Author :
Publisher : World Health Organization
ISBN 13 : 9240055746
Total Pages : 44 pages
Book Rating : 4.2/5 (4 download)
Book Synopsis Therapeutics for Ebola virus disease, 19 August 2022 by :
Download or read book Therapeutics for Ebola virus disease, 19 August 2022 written by and published by World Health Organization. This book was released on 2022-08-19 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ebola virus disease (EVD) is a life-threatening disease caused by Ebola virus (EBOV; Zaire ebolavirus). Viruses of the genus Ebolavirus (of the family Filoviridae) can cause life-threatening disease. EBOV causes outbreaks of EVD, historically the most severe and most frequent. This guidance, due to the evidence available, is directed only to the treatment of EVD, the disease caused by EBOV (Zaire ebolavirus). During early EVD, patients present with a non-specific febrile illness, followed by gastrointestinal signs and symptoms that frequently lead to hypovolaemia, metabolic acidosis, hypoglycaemia, and multi-organ failure. EVD case fatality remains high, with a pooled case fatality rate of 60% (95% confidence interval [CI]: 47–73%) in outbreaks from 2010–2020. Following the publication of an RCT demonstrating superior efficacy of two EVD therapeutics, in comparison to the ZMapp control arm, WHO proposed to develop a new guideline. This is a new guideline written to accompany the optimized supportive care (oSoC) for EVD standard operating procedures. The guideline aims to summarize high quality evidence for EVD therapeutics and make recommendations for their use.