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Author : Heidi Carol Newman
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (593 download)
Download or read book The Yield and Distribution of Radiation-induced DNA Damage written by Heidi Carol Newman and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Heidi Carol Newman
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (496 download)
Download or read book The Yields and Distribution of Radiation-induced DNA Damage written by Heidi Carol Newman and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John T. Lett
Publisher : Academic Press
ISBN 13 : 1483282279
Total Pages : 520 pages
Book Rating : 4.4/5 (832 download)
Download or read book DNA and Chromatin Damage Caused by Radiation written by John T. Lett and published by Academic Press. This book was released on 2013-10-22 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Radiation Biology, Volume 17: DNA and Chromatin Damage Caused by Radiation outlines the different biological reactions to radiation. This book discusses the linear energy transfer and energy loss; DNA breaks and track structure; DNA radicals from water radicals; and radiation-induced strand breaks in isolated DNA. The radiation damage to DNA and its nearby environment; thiol radioprotectors and mechanism of action; radiolysis of water and track reactions; and computer simulation of higher order structure of DNA are also elaborated. This publication likewise covers the concept of chromatin structure; DNA supercoiling studied by sedimentation; measurement of radiation-induced DNA breakage; and analysis of damage in interphase cells. This volume is a useful reference to biologists and students concerned with DNA and chromatin damage caused by radiation.
Author : E.M. Fielden
Publisher : Springer Science & Business Media
ISBN 13 : 3642751482
Total Pages : 437 pages
Book Rating : 4.6/5 (427 download)
Download or read book The Early Effects of Radiation on DNA written by E.M. Fielden and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the biological effects of ionising radiation closely followed the identification of such radiation. The realisation that DNA is the site of genetic infonnation in cells subsequently focussed attention on DNA as an important target in the lethal and mutagenic effects of ionising radiation. Thus radiation effects upon DNA became an important area for fundamental scientific studies by radiation biologists, chemists and physicists. To a first approximation, the concerns of the three disciplines can be divided by time scales: the physical process of energy deposition from photon or charged 16 12 particle and subsequent relaxation (-10- to 10- secs), followed by chemical 12 2 reactions (- 10- to 10 secs), and fmally, the expression of biological effect (minutes to years). Thus, the concept of 'early processes' conveys different ideas to different scientists, although they are all interrelated. To attempt to describe in any detail all these processes is a mammoth task which is not made easier by the different conventions and experimental approaches of the three disciplines. However, the recent advances in all these scientific areas seemed, to the organisers at least, to offer the opportunity to stimulate more active interaction between physicists, chemists and biologists. With this in mind, a multi-disciplinary workshop was organised, which brought together some fifty scientists to present their own specialist interests and, through extensive discussion, explore which problems are of high priority and require input from the different disciplines to resolve them.
Author : D. Schulte-Frohlinde
Publisher : CRC Press
ISBN 13 : 9783718648740
Total Pages : 138 pages
Book Rating : 4.6/5 (487 download)
Download or read book Free-Radical and Radiation-Induced Damage to DNA written by D. Schulte-Frohlinde and published by CRC Press. This book was released on 1989 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Clemens Sonntag
Publisher : Springer Science & Business Media
ISBN 13 : 3540305920
Total Pages : 528 pages
Book Rating : 4.5/5 (43 download)
Download or read book Free-Radical-Induced DNA Damage and Its Repair written by Clemens Sonntag and published by Springer Science & Business Media. This book was released on 2006-03-20 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: The free-radical chemistry of DNA had been discussed in some detail in 1987 in my book The Chemical Basis of Radiation Biology. Obviously, the more recent developments and the concomitant higher level of understanding of mechanistic details are missing. Moreover, in the living cell, free-radical DNA damage is not only induced by ionizing radiation, but free-radical-induced DNA damage is a much more general phenomenon. It was, therefore, felt that it is now timely to review our present knowledge of free-radical-induced DNA damage induced by all conceivable free-radical-generating sources. Originally, it had been thought to include also a very important aspect, the repair of DNA damage by the cell’s various repair enzymes. Kevin Prise (Cancer Campaign, Gray Laboratory, L- don) was so kind to agree to write this part. However, an adequate description of this strongly expanding area would have exceeded the allocated space by much, and this section had to be omitted. The directors of the Max-Planck-Institut für Strahlenchemie (now MPI für Bioanorganische Chemie), Karl Wieghardt and Wolfgang Lubitz, kindly allowed me to continue to use its facilities after my retirement in 2001. Notably, our - brarian, Mrs. Jutta Theurich, and her right-hand help, Mrs. Rosemarie Schr- er, were most helpful in getting hold of the literature. I thank them very much. Without their constant help, this would have been very difficult indeed.
Author : Piotr Pater
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (979 download)
Download or read book Numerical Models for Radiation-induced DNA Damage written by Piotr Pater and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "This thesis introduces and explores various numerical models for calculating DNA damage produced by photons, electrons, protons, and other light ion beams. Clustered DNA damage in the form of single-strand and double-strand breaks are a hallmark of radiation and a known initiating agent of loss of cellular reproductive ability. A rigorous analysis of the Monte Carlo track structure calculation methodology is presented with emphasis put on standardization of the definitions, values, and algorithms relating the various adjustable parameters in the model. Commonly overlooked problems associated with the strand break threshold energy, the clustering algorithm, the impact of the dose distribution, and the lack of charged particle equilibrium are presented. Estimates of nucleosome strand breakage clustering are obtained to highlight the higher damage complexity of lower kinetic energy electron beams. The algorithms presented offer innovative and fast DNA damage induction searches inside geometrical models of the complete human DNA genome of a biological cell nucleus. Strand break yields induced by proton and light ion beams are described and quantified with respect to the linear energy transfer (LET). It was found that protons create statistically more double-strand breaks than carbon ions of the same LET. In these simulations, computation time places a fundamental limit on the level of detail simulated; however, the data presented shows that the radiation field affecting the nuclear DNA needsto be described with precision in order to reproduce clinical irradiation setups. Firstly, an introduction to the track overlay algorithm built upon a pre-generated library of electron tracks obtained from a precise description of the photon field experienced around a cell nucleus is presented. Subsequently, an analysis was performed to quantify the creation of double-strand breaks by clinical photon fields, including cone-beam computed-tomography, electronic brachytherapy, and several radio-isotopes. Lastly, the effectiveness at inducing double-strand breaks are computed using the relative biological effectiveness metric. This is complemented by an investigation of the trends of this quantity with respect to particle type and energy." --
Author : Antonio Monari
Publisher : Frontiers Media SA
ISBN 13 : 2889196607
Total Pages : 95 pages
Book Rating : 4.8/5 (891 download)
Download or read book Radiation-induced and oxidative DNA damages written by Antonio Monari and published by Frontiers Media SA. This book was released on 2015-10-02 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA stores and passes the genetic information of almost all living organisms. Its molecular structure and their intramolecular interactions are particularly suitable to maximize stability against oxidative stress and UV-light absorption. Yet the protection and repair strategies are still error-prone: DNA lesions are produced, including the most complex and highly mutagenic ones. An important threat to DNA stability comes from photosensitization, i.e. from the dramatic multiplication of radiation-induced defects mediated by the presence of organic or organometallic dyes compared to the direct exposure to UVA radiation. Moreover, the photo-induced production of singlet oxygen generates an extremely high oxidative stress on DNA that, in vivo, normally results in extended cellular apoptosis. Elucidating the processes leading to DNA damages, from the production of a simple radical entity to deleterious lesions, as well as the opportunities of repair by devoted enzymes, is a cornerstone towards the development of more efficient protection strategies. Sensitization and selective production of DNA lesions can also be exploited to induce the selective apoptosis of cancer cells upon exposition to radiation or to oxidative stress, for instance in the field of photodynamic therapy. The importance and relevance of the field is witnessed by the impressive amount of high-level papers dealing with this complex subject, and notably tackling the structural elucidation of DNA and DNA-drug adducts, the mechanisms of formation of DNA lesions (including the precise detection of the final lesion products), as well as the influence of the lesions on the DNA stability and dynamics and the consequences on the ease of repair. Due to the complexity of the field lying at the frontiers between chemistry, physics and biology, multidisciplinary strategies allying modeling and experience are needed. This topic aims at giving an extended overview of the current research in the domain, with fundamental contribution from the leading groups in the field of DNA reactivity, structural characterization, photo-chemistry and photo-physics, as well as repair mechanism. It will therefore be a fundamental guide for scientists wanting to address the field of DNA lesion and repair, but also more generally for researchers working in rational drug design or in the development of biomarkers and medical imaging techniques
Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author : Alfred F. Fuciarelli
Publisher :
ISBN 13 :
Total Pages : 472 pages
Book Rating : 4.3/5 (91 download)
Download or read book Radiation Damage in DNA written by Alfred F. Fuciarelli and published by . This book was released on 1995 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jochen Dahm-Daphi
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (248 download)
Download or read book Radiation-induced DNA Damage, DNA Repair and Biological Effects written by Jochen Dahm-Daphi and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lorenzo Manti
Publisher : Frontiers Media SA
ISBN 13 : 2889740005
Total Pages : 340 pages
Book Rating : 4.8/5 (897 download)
Download or read book Ionizing Radiation and Human Health: A Multifaceted Relationship written by Lorenzo Manti and published by Frontiers Media SA. This book was released on 2022-01-07 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : National Research Council
Publisher : National Academies
ISBN 13 : 0309039959
Total Pages : 436 pages
Book Rating : 4.3/5 (9 download)
Download or read book Health Effects of Exposure to Low Levels of Ionizing Radiation written by National Research Council and published by National Academies. This book was released on 1990-02-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.
Author : Jason S. Gobey
Publisher :
ISBN 13 :
Total Pages : 108 pages
Book Rating : 4.:/5 (356 download)
Download or read book The Characterization of Radiation-induced DNA Damage by Mass Spectrometry written by Jason S. Gobey and published by . This book was released on 1996 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Agnieszka Stypczyńska
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (715 download)
Download or read book Experimental Investigations of Radiation Induced DNA Damage written by Agnieszka Stypczyńska and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Susan Helen MacPhail
Publisher :
ISBN 13 :
Total Pages : 190 pages
Book Rating : 4.:/5 (22 download)
Download or read book Effect of Intercellular Contact on Radiation-induced DNA Damage written by Susan Helen MacPhail and published by . This book was released on 1988 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael G. Simic
Publisher : Springer
ISBN 13 :
Total Pages : 604 pages
Book Rating : 4.3/5 (91 download)
Download or read book Mechanisms of DNA Damage and Repair written by Michael G. Simic and published by Springer. This book was released on 1986-06-30 with total page 604 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on the papers presented at the conference on "Mecha nisms of DNA Damage and Repair: Implications for Carcinogenesis and Risk Assessment," held at the National Bureau of Standards on June 2-7, 1985, This volume deals with mechanisms of DNA damage and repair at the molecular level; consequences of unrepaired or misrepaired damage, with major emphasis on carcinogenesis; drugs which bind selectively to altered and potentially damaging DNA sequences; and potential utilization of DNA damage as an endpoint for assessing risks of UV light, ionizing radiations, chemicals, drugs, and hazardous agents in foods. Because the induction of mutations by radiation and genotoxic chemicals has been observed to follow one-hit kinetics in some instances, it is generally assumed that any level of exposure to a DNA-damaging agent may increase the risk of genetic disease or cancer in an exposed population. At the same time, however, there is evidence that although the DNA of living cells is continually damaged by natural background radiation, free radicals, and other naturally occurring processes, most of the damage is normally repaired.
