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The Roles Of E2a And Ebf In The Regulation Of The Recombination Of The Immunoglobulin Loci
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Book Synopsis The Roles of E2A and EBF in the Regulation of the Recombination of the Immunoglobulin Loci by : William Joseph Jr Romanow
Download or read book The Roles of E2A and EBF in the Regulation of the Recombination of the Immunoglobulin Loci written by William Joseph Jr Romanow and published by . This book was released on 2000 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Mechanisms that Underpin Antigen Receptor Recombination by : Tatiana Fourfouris
Download or read book Molecular Mechanisms that Underpin Antigen Receptor Recombination written by Tatiana Fourfouris and published by . This book was released on 2019 with total page 33 pages. Available in PDF, EPUB and Kindle. Book excerpt: A diverse antibody repertoire is the backbone of a successful adaptive immune response. This diversity is created in developing B cells by the rearrangement of the V (variable), D (diversity), and J (joining) gene segments, termed V(D)J recombination, to produce unique antigen specific B cell receptors (BCRs). V(D)J recombination is regulated by an ensemble of transcription factors, co-activators as well as architectural proteins. We know that certain V gene regions are more highly rearranged in wild type cells, yet the mechanism for this bias is not well known. We propose that the enhancer-associated E2A, p300 and BRD4 proteins influence the frequency and pattern of gene rearrangement. Using CRISPR/Cas9 technology, we have successfully deleted E2A as well as BRD4 to determine the effects of each mutation on the frequency and pattern of rearrangement in the immunoglobulin kappa locus (Ig[kappa]) locus of an inducible cell line. We have examined the consequences of these deletions on V[kappa] rearrangements. Notably, our results indicate that E2A and BRD4 are responsible for influencing the pattern and frequency of V[kappa] gene rearrangement. These data indicate that E2A and BRD4 are key factors in modulating nuclear architecture and the Ig[kappa] repertoire.
Book Synopsis Investigating the Function of E2A in the Regulation of B-lymphocyte Gene Expression, Antigen Receptor Recombination and Cell Survival by : Adam Stephen Lazorchak
Download or read book Investigating the Function of E2A in the Regulation of B-lymphocyte Gene Expression, Antigen Receptor Recombination and Cell Survival written by Adam Stephen Lazorchak and published by . This book was released on 2006 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis V(D)J Recombination by : Pierre Ferrier
Download or read book V(D)J Recombination written by Pierre Ferrier and published by Springer Science & Business Media. This book was released on 2009-12-24 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: v(D)J recombination: for the community of immunologists and developmental biologists, the molecular route by which B and T lymphocytes acquire their unique function of affording adaptive immunity. Yet, for many-from experienced scientists to trainees-it represents a (rather too) sophisticated process whose true insight is excessively demanding. However, when not simplyconsidered as a private ground for a few aficionados, it can be seen as a way of understanding how maturelympho cytes carry on their basic functions. For the group of aficionados-which includes this editor-it is an elegant paradigm featuring many fascinating evolutionary achievements of which the biological world alone has the secret. These include a subtle biochemical principle most likelyhijacked some 470 million years ago from an ancestral gene invader and since then cleverly adapted by jawed vertebrates to precisely cleave and rearrange their antigen receptor (Ig andTCR)loci. This invader would itself have assigned the services of the nonhomologous end joining (NHEJ) DNArepair machinery as well as various DNApolymerases or transferases to work in concert with developmental clues in lymphoid cell lineages to generate an immune repertoire and efficient host surveillance while avoiding autoimmunity. Recently, important new refinements in these systems have emerged, continuing to challenge ourknowledge andbeliefs. These arejust thetopics covered by the senior authors-all established leaders in this field-and their colleagues, whilst writing the various chapters in V(D)J Recombination.
Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Download or read book Encyclopedia of Immunobiology written by and published by Academic Press. This book was released on 2016-04-27 with total page 3161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices
Book Synopsis Molecular Biology of B Cells by : Tasuku Honjo
Download or read book Molecular Biology of B Cells written by Tasuku Honjo and published by Elsevier. This book was released on 2014-10-09 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. Covers signaling mechanisms regulating B cell differentiation Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab Contains studies on B cell tumors from various stages of B lymphocytes Offers an integrated view of all aspects of B cells to produce a normal immune response
Book Synopsis Handbook of Stem Cells by : Robert Paul Lanza
Download or read book Handbook of Stem Cells written by Robert Paul Lanza and published by Gulf Professional Publishing. This book was released on 2004 with total page 896 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accompanying CD-ROM (in v. 2) has image collections which can be saved in PowerPoint or HTML.
Book Synopsis Handbook of Stem Cells, Two-Volume Set by : Robert Lanza
Download or read book Handbook of Stem Cells, Two-Volume Set written by Robert Lanza and published by Elsevier. This book was released on 2004-10-05 with total page 889 pages. Available in PDF, EPUB and Kindle. Book excerpt: New discoveries in the field of stem cell research have frequently appeared in the news and in scientific literature. Research in this area promises to lead to new therapies for cancer, heart disease, diabetes, and a wide variety of other diseases. This two-volume reference integrates this exciting area of biology, combining the prerequisites for a general understanding of adult and embryonic stem cells, the tools, methods, and experimental protocols needed to study and characterize stem cells and progenitor populations, as well as a presentation by the world's experts of what is currently known about each specific organ system. The editors of the Handbook of Stem Cells include: Robert Lanza, Helen Blau, John Gearhart, Brigid Hogan, Douglas Melton, Malcolm Moore, Roger Pedersen, E. Donnall Thomas, James Thomson, Catherine Verfaillie, Irving Weissman, and Michael West. The Editorial Board includes: W. French Anderson, Peter Andrews, Anthony Atala, Jose Cibelli, Giulio Cossu, Robert Edwards, Martin Evans, Elaine Fuchs, Margaret Fuller, Fred Gage, Richard Gardner, Margaret Goodell, Ronald Green, William Haseltine, Joseph Itskovitz-Eldor, Rudolf Jaenisch, Ihor Lemischka, Dame Anne McLaren, Richard Mulligan, Stuart Orkin, Martin Pera, Benjamin Reubinoff, Janet Rossant, Hans Scholer, Austin Smith, Evan Snyder, Davor Solter, Alan Trounson, and Leonard Zon. This comprehensive set should be a much-needed addition to the library of students and researchers alike. * Provides comprehensive coverage on this highly topical subject * Contains contributions by the foremost authorities and premiere names in the field of stem cell research * The accompanying CD-ROM includes over 250 color figures
Book Synopsis Molecular Mechanisms that Orchestrate the Assembly of Antigen Receptor Loci by :
Download or read book Molecular Mechanisms that Orchestrate the Assembly of Antigen Receptor Loci written by and published by Academic Press. This book was released on 2015-11-16 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Mechanisms That Orchestrate the Assembly of Antigen Receptor Loci, the latest volume in the Advances in Immunology series focuses on the generation of an effective immune response to invading pathogens As B and T lymphocytes are characterized by the expression of antigen receptors that specifically recognize determinants expressed on pathogens, this volume discusses how antigen receptors are synthesized in B and T lymphocytes. Focuses on the generation of an effective immune response to invading pathogens Contains contributions from leading authorities Informs and updates on all the latest developments in the field of immunology
Book Synopsis Molecular Switches of the Immune System: The E Protein/Id Axis in Hematopoietic Development and Function by : Michele Kay Anderson
Download or read book Molecular Switches of the Immune System: The E Protein/Id Axis in Hematopoietic Development and Function written by Michele Kay Anderson and published by Frontiers Media SA. This book was released on 2022-12-01 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Biology of B Cells by : Tasuku Honjo
Download or read book Molecular Biology of B Cells written by Tasuku Honjo and published by Academic Press. This book was released on 2014-12-22 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics.
Book Synopsis bHLH Transcription Factors in Development and Disease by :
Download or read book bHLH Transcription Factors in Development and Disease written by and published by Academic Press. This book was released on 2014-09-09 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Current Topics in Developmental Biology provides a comprehensive set of reviews on bHLH transcription factors. bHLH factors are vastly recognized for their diverse roles in developmental processes and their dysfunction underlies various human pathologies. Each chapter is authoritatively written by a leading expert in the field and discusses every possible aspect of this huge and diverse field. Covers the area of basic helix-loop-helix (bHLH) transcription factors in development and disease International board of authors Provides a comprehensive set of reviews on our current understanding on the function of bHLH factors in development of various tissues and how de-regulation of these factors can cause, or is linked to, various human diseases
Book Synopsis Kelley's Textbook of Rheumatology by : Gary S. Firestein
Download or read book Kelley's Textbook of Rheumatology written by Gary S. Firestein and published by Elsevier Health Sciences. This book was released on 2013 with total page 2345 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helps you to better understand scientific underpinnings of rheumatic diseases, so that you can better manage your patients.
Book Synopsis Reversible Protein Acetylation by : Gregory R. Bock
Download or read book Reversible Protein Acetylation written by Gregory R. Bock and published by John Wiley & Sons. This book was released on 2004-07-16 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of recent work on chromatin and non-histone proteins, this book arises from the interactions of a multidisciplinary group of scientists involved in the study of acetylation. This area of research opens up new and exciting possibilities for drug design, and so the final chapters in the book examine some of the potential applications in the treatment of various diseases.
Download or read book The Journal of Immunology written by and published by . This book was released on 2005 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Clinical Immunology,Principles and Practice (Expert Consult - Online and Print),4 by : Thomas A. Fleisher
Download or read book Clinical Immunology,Principles and Practice (Expert Consult - Online and Print),4 written by Thomas A. Fleisher and published by Elsevier Health Sciences. This book was released on 2013-01-01 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written and edited by international leaders in the field, this book has, through two best-selling editions, been the place to turn for authoritative answers to your toughest challenges in clinical immunology. Now in full color and one single volume, the 3rd Edition brings you the very latest immunology knowledge - so you can offer your patients the best possible care. The user-friendly book and the fully searchable companion web site give you two ways to find the answers you need quickly...and regular online updates keep you absolutely current. Leading international experts equip you with peerless advice and global best practices to enhance your diagnosis and management of a full range of immunologic problems. A highly clinical focus and an extremely practical organization expedite access to the answers you need in your daily practice. Cutting-edge coverage of the human genome project, immune-modifier drugs, and many other vital updates keeps you at the forefront of your field. A new organization places scientific and clinical material side by side, to simplify your research and highlight the clinical relevance of the topics covered. A multimedia format allows you to find information conveniently, both inside the exceptionally user-friendly book and at the fully searchable companion web site. Regular updates online ensure that you'll always have the latest knowledge at your fingertips. Includes many new and improved illustrations and four color design. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.
