Therapeutic Targets Of The Tnf Superfamily

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Therapeutic Targets of the TNF Superfamily

Author : Iqbal S. Grewal
Publisher : Springer Science & Business Media
ISBN 13 : 0387895205
Total Pages : 220 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Therapeutic Targets of the TNF Superfamily by : Iqbal S. Grewal

Download or read book Therapeutic Targets of the TNF Superfamily written by Iqbal S. Grewal and published by Springer Science & Business Media. This book was released on 2009-09-17 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor necrosis factor (TNF) superfamily is a rapidly growing family of cytokines that interacts with a corresponding superfamily of receptors. Liga- receptor interactions of this superfamily are involved in numerous biological processes ranging from hematopoiesis to pleiotropic cellular responses, including activation, proliferation, differentiation, and apoptosis. The particular response depends on the receptor, the cell type, and the concurrent signals received by the cell. Worldwide interest in the TNF field surged dramatically early in 1984 with the cloning and defining of the profound cellular effects of the first member of this family, TNF . Subsequently, the major influence of TNF on the development and functioning of the immune system was established. Today, over 20 human TNF ligands and their more than 30 corresponding receptors have been identified. Few receptors still remain orphans. What has emerged over the years is that most TNF ligands bind to one distinct receptor and some of the TNF ligands are able to bind to multiple TNF receptors, explaining to some extent the apparent disparity in the number of TNF receptors and ligands. Yet, in spite of some redundancy in TNF ligand/receptor interactions, it is clear that in vivo spatial, temporal, and indeed cell- and tissue-specific expression of both ligands and their receptors are important factors in determining the precise nature of cellular, physiological and pathological processes they control. TNF superfamily has been the most highly investigated area of basic medical research for over two decades.

The Cytokine Handbook

Author : Angus W. Thomson
Publisher : Gulf Professional Publishing
ISBN 13 : 9780126896633
Total Pages : 878 pages
Book Rating : 4.8/5 (966 download)

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Book Synopsis The Cytokine Handbook by : Angus W. Thomson

Download or read book The Cytokine Handbook written by Angus W. Thomson and published by Gulf Professional Publishing. This book was released on 2003 with total page 878 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Expanded to two volumes, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems.

Encyclopedia of Cancer

Author :
Publisher :
ISBN 13 : 9780122275555
Total Pages : 2800 pages
Book Rating : 4.2/5 (755 download)

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Book Synopsis Encyclopedia of Cancer by :

Download or read book Encyclopedia of Cancer written by and published by . This book was released on 2002 with total page 2800 pages. Available in PDF, EPUB and Kindle. Book excerpt:

TNF Superfamily

Author : Sanjay V. Khare
Publisher : CRC Press
ISBN 13 : 1498713254
Total Pages : 109 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis TNF Superfamily by : Sanjay V. Khare

Download or read book TNF Superfamily written by Sanjay V. Khare and published by CRC Press. This book was released on 2007-10-01 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tumor necrosis factor/receptor [TNF/TNFR] superfamily consists of more than 20 transmembrane proteins with conserved N-terminal cysteine-rich domains [CRDs] in the extracellular ligand binding region. Members have wide tissue distribution and play important roles in biological processes such as lymphoid and neuronal development, innate and adap

Cancer Signaling

Author : Christoph Wagener
Publisher : John Wiley & Sons
ISBN 13 : 352780045X
Total Pages : 357 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis Cancer Signaling by : Christoph Wagener

Download or read book Cancer Signaling written by Christoph Wagener and published by John Wiley & Sons. This book was released on 2016-08-12 with total page 357 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online for users of the print edition and have been integrated into the text in the enhanced e-book edition.

Nanomedicine for Cancer Therapy

Author : Piyush Kumar
Publisher : Springer
ISBN 13 : 3319458264
Total Pages : 77 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Nanomedicine for Cancer Therapy by : Piyush Kumar

Download or read book Nanomedicine for Cancer Therapy written by Piyush Kumar and published by Springer. This book was released on 2016-11-21 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Brief focuses on the cancer therapy available till date, from conventional drug delivery to nanomedicine in clinical trial. In addition, it reports on future generation based nanotherapeutics and cancer theranostic agent for effective therapeutic diagnosis and treatment. Breast cancer was chosen as the model system in this review. The authors give emphasis to multiple drug resistance (MDR) and its mechanism and how to overcome it using the nanoparticle approach.

Fas Signaling

Author : Harald Wajant
Publisher : Springer Science & Business Media
ISBN 13 : 0387345736
Total Pages : 169 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Fas Signaling by : Harald Wajant

Download or read book Fas Signaling written by Harald Wajant and published by Springer Science & Business Media. This book was released on 2007-04-03 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fas Signaling is focused on the signaling mechanisms and biology of the prototypic death receptor Fas, also called CD95 or APO-1. The chapters of this book cover, besides the well recognized apoptosis-related functions of Fas, its emerging role as a proinflammatory cytokine and as an inducer of alternative forms of cell death. Fas Signaling aims to provide the reader with an up-to-date survey of the various aspects of Fas biology and the open questions of the field are addressed. This title is intended for Ph.D and post-doctoral students starting to work in the field, but is also useful for everyone with an interest in the biology of this exciting molecule.

The Cytokine Factsbook and Webfacts

Author : Katherine A. Fitzgerald
Publisher : Elsevier
ISBN 13 : 0080530206
Total Pages : 526 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Cytokine Factsbook and Webfacts by : Katherine A. Fitzgerald

Download or read book The Cytokine Factsbook and Webfacts written by Katherine A. Fitzgerald and published by Elsevier. This book was released on 2001-09-03 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised and expanded, this second edition of The Cytokine FactsBook is the most up-to-date reference manual available for all current well-characterized interleukins, cytokines, and their receptors. An additional 52 cytokines are included, doubling the number of entries from the previous edition. The key properties of each cytokine are described and presented in a very accessible format with diagrams for each of the receptors. The Cytokine FactsBook includes free online access to the regularly updated Cytokine Webfacts. Cytokine Webfacts is a web-based comprehensive compendium of facts about cytokines and their receptors that includes a variety of data representations, such as text, signal pathway diagrams and 3D images. This exciting resource is integrated into other databases via hypertext links to provide a unique network, and contains a web-enabled version of RasMol for viewing structures.

Textbook of Autoinflammation

Author : Philip J. Hashkes
Publisher : Springer
ISBN 13 : 3319986058
Total Pages : 793 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Textbook of Autoinflammation by : Philip J. Hashkes

Download or read book Textbook of Autoinflammation written by Philip J. Hashkes and published by Springer. This book was released on 2019-02-13 with total page 793 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, the first complete textbook on this novel field in Medicine, comprehensively covers the clinical presentation, pathogenesis, genetics, and latest management strategies for autoinflammatory disorders as well as the basic science of autoinflammation. Relevant concepts such as how translational science of genetics and immunology relates to the innate immune system and autoinflammation are covered. Descriptions of the monogenic and polygenic/complex diseases that fall under the umbrella of autoinflammatory diseases are provided. Further topics covered include the latest clinical and genetic diagnostic approaches, concepts on the relationship between autoinflammation and autoimmunity/immunodeficiency, the role of autoinflammation in cancer, treatments and management strategies for these diseases, and potential areas of future development. The Textbook of Autoinflammation systematically describes and reviews diagnostic and treatment options for autoinflammatory disorders as well as all aspects of the concept of autoinflammation, and represents a valuable resource for professionals in a variety of disciplines who encounter these patients or who study autoinflammation.

Calcium-Binding Proteins of the EF-Hand Superfamily

Author : Claus W. Heizmann
Publisher : Humana Press
ISBN 13 : 9781493990290
Total Pages : 779 pages
Book Rating : 4.9/5 (92 download)

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Book Synopsis Calcium-Binding Proteins of the EF-Hand Superfamily by : Claus W. Heizmann

Download or read book Calcium-Binding Proteins of the EF-Hand Superfamily written by Claus W. Heizmann and published by Humana Press. This book was released on 2019-02-02 with total page 779 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores protocols for studying the many facets of Ca2+-imaging, Ca2+-signaling, and Ca2+-binding along with background information on the principles and application of these techniques. The content of the book delves into 48 chapters including subjects such as data analysis and modern technologies to study calcium-binding and signaling in cells, the superfamily of calcium-binding proteins characterized by the EF-hand structural motif, as well as their use as diagnostic and prognostic biomarkers in Laboratory Medicine and novel therapeutic drug targets. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Calcium-Binding Proteins of the EF-Hand Superfamily: From Basics to Medical Applications presents state-of-the-art, lab-based methods and easy-to-follow protocols for daily use, making it interesting for basic and medical researchers, cell- and molecular biologists, clinicians, clinical chemists, and the diagnostic industry.

Pediatric Allergy: Principles and Practice E-Book

Author : Donald Y. M. Leung
Publisher : Elsevier Health Sciences
ISBN 13 : 1437737781
Total Pages : 705 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Pediatric Allergy: Principles and Practice E-Book by : Donald Y. M. Leung

Download or read book Pediatric Allergy: Principles and Practice E-Book written by Donald Y. M. Leung and published by Elsevier Health Sciences. This book was released on 2010-10-13 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Allergy supplies the comprehensive guidance you need to diagnose, manage, and treat virtually any type of allergy seen in children. Drs. Leung, Sampson, Geha, and Szefler present the new full-color second edition, with coverage of the diagnosis and management of anaphylaxis, the immune mechanisms underlying allergic disease, the latest diagnostic tests, and more. Treat the full range of pediatric allergic and immunologic diseases through clinically focused coverage relevant to both allergists and pediatricians. Understand the care and treatment of pediatric patients thanks to clinical pearls discussing the best approaches. Easily refer to appendices that list common food allergies and autoantibodies in autoimmune diseases. Apply the newest diagnostic tests available—for asthma, upper respiratory allergy, and more—and know their benefits and contraindications. Treat the allergy at its source rather than the resulting reactions through an understanding of the immune mechanisms underlying allergic diseases. Get coverage of new research that affects methods of patient treatment and discusses potential reasons for increased allergies in some individuals. Better manage potential anaphylaxis cases through analysis of contributing facts and progression of allergic disease. Effectively control asthma and monitor its progression using the new step-by-step approach. Eliminate difficulty in prescribing antibiotics thanks to coverage of drug allergies and cross-reactivity.

Muscle Atrophy

Author : Junjie Xiao
Publisher : Springer
ISBN 13 : 9811314357
Total Pages : 618 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Muscle Atrophy by : Junjie Xiao

Download or read book Muscle Atrophy written by Junjie Xiao and published by Springer. This book was released on 2018-11-02 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses the development of muscle atrophy, which can be caused by denervation, disuse, excessive fasting, aging, and a variety of diseases including heart failure, chronic kidney diseases and cancers. Muscle atrophy reduces quality of life and increases morbidity and mortality worldwide. The book is divided into five parts, the first of which describes the general aspects of muscle atrophy including its characteristics, related economic and health burdens, and the current clinical therapy. Secondly, basic aspects of muscle atrophy including the composition, structure and function of skeletal muscle, muscle changes in response to atrophy, and experimental models are summarized. Thirdly, the book reviews the molecular mechanisms of muscle atrophy, including protein degradation and synthesis pathways, noncoding RNAs, inflammatory signaling, oxidative stress, mitochondria signaling, etc. Fourthly, it highlights the pathophysiological mechanisms of muscle atrophy in aging and disease. The book’s fifth and final part covers the diagnosis, treatment strategies, promising agents and future prospects of muscle atrophy. The book will appeal to a broad readership including scientists, undergraduate and graduate students in medicine and cell biology.

Co-signal Molecules in T Cell Activation

Author : Miyuki Azuma
Publisher : Springer Nature
ISBN 13 : 9813297174
Total Pages : 326 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Co-signal Molecules in T Cell Activation by : Miyuki Azuma

Download or read book Co-signal Molecules in T Cell Activation written by Miyuki Azuma and published by Springer Nature. This book was released on 2019-11-22 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book equips young immunologists and health professionals with a clear understanding of the fundamental concepts and roles of co-signal molecules and in addition presents the latest information on co-stimulation. The first part of the book is devoted to co-signal molecules and the regulation of T cells. Following an initial overview, subsequent chapters examine each co-signal molecule in turn and discuss the mechanisms by which co-signal molecules regulate the different types of T cell. The second part covers various clinical applications, including in autoimmune disease, neurological disorders, transplantation, graft-versus-host disease, and cancer immunotherapy. To date, co-stimulation blockade and co-inhibition blockade have shown beneficial effects and many additional clinical trials targeting co-signal molecules are ongoing. The mechanisms underlying these successful treatments are explained and the future therapeutic potential in the aforementioned diseases is evaluated. Co-signal Molecules in T Cell Activation will be a valuable reference guide to co-stimulation for basic and clinical researchers in the fields of both immunology and pharmaceutical science.

Nitric Oxide and Cancer: Pathogenesis and Therapy

Author : Benjamin Bonavida
Publisher : Springer
ISBN 13 : 3319136119
Total Pages : 319 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Nitric Oxide and Cancer: Pathogenesis and Therapy by : Benjamin Bonavida

Download or read book Nitric Oxide and Cancer: Pathogenesis and Therapy written by Benjamin Bonavida and published by Springer. This book was released on 2015-05-12 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. The volume explores nitric oxide and its relationship to cancer spanning from its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxics, and therapeutic applications. With chapters written by leading experts, the volume addresses the burgeoning interest in a rapidly advancing field and provides a valuable resource to scientists who have initiated research as well as clinical investigations in their laboratories on the various roles of NO and cancer.

Periodic and Non-Periodic Fevers

Author : Rolando Cimaz
Publisher : Springer Nature
ISBN 13 : 3030190552
Total Pages : 287 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Periodic and Non-Periodic Fevers by : Rolando Cimaz

Download or read book Periodic and Non-Periodic Fevers written by Rolando Cimaz and published by Springer Nature. This book was released on 2019-10-29 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by very well-known opinion leaders in the field, covers all aspects of periodic and non –periodic fevers, and related disorders. The expression refers to several different auto-inflammatory diseases, showing similar symptoms–the primary symptom being a recurrent fever for an infectious cause cannot be found. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications in both pediatric and adult patients. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springer’s series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. Autoinflammatory diseases are hereditary disorders that are caused by single-gene defects in innate immune regulatory pathways and are characterized by a clinical and biological inflammatory syndrome in which there is limited, if any, evidence of autoimmunity. Periodic and Non-Periodic Fevers will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these disease.

Dubois' Lupus Erythematosus and Related Syndromes - E-Book

Author : Daniel J. Wallace
Publisher : Elsevier Health Sciences
ISBN 13 : 0323550649
Total Pages : 848 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Dubois' Lupus Erythematosus and Related Syndromes - E-Book by : Daniel J. Wallace

Download or read book Dubois' Lupus Erythematosus and Related Syndromes - E-Book written by Daniel J. Wallace and published by Elsevier Health Sciences. This book was released on 2018-08-16 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 50 years, Dubois' Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It's an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. - Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. - Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. - Offers an increased focus on the clinical management of related disorders such as Sjogren's syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). - Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. - Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.

Infections in Systemic Autoimmune Diseases

Author :
Publisher : Elsevier
ISBN 13 : 044464217X
Total Pages : 228 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Infections in Systemic Autoimmune Diseases by :

Download or read book Infections in Systemic Autoimmune Diseases written by and published by Elsevier. This book was released on 2020-03-10 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infections in Systemic Autoimmune Diseases: Risk Factors and Management, Volume Sixteen describes the state-of-the-art of the risk factors and management treating the most common systemic autoimmune diseases (SADS). This updated volume consists of an introductory chapter that provides a brief overview of what different types of infectious diseases exist, followed by eight chapters detailing risk factors, guidelines and recommendations per different disease and bacterial infections. International in scope, the list of more than 20 contributors from Europa and America reads like a who's who of clinical researchers in the field.