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Author : Marie Nicole Krause
Publisher :
ISBN 13 :
Total Pages : 224 pages
Book Rating : 4.:/5 (17 download)
Download or read book ˜Theœ establishment of a novel therapeutic approach in Glioblastoma multiforme written by Marie Nicole Krause and published by . This book was released on 2012 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : James Markert
Publisher : Jones & Bartlett Learning
ISBN 13 : 9780763726409
Total Pages : 348 pages
Book Rating : 4.7/5 (264 download)
Download or read book Glioblastoma Multiforme written by James Markert and published by Jones & Bartlett Learning. This book was released on 2005 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Treatment of malignant glioma remains a major challenge for neurosurgeons, neurologists, medical oncologists, and radiation oncologists caring for patients with these tumors. Glioblastoma multiforme, the most common type of brain tumor, is also the most deadly -- only five percent of patients or fewer will be alive at five years after diagnosis. This comprehensive new reference is edited by a renowned team consisting of a neurosurgeon, medical oncologist, oncologic surgeon, and radiation oncologist. The book provides basic researchers and clinicians with a contemporary review of the epidemiology, diagnosis, and treatment of glioblastoma multiforme, and also imparts to experienced investigators outside of the field sufficient background to apply their skills to the treatment of this deadly disease. Expert malignant glioma researchers and clinicians provide state-of-the-art chapters on important topics such as molecular genetic classification of glioblastoma, surgical management, stem cell therapy, chemotherapy, angiogenesis, and more.
Author : Alexandra JD Sufit
Publisher :
ISBN 13 :
Total Pages : 163 pages
Book Rating : 4.:/5 (956 download)
Download or read book Novel Approaches in the Treatment for Glioblastoma Multiforme written by Alexandra JD Sufit and published by . This book was released on 2016 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glioblastoma multiforme is a dismal disease with a prognosis of 12-14 months following diagnosis. Patients diagnosed with this disease have a 5% 5-year survival rate. Unfortunately, these statistics have not changed in 30 years despite ongoing research within the field. The current standard of care therapy of gross total resection (if eligible) followed by radiation and chemotherapy, temozolomide, is limited and only offer a few months of prolonged life. Genomic analysis of tumors has identified many mutations, amplifications, and genetic anomalies within the cancer DNA repertoire. Improving our understanding of the molecular alterations in this disease through these identifications provide us with the potential ability to target proteins specifically aiding to the survival of cancer. Some of these mutations have been targeted successfully and have prolonged life in other cancers, e.g.CML and lung cancer. However, clinical trials have revealed that certain targeted therapies, such as avastin and cetuximab, do not prolong life in glioblastoma. Glioblastoma is known for its highly mutated DNA, its highly migratory phenotype, and its high heterogeneity, making this tumor difficult to target. One goal is to find an essential oncoprotein that the tumor is addicted to, a theory known as oncogene addiction, to target and eliminate the cells upon inactivation of the oncogene. Another is to find a protein that is only expressed by the tumor cell, known as a tumor specific antigen, to reduce toxicity levels of therapy. Unfortunately, these tasks are not as easily accomplished as they were originally theorized. MERTK, a receptor tyrosine kinase, is a protein that is essential in glioblastoma with regard to signaling for cellular migration, pro-survival and pro-proliferative signaling pathways. Targeting MERTK is promising because it is aberrantly expressed in 90% of glioblastoma patient samples tested. However, taking into consideration the failed clinical trials for monotherapy against EGFR, another receptor tyrosine kinase targeted in GBM, combination therapy may provide a better approach in the treatment of GBM. Two approaches were tested. One approach combined therapy of MERTK inhibition with either chemotherapy or autophagy manipulation. The second approach is to stimulate the immune system alongside EGFR inhibition, with the hope of enabling a greater response in patients.
Author : Swapan K. Ray
Publisher : Springer Science & Business Media
ISBN 13 : 1441904107
Total Pages : 427 pages
Book Rating : 4.4/5 (419 download)
Download or read book Glioblastoma: written by Swapan K. Ray and published by Springer Science & Business Media. This book was released on 2009-10-31 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new areas to find successful therapeutic strategies. Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.
Author : Mostafa Khairy
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)
Download or read book Novel Therapeutic Approaches for Glioblastoma written by Mostafa Khairy and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glioblastoma has a devastating prognosis, and a remarkably low survival rate. Current therapeutic strategies including surgery, radiation and temozolomide are only useful as a palliative therapy, with no significant increase in overall survival. In this study, we investigated multiple therapeutic approaches, both as a new main treatment and as an adjuvant therapy to enhance the sensitivity of glioblastoma cells to radiation. Histone acetylation and deacetylation is an important epigenetic mechanism for controlling gene expression and DNA repair. Histone acetylation and deacetylation are controlled by two classes of enzymes: Histone acetyltransferases (HATs) and Histone deacetylases (HDACs). Histone acetylation occurs on the lysine residues of histones, which neutralizes the lysine positive charge, leading to weakening of the electrostatic attraction between those residues and DNA. This induces a less condensed chromatin condition, which enhances the accessibility of DNA binding proteins to DNA. We postulated that the inhibition of histone acetylation will increase the sensitivity of glioblastoma cells to radiation. In the first part of my thesis, I used immunofluorescence microscopy to examine the effect of HAT inhibition on chromatin condensation and DNA double strand breaks after radiation, with no significant effect observed. HATs use acetyl CoA as the substrate for histone acetylation. Acetyl CoA is produced in the cell through various metabolic pathways, which include glucose, fatty acids, and glutamine metabolism. It has been reported that the acetyl CoA that is used for histone acetylation comes mainly from glucose metabolism in a panel of colorectal, prostate, glioblastoma and breast cancer cell lines. In the second part of my thesis, I investigated the effect of glucose concentrations in culture media on histone H3 and histone H4 acetylation, with the goal of controlling histone acetylation with glucose concentration and determining the impact on DNA repair. However, glucose concentration in the media had no effect histone acetylation. Finally, in the third part of my thesis, I examined whether tumor selective energy deprivation using 'ketogenic diet' culture media might affect the growth of glioblastoma cells. Research from different labs showed that glioblastoma cells have impaired mitochondrial function, and less active OXCT1 3-oxoacid-CoA transferase 1, leaving them with a disrupted ability to metabolize a ketogenic diet. We saw this as a therapeutic window opportunity, with a ketogenic diet affecting energy production in glioblastoma cells but not affecting the normal cells in the brain. Our results indicated that both healthy tissue and glioblastoma cells were unable to use the ketogenic diet for energy production. Therefore, we did not pursue this approach.Finally, in the last part of my thesis, I evaluated sulforaphane, a natural product that occurs in broccoli sprouts, as a new therapeutic approach for glioblastoma, for its anti-cancer properties. I found that sulforaphane exerted a cytotoxic effect on both U251 and U87 cells in a dose responsive manner. In addition, sulforaphane showed anti-invasion in U87 cells and cell cycle inhibition effects in U251 glioblastoma cells. Sulforaphane, however, did not enhance radiation cytotoxicity using the alamarBlue cytotoxicity assay. In conclusion, we believe that sulforaphane is a good candidate for in vivo studies and further research for glioblastoma therapy. In conclusion, in this thesis we investigated different strategies to increase the efficacy of radiation treatment in glioblastoma therapy. The methods we used included HAT inhibition, changing the glucose concentration to affect histone acetylation, ketogenic diet media and sulforaphane. Among these, only sulforaphane showed cytotoxic, anti-invasive and cell cycle inhibition effects on glioblastoma cells. For future directions, we plan to test sulforaphane synergy with radiation.
Author : Stanley Stylli
Publisher : Mdpi AG
ISBN 13 : 9783036525990
Total Pages : 282 pages
Book Rating : 4.5/5 (259 download)
Download or read book Novel Treatment Strategies for Glioblastoma written by Stanley Stylli and published by Mdpi AG. This book was released on 2021-12-21 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of articles that brings together current knowledge from an international team of contributors who are dedicated investigators exploring novel strategies for the treatment of glioblastoma. These articles describe some of the latest concepts that will provide students, researchers and clinicians with an overview of the therapeutic approaches being developed in the field of neuro-oncology to combat this deadly disease.
Author : Timo Marian Kauer
Publisher :
ISBN 13 :
Total Pages : 104 pages
Book Rating : 4.:/5 (8 download)
Download or read book Engineered Neural Stem Cells Encapsulated in a Biocompatible Synthetic Extracellular Matrix as a Novel Therapeutic Strategy for Recurrent Glioblastoma Multiforme written by Timo Marian Kauer and published by . This book was released on 2010 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Carsten Nieder
Publisher : Springer
ISBN 13 : 3319418254
Total Pages : 368 pages
Book Rating : 4.3/5 (194 download)
Download or read book Re-Irradiation: New Frontiers written by Carsten Nieder and published by Springer. This book was released on 2016-10-25 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, now in its second edition, provides a comprehensive overview of current re-irradiation strategies, with detailed discussion of re-irradiation methods, technical aspects, the role of combined therapy with anticancer drugs and hyperthermia, and normal tissue tolerance. In addition, disease specific chapters document recent clinical results and future research directions. All chapters from the first edition have been revised and updated to take account of the latest developments and research findings, including those from prospective studies. Due attention is paid to the exciting developments in the fields of proton irradiation and frameless image-guided ablative radiotherapy. The book documents fully how refined combined modality approaches and significant technical advances in radiation treatment planning and delivery have facilitated the re-irradiation of previously exposed volumes, allowing both palliative and curative approaches to be pursued at various disease sites. Professionals involved in radiation treatment planning and multimodal oncology treatment will find it to be an invaluable aid in understanding the benefits and limitations of re-irradiation and in designing prospective trials.
Author : Anne Le
Publisher : Springer
ISBN 13 : 331977736X
Total Pages : 186 pages
Book Rating : 4.3/5 (197 download)
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Author : Herbert B. Newton
Publisher : Academic Press
ISBN 13 : 0128121017
Total Pages : 848 pages
Book Rating : 4.1/5 (281 download)
Download or read book Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy written by Herbert B. Newton and published by Academic Press. This book was released on 2018-03-28 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Brain Tumor Chemotherapy, Molecular Therapeutics, and Immunotherapy, Second Edition, provides a comprehensive overview of the molecular methodologies in the neuro-oncology field. There have been profound changes in the landscape of approaches to brain tumor therapy since the first edition—mainly in the areas of molecular biology and molecular therapeutics, as well as in the maturation of immunotherapy approaches (e.g., vaccines). This updated edition has a new, primary focus on multidisciplinary molecular methods, and is broadened to include the latest cutting-edge molecular biology, therapeutics, immunobiology and immunotherapy approaches. As the first comprehensive book to address the molecular research into these concepts, users will find it to be an invaluable resource on the topics discussed. Provides the most up-to-date information regarding conventional forms of cytotoxic chemotherapy, as well as the basic science and clinical application of molecular therapeutics for the treatment of brain tumors Broadly appeals to anyone interested in neuro-oncology and the treatment of brain tumors Features updated chapters on molecular biology, molecular therapeutics, maturation of immunotherapy approaches, and a focus on multidisciplinary molecular methods Includes a new section on the basic science of immunology, as well as thorough updates on the use of vaccine technology and immunotherapy for the treatment of brain tumors
Author : Boris Rubinsky
Publisher : Springer Science & Business Media
ISBN 13 : 364205420X
Total Pages : 320 pages
Book Rating : 4.6/5 (42 download)
Download or read book Irreversible Electroporation written by Boris Rubinsky and published by Springer Science & Business Media. This book was released on 2009-11-25 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-thermal irreversible electroporation is a new minimally invasive surgical p- cedure with unique molecular selectivity attributes – in fact it may be considered the first clinical molecular surgery procedure. Non-thermal irreversible electro- ration is a molecular selective mode of cell ablation that employs brief electrical fields to produce nanoscale defects in the cell membrane, which can lead to cell death, without an effect on any of the other tissue molecules. The electrical fields can be produced through contact by insertion of electrode needles around the undesirable tissue and non-invasively by electromagnetic induction. This new - dition to the medical armamentarium requires the active involvement and is of interest to clinical physicians, medical researchers, mechanical engineers, che- cal engineers, electrical engineers, instrumentation designers, medical companies and many other fields and disciplines that were never exposed in their training to irreversible electroporation or to a similar concept. This edited book is designed to be a comprehensive introduction to the field of irreversible electroporation to those that were not exposed or trained in the field before and can also serve as a reference manual. Irreversible electroporation is broad and interdisciplinary. Therefore, we have made an attempt to cover every one of the various aspects of the field from an introductory basic level to state of the art.
Author : Elke Hattingen
Publisher : Springer
ISBN 13 : 3642450407
Total Pages : 166 pages
Book Rating : 4.6/5 (424 download)
Download or read book Brain Tumor Imaging written by Elke Hattingen and published by Springer. This book was released on 2015-09-02 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.
Author : Thomas Seyfried
Publisher : John Wiley & Sons
ISBN 13 : 1118310306
Total Pages : 482 pages
Book Rating : 4.1/5 (183 download)
Download or read book Cancer as a Metabolic Disease written by Thomas Seyfried and published by John Wiley & Sons. This book was released on 2012-05-18 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book addresses controversies related to the origins of cancer and provides solutions to cancer management and prevention. It expands upon Otto Warburg's well-known theory that all cancer is a disease of energy metabolism. However, Warburg did not link his theory to the "hallmarks of cancer" and thus his theory was discredited. This book aims to provide evidence, through case studies, that cancer is primarily a metabolic disease requring metabolic solutions for its management and prevention. Support for this position is derived from critical assessment of current cancer theories. Brain cancer case studies are presented as a proof of principle for metabolic solutions to disease management, but similarities are drawn to other types of cancer, including breast and colon, due to the same cellular mutations that they demonstrate.
Author : Jahangir Moini
Publisher : Academic Press
ISBN 13 : 0128217553
Total Pages : 554 pages
Book Rating : 4.1/5 (282 download)
Download or read book Epidemiology of Brain and Spinal Tumors written by Jahangir Moini and published by Academic Press. This book was released on 2021-04-09 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiology of Brain and Spinal Tumors provides a single volume resource on imaging methods and neuroepidemiology of both brain and spinal tumors. The book covers a variety of imaging techniques, including computed tomography (CT), MRI, positron emission tomography (PET), and other laboratory tests used in diagnosis and treatment. Detailed epidemiology, various imaging methods, and clinical considerations of tumors of the CNS make this an ideal reference for users who will also find diverse information about structures and functions, cytology, epidemiology (including molecular epidemiology), diagnosis and treatment. This book is appropriate for neuroscience researchers, medical professionals and anyone interested in a complete guide to visualizing and understanding CNS tumors. Provides the most up-to-date information surrounding the epidemiology, biology and imaging techniques for brain and spinal tumors, including CT, MRI, PET, and others Includes full color figures, photos, tables, graphs and radioimaging Contains information that will be valuable to anyone interested in the field of neurooncology and the treatment of patients with brain and spinal tumors Serves as a source of background information for basic scientists and pharmaceutical researchers who have an interest in imaging and treatment
Author : Sergey Makarov
Publisher : Springer Nature
ISBN 13 : 3030212939
Total Pages : 398 pages
Book Rating : 4.0/5 (32 download)
Download or read book Brain and Human Body Modeling written by Sergey Makarov and published by Springer Nature. This book was released on 2019-08-27 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes modern applications of computational human modeling with specific emphasis in the areas of neurology and neuroelectromagnetics, depression and cancer treatments, radio-frequency studies and wireless communications. Special consideration is also given to the use of human modeling to the computational assessment of relevant regulatory and safety requirements. Readers working on applications that may expose human subjects to electromagnetic radiation will benefit from this book’s coverage of the latest developments in computational modelling and human phantom development to assess a given technology’s safety and efficacy in a timely manner. Describes construction and application of computational human models including anatomically detailed and subject specific models; Explains new practices in computational human modeling for neuroelectromagnetics, electromagnetic safety, and exposure evaluations; Includes a survey of modern applications for which computational human models are critical; Describes cellular-level interactions between the human body and electromagnetic fields.
Author : Herbert B. Newton
Publisher : Academic Press
ISBN 13 : 0128229950
Total Pages : 1022 pages
Book Rating : 4.1/5 (282 download)
Download or read book Handbook of Neuro-Oncology Neuroimaging written by Herbert B. Newton and published by Academic Press. This book was released on 2022-08-21 with total page 1022 pages. Available in PDF, EPUB and Kindle. Book excerpt: With treatment approaches and the field of neuro-oncology neuroimaging changing rapidly, this third edition of the Handbook of Neuro-Oncology Neuroimaging is very relevant to those in the field, providing a single-source, comprehensive, reference handbook of the most up-to-date clinical and technical information regarding the application of neuroimaging techniques to brain tumor and neuro-oncology patients. This new volume will have updates on all of the material from the second edition, and in addition features several new important chapters covering diverse topics such as imaging for the use of Laser Interstitial Thermal Therapy, advanced imaging techniques in radiation therapy, therapeutic treatment fields, response assessment in clinical trials, surgical planning of neoplastic disease of the spine, and more. Sections first overview neuro-oncological disorders before delving into the physics and basic science of neuroimaging and great focus on CT and MRI. The book then focuses on advances in the neuroimaging of brain tumors and neuroimaging of specific tumor types. There is also discussion of neuroimaging of other neuro-oncological syndromes. This book will serve as a resource of background information to neuroimaging researchers and basic scientists with an interest in brain tumors and neuro-oncology. Summarizes translational research on brain imaging for brain tumors Discusses limitations of neuroimaging for diagnosis and treatment Presents advanced imaging technologies, including CT, MRI, and PET Contains new coverage on Laser Interstitial Thermal Therapy, radiation therapy, clinical trials, and more
Download or read book Lee V. Murphy written by and published by . This book was released on 1994 with total page 42 pages. Available in PDF, EPUB and Kindle. Book excerpt:
