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Author : George A. Lopez
Publisher :
ISBN 13 :
Total Pages : 380 pages
Book Rating : 4.:/5 (66 download)
Download or read book The Structure and Function of the Shaker Voltage-gated Potassium Channel written by George A. Lopez and published by . This book was released on 1995 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Craig Dustin Patten
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.:/5 (318 download)
Download or read book Structure and Function of Voltage Gated Potassium Channels written by Craig Dustin Patten and published by . This book was released on 1998 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Leslie Karen Sprunger
Publisher :
ISBN 13 :
Total Pages : 246 pages
Book Rating : 4.:/5 (319 download)
Download or read book Structure/function Studies of Voltage-gated Potassium Channels written by Leslie Karen Sprunger and published by . This book was released on 1995 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Howard Sherman Krovetz
Publisher :
ISBN 13 :
Total Pages : 454 pages
Book Rating : 4.:/5 (381 download)
Download or read book The Structure and Function of a Voltage-gated Potassium Channel Pore written by Howard Sherman Krovetz and published by . This book was released on 1997 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jessica Lindsay Richardson
Publisher :
ISBN 13 :
Total Pages : 348 pages
Book Rating : 4.:/5 ( download)
Download or read book The Structure of Function of Voltage-dependant Potassium and Sodium Channels written by Jessica Lindsay Richardson and published by . This book was released on 2008 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 0080585175
Total Pages : 522 pages
Book Rating : 4.0/5 (85 download)
Download or read book Potassium Ion Channels: Molecular Structure, Function, and Diseases written by and published by Academic Press. This book was released on 1999-05-04 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the first to focus on potassium ion channels and covers the recent remarkable progress made in research on these proteins. Many diseases are caused by the abnormalities of potassium ion channels. They include diabetes mellitus, life-threatening hereditary cardiac arrhythmia, epilepsy, neural degeneration, and renal hypertension. Written by leading scientists in the field, this volume offers readers a comprehensive update of this field in the understanding of the genes, molecular structure, function and diseases of potassium ion channels. Key Features * The first comprehensive volume on potassium ion channels in all aspects of genes, molecular structure, function, and diseases * Completely up-to-date information * Written by leading scientists in the field
Author : Valentin K. Gribkoff
Publisher : John Wiley & Sons
ISBN 13 : 0470429895
Total Pages : 505 pages
Book Rating : 4.4/5 (74 download)
Download or read book Structure, Function, and Modulation of Neuronal Voltage-Gated Ion Channels written by Valentin K. Gribkoff and published by John Wiley & Sons. This book was released on 2008-12-09 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses voltage-gated ion channels and their importance in drug discovery and development. The book includes reviews of the channel genome, the physiological bases of targeting ion channels in disease, the unique technologies developed for ion channel drug discovery, and the increasingly important role of ion channel screening in cardiac risk assessment. It provides an important reference for research scientists and drug discovery companies.
Author : Christopher James Partridge
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (118 download)
Download or read book Structure-function Studies on a Voltage Gated Potassium Channel written by Christopher James Partridge and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Oliver Samuel Baker
Publisher :
ISBN 13 :
Total Pages : 310 pages
Book Rating : 4.:/5 (34 download)
Download or read book A Study of the Mechanism of Ion-channel Voltage Sensing in the Shaker Potassium Channel written by Oliver Samuel Baker and published by . This book was released on 1997 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert H. Kretsinger
Publisher : Springer
ISBN 13 : 9781461415329
Total Pages : 0 pages
Book Rating : 4.4/5 (153 download)
Download or read book Encyclopedia of Metalloproteins written by Robert H. Kretsinger and published by Springer. This book was released on 2013-05-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics.
Author : Kwang Hee Hong
Publisher :
ISBN 13 :
Total Pages : 134 pages
Book Rating : 4.:/5 (58 download)
Download or read book Structural and Functional Studies of the Shaker Potassium Channel Gating Domain written by Kwang Hee Hong and published by . This book was released on 2002 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sarah MacKenzie Webster
Publisher :
ISBN 13 :
Total Pages : 202 pages
Book Rating : 4.:/5 (712 download)
Download or read book Structures and Mechanisms of Gating in Shaker Voltage-dependent Potassium Channels written by Sarah MacKenzie Webster and published by . This book was released on 2003 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Jie Zheng
Publisher : CRC Press
ISBN 13 : 1466551429
Total Pages : 682 pages
Book Rating : 4.4/5 (665 download)
Download or read book Handbook of Ion Channels written by Jie Zheng and published by CRC Press. This book was released on 2015-02-25 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New Benchmark for Understanding the Latest Developments of Ion ChannelsIon channels control the electrical properties of neurons and cardiac cells, mediate the detection and response to sensory stimuli, and regulate the response to physical stimuli. They can often interact with the cellular environment due to their location at the surface of ce
Author : Gildas Loussouarn
Publisher : Frontiers E-books
ISBN 13 : 288919115X
Total Pages : 211 pages
Book Rating : 4.8/5 (891 download)
Download or read book Mechanisms of ion channels voltage-dependency written by Gildas Loussouarn and published by Frontiers E-books. This book was released on with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Voltage-gated ion channels are transmembrane proteins in which at least one gate is controlled by the transmembrane potential. They are frequently very selectively permeable to sodium (Nav channels), potassium (Kv channels) or calcium (Cav channels) ions. Depending on the channels, opening of the activation gate is triggered by membrane depolarization (Kv, Nav and Cav channels) or hyperpolarization (HCN channels for instance). In addition, in many voltage-gated channels, a so-called inactivation gate is also present. Compared to the activation gate, the latter is oppositely coupled to the potential: In Kv, Nav and Cav channels, upon membrane depolarization, the inactivation gate closes whereas the activation gate opens. Depending on the cell types in which they are expressed and their physiological role, various voltage-dependent channels can be characterized by their conductance, ion selectivity, pharmacology and voltage-sensitivity. These properties are mainly dictated by the amino-acids sequence and structure of the pore forming subunit(s), presence of accessory subunit(s), membrane composition, intra- and extracellular ions concentration. Noteworthy, despite a profound variety of these ion channels characteristics, it seems that most of them obey to the same global, four-fold structure now obtained by several X-ray crystallography experiments. Given the wealth of electrophysiological, biochemical, optical, and structural data regarding ion channels voltage-dependency, we decided to put together in this e-book, up to date reviews describing the molecular details of these complex voltage-gated channels.
Author : Jakob Renhorn
Publisher : Linköping University Electronic Press
ISBN 13 : 9176853381
Total Pages : 71 pages
Book Rating : 4.1/5 (768 download)
Download or read book Conformational Changes during Potassium-Channel Gating written by Jakob Renhorn and published by Linköping University Electronic Press. This book was released on 2018-04-09 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt: Voltage-gated ion channels have a paramount importance in many physiological processes such as cell-to-cell communication, action potential-propagation, and cell motility. Voltage-gated ion channels are characterized by their ability to sense membrane voltage and to greatly change channel activity in response to small changes in the voltage. The ability to sense voltage resides in the four voltage-sensor domains (VSDs) surrounding the central ion-conducting pore. Membrane depolarization causes the inside of the membrane to become positively charged, electrostatically repelling the positively charged fourth transmembrane segment (S4), or voltage sensor, in the VSD, causing the voltage sensor to move outwards. This motion provides necessary energy to open the pore and allow ion conductivity. Prolonged channel activation leads to alterations in the selectivity filter which cease ion conductivity, in a process called slow inactivation. In this thesis, we investigated the movement of S4 during activation of the channel. We also studied the communication between the four subunits during activation as well as the communication between the pore domain and VSD during slow inactivation. We have shown that voltage sensors move approximately 12 Å outwards during activation. The positively charged amino acid residues in S4 create temporary salt bridges with negative counter-charges in the other segments of the VSD as it moves through a membrane. We have also shown that the movement of one of the four voltage sensors can affect the movement of the neighboring voltage sensors. When at least one voltage sensor has moved to an up-position, it stabilizes other voltage sensors in the up-position, increasing the energy required for the voltage sensor to return to the down position. We have also shown reciprocal communication between the pore domain and the VSDs. Alterations in the VSD or the interface between the pore and the VSD cause changes in the rate of slow inactivation. Likewise, modifications in the pore domain cause changes to the voltage-sensor movement. This indicates communication between the pore and the VSD during slow inactivation. The information from our work could be used to find new approaches when designing channel-modifying drugs for the treatment of diseases caused by increased neuronal excitability, such as chronic pain and epilepsy.
Author : Drew Charles Tilley
Publisher :
ISBN 13 : 9780355967623
Total Pages : pages
Book Rating : 4.9/5 (676 download)
Download or read book The Structure and Function Relationship Between Guangxitoxin and the Voltage-gated Potassium Channel Kv2.1 written by Drew Charles Tilley and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Proteins are the functional units of biology. They are essential in physiological processes. To achieve their functions, each protein folds into a characteristic three dimensional structure encoded by its primary amino acid sequence. Voltage-gated ion channels (VGICs) are a well-studied class of proteins which form pores in membranes permitting the conduction of ions. Voltage-gated potassium (Kv) channels are a specific subtype of VGICs in which the functional protein is tetrameric with each monomer consisting of six transmembrane (S1-S6) helices. Kv channels are all selective for potassium ions, yet are composed of many different subtypes which show sequence diversity and variation in cellular expression. With such diversity, their physiological contribution is difficult to determine without selective inhibitors of specific ion channel subtypes. Fortunately, natural sources of ion channel inhibitors have been found in venoms of animals such as tarantulas and scorpions. In this work I focused on the Kv2.1 channel and its interaction with the tarantula venom peptide Guangxitoxin (GxTX). In the subsequent chapters it will first introduce the physiological context of Kv2.1 activity. Functionally, Kv2.1 belongs to the delayed rectifier class of Kv channels showing sigmoidal activation in response to voltage and slow inactivation. Secondly; I will present electrophysiological measurements and chemical modification of GxTX to show the functional state of Kv2.1 modulates toxin affinity and binding kinetics. Thirdly, I will present a study using homology modeling to develop structural hypotheses of complexes of GxTX binding to the channel. Lastly, I will propose a functional mechanism for how Kv2.1 activity is modulated when GxTX is bound.
Author : Osei Kwame Asamoah
Publisher :
ISBN 13 :
Total Pages : 350 pages
Book Rating : 4.:/5 ( download)
Download or read book An Optical Approach to Structure-function Relationships in Voltage-gated Ion Channels written by Osei Kwame Asamoah and published by . This book was released on 2004 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
