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Author : Michael Dale Johnson
Publisher :
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.:/5 (434 download)
Download or read book Total Synthesis of Lignan Natural Products written by Michael Dale Johnson and published by . This book was released on 1998 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anna Albertson
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (111 download)
Download or read book Total Synthesis of Lignan Natural Products written by Anna Albertson and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Lignans encompass a structurally diverse array of highly oxygenated, polyaromatic natural products with important biological activities. Despite their structural diversity, lignan biosynthesis begins by the oxidative coupling of only a small number of relatively simple propenyl phenols. Previous attempts to mimic this oxidative coupling have suffered from poor regio- and chemoselectivity. Other approaches to these compounds have proven efficient and relatively diversifiable but they have often been designed to access a single structural class and do not capitalize on the divergency of the biosynthesis. This thesis details a bio-inspired method that aims to solve the challenge of selectivity in the oxidative coupling. By coupling two propenyl phenols through a [2+2]-cycloaddition, the key carbon-carbon bond is formed prior to the oxidation. A subsequent oxidative fragmentation of the resulting cyclobutane allows us to intercept the proposed biosynthetic intermediate with high levels of control. We have demonstrated the utility of this method in the synthesis of several natural and non-natural 2-aryl-4-benzyltetrahydrofuran and furofuran-based lignans. To expand this strategy to access other structural classes of lignans, we developed a complementary approach. The corresponding dibenzylbutane was obtained by cleaving the diarylcyclobutane bond through a reductive ring opening. Through selective functionalization and oxidative cyclization, several aryltetralins and dibenzocyclooctadienes were afforded. This provided a unified approach to this diverse class of natural products, in which molecular complexity is rapidly increased." --
Author : David C. Ayres
Publisher : Cambridge University Press
ISBN 13 : 9780521304214
Total Pages : 428 pages
Book Rating : 4.3/5 (42 download)
Download or read book Lignans written by David C. Ayres and published by Cambridge University Press. This book was released on 1990-11-30 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lignans are widely occurring plant compounds and are closely related to lignin, which forms the woody component of trees and other plants. The lignans are characterized by their dimeric composition from cinnamic acids, and they are attracting increasing attention as a result of their pharmacological properties. The volume surveys the chemical, biological and clinical properties of lignans as well as providing information on their isolation, purification, identification and chemical synthesis.
Author : Junbiao Chang
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128084715
Total Pages : 43 pages
Book Rating : 4.1/5 (28 download)
Download or read book Studies in Natural Products Chemistry written by Junbiao Chang and published by Elsevier Inc. Chapters. This book was released on 2013-06-25 with total page 43 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept, origin, and classification of lignan will be briefly introduced first, which will lead the readers naturally to dibenzocyclooctadiene lignan. The properties of dibenzocyclooctadiene lignan will then be introduced, including the axial chirality, the substitution pattern on the aromatic ring, etc. Next, a detailed list of the structures of dibenzocyclooctadiene lignan isolated so far will be provided. Next, we will turn to the most important part—synthesis. The general strategies for the formation of the eight-membered ring will be introduced first. Detailed examples will then follow, which is not aimed to provide a full list of dibenzocyclooctadiene lignan syntheses, but mainly focus on different strategies. However, all the references for the synthesis of different compounds with similar strategy will be provided. Recent advances on the asymmetric synthesis will be our main concern for this part.
Author : Samuel Davidson
Publisher :
ISBN 13 :
Total Pages : 397 pages
Book Rating : 4.:/5 (14 download)
Download or read book Synthesis of Lignans Utilising the Acyl-claisen Rearrangement written by Samuel Davidson and published by . This book was released on 2017 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David Barker
Publisher : MDPI
ISBN 13 : 3038979082
Total Pages : 384 pages
Book Rating : 4.0/5 (389 download)
Download or read book Lignans written by David Barker and published by MDPI. This book was released on 2019-05-03 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lignans are a class of natural products found mainly in plants. They have a wide variety of structures and exhibit a range of potent biological activities. Lignans are also well-known components of a number of widely eaten foods and are frequently studied for their dietary impact. Owing to these factors, lignans have been extensively studied by scientists from a large number of disciplines. This collection of research and review articles describes topics ranging in scope from the recent isolation and structural elucidation of new lignans, strategies towards the chemical synthesis of lignans, assessment of their biological activities and potential for further therapeutic development. Research showing the impact of lignans in the food and agricultural industries is also presented.
Author : Norman G. Lewis
Publisher :
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.3/5 (91 download)
Download or read book Lignin and Lignan Biosynthesis written by Norman G. Lewis and published by . This book was released on 1998 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides new information on the control of monolignal coupling and on modifying the biochemical steps in their formation and configuration. The text provides a critical assessment of recent advances in delineating the relationships and biosynthetic pathways of lignins and lignans. The discussion emphasizes lignin and lignan formation, particularly the templates for lignin assembly and the control of stereochemical coupling.
Author : Véronique Cheynier
Publisher : John Wiley & Sons
ISBN 13 : 1118299744
Total Pages : 393 pages
Book Rating : 4.1/5 (182 download)
Download or read book Recent Advances in Polyphenol Research, Volume 3 written by Véronique Cheynier and published by John Wiley & Sons. This book was released on 2012-02-21 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant polyphenols are secondary metabolites that constitute one of the most common and widespread groups of natural products. They express a large and diverse panel of biological activities including beneficial effects on both plants and humans. Many polyphenols, from their structurally simplest representatives to their oligo/polymeric versions (also referred to as vegetable tannins) are notably known as phytoestrogens, plant pigments, potent antioxidants, and protein interacting agents. Sponsored by Groupe Polyphénols, this publication, which is the third volume in this highly regarded Recent Advances in Polyphenol Research series, is edited by Véronique Cheynier, Pascale Sarni-Manchado, and Stéphane Quideau (the current President of Groupe Polyphénols). Like their predecessors, they have once again put together an impressive collection of cutting-edge chapters written by expert scientists internationally respected in their respective field of polyphenol sciences. This Volume 3 provides the latest information and opinion on the following major research topics about polyphenols: Organic chemistry and physical chemistry Biosynthesis, genetics and metabolic engineering The role of polyphenols in plants and ecosystems Health and nutrition Analysis and metabolomics Chemists, biochemists, plant scientists, pharmacognosists and pharmacologists, biologists, ecologists, food scientists and nutritionists will all find this book an invaluable resource. Libraries in all universities and research institutions where these disciplines are studied and taught should have copies on their bookshelves.
Author : Thomas A. Gilmore
Publisher :
ISBN 13 :
Total Pages : 142 pages
Book Rating : 4.:/5 (366 download)
Download or read book Total Synthesis of the Arylnaphthalene Lignan, Haplomyrtin written by Thomas A. Gilmore and published by . This book was released on 1996 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lisa Ivy Pilkington
Publisher :
ISBN 13 :
Total Pages : 481 pages
Book Rating : 4.:/5 (935 download)
Download or read book The Asymmetric Synthesis of 1,4-benzodioxane Lignan Natural Products written by Lisa Ivy Pilkington and published by . This book was released on 2014 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lignans are a large class of natural products defined as the products of an oxidative dimerisation of two or more phenylpropanoid units. 1,4-Benzodioxane neolignans are a significant subtype of lignan natural products that showcase a range of biological activities. Previous syntheses of 1,4-benzodioxane lignans are predominantly racemic and do not easily allow for the main points of variation between related and analogous products. This thesis focuses on the development of a flexible asymmetric synthesis of 1,4-benzodioxane compounds and its subsequent application to natural product synthesis. Initially, a model study was undertaken to investigate the key steps required in this synthesis. Following the model study, the developed synthesis was then applied to the first asymmetric synthesis of the rodgersinine family, successfully yielding all rodgersinine natural products 21, 83, 84 and 87 and their enantiomers. Through chiroptical analysis, it was found that the original assignment of 83 and 87 was incorrect, and the ECD comparison of 1,4-benzodioxane natural products and model compounds is not reliable. Members of the eusiderin family, eusiderins A (19), B (243), C (194), G (37), L (260) and M (245) and analogues were synthesised in a highly divergent manner from chiral aldehyde 259. An ECD study also confirmed the absolute stereochemistry of 19 and 194 from different natural sources, and provided a reference for stereochemical assignment of future eusiderins. The adaptation of the synthesis to 2-hydroxymethyl-1,4-benzodioxane neolignans was shown with the successful synthesis of (-)-isoamericanin A (24) and (+)-isoamericanol A (20). Further application of this synthesis to complex trilignan magnolianin 278 was unsuccessful following the failure to synthesise ether 351 because of steric restrictions. The formal asymmetric synthesis of silybin B (358) and isosilandrin B (364); 1,4-benzodioxane flavonolignans well-regarded for their potent activities, was achieved, demonstrating the applicability of the developed synthesis to this notable group of compounds. Subsequent testing by Eli Lilly and a leading anti-HCV expert, of selected synthesised 1,4-benzodioxane compounds identified them to exhibit activities with applications in areas of cancer and neurological treatments, as well as hepaprotective properties that are currently undergoing further exploration.
Author : Sasadhar Majhi
Publisher : World Scientific
ISBN 13 : 9811268703
Total Pages : 469 pages
Book Rating : 4.8/5 (112 download)
Download or read book Modern Sustainable Techniques In Total Synthesis Of Bioactive Natural Products written by Sasadhar Majhi and published by World Scientific. This book was released on 2023-04-25 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Sustainable Techniques in Total Synthesis of Bioactive Natural Products comprises five parts for green tools, such as ultrasonic waves, microwave heating, visible-light photochemistry, organic electrochemistry, and flow chemistry, along with 72 chapters for each bioactive molecule of natural origin. Each chapter explores the natural source, structure, systematic name, structural features, compound class, biological activity, conventional approaches for their chemical synthesis, and demerit(s) of conventional approaches (where applicable). Finally, critical features of total synthesis using modern sustainable techniques, including reaction types, synthetic strategy, and synthetic route utilizing modern sustainable tools for each bioactive natural product and secondary metabolites, are discussed brilliantly. The spectrum of application of total synthesis of bioactive natural products using modern sustainable techniques may promote the development of more eco-friendly synthetic processes so that the next generations can live on this planet with a minimum energy requirement for chemical reactions with the least pollution.
Author : Francisco G. Calvo-Flores
Publisher : John Wiley & Sons
ISBN 13 : 1118597869
Total Pages : 520 pages
Book Rating : 4.1/5 (185 download)
Download or read book Lignin and Lignans as Renewable Raw Materials written by Francisco G. Calvo-Flores and published by John Wiley & Sons. This book was released on 2015-09-28 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: As naturally occurring and abundant sources of non-fossil carbon, lignin and lignans offer exciting possibilities as a source of commercially valuable products, moving away from petrochemical-based feedstocks in favour of renewable raw materials. Lignin can be used directly in fields such as agriculture, livestock, soil rehabilitation, bioremediation and the polymer industry, or it can be chemically modified for the fabrication of specialty and high-value chemicals such as resins, adhesives, fuels and greases. Lignin and Lignans as Renewable Raw Materials presents a multidisciplinary overview of the state-of-the-art and future prospects of lignin and lignans. The book discusses the origin, structure, function and applications of both types of compounds, describing the main resources and values of these products as carbon raw materials. Topics covered include: • Structure and physicochemical properties • Lignin detection methods • Biosynthesis of lignin • Isolation methods • Characterization and modification of lignins • Applications of modified and unmodified lignins • Lignans: structure, chemical and biological properties • Future perspectives This book is a comprehensive resource for researchers, scientists and engineers in academia and industry working on new possibilities for the application of renewable raw materials. For more information on the Wiley Series in Renewable Resources, visit www.wiley.com/go/rrs
Author : Dennis Patrick Curran
Publisher :
ISBN 13 :
Total Pages : 248 pages
Book Rating : 4.:/5 (661 download)
Download or read book Part I. The Total Synthesis of Juncusol written by Dennis Patrick Curran and published by . This book was released on 1980 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Zheng Huang
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (119 download)
Download or read book Biomimetic Aerobic Catalysis and Total Synthesis of Dibenzocyclooctadiene Lignans written by Zheng Huang and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Aerobic oxidation is a necessary adaptation to life on earth that has given rise to many intricate enzymatic processes. Over the course of my PhD studies, I have attempted to mimic certain enzymatic mechanisms of aerobic oxidation, in order to develop new synthetic tools for the preparation of complex, organic molecules. These studies can be divided into two phases, representative of the respective enzymes under consideration. The first focused on the development of Cu-catalysts based upon the Type III, di-copper enzyme tyrosinase. Tyrosinase is an essential enzyme that is part of the melanogenic pathway. At its center are two Cu-atoms that activate molecular oxygen (O2) as a characteristic Cu2-peroxo, in order to de-aromatize L-tyrosine. Inspired by this mechanism of O2-activation and oxygen atom transfer, I developed a series of catalytic aerobic processes for the functionalization of phenols. This included the synthesis of diaryl ethers by dehydrogenative C-O bond formation, as well as a direct synthesis of polyfunctional indoles starting from commercially available derivatives of L-tyrosine.The second phase of my studies focused on aerobic oxidations catalyzed by Fe-containing enzymes in the late stages of lignan biosynthesis. Here, our focus shifted towards the substrate, and we developed conditions to explore the fates of proposed biosynthetic radicals that are implicated in the biosynthesis of lignan-derived dibenzocyclooctadiene (DBCOD) natural products. DBCODs are secondary metabolites produced by medicinal plants of Schisandra and Kadsura that display a range of health benefits. In the final stages of their biosynthesis, certain family members are believed to be oxidized by Fe-containing oxygenases that leads to dramatic structural changes following radical cyclization. Typically, radical cyclizations are much slower than the more typical hydroxylation pathway, raising interesting mechanistic questions about how these enzymes delay or divert more traditional pathways of C-H oxidation. My work in this area led to mild, photoredox mediated conditions for late-stage radical cyclizations that could be applied to a number of highly oxidized and structurally distinct family members"--
Author : Goutam Brahmachari
Publisher : Elsevier
ISBN 13 : 0081028237
Total Pages : 352 pages
Book Rating : 4.0/5 (81 download)
Download or read book Total Synthesis of Bioactive Natural Products written by Goutam Brahmachari and published by Elsevier. This book was released on 2019-04-27 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Total Synthesis of Bioactive Natural Products provides step-by-step guidelines for effectively synthesizing the most promising bioactive agents from a broad range of natural products. Beginning with a concise background that outlines the benefits and challenges faced in effective synthesis, the book goes on to provide individual outlines for approximately 100 of the most promising bioactive agents. Taking a logical, user-friendly approach, the systematic name, compound class, structure, natural source, pharmaceutical potential and synthetic routes for each structure are detailed, with clear illustrations throughout, making this book an essential and practical guide for anyone working with both synthesis and natural products. - Provides individual outlines for the total synthesis of approximately 100 bioactive natural molecules - Outlines each step of the process in detail, with full experimental information supported by extensive schemes - Includes retrosynthetic analyses, reaction sequences and stereochemically crucial steps for each molecule
Author : Tao Wang
Publisher : Frontiers Media SA
ISBN 13 : 2889660869
Total Pages : 99 pages
Book Rating : 4.8/5 (896 download)
Download or read book Discovery and Total Synthesis of Bio-functional Natural Products from Traditional Medicinal Plants written by Tao Wang and published by Frontiers Media SA. This book was released on 2020-10-23 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Author : Christophe F. Hano
Publisher : Frontiers Media SA
ISBN 13 : 2889664910
Total Pages : 65 pages
Book Rating : 4.8/5 (896 download)
Download or read book Lignans: Insights into Their Biosynthesis, Metabolic Engineering, Analytical Methods and Health Benefits written by Christophe F. Hano and published by Frontiers Media SA. This book was released on 2021-02-17 with total page 65 pages. Available in PDF, EPUB and Kindle. Book excerpt:
