehzadeh, currently continues in the program. These students were provided a stipend, a nominal budget for research supplies, and travel funds which enabled them to present their data at national scientific conferences. The students utilized nuclear magnetic resonance techniques in toxicology research concerning peroxisome proliferators (PPs). This work has culminated in five publications and eight published abstracts. PPs are a diverse series of chemicals with various commercial and Air Force applicabilities. Perfluorocarboxylic acids and various other halocarbons, for instance, are useful as nonflammable solvents, lubricants, and degreasers. Our research has shown that the berfluorocarboxylic acids are not metabolized, yet they produce significant effects on liver carbohydrate and phospholipid metabolism. Perfluorodecanoic acid, in particular, enhances the biosynthesis of liver phosphatidylcholine (PC), causes a significant increase in phosphocholine and diacylglycerol, and inhibits the major de novo pathway for the synthesis of PC. These data suggest that other pathways of phospholipid metabolism are activated following treatment with these PPs. Such effects may alter cellular signaling processes and help to explain the hepatotoxicity and carcinogenicity associated with these compounds.

The Acute Toxicity of Perfluorooctanoic and Perfluorodecanoic Acids in Male Rats and Effects on Tissue Fatty Acids

Author : C. T. Olson
Publisher :
ISBN 13 :
Total Pages : 9 pages
Book Rating : 4.:/5 (227 download)

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Book Synopsis The Acute Toxicity of Perfluorooctanoic and Perfluorodecanoic Acids in Male Rats and Effects on Tissue Fatty Acids by : C. T. Olson

Download or read book The Acute Toxicity of Perfluorooctanoic and Perfluorodecanoic Acids in Male Rats and Effects on Tissue Fatty Acids written by C. T. Olson and published by . This book was released on 1983 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Determination of Hepatotoxicity by the Peroxisome Proliferators Perfluorodecanoic Acid (PFAD) and Ciprofibrate in Female Sprague Dawley Rats

Download Determination of Hepatotoxicity by the Peroxisome Proliferators Perfluorodecanoic Acid (PFAD) and Ciprofibrate in Female Sprague Dawley Rats PDF Online Free

Author : Hui Chen
Publisher :
ISBN 13 :
Total Pages : 230 pages
Book Rating : 4.:/5 (283 download)

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Book Synopsis Determination of Hepatotoxicity by the Peroxisome Proliferators Perfluorodecanoic Acid (PFAD) and Ciprofibrate in Female Sprague Dawley Rats by : Hui Chen

Download or read book Determination of Hepatotoxicity by the Peroxisome Proliferators Perfluorodecanoic Acid (PFAD) and Ciprofibrate in Female Sprague Dawley Rats written by Hui Chen and published by . This book was released on 1991 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mammalian Toxicology

Author : Mohamed Abou-Donia
Publisher : John Wiley & Sons
ISBN 13 : 1119940419
Total Pages : 716 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Mammalian Toxicology by : Mohamed Abou-Donia

Download or read book Mammalian Toxicology written by Mohamed Abou-Donia and published by John Wiley & Sons. This book was released on 2015-05-04 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammalian Toxicology surveys chemical agents and examines how such chemicals impact on human health, emphasizing the importance in minimizing environmental exposure to chemical and physical hazards in our homes, communities and workplaces through such media as contaminated water, soil and air. Starting with the basic principles on a wide range of toxic agents, this textbook describes how they enter the body, their mechanisms of action once inside, and strategies for diagnosis, prevention and treatment. Topics covered include: General principles of toxicology: pharmacological and toxicological principles underpinning the study of toxicology, risk assessments and mechanisms of cell death Disposition: routes of chemical exposures, entry into the body and various tissues, storage, metabolic biotransformation and elimination, with examples from various toxicants. Toxic agents: the occurrences, disposition in the body, health effects, toxic mechanisms, antidotes and treatments of a range of agents including pesticides, metals, solvents, gases, nanomaterials, food components and additives, pharmaceuticals, drugs of abuse, natural toxins, endocrine disruptors, radiation, and warfare weapons. Toxic effects: including neurotoxicity, developmental toxicity, immunotoxicity, teratogenecity, male and female reproductive toxicity, mutagenecity, carcinogenicity, pulmonary toxicity, cardiovascular toxicity, hepatotoxicity, gastrointestinal toxicity and cardiovascular toxicity Toxicology and society: epidemiological studies of chemical-induced diseases in human populations, and a vision for toxicology in the 21st century. Mammalian Toxicology is an essential primer for students of toxicology, biochemistry, biology, medicine and chemistry. It is also appropriate for professional toxicologists in research or regulatory affairs, and anyone who needs to understand the adverse effects of toxic agents on the human body.

Per and polyfluorinated substances in the Nordic Countries

Author : Stefan Posner
Publisher : Nordic Council of Ministers
ISBN 13 : 9289325623
Total Pages : 230 pages
Book Rating : 4.2/5 (893 download)

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Book Synopsis Per and polyfluorinated substances in the Nordic Countries by : Stefan Posner

Download or read book Per and polyfluorinated substances in the Nordic Countries written by Stefan Posner and published by Nordic Council of Ministers. This book was released on 2013-06-19 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Tema Nord report presents a study based on open information and custom market research to review the most common perfluorinated substances (PFC) with less focus on PFOS and PFOA. The study includes three major parts:1) Identification of relevant per-and polyfluorinated substances and their use in various industrial sectors in the Nordic market by interviews with major players and database information; 2) Emissions to and occurence in the Nordic environment of the substances described in 1); 3) A summary of knowledge of the toxic effects on humans and the environment of substances prioritized in 2); There is a lack of physical chemical data, analystical reference substances, human and environmental occurrence and toxicology data, as well as market information regarding PFCs other than PFOA and PFOS and the current legislation cannot enforce disclosure of specific PFC substance information.

Comparative toxicity of halogenated hydrocarbons

Author : Gordon G. Gibson
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (556 download)

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Book Synopsis Comparative toxicity of halogenated hydrocarbons by : Gordon G. Gibson

Download or read book Comparative toxicity of halogenated hydrocarbons written by Gordon G. Gibson and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Contamination of Water

Author : Arif Ahamad
Publisher : Elsevier
ISBN 13 : 0128240598
Total Pages : 614 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Contamination of Water by : Arif Ahamad

Download or read book Contamination of Water written by Arif Ahamad and published by Elsevier. This book was released on 2021-08-06 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Water containing significant amounts of inorganic and organic contaminants can have serious environmental consequences and serious health implications when ingested. Contamination of Water: Health Risk Assessment and Treatment Strategies takes an interconnected look at the various pollutants, the source of contamination, the effects of contamination on aquatic ecosystems and human health, and what the potential mitigation strategies are. This book is organized into three sections. The first section examines the sources of potential contamination. This includes considering the current scenario of heavy metal and pesticide contamination in water as well as the regions impacted due to industrialization, mining, or urbanization. The second section goes on to discuss water contamination and health risks caused by toxic elements, radiological contaminants, microplastics and nanoparticles, and pharmaceutical and personal care products. This book concludes with a section exploring efficient low-cost treatment technologies and remediation strategies that remove toxic pollutants from water. Contamination of Water incorporates both theoretical and practical information that will be useful for researchers, professors, graduate students, and professionals working on water contamination, environmental and health impacts, and the management and treatment of water resources. Provides practical case studies of various types and sources of contamination Discusses inorganic and organic contaminants and their impact on human health Evaluates effective water treatment and remediation technologies to remove toxins from water and minimize risk

Mixture Toxicity

Author : Cornelis A. M. van Gestel
Publisher : CRC Press
ISBN 13 : 1439830096
Total Pages : 312 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Mixture Toxicity by : Cornelis A. M. van Gestel

Download or read book Mixture Toxicity written by Cornelis A. M. van Gestel and published by CRC Press. This book was released on 2016-04-19 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade and a half, great progress has been made in the development of concepts and models for mixture toxicity, both in human and environmental toxicology. However, due to their different protection goals, developments have often progressed in parallel but with little integration. Arguably the first book to clearly link ecotoxicology an

The cost of inaction

Author : Gretta Goldenman
Publisher : Nordic Council of Ministers
ISBN 13 : 9289360658
Total Pages : 194 pages
Book Rating : 4.2/5 (893 download)

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Book Synopsis The cost of inaction by : Gretta Goldenman

Download or read book The cost of inaction written by Gretta Goldenman and published by Nordic Council of Ministers. This book was released on 2019-03-17 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: PFAS (per and polyfluoroalkylsubstances) are known to be extremely difficult to degrade in the environment and to be bioaccumulative and toxic. Exposure to PFAS is suspected to increase the risk of adverse health effects, such as impacts on the thyroid gland, the liver, fat metabolism and the immune system. This study estimates the socioeconomic costs that may result from impacts on human health and the environment from the use of PFAS. Better awareness of the costs and problems associated with PFAS exposure will assist decision-makers and the general public to make more efficient and timely risk management decisions. Findings indicate that the costs are substantial, with annual health-related costs estimated to 2.8 – 4.6 billion EUR for the Nordic countries and 52 – 84 billion EUR for all EEA countries. Overall non-health costs are estimated at 46 million – 11 billion EUR for the Nordic countries.Upon request the excel spreadsheets used for the monetarisation and valuation in this report can also be provided along with a guidance on how to use the estimation of costs for value transfer. Please contact any of the consultants or members of the steering group from the Swedish Chemicals Agency or the Danish Environmental Protection Agency if you are interested in receiving these excel spreadsheets.

Toxicological Profile for Perfluoroalkyls

Author :
Publisher :
ISBN 13 :
Total Pages : 412 pages
Book Rating : 4.:/5 (9 download)

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Book Synopsis Toxicological Profile for Perfluoroalkyls by :

Download or read book Toxicological Profile for Perfluoroalkyls written by and published by . This book was released on 2009 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This toxicological profile for perfluoroalkyls was prepared consistent with guidelines developed by the Agency for Toxic Substances and Disease Registry (ATSDR) and the Environmental Protection Agency (EPA) for the preparation of toxicological profiles. The original guidelines were published in the Federal Register on April 17, 1987. While Perfluoroalkyls are not found on the ATSDR list of Priority Hazardous Substances, ATSDR has determined that a profile for these substances was necessary because data indicate that some perfluoroalkyls are found in the blood of the U.S. general population and in the environment. The agency also determined that it was important to characterize the current available information regarding the health effects from exposure in order to support and inform public health responses and activities by ATSDR and other." -- p. v