The Story Of Interferon

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Story Of Interferon, The: The Ups And Downs In The Life Of A Scientist

Author : Kari Cantell
Publisher : World Scientific
ISBN 13 : 9814497363
Total Pages : 267 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Story Of Interferon, The: The Ups And Downs In The Life Of A Scientist by : Kari Cantell

Download or read book Story Of Interferon, The: The Ups And Downs In The Life Of A Scientist written by Kari Cantell and published by World Scientific. This book was released on 1998-05-21 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Finnish doctor Kari Cantell is one of the scientists to whom the development of the drugs called interferons can be attributed. Interferons have achieved an important place in the treatment of cancer, viral infections and multiple sclerosis. In the 1960s Cantell and his coworkers developed a method for the preparation of interferon in white blood cells. During those years, most of the global production of interferon took place in Finland and the vast majority of the clinical studies in the world employed Finnish interferon.The memoirs of Cantell record interferon's long road from the laboratory to the pharmacy shelf. The journey took more than three decades and involved moments of triumph as well as desperation in the lives of many scientists.The book will give the reader a glimpse of the world of science; how research is carried out in the laboratory and the clinic; how the mind of the scientist operates and how he experiences success and failure; how warm friendships and bitter conflicts develop between investigators; how the involvement of money and politics harms as well as helps research.The Interferon Story is a richly rewarding book written for ordinary people without a basic knowledge of biology or medicine. It can be read as a thriller describing the struggle of scientists against the most feared diseases of mankind.

The Story of Interferon

Author : Kari Cantell
Publisher : World Scientific
ISBN 13 : 9789810231484
Total Pages : 274 pages
Book Rating : 4.2/5 (314 download)

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Book Synopsis The Story of Interferon by : Kari Cantell

Download or read book The Story of Interferon written by Kari Cantell and published by World Scientific. This book was released on 1998 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: "... It is likely to be useful to future historians of science as a primary source. Its factual content is, as far as I can tell, entirely accurate."

Interferon

Author : Toine Pieters
Publisher : Routledge
ISBN 13 : 1134293062
Total Pages : 285 pages
Book Rating : 4.1/5 (342 download)

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Book Synopsis Interferon by : Toine Pieters

Download or read book Interferon written by Toine Pieters and published by Routledge. This book was released on 2005 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book charts the history and development of one of the most important medical substances of the twentieth century, Interferon, as a drug.

The Interferon Story

Author : Frances R. Balkwill
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (593 download)

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Book Synopsis The Interferon Story by : Frances R. Balkwill

Download or read book The Interferon Story written by Frances R. Balkwill and published by . This book was released on 1981 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Interferons

Author : Carlo Aul
Publisher : Springer Science & Business Media
ISBN 13 : 3642604110
Total Pages : 302 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Interferons by : Carlo Aul

Download or read book Interferons written by Carlo Aul and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interferons were among the first cytokines to be studied clinically in recombinant form in the 1980s, beginning a new era of pharmacotherapy in internal medicine. Interferons were soon employed in the treatment of tumors and it was shown that those hematopoietic neoplasias which had been difficult to treat with chemotherapy responded well to interferon treatment. In the present volume, renowned international authors update the importance of interferons in various fields of internal medicine, dermatology, and urology. The book also contains a general introduction into the classification, structure, and mode of action of interferons. Further chapters discuss the range of side effects of these substances and point out possible focuses of further clinical interferon research.

The Interferon System

Author : W.E. Stewart II
Publisher : Springer Science & Business Media
ISBN 13 : 3709186153
Total Pages : 505 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis The Interferon System by : W.E. Stewart II

Download or read book The Interferon System written by W.E. Stewart II and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an update of Interferon, published in 1969 by Dr. Jan Vilcek. The field of interferon research has since expanded from its former narrow treatment of interferon strictly as an antiviral substance, such that The Interferon System now encompasses cellular modulations ranging from immune alterations to cell proliferative restrictions to antitumor activities. The steadily increasing number of these non-antiviral functions of interferons emphasizes the need for a comprehensive - and critical - review of the entire literature of interferon studies. The text, with its supporting bibliography, provides complete coverage of interferon research. A newcomer to the area should find here all the informa tion necessary to understand why interferon, which has been studied for more than twenty years and which originally stirred excitement over its clinical pros pects, is still inspiring speculation about this potential. For those already fa miliar with the seemingly perpetual clinical promise of interferon, this volume should serve as a valuable reference source, the largest bibliography on the subject ever to appear under one cover. Clearly, this book should be considered only as an introduction to the topic and as a reference source; most questions about the interferon system are still unanswered - even unasked. Hopefully this summation and critical evalua tion of work done to date will stimulate and facilitate further progress.

Viruses and Man: A History of Interactions

Author : Milton W. Taylor
Publisher : Springer
ISBN 13 : 3319077589
Total Pages : 433 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Viruses and Man: A History of Interactions by : Milton W. Taylor

Download or read book Viruses and Man: A History of Interactions written by Milton W. Taylor and published by Springer. This book was released on 2014-07-21 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Milton Taylor, Indiana University, offers an easy-to-read and fascinating text describing the impact of viruses on human society. The book starts with an analysis of the profound effect that viral epidemics had on world history resulting in demographic upheavals by destroying total populations. It also provides a brief history of virology and immunology. Furthermore, the use of viruses for the treatment of cancer (viral oncolysis or virotherapy) and bacterial diseases (phage therapy) and as vectors in gene therapy is discussed in detail. Several chapters focus on viral diseases such as smallpox, influenza, polio, hepatitis and their control, as well as on HIV and AIDS and on some emerging viruses with an interesting story attached to their discovery or vaccine development. The book closes with a chapter on biological weapons. It will serve as an invaluable source of information for beginners in the field of virology as well as for experienced virologists, other academics, students, and readers without prior knowledge of virology or molecular biology.

Cold War Triangle

Author : Renilde Loeckx
Publisher : Leuven University Press
ISBN 13 : 9461663978
Total Pages : 188 pages
Book Rating : 4.4/5 (616 download)

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Book Synopsis Cold War Triangle by : Renilde Loeckx

Download or read book Cold War Triangle written by Renilde Loeckx and published by Leuven University Press. This book was released on 2021-03-22 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extraordinary story of scientists in East and West combatting HIV A small group of scientists were doggedly working in the field of antiviral treatments when the AIDS epidemic struck. Faced with one of the grand challenges of modern biology of the twentieth century, scientists worked across the political divide of the Cold War to produce a new class of antivirals. Their molecules were developed by a Californian start-up together with teams of scientists at the Rega Institute of KU Leuven and the Institute of Organic Chemistry and Biochemistry (IOCB) of the Academy of Sciences in Prague. These molecules became the cornerstone of the blockbuster drugs now used to combat and prevent HIV. Cold War Triangle gives an insight into the human face of science as it recounts the extraordinary story of scientists in East and West who overcame ideological barriers and worked together for the benefit of humanity.

Interferons

Author : Thomas C. Merigan
Publisher :
ISBN 13 :
Total Pages : 520 pages
Book Rating : 4.:/5 (44 download)

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Book Synopsis Interferons by : Thomas C. Merigan

Download or read book Interferons written by Thomas C. Merigan and published by . This book was released on 1982 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Beautiful Cure

Author : Daniel M. Davis
Publisher : University of Chicago Press
ISBN 13 : 022637114X
Total Pages : 271 pages
Book Rating : 4.2/5 (263 download)

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Book Synopsis The Beautiful Cure by : Daniel M. Davis

Download or read book The Beautiful Cure written by Daniel M. Davis and published by University of Chicago Press. This book was released on 2021-03-19 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Visceral.”—Wall Street Journal “Illuminating.”—Publishers Weekly “Heroic.”—Science The immune system holds the key to human health. In The Beautiful Cure, leading immunologist Daniel M. Davis describes how the scientific quest to understand how the immune system works—and how it is affected by stress, sleep, age, and our state of mind—is now unlocking a revolutionary new approach to medicine and well-being. The body’s ability to fight disease and heal itself is one of the great mysteries and marvels of nature. But in recent years, painstaking research has resulted in major advances in our grasp of this breathtakingly beautiful inner world: a vast and intricate network of specialist cells, regulatory proteins, and dedicated genes that are continually protecting our bodies. Far more powerful than any medicine ever invented, the immune system plays a crucial role in our daily lives. We have found ways to harness these natural defenses to create breakthrough drugs and so-called immunotherapies that help us fight cancer, diabetes, arthritis, and many age-related diseases, and we are starting to understand whether activities such as mindfulness might play a role in enhancing our physical resilience. Written by a researcher at the forefront of this adventure, The Beautiful Cure tells a dramatic story of scientific detective work and discovery, of puzzles solved and mysteries that linger, of lives sacrificed and saved. With expertise and eloquence, Davis introduces us to this revelatory new understanding of the human body and what it takes to be healthy.

Multiple Sclerosis

Author : T. Jock Murray, MD
Publisher : Demos Medical Publishing
ISBN 13 : 193455927X
Total Pages : 594 pages
Book Rating : 4.9/5 (345 download)

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Book Synopsis Multiple Sclerosis by : T. Jock Murray, MD

Download or read book Multiple Sclerosis written by T. Jock Murray, MD and published by Demos Medical Publishing. This book was released on 2004-12-01 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Sclerosis: The History of a Disease won a 2005 ForeWord Book of the Year Silver Medal! The basic facts about multiple sclerosis are well known: it is the most common neurologic disease of young adults, usually beginning with episodic attacks of neurologic symptoms, then entering a progressive phase some years later. Its onset has an average age of 30, and occurs in about 1 in 500 individuals of European ancestry living primarily in temperate climates. There appears to be a complex interaction between a genetic predisposition and an environmental trigger that initiates the disease. But these facts do not convey the impact of the disease on the people whose lives it affects. In this elegantly written and comprehensive history, we meet individuals who suffered with MS in the centuries before the disease had a name, including blessed Lidwina of Holland, who took joy from her misery, believing that she was sent to accept suffering for the sins of others; Augustus d'Est, grandson of George III and cousin of Queen Victoria, whose case shows how someone with access to the best of medical care of the age was understood and managed; and Heinrich Heine, the great German poet, who also had access to all medical services that were available, but who progressed into his mattress grave in two decades, aware of the loss of physical ability while still able to compose great poetry to the end. From these early cases the author demonstrates how progress in diagnosing and managing multiple sclerosis has paralleled the development of medical science, from the early developments in modern studies of anatomy and pathology, to the framing of the disease in the nineteenth century, and eventually to modern diagnosis and treatment. From beginning to end, Dr. Murray takes us on a fascinating journey of discovery, in the process showing how the evolution of our understanding of multiple sclerosis has been part of the greater history of medical knowledge.

Her-2

Author : Robert Bazell
Publisher : Random House
ISBN 13 : 0307764982
Total Pages : 241 pages
Book Rating : 4.3/5 (77 download)

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Book Synopsis Her-2 by : Robert Bazell

Download or read book Her-2 written by Robert Bazell and published by Random House. This book was released on 2011-04-27 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free. Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers. Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.

Love and Science

Author : Jan Vilcek
Publisher : Seven Stories Press
ISBN 13 : 1609806697
Total Pages : 328 pages
Book Rating : 4.6/5 (98 download)

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Book Synopsis Love and Science by : Jan Vilcek

Download or read book Love and Science written by Jan Vilcek and published by Seven Stories Press. This book was released on 2016-12-20 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long before he became one of the world's most celebrated immunologists, Jan Vilcek began life in Slovakia as the child of Jewish parents at a time when Jews were being exterminated all across Europe. He owes his and his mother’s survival to the courage of brave people and good luck. As a young man growing up in Czechoslovakia in the aftermath of the Second World War, Vilcek went to medical school and chose a career in virology and immunology at a time when these fields were still in their infancy. While still in his twenties he published a paper in the prestigious journal Nature, and he hosted the first international conference on interferon. Fleeing Communist Czechoslovakia with his wife Marica, Vilcek continued his research at NYU School of Medicine, going on to establish a highly successful career in biomedical research, and creating one of the most important and trailblazing medicines of our age. After his arrival in the US in 1965 as a penniless refugee, he soon went on to spearhead some of the key advances in the research of interferon that enabled its therapeutic application, and through his research into tumor necrosis factor (TNF) made advances that led to the discovery of new genes and proteins and signaling pathways, opening up previously uncharted areas of medical innovation that have led to important new treatments for a wide range of autoimmune and inflammatory diseases. Along the way Vilcek acquired material wealth he had never aspired to, catapulting him into the world of philanthropy. Love and Science shows how advances in science sometimes result from the greatest disappointments, and how achievement in medical research is usually a team effort, where ideas are shared, where friendship and love sometimes matter most and serendipity is as important as a will to succeed—and where, over time, the least expected thing sometimes becomes the most important. In Vilcek's case the vaunted cure for cancer that many saw in TNF never materialized. However, out of the ashes of that hope came many related treatments that have changed countless lives and alleviated much suffering.

Fields Virology: Emerging Viruses

Author : Peter M. Howley
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1975112555
Total Pages : 2597 pages
Book Rating : 4.9/5 (751 download)

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Book Synopsis Fields Virology: Emerging Viruses by : Peter M. Howley

Download or read book Fields Virology: Emerging Viruses written by Peter M. Howley and published by Lippincott Williams & Wilkins. This book was released on 2020-02-11 with total page 2597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: Emerging Viruses, 7th Edition covers recent changes in emerging viruses, providing new or extensively revised chapters that reflect these advances in this dynamic field.

Genentech

Author : Sally Smith Hughes
Publisher : University of Chicago Press
ISBN 13 : 0226359204
Total Pages : 231 pages
Book Rating : 4.2/5 (263 download)

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Book Synopsis Genentech by : Sally Smith Hughes

Download or read book Genentech written by Sally Smith Hughes and published by University of Chicago Press. This book was released on 2011-09-21 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the fall of 1980, Genentech, Inc., a little-known California genetic engineering company, became the overnight darling of Wall Street, raising over $38 million in its initial public stock offering. Lacking marketed products or substantial profit, the firm nonetheless saw its share price escalate from $35 to $89 in the first few minutes of trading, at that point the largest gain in stock market history. Coming at a time of economic recession and declining technological competitiveness in the United States, the event provoked banner headlines and ignited a period of speculative frenzy over biotechnology as a revolutionary means for creating new and better kinds of pharmaceuticals, untold profit, and a possible solution to national economic malaise. Drawing from an unparalleled collection of interviews with early biotech players, Sally Smith Hughes offers the first book-length history of this pioneering company, depicting Genentech’s improbable creation, precarious youth, and ascent to immense prosperity. Hughes provides intimate portraits of the people significant to Genentech’s science and business, including cofounders Herbert Boyer and Robert Swanson, and in doing so sheds new light on how personality affects the growth of science. By placing Genentech’s founders, followers, opponents, victims, and beneficiaries in context, Hughes also demonstrates how science interacts with commercial and legal interests and university research, and with government regulation, venture capital, and commercial profits. Integrating the scientific, the corporate, the contextual, and the personal, Genentech tells the story of biotechnology as it is not often told, as a risky and improbable entrepreneurial venture that had to overcome a number of powerful forces working against it.

Molecular Biology of The Cell

Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of The Cell by : Bruce Alberts

Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

A Cure Within

Author : Neil Canavan
Publisher :
ISBN 13 : 9781621822172
Total Pages : 277 pages
Book Rating : 4.8/5 (221 download)

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Book Synopsis A Cure Within by : Neil Canavan

Download or read book A Cure Within written by Neil Canavan and published by . This book was released on 2018 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer. There are few words in the English language having such a visceral, personal impact. Cancer patient. Cancer survivor. Pretty much anyone over the age of 30 knows one. A family member. A friend. Someone lost too soon. Someone forever changed. But we don't really like to talk about it, because there's really not much we can do. We fight cancer, sure, but we rarely win. Defeating cancer is one of medical science's greatest challenges. So when a novel approach to treatment seems promising, there is an intense interest in its progress and those who are making it. This book is about both - the progress and the pioneers - and its focus is the revolutionary science of something called cancer immunotherapy. This medical marvel, cancer immunotherapy - also called immuno-oncology - is still in its infancy. Yet, mobilizing the immune system to recognize and attack cancer has long been imagined, and occasionally attempted, for more than 100 years: It is only just recently that significant - in fact, unprecedented - progress has been made. With the use of newly approved immunotherapy treatments, there are now reports of hundreds, if not thousands of cancer patients with advanced disease living years beyond all prior expectation. Some of these once-terminally ill patients are now called "cured." This has never happened before. As Dr. Jill O'Donnell-Tormey comments in the Foreword, "It has taken decades of basic research and billions of dollars of investment to build the foundation upon which today's lifesaving treatments are based. This book offers a uniquely entertaining yet inspiring glimpse into the lives and minds of the academic and industry pioneers who forged this new field. It is a story of how an obscure and oft-derided field of cancer research - and the tenacious few scientists who refused to abandon it - came from behind to become the new 'darling of oncology.'" The book's author, Neil Canavan, is an experienced commentator on new developments in medical science. His portraits of 25 of the pioneers in immunotherapy are the culmination of two years of travel to laboratories, offices, and conferences around the world and countless hours of conversation with individuals immersed in a vitally important, promising assault on a dread disease that kills more than eight million people each year worldwide. -- from dust jacket.