The Solution Structure And Dynamics Of A Polypeptide Cardiostimulant Studied By 1h Nmr Spectroscopy

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Structure-Based Drug Design

Author : Pandi Veerapandian
Publisher : Routledge
ISBN 13 : 1351413058
Total Pages : 668 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Structure-Based Drug Design by : Pandi Veerapandian

Download or read book Structure-Based Drug Design written by Pandi Veerapandian and published by Routledge. This book was released on 2018-03-29 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more!

Nuclear Magnetic Resonance

Author : Norman J. Oppenheimer
Publisher :
ISBN 13 :
Total Pages : 548 pages
Book Rating : 4.X/5 (1 download)

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Book Synopsis Nuclear Magnetic Resonance by : Norman J. Oppenheimer

Download or read book Nuclear Magnetic Resonance written by Norman J. Oppenheimer and published by . This book was released on 1989 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation This volume, as does Volume 176, provides a general background of modern NMR techniques, with a specific focus on NMR techniques that pertain to proteins and enzymology, and a "snapshot" of the current state-of-the-art in NMR experimental techniques. These books enable the reader to understand a given technique, to evaluate its strengths and limitations, to decide which is the best approach, and, finally, to design an experiment using the chosen technique to solve a problem.

Dissertation Abstracts International

Author :
Publisher :
ISBN 13 :
Total Pages : 548 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Dissertation Abstracts International by :

Download or read book Dissertation Abstracts International written by and published by . This book was released on 1989-09 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Union List of Higher Degree Theses in Australian Libraries

Author :
Publisher :
ISBN 13 :
Total Pages : 734 pages
Book Rating : 4.X/5 (1 download)

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Book Synopsis Union List of Higher Degree Theses in Australian Libraries by :

Download or read book Union List of Higher Degree Theses in Australian Libraries written by and published by . This book was released on 1987 with total page 734 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Comprehensive Dissertation Index

Author :
Publisher :
ISBN 13 :
Total Pages : 712 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Comprehensive Dissertation Index by :

Download or read book Comprehensive Dissertation Index written by and published by . This book was released on 1989 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt:

New Psychoactive Substances

Author : Hans H. Maurer
Publisher : Springer
ISBN 13 : 303010561X
Total Pages : 563 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis New Psychoactive Substances by : Hans H. Maurer

Download or read book New Psychoactive Substances written by Hans H. Maurer and published by Springer. This book was released on 2019-02-20 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is designed to feature the pharmacology of new psychoactive substances, legislative aspects, information exchange including epidemiology, and clinical, forensic, and analytical toxicology in order to facilitate the understanding of this complex and rapidly developing phenomenon.

Current Advances in Protein Biochemistry

Author :
Publisher :
ISBN 13 :
Total Pages : 212 pages
Book Rating : 4.X/5 (2 download)

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Book Synopsis Current Advances in Protein Biochemistry by :

Download or read book Current Advances in Protein Biochemistry written by and published by . This book was released on 1995 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Excitation-Contraction Coupling and Cardiac Contractile Force

Author : Donald Bers
Publisher : Springer Science & Business Media
ISBN 13 : 9780792371588
Total Pages : 458 pages
Book Rating : 4.3/5 (715 download)

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Book Synopsis Excitation-Contraction Coupling and Cardiac Contractile Force by : Donald Bers

Download or read book Excitation-Contraction Coupling and Cardiac Contractile Force written by Donald Bers and published by Springer Science & Business Media. This book was released on 2001-08-31 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: How is the heartbeat generated? What controls the strength of contraction of heart muscle? What are the links between cardiac structure and function? How does our understanding of skeletal and smooth muscle and non-muscle cells influence our thinking about force development in the heart? Are there important species differences in how contraction is regulated in the heart? How do the new molecular data fit together in understanding the heart beat? What goes wrong in ischemia, hypertrophy, and heart failure? This book paints a modern `portrait' of how the heart works and in this picture the author shows a close-up of the structural, biochemical, and physiological links between excitation and contraction. The author takes the reader through a series of important, interrelated topics with great clarity and continuity and also includes many useful illustrations and tables. The book starts by considering the cellular structures involved in excitation-contraction coupling and then described the characteristics of the myofilaments as the end effector of excitation-contraction coupling. A general scheme of calcium regulation is described and the possible sources and sinks of calcium are discussed in simple, but quantitative terms. The cardiac action potential and its many underlying currents are reviewed. Then the characteristics of some key calcium transport systems (calcium channels, sodium/calcium exchange and SR calcium uptake and release) are discussed in detail. This is then built into a more integrated picture of calcium regulation in succeeding chapters by detailed discussions of excitation-calcium coupling mechanisms (in skeletal, cardiac, and smooth muscle), the interplay between calcium regulatory processes, and finally mechanisms of cardiac inotropy, calcium overload, and dysfunction (e.g., ischemia, hypertrophy, and heart failure). Excitation-Contraction Coupling and Cardiac Contractile Force – Second Edition is an invaluable source of information for anyone who is interested in how the heart beat is controlled and especially suited for students of the cardiovascular system at all levels from medical/graduate students through senior investigators in related fields.

Branched-chain Amino Acids

Author : Robert Allison Harris
Publisher : Academic Press
ISBN 13 : 0121822257
Total Pages : 587 pages
Book Rating : 4.1/5 (218 download)

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Book Synopsis Branched-chain Amino Acids by : Robert Allison Harris

Download or read book Branched-chain Amino Acids written by Robert Allison Harris and published by Academic Press. This book was released on 2000 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 324 of Methods in Enzymology supplements Volume 166. It includes genetic information (cloning, gene expression) and information on human genetic diseases not available when Volume 166 was published.

NMR in Biological Research

Author : Kurt Wüthrich
Publisher : Elsevier Science & Technology
ISBN 13 : 9780720403893
Total Pages : 379 pages
Book Rating : 4.4/5 (38 download)

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Book Synopsis NMR in Biological Research by : Kurt Wüthrich

Download or read book NMR in Biological Research written by Kurt Wüthrich and published by Elsevier Science & Technology. This book was released on 1976 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Crop Production and Crop Protection

Author : E.-C. Oerke
Publisher : Elsevier
ISBN 13 : 0444597948
Total Pages : 829 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Crop Production and Crop Protection by : E.-C. Oerke

Download or read book Crop Production and Crop Protection written by E.-C. Oerke and published by Elsevier. This book was released on 2012-12-02 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this book is to provide information to be used as a basis for evaluating the fragile, shaky structure of global food production. The volume analyses the data by region and by intensity of cultivation; and furnishes information about the yield response, giving some indication of the health of the plants. It will be invaluable to all plant and crop scientists as well as to agriculturalists.

Marine Toxins as Research Tools

Author : Nobuhiro Fusetani
Publisher : Springer
ISBN 13 : 9783642099687
Total Pages : 0 pages
Book Rating : 4.0/5 (996 download)

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Book Synopsis Marine Toxins as Research Tools by : Nobuhiro Fusetani

Download or read book Marine Toxins as Research Tools written by Nobuhiro Fusetani and published by Springer. This book was released on 2010-11-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine organisms produce a wide array of toxins, many of which are not only structurally unusual, but also show potent and interesting modes of action. Since the discovery of tetrodotoxin, a pufferfish toxin, as a potent and selective blocker of Na+ channels in 1964, it has been widely used as a research tool in pharmacological and physiological research. This has led to the identification of a number of important biological functions for Na+ channels. In recent years, much biological research has been carried out at molecular and cellular levels, and therefore selective inhibitors of enzymes and selective antagonist/agonists of receptors and channels have become increasingly important research tools. Accordingly, interest in using such compounds as reagents has increased. Marine toxins are some of the most popular research tools and have already contributed much to our understanding of biological processes and disease mechanisms.

Medicinal Spices and Vegetables from Africa

Author : Victor Kuete
Publisher : Academic Press
ISBN 13 : 0128094419
Total Pages : 692 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Medicinal Spices and Vegetables from Africa by : Victor Kuete

Download or read book Medicinal Spices and Vegetables from Africa written by Victor Kuete and published by Academic Press. This book was released on 2017-01-14 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Spices and Vegetables from Africa: Therapeutic Potential against Metabolic, Inflammatory, Infectious and Systemic Diseases provides a detailed look at medicinal spices and vegetables that have proven safe-and-effective for consumption and the treatment of diseases, including infectious diseases, cardiovascular disease, and cancer. It provides pharmacological evidence, such as the latest information related to efficacy and safety data, in vitro and in vivo studies, clinical trials, and more, to illustrate the use of these spices and vegetables as both palliative and alternative treatments with the goal of furthering research in this area to produce safer and more effective drugs. - Provides scientific evidence for the potential of medicinal spices and vegetables used in Africa to fight metabolic, inflammatory, and infectious diseases - Includes a review of the latest methods used to investigate the effects of medicinal plants in the treatment of disease - Offers an updated resource for students sand scientists in the fields of pharmaceutical science, pharmacognosy, complementary and alternative medicine, ethnopharmacology, phytochemistry, biochemistry, and more

A Functional Biology of Sea Anemones

Author : J. Malcolm Shick
Publisher : Springer Science & Business Media
ISBN 13 : 9401130809
Total Pages : 416 pages
Book Rating : 4.4/5 (11 download)

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Book Synopsis A Functional Biology of Sea Anemones by : J. Malcolm Shick

Download or read book A Functional Biology of Sea Anemones written by J. Malcolm Shick and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: General Editor: Peter Calow, Department of Zoology, University of Sheffield, England The main aim of this series will be to illustrate and to explain the way organisms 'make a living' in nature. At the heart of this - their Junctional biology - is the way organisms acquire and then make use of resources in metabolism, movement, growth, reproduction, and so on. These processes will form the fundamental framework of all the books in the series. Each book will concentrate on a particular taxon (species, family, class or even phylum) and will bring together information on the form, physiology, ecology and evolutionary biology of the group. The aim will be not only to describe how organisms work, but also to consider why they have come to work in that way. By concentrating on taxa which are well known, it is hoped that the series will not only illustrate the success of selection, but also show the constraints imposed upon it by the physiological, morphological and developmental limitations of the groups. Another important feature of the series will be its organismic orientation. Each book will emphasize the importance of functional integration in the day-to-day lives and the evolution of organisms. This is crucial since, though it may be true that organisms can be considered as collections of gene determined traits, they nevertheless interact with their environment as integrated wholes and it is in this context that individual traits have been subjected to natural selection and have evolved.

Modern Anesthetics

Author : Jürgen Schüttler
Publisher : Springer Science & Business Media
ISBN 13 : 3540748067
Total Pages : 497 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Modern Anesthetics by : Jürgen Schüttler

Download or read book Modern Anesthetics written by Jürgen Schüttler and published by Springer Science & Business Media. This book was released on 2008-01-08 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.

Neglected Tropical Diseases and Phytochemicals in Drug Discovery

Author : Chukwuebuka Egbuna
Publisher : John Wiley & Sons
ISBN 13 : 1119616603
Total Pages : 628 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Neglected Tropical Diseases and Phytochemicals in Drug Discovery by : Chukwuebuka Egbuna

Download or read book Neglected Tropical Diseases and Phytochemicals in Drug Discovery written by Chukwuebuka Egbuna and published by John Wiley & Sons. This book was released on 2021-11-09 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt: NEGLECTED TROPICAL DISEASES AND PHYTOCHEMICALS IN DRUG DISCOVERY Explore novel drug discovery updates from medicinal plants to help fight the devastating effects of neglected tropical diseases Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections. This book provides readers with insightful perspectives from leading industry voices on fifty years of trends and progress in the search for new, safe, and affordable therapeutic drugs in the fight against neglected tropical diseases. It includes information beneficial to researchers in a variety of fields of biology, chemistry, medicine, and pharmaceuticals. The distinguished authors cover topics including the effects of phytochemicals on the causative agent of leprosy and the potential applicability of phytochemicals in the management of Dengue fever. Readers will also enjoy the inclusion of: Thorough introductions to neglected tropical diseases, phytochemicals, protein targets, and mechanisms in drug discovery, as well as the epidemiology of neglected tropical diseases An exploration of novel bioactive lead compounds for drug discovery against neglected tropical diseases, leishmaniasis, lymphatic filariasis, trypanosomiasis, and schistosomiasis Discussions of protozoan infections, including herbal, nutritional, and traditional remedies for giardiasis and the anti-leishmanial potentials of phytochemicals Examinations of helminth infections, including the prospects of phytochemicals in the treatment of helminthiasis Perfect for medicinal chemists, drug developers, and research and development scientists, Neglected Tropical Diseases and Phytochemicals in Drug Discovery will also earn a place in the libraries of toxicologists and researchers in biology, chemistry, medicinal chemistry, ethnobotany, and bioinformatics seeking a one-stop resource for drug discovery for neglected tropical diseases.

Advanced Practical Medicinal Chemistry

Author : Ashutosh Kar
Publisher : New Age International
ISBN 13 : 8122415393
Total Pages : 15 pages
Book Rating : 4.1/5 (224 download)

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Book Synopsis Advanced Practical Medicinal Chemistry by : Ashutosh Kar

Download or read book Advanced Practical Medicinal Chemistry written by Ashutosh Kar and published by New Age International. This book was released on 2007 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Present Compendium On Advanced Practical Medicinal Chemistry Is Designed Specifically To Serve As A Text-Cum-Reference Book Not Only Intended For The Advanced Undergraduate And Graduate Students Of Pharmacy Specializing In Pharmaceutical Chemistry But Also For The Bulk-Drug Industrial Researchers And Academics Who Work Intimately With Medicinal Compounds. It Mainly Comprises Of Four Comprehensive Chapters. First Chapter Is Entirely Devoted To Safety In Chemical Laboratory, Which Is An Absolute Must For Each Medicinal Chemist. Second Chapter Is On Drug Synthesis And Concentrates On Three Vital Aspects, Namely : Conceptualization Of A Synthesis, Reaction Variants, And Stereochemistry. Third Chapter Exclusively Deals With Performing The Reactions And Entails The Wide Range Of Latest Laboratory Techniques Used In A Good Chemical Laboratory To Facilitate Synthesis Of Drugs.Fourth Chapter Is Particularly Focused And Earmarked To Synthesis Of Medicinal Compounds, And Essentially Include Various Cardinal Aspects, Such As :Types Of Chemical Reactions, Organic Name Reactions (Onrs), And Selected Medicinal Compounds. A Galaxy Of Eighty Carefully Chosen Medicinal Compounds Have Been Presented In Anoriginal-Unique-Style Comprising Of : Chemical Structure-Synonym (S)/Chemical Name(S)-Theory-Chemicals Required-Procedure-Precautions- Recrystallizatio-Theoretical Yield/Practical Yield-Physical Parameters-Uses, And -Questions For Viva-Voce.It Is Hoped That Advanced Practical Medicinal Chemistry Would Certainly Help To Bridge Existing Gap And Fill Up The Long Needed Vacuum In The Synthesis Of Drugs In Pharmaceutical Chemistry Departments, Academics And Bulk-Drug Industries, And May Provide The Basis For Meaningful Productive Group Discussions Of Synthetic Problems On A Broader Perspective.