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Author : Zaven Ovanesyan
Publisher :
ISBN 13 :
Total Pages : 116 pages
Book Rating : 4.:/5 (699 download)
Download or read book Towards Depth-resolved Fluorescence Guided Neurosurgery written by Zaven Ovanesyan and published by . This book was released on 2010 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Constantinos G. Hadjipanayis
Publisher : Thieme
ISBN 13 : 1626237158
Total Pages : 376 pages
Book Rating : 4.6/5 (262 download)
Download or read book Fluorescence-Guided Neurosurgery written by Constantinos G. Hadjipanayis and published by Thieme. This book was released on 2018-08-16 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive textbook on state-of-the-art fluorescence-guided neurosurgery Advances in fluorescence-guided surgery (FGS) have resulted in a paradigm shift in neurosurgical approaches to neuro-oncological and cerebrovascular pathologies. Edited by two of the foremost authorities on the topic, Fluorescence-Guided Neurosurgery: Neuro-oncology and Cerebrovascular Applications encompasses the depth and breadth of this groundbreaking, still nascent technology. The book reflects significant contributions made by world renowned neurosurgeons Constantinos Hadjipanayis, Walter Stummer, and esteemed contributors on the growing uses of 5-aminolevulinic acid (5-ALA) and other FGS agents. The European Medicine Agency approved 5-ALA in 2007, heralding the birth of FGS globally. In 2017, the U.S. Food and Drug Administration approved 5-ALA (Gleolan) as an imaging agent to facilitate realtime detection and visualization of malignant tissue during glioma surgery. In the two decades since Dr. Stummer's initial description of 5-ALA FGS in a human patient, major strides have been made in its practical applications, leading to improved resection outcomes. As FGS is increasingly incorporated into neurosurgical practice, it holds promise for future innovations. Generously-illustrated and enhanced with online videos, this textbook is the definitive resource on the subject. Key Features The improved efficacy of 5-ALA for resecting high- and low-grade gliomas, recurrences, meningiomas, brain metastases, spinal cord tumors, pediatric brain tumors, and other adult tumors The future of fluorescence, including potentially powerful new fluorophores molecularly targeted specifically to tumors The use of the fluorescent agent indocyanine green (ICG) for brain tumors, cerebral aneurysms, AVMs, and cerebral vascularization Special topics such as fluorescein, illuminating tumor paint, confocal microscopy, Raman spectroscopy, and integrating FGS with intraoperative imaging and brain mapping This single accessible reference presents the current state-of-the-art on this emerging, exciting surgical technology. As such, it is a must-have for neurosurgical residents, fellows, and practicing neurosurgeons.
Author : Michael John Daly
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (133 download)
Download or read book An Image-Guided Computational Framework for Intraoperative Fluorescence Quantification written by Michael John Daly and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescence-guided surgery uses molecular agents that target tumors, lymph nodes, or blood vessels. Optical devices measure fluorescence light emissions from these functional biomarkers to help surgeons differentiate diseased and healthy anatomy. Clinical indications for fluorescence guidance continue to expand, and are being spurred by the rapid development of new agents that improve biological targeting. To capitalize fully on these advances, there is a corresponding need to engineer high-resolution imaging systems that provide objective measurements of fluorescence. The key innovation in this thesis is the development of a computational framework for image-guided fluorescence quantification. The underlying principle is to directly incorporate spatial localization of patient anatomy and optical devices into multi-stage models of fluorescence light transport. This technique leverages technology for intraoperative cone-beam CT (CBCT) imaging and surgical navigation to account for tissue deformation and surgical excision. A novel calibration algorithm enables real-time compensation for fluorescence variations due to illumination inhomogeneities, tissue topography, and camera response. In endoscopic images of realistic oral cavity phantoms, navigated light transport modeling not only improved fluorescence quantification accuracy at the tissue surface, but also reduced tissue misclassification in a simulated model of surgical decision making (e.g., tumor vs. normal, perfused vs. necrotic) in comparison to an unguided approach. The image-guidance framework was also applied to a finite-element implementation of diffuse fluorescence tomography. Camera and laser tracking enabled adaptive, non-contact acquisition. Sub-surface spatial priors from CBCT imaging improved the depth-resolved spatial resolution and fluorescence quantification accuracy in liquid phantom experiments. These investigations elucidate the deleterious effects of view-dependent illumination inhomogeneities and depth-dependent diffuse tissue transport on fluorescence quantification accuracy. Moreover, the direct use of 3D data from a CBCT-guided surgical navigation system in computational light transport models improves fluorescence quantification and tissue classification accuracy in pre-clinical experiments. Future clinical translation of these fluorescence-guided surgery techniques is an essential next step to further assess the potential impact on intraoperative decision making and cancer patient care.
Author : Takeaki Ishizawa
Publisher : Springer Nature
ISBN 13 : 9811973725
Total Pages : 254 pages
Book Rating : 4.8/5 (119 download)
Download or read book Fluorescence-Guided Surgery written by Takeaki Ishizawa and published by Springer Nature. This book was released on 2023-12-05 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a practical guide of theranostics using intraoperative fluorescence imaging technology, as an all-out effort by the Japanese Society for Fluorescence Guided Surgery. It describes the various approaches the technique is being used such as vascular imaging, identification of lymphatic vessels by intratissue injection, lymph node imaging, and imaging for identification of anatomical structures. The book is organized into three major parts and the first one delivers the basics, introducing the use of the technology in clinical settings and initial setups. Next comes the description of clinical applications where chapters illustrate perfusion assessment, cancer localization, anatomy visualization, and lymph nodes/ducts mapping. Each chapter is devoted to the specific surgical field and disease areas, presenting images and videos of case studies. The last part presents some upcoming techniques for treatments. The Editor and the authors wish the ideas presented here will be hints to bridge the knowledge between surgeons and basic researchers for further innovation and practicality. It is important to stay up-to-date since intraoperative fluorescence imaging has been applied to clinical settings in various surgical fields and at the same time, novel techniques improving the efficacy of the technology have also been developed actively. Fluorescence-Guided Surgery – From Lab to Operation Room is recommended for surgeons, operating nurses, medical experts, basic researchers and, industry engineers worldwide beyond boundaries of specialties. Edited and written by experts of The Japanese Society for Fluorescence-Guided Surgery, those who are the founders of the technology, it describes the accurate development history and cutting-edge techniques based on the knowledge accumulated over the years.
Author : Mira Sibai
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (133 download)
Download or read book Quantitative Surface and Sub-Surface Fluorescence Spatial Frequency Domain Imaging for the Enhanced Resection of Glioma written by Mira Sibai and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extent of resection is now considered a significant prognostic factor; yet, safe complete resection is achieved in only 30% glioma patients. The challenge of surgery arises from the diffusive nature of gliomas known to infiltrate normal parenchyma beyond the resection cavity, which are left undetected. To better visualize glioma, intra-operative fluorescence-guided resection (FGR) has been a practical solution, providing real-time tumor contrast. In its most widely used form, FGR is mediated by the preferential overproduction of the fluorophore protoporphyrin IX (PpIX) in malignant tissue after an oral dose of its precursor 5-Aminolevulinic Acid (ALA). ALA-PpIX-FGR has been shown to significantly increase extent of resection. However, the visual assessment and the variable intrinsic optical attenuation of tissue limit this technique to delineating only high-grade tumors that display strong fluorescence. To this end, the work described in this thesis outlines the development of intraoperative quantitative fluorescence imaging (qFI) to quantify tissue fluorescence from superficial and from sub-surface tumors, by exploiting PpIX's secondary absorption peak at 635 nm. Both developments were facilitated by enabling the quantitative optical-property-mapping and depth-resolving capabilities of a technique called Spatial Frequency Domain Imaging (SFDI). SFDI is a unique form of diffuse optical imaging. Light is spatially modulated at predetermined spatial frequencies and spatially-resolved diffuse reflectance images are collected. Recovering 2D maps of tissue optical properties is a prerequisite for both qFI and depth imaging, thus, a custom-built SFDI system was developed and optimized for both techniques. By determining tissue optical properties at both the absorption and emission wavelengths of PpIX, the raw hyperspectral fluorescence images are converted to 2D maps of PpIX concentration, [PpIX], after applying a quantitative fluorescent model. qFI is now being integrated on a surgical microscope for future clinical trials. While SFD-enabled-qFI proved to be a practical extension to the quantitative probe, both are still blind to sub-surface tumors, due to the limited penetration depth of the excitation light. This limitation prompted the development of quantitative sub-surface fluorescence imaging, where tumor depth and [PpIX] can be recovered to assist the surgeon in making an informed decision on whether to continue resection.
Author : Robert Hoffman
Publisher : Academic Press
ISBN 13 : 0128126779
Total Pages : 296 pages
Book Rating : 4.1/5 (281 download)
Download or read book Strategies for Curative Fluorescence-Guided Surgery of Cancer written by Robert Hoffman and published by Academic Press. This book was released on 2020-05-27 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategies for Curative Fluorescence-Guided Surgery of Cancer is the first book to discuss how fluorescence-guided surgery can be successfully used during surgeries with several tumor types. FGS is one of the most exciting emerging modalities of surgery, especially cancer surgery, as it potentially allows the surgeon to visualize the actual margin of the tumor, thus greatly increasing the possibility of curative resection. The book discusses the applicability of FGS for several types of cancer, such as pancreatic cancer, liver metastasis, soft-tissue sarcoma, glioma, melanoma, and breast and lung cancer. This book is a valuable resource for cancer surgeons, cancer researchers and members of several other areas in the biomedical field who are interested in understanding this powerful technique. Presents an overview of fluorescence-guided surgery Explains general strategies for curative fluorescence-guided surgery and their applicability for each major tumor type Discusses the current and future achievements of FGS as a precise technique for cancer surgeries
Author : Nova Szoka
Publisher : Springer Nature
ISBN 13 : 3031406850
Total Pages : 515 pages
Book Rating : 4.0/5 (314 download)
Download or read book The SAGES Manual of Fluorescence-Guided Surgery written by Nova Szoka and published by Springer Nature. This book was released on 2023-11-27 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescence-guided surgery (FGS) is defined as a medical imaging technique that uses a fluorescent dye or a near-infrared emitting light source to identify anatomic structures during surgical procedures. In 2020 alone, over 1200 academic articles were published on the topic of fluorescence-guidance surgery, a sign that this modality is making significant inroads into surgical practice. The use of near-infrared imaging and FGS is a rapidly growing modality, allowing surgeons to see more intraoperatively, enhance surgical precision, and improve surgical decision-making and patient outcomes. This manual provides a comprehensive, state-of-the art review of this field and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in fluorescence-guided surgery, guiding patient management and stimulating investigative efforts. After initial chapters discussing the history of FGS and the current platforms and devices, it presents the most up-to-date data regarding the use of FGS in multiple surgical fields - colorectal, hepatic, endocrine, reconstructive, pediatric, among others - as well as in the treatment of specific conditions such as burns. Chapters are generously illustrated with full-color figures and intraoperative photographs, and selected chapters include video segments. Access to a comprehensive resource such as this is currently limited by the relatively new inroads that fluorescence-guided technology has made into surgery. The SAGES Manual of Fluorescence-Guided Surgery fills this gap in the literature.
Author : Mark Preul
Publisher : Frontiers Media SA
ISBN 13 : 2889668568
Total Pages : 368 pages
Book Rating : 4.8/5 (896 download)
Download or read book Applications of Fluorescence in Surgery and Interventional Diagnostics written by Mark Preul and published by Frontiers Media SA. This book was released on 2021-06-04 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gil Gonçalves
Publisher : Springer
ISBN 13 : 3319898787
Total Pages : 457 pages
Book Rating : 4.3/5 (198 download)
Download or read book Nanooncology written by Gil Gonçalves and published by Springer. This book was released on 2018-06-01 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a systematic overview of the most relevant nanomaterials and their respective intrinsic properties that have been highly explored by the scientific community and pharmaceutical companies in several different modalities for cancer therapy and bioimaging. The chapters explore the synergistic effects provided by the different nanostructured materials and highlight the main in vitro and in vivo therapeutic achievements on cancer. This work also provides relevant discussion about the recent progresses and future challenges that nanotechnology faces on the conception of more efficient nanoformulations against primary tumors, circulating cancer cells and metastases.
Author : Alexandra J. Golby
Publisher : Academic Press
ISBN 13 : 0128011890
Total Pages : 537 pages
Book Rating : 4.1/5 (28 download)
Download or read book Image-Guided Neurosurgery written by Alexandra J. Golby and published by Academic Press. This book was released on 2015-05-05 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: Image-Guided Neurosurgery provides readers with an update on the revolutionary improvements in imaging and visualization relating to neurosurgery. From the development of the pneumoencephalogram, to the operating microscope, to cross sectional imaging with CT and later MRI, to stereotaxy and neuronavigation, the ability to visualize the pathology and surrounding neural structures has been the driving factor leading surgical innovation and improved outcomes. The book provides a comprehensive reference on the application of contemporary imaging technologies used in neurosurgery. Specific techniques discussed include brain biopsies, brain tumor resection, deep brain stimulation, and more. The book is ideal for neurosurgeons, interventional radiologists, neurologists, psychiatrists, and radiologists, as well as technical experts in imaging, image analysis, computer science, and biomedical engineering. A comprehensive reference on image-guided neurosurgery Includes coverage of neuronavigation in cranial surgery and advanced imaging, including functional imaging, adoption of intra-operative MRI and emerging technologies Covers all image-guided neurosurgery tools, including robotic surgical devices Ideal reference for topics relating to neurosurgery, imaging, stereotaxis, radiosurgery, radiology, epilepsy, MRI, the use of medical robotics, lasers, and more
Author : Mei Tian
Publisher : Elsevier
ISBN 13 : 0323952240
Total Pages : 408 pages
Book Rating : 4.3/5 (239 download)
Download or read book Transpathology written by Mei Tian and published by Elsevier. This book was released on 2024-06-25 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transpathology: Molecular Imaging-Based Pathology is a multidisciplinary reference on molecular imaging and pathology. The book is intended for professionals in the fields of molecular imaging, nuclear medicine, radiology, and pathology as well as students and clinical residents. The book describes the importance of non-invasive diagnosis-based precision medicine and presents a detailed description of current transpathological approaches in different aspects essential for the future development of precision medicine. It’s molecular imaging approach to experimental research and clinical practice will drive the field forward and improve research outcomes. Introduces a new concept of molecular imaging-guided precise biopsy Links in vivo and ex vivo information at various scales by using multi-modality imaging technologies Integrates future technologies for the non-invasive cross-validation of underlying mechanisms
Author : Maxime Slooter
Publisher :
ISBN 13 :
Total Pages : 244 pages
Book Rating : 4.:/5 (124 download)
Download or read book Dynamic Fluorescence-guided Surgery written by Maxime Slooter and published by . This book was released on 2021 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Francesco Acerbi
Publisher : Frontiers Media SA
ISBN 13 : 2889747735
Total Pages : 147 pages
Book Rating : 4.8/5 (897 download)
Download or read book Intraoperative Fluorescence Imaging and Diagnosis in Central and Peripheral Nervous System Tumors: Established Applications and Future Perspectives written by Francesco Acerbi and published by Frontiers Media SA. This book was released on 2022-03-30 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : H. Richard Winn
Publisher : Elsevier Health Sciences
ISBN 13 : 0323674992
Total Pages : 7439 pages
Book Rating : 4.3/5 (236 download)
Download or read book Youmans and Winn Neurological Surgery E-Book written by H. Richard Winn and published by Elsevier Health Sciences. This book was released on 2022-01-21 with total page 7439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Widely regarded as the definitive reference in the field, Youmans and Winn Neurological Surgery offers unparalleled, multimedia coverage of the entirety of this complex specialty. Fully updated to reflect recent advances in the basic and clinical neurosciences, the 8th Edition covers everything you need to know about functional and restorative neurosurgery, deep brain stimulation, stem cell biology, radiological and nuclear imaging, and neuro-oncology, as well as minimally invasive surgeries in spine and peripheral nerve surgery, and endoscopic and other approaches for cranial procedures and cerebrovascular diseases. In four comprehensive volumes, Dr. H. Richard Winn and his expert team of editors and authors provide updated content, a significantly expanded video library, and hundreds of new video lectures that help you master new procedures, new technologies, and essential anatomic knowledge in neurosurgery. Discusses current topics such as diffusion tensor imaging, brain and spine robotic surgery, augmented reality as an aid in neurosurgery, AI and big data in neurosurgery, and neuroimaging in stereotactic functional neurosurgery. 55 new chapters provide cutting-edge information on Surgical Anatomy of the Spine, Precision Medicine in Neurosurgery, The Geriatric Patient, Neuroanesthesia During Pregnancy, Laser Interstitial Thermal Therapy for Epilepsy, Fetal Surgery for Myelomeningocele, Rehabilitation of Acute Spinal Cord Injury, Surgical Considerations for Patients with Polytrauma, Endovascular Approaches to Intracranial Aneurysms, and much more. Hundreds of all-new video lectures clarify key concepts in techniques, cases, and surgical management and evaluation. Notable lecture videos include multiple videos on Thalamotomy for Focal Hand Dystonia and a video to accompany a new chapter on the Basic Science of Brain Metastases. An extensive video library contains stunning anatomy videos and videos demonstrating intraoperative procedures with more than 800 videos in all. Each clinical section contains chapters on technology specific to a clinical area. Each section contains a chapter providing an overview from experienced Section Editors, including a report on ongoing controversies within that subspecialty. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Author : Isabelle M. Germano
Publisher : Thieme
ISBN 13 : 9781588900678
Total Pages : 254 pages
Book Rating : 4.9/5 (6 download)
Download or read book Advanced Techniques in Image-guided Brain and Spine Surgery written by Isabelle M. Germano and published by Thieme. This book was released on 2002 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: This oustanding book provides an in-depth analysis of current and developing applications in a rapidly growing field. A highly acclaimed team of authors share their experience with image-guided technology, outlining the benefits and limitations of each procedure.
Author : J. Bradley Elder
Publisher : Elsevier Health Sciences
ISBN 13 : 0323546730
Total Pages : pages
Book Rating : 4.3/5 (235 download)
Download or read book Intraoperative Imaging, An Issue of Neurosurgery Clinics of North America, E-Book written by J. Bradley Elder and published by Elsevier Health Sciences. This book was released on 2017-09-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of Neurosurgery Clinics focus on Intraoperative Imaging. Article topics will include historical, current and future intraoperative imaging modality; iMRI suites: history, design, utility and cost-effectiveness; Stereotactic platforms for iMRI; iMRI for tumor: maximizing extent of resection of glioma; IMRI for tumor: combining iMRI with functional MRI; iMRI for tumor: pituitary adenoma; iMRI for tumor: MR thermometry; iMRI for tumor: LITT for spinal tumors; iMRI for functional/epilepsy neurosurgery: DBS placement; iMRI for functional/epilepsy neurosurgery: MR thermometry for mesial temporal epilepsy; iMRI for functional/epilepsy neurosurgery: MR thermometry HIFU; Fluorescence imaging/agents in tumor resection; Intraoperative 3D ultrasound; Intraoperative 3D CT: spine surgery; Intraoperative 3D CT: cranial/functional/trigem; Intraoperative imaging for vascular lesions; Imaging of intraoperative drug delivery; Intraoperative ultrasound for peripheral nerve; and Intraoperative Raman Spectroscopy.
Author : David Robertson
Publisher : Academic Press
ISBN 13 : 012802111X
Total Pages : 812 pages
Book Rating : 4.1/5 (28 download)
Download or read book Clinical and Translational Science written by David Robertson and published by Academic Press. This book was released on 2016-11-25 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs
