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Author : Hsien-Ching Liu
Publisher :
ISBN 13 :
Total Pages : 198 pages
Book Rating : 4.:/5 (29 download)
Download or read book Thyroid Hormone Receptor Regulation of S14 Gene Expression in Hepatocytes written by Hsien-Ching Liu and published by . This book was released on 1992 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Benoit J. Deschamps
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (15 download)
Download or read book Thyroid Hormone Regulation of Hepatic S14 Gene Expression written by Benoit J. Deschamps and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Thyroid Hormone Regulation of Hepatic S14 Gene Expression [microform] PDF Online Free](https://books.google.com/books/content/images/frontcover/vLC8NwAACAAJ?fife=w200-h370)
Author : Benoit J. (Benoit Jeannot) Deschamps
Publisher : National Library of Canada = Bibliothèque nationale du Canada
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (15 download)
Download or read book Thyroid Hormone Regulation of Hepatic S14 Gene Expression [microform] written by Benoit J. (Benoit Jeannot) Deschamps and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : G.R. Williams
Publisher : Springer
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.F/5 ( download)
Download or read book Thyroid Hormone Regulation of Gene Expression written by G.R. Williams and published by Springer. This book was released on 1994 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the historical perspective and physiological background of the role of thyroid hormones. In both specific target tissues and during development, it provides clinical perspectives and physiological and developmental implications of the interactions between retinoid and vitamin D3 signalling pathways.
Author : Gerald Joseph Lepar
Publisher :
ISBN 13 :
Total Pages : 404 pages
Book Rating : 4.3/5 (129 download)
Download or read book Hormonal Regulation of the S14 in 3T3-F442A Adipocytes written by Gerald Joseph Lepar and published by . This book was released on 1990 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Daniel F. Lyman
Publisher :
ISBN 13 :
Total Pages : 432 pages
Book Rating : 4.:/5 (23 download)
Download or read book Thyroid Hormone Regulation of Liver Gene Expression During Metamorphosos in Rana Catesbeiana written by Daniel F. Lyman and published by . This book was released on 1988 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Phani Kumar Talasila
Publisher :
ISBN 13 :
Total Pages : 80 pages
Book Rating : 4.:/5 (835 download)
Download or read book Novel Thyroid Hormone Target Genes in the Liver, and Their Roles in Thyroid Hormone Signaling and Physiology written by Phani Kumar Talasila and published by . This book was released on 2012 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thyroid hormone plays a critical role in growth, development and energy metabolism. The identification of novel target genes of thyroid hormone would greatly inform our complete understanding of T3 physiology. I have studied two genes, SGK1 (serum and glucocorticoid inducible kinase1), and ANGPTL4 (Angiopoietin like protein-4) as the potential target genes of thyroid hormone in the liver. SGK1, a component of the PI-3 kinase pathway, is ubiquitously expressed and plays a role in numerous physiological functions. Previous studies in our lab showed T3-mediated induction of SGK1, and also a PI-3kinase dependent phosphorylation of SGK1 by T3. As T3 induces and activates SGK1, I speculated that SGK1 might be contributing to T3- mediated transcription of its target genes. Dual luciferase assays following SGK1 activity inhibition by GSK650394 and T3 treatment, showed a dose-dependent decrease in the activity of the DR4 and CPT1alpha promoters. Also, real time PCRs performed following SGK1 activity inhibition and T3 treatment, showed a decreased induction of endogenous T3-target genes like G6P, PEPCK, and CPT1alpha suggesting that SGK1 is a modulator of transcriptional activity of T3. ANGPTL4 is expressed mainly in metabolic tissues like liver and adipose tissue. ANGPTL4 inhibits LPL activity, and the role of thyroid hormone in regulation of LPL has led me to hypothesize that T3 regulates ANGPTL4. My studies showed that T3 induces ANGTPL4 mRNA and protein. I have also looked at the role of PGC1alpha, a transcriptional co-activator, in the T3 regulation of ANGPTL4. PGC1alpha overexpression not only enhanced T3 induction of ANGPTL4, but also induced ANGPTL4 expression even in the absence of T3. However, T3 did not induce PGC1alpha which is contrary to the observations in rat livers. LPL assays using fluorescence based substrate DGGR were performed to look for the functional significance of T3 induction of ANGPTL4. The concentrated conditioned media samples from HepG2 cells treated with vehicle/T3 after ANGPTL4 siRNA knockdown were used for the LPL assays. However, there was no difference in LPL activities among the treatment samples at 8 hours or 24 hours. Thus, I have identified SGK1, a novel T3 target gene as a transcriptional modulator of T3 signaling, and ANGPTL4 as a novel T3 target gene in the liver, and signified the role of PGC1alpha in the T3 regulation of ANGPTL4.
Author : Hsien-Ching Liu
Publisher :
ISBN 13 :
Total Pages : 208 pages
Book Rating : 4.:/5 (311 download)
Download or read book Multiple Thyroid Hormone Response Elements Synergistically Regulate the Hepatic Expression of the Rat S14 Gene written by Hsien-Ching Liu and published by . This book was released on 1994 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alan R. Brooks
Publisher :
ISBN 13 :
Total Pages : 622 pages
Book Rating : 4.:/5 (13 download)
Download or read book Thyroid Hormone Receptor and Albumin Gene Expression in Xenopus Laevis Ovary and Liver written by Alan R. Brooks and published by . This book was released on 2018 with total page 622 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nathan Douglas Zilz
Publisher :
ISBN 13 :
Total Pages : 12 pages
Book Rating : 4.:/5 (29 download)
Download or read book The Thyroid Hormone Receptor (C-ErBA) and the Regulation of Hepatic Gene Expression written by Nathan Douglas Zilz and published by . This book was released on 1990 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Arun K. Roy
Publisher : Springer Science & Business Media
ISBN 13 : 1461236665
Total Pages : 247 pages
Book Rating : 4.4/5 (612 download)
Download or read book Gene Regulation by Steroid Hormones IV written by Arun K. Roy and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first Meadowbrook Symposium was held in 1978 and during the intervening ten years our knowledge concerning how steroid hormones function at the level of gene expression has advanced by leaps and bounds. In this volume, which sum marizes our fourth meeting, these advances are very evident. What seemed like science fiction ten years ago has become commonplace science. Who would have imagined that we could synthesize a nucleotide sequence that binds a specific steroid receptor and acts as a controlling element for gene expression? No one; but as is evident from the results reported in several chapters, this technique is yielding a wealth of information. Using these and other techniques it has become apparent that gene transcription is controlled by interactions between transacting factors and DNA recognition sequences (response elements). These transacting factors appear to be members of a large gene family that includes steroid hormone receptors, transcription factors, protooncogenes and homeobox proteins. Thus a great deal has been learned, but as usual, questions remain. Many of these questions are posed by the findings and observations found in several chapters in this volume. Non hormone binding forms of steroid receptors and their relevance to receptor down regulation, recycling and biological response remain a mystery. The quantitative relationship between receptor binding and biological response still presents agonizing problems. These and many other intriguing questions are discussed in this volume and set the stage for what should be a most rewarding time in endocrinology. Winter 1989 ARUN K.
Author : Carolyn D. Berdanier
Publisher : CRC Press
ISBN 13 : 1351083562
Total Pages : 591 pages
Book Rating : 4.3/5 (51 download)
Download or read book Nutrition and Gene Expression written by Carolyn D. Berdanier and published by CRC Press. This book was released on 2018-01-18 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nutrition and Gene Expression is devoted to exploring the tissue-specific and developmental aspects of the interaction between nutrients and the genome. The book discusses chemical sensitivity in relation to the ability of cells to detect nutrients; reviews the means by which lower organisms respond to nutrients; and provides examples on how each of the classes of nutrients affects genetic transcription, mRNA translation or stability. The receptor-mediated actions of vitamin D and retinoic acid on gene expression are discussed, including the case of bone formation and dissolution. Other important topics covered in the volume include newly discovered effects of fatty acids on regulating gene expression, the effects of diet on mRNA editing, the interplay between dietary carbohydrates and proteins in regulating metabolism of liver cells, the effects of metal ions on protein synthesis, and much more. Nutrition and Gene Expression is an important reference for nutritionists, physiologists, biochemists, clinical nutritionists, pharmaceutical researchers, geneticists, and food scientists.
Author : Jack H. Oppenheimer
Publisher :
ISBN 13 :
Total Pages : 530 pages
Book Rating : 4.3/5 (91 download)
Download or read book Molecular Basis of Thyroid Hormone Action written by Jack H. Oppenheimer and published by . This book was released on 1983 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Basis of Thyroid Hormone Action focuses on the actions of thyroid hormones in eukaryotic cells. This book discusses the profound effects of thyroid hormones on the growth, development, and metabolism of practically all tissues of higher organisms. Organized into 15 chapters, this volume starts with an overview of the kinetic interrelationships of hormone bound to specific receptors and hormone associated with other tissue and plasma pools in living animals. This book then discusses the thyroid hormone receptor, a chromatin-associated protein that appears to mediate the actions of the ...
Author : Wade H. Shafer
Publisher : Springer Science & Business Media
ISBN 13 : 1461524539
Total Pages : 391 pages
Book Rating : 4.4/5 (615 download)
Download or read book Masters Theses in the Pure and Applied Sciences written by Wade H. Shafer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Masters Theses in the Pure and Applied Sciences was first conceived, published, and disseminated by the Center for Information and Numerical Data Analysis and Synthesis (CINDAS)* at Purdue University in 1957, starting its coverage of theses with the academic year 1955. Beginning with Volume 13, the printing and dis semination phases of the activity were transferred to University Microfilms/Xerox of Ann Arbor, Michigan, with the though that such an arrangement would be more beneficial to the academic and general scientific and technical community. After five years of this joint undertaking we had concluded that it was in the interest of all concerned if the printing and distribution of the volumes were handled by an international publishing house to assure improved service and broader dissemi nation. Hence, starting with Volume 18, Masters Theses in the Pure and Applied Sciences has been disseminated on a worldwide basis by Plenum Publishing Corporation of New York, and in the same year the coverage was broadened to include Canadian universities. All back issues can also be ordered from Plenum. We have reported in Volume 37 (thesis year 1992) a total of 12,549 thesis titles from 25 Canadian and 153 United States universities. We are sure that this broader base for these titles reported will greatly enhance the value of this impor tant annual reference work. While Volume 37 reports theses submitted in 1992, on occasion, certain uni versities do report theses submitted in previous years but not reported at the time.
Author : Gerard N. Burrow
Publisher : Elsevier Health Sciences
ISBN 13 : 1483284603
Total Pages : 335 pages
Book Rating : 4.4/5 (832 download)
Download or read book Thyroid Function & Disease written by Gerard N. Burrow and published by Elsevier Health Sciences. This book was released on 1989-06-27 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: This integrated clinical reference offers candid coverage and informed views on thyroid function and disease. Carefully detailed line drawings elucidate the discussions by 3 renowned clinicians. Coverage includes thyroid hormone biosynthesis, laboratory evaluation, nontoxic goiter, hyperthyroidism, thyroid disease in pregnancy, malignant diseases, thyroiditis, and much more.
Author : Michelle Kay Mater
Publisher :
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (129 download)
Download or read book Arachidonic Acid Regulation of Lipogenic Gene Expression in Adipocyctes and Hepatocytes written by Michelle Kay Mater and published by . This book was released on 1998 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Martha H. Stipanuk
Publisher : Elsevier Health Sciences
ISBN 13 : 0323266959
Total Pages : 968 pages
Book Rating : 4.3/5 (232 download)
Download or read book Biochemical, Physiological, and Molecular Aspects of Human Nutrition - E-Book written by Martha H. Stipanuk and published by Elsevier Health Sciences. This book was released on 2013-08-13 with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering advanced nutrition with a comprehensive, easy-to-understand approach, Biochemical, Physiological, and Molecular Aspects of Human Nutrition, 3rd Edition focuses on the biology of human nutrition at the molecular, cellular, tissue, and whole-body levels. It addresses nutrients by classification, and describes macronutrient function from digestion to metabolism. This edition includes the new MyPlate dietary guide and recommendations from the Dietary Guidelines for Americans 2010, plus coverage of the historical evolution of nutrition and information on a wide range of vitamins, minerals, and other food components. In Biochemical, Physiological, and Molecular Aspects of Human Nutrition, lead authors Martha H. Stipanuk and Marie A. Caudill are joined by a team of nutrition experts in providing clear, concise, coverage of advanced nutrition. 55 expert contributors provide the latest information on all areas of the nutrition sciences. Nutrition Insight boxes discuss hot topics and take a closer look at basic science and everyday nutrition. Clinical Correlation boxes show the connection between nutrition-related problems and their effects on normal metabolism. Food Sources boxes summarize and simplify data from the USDA National Nutrient Database on the amount and types of foods needed to reach the recommended daily allowances for vitamins and minerals. DRIs Across the Life Cycle boxes highlight the latest data from the Institute of Medicine on dietary reference intakes for vitamins and minerals, including coverage of infants, children, adult males and females, and pregnant and lactating women. Life Cycle Considerations boxes highlight nutritional processes or concepts applicable to individuals of various ages and in various stages of the life span. Thinking Critically sections within boxes and at the end of chapters help in applying scientific knowledge to "real-life" situations. Lists of common abbreviations provide an overview of each chapter's content at a glance. Comprehensive cross-referencing by chapters and illustrations is used throughout. Current references and recommended readings connect you to nutrition-related literature and provide additional tools for research. Coverage of the USDA's MyPlate dietary guide reflects today's new approach to diet and nutrition. Recommendations outlined in the Dietary Guidelines for Americans 2010 are incorporated throughout the book. Updated format features more subheadings, tables, and bullets, making it easier to learn and recall key points. Updates of key chapters and boxes reflect significant changes within the fields of nutrition, biology, molecular biology, and chemistry. NEW illustrations simplify complex biochemical, physiological, and molecular processes and concepts.
