The Role Of The Nrf2 Keap1 Signaling Pathway In The Early Events Following Jurkat T Cell Activation

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A Master Regulator of Oxidative StressThe Transcription Factor Nrf2

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Author : Jose Antonio Morales-Gonzalez
Publisher : BoD – Books on Demand
ISBN 13 : 953512837X
Total Pages : 212 pages
Book Rating : 4.5/5 (351 download)

Book Synopsis A Master Regulator of Oxidative StressThe Transcription Factor Nrf2 by : Jose Antonio Morales-Gonzalez

Download or read book A Master Regulator of Oxidative StressThe Transcription Factor Nrf2 written by Jose Antonio Morales-Gonzalez and published by BoD – Books on Demand. This book was released on 2016-12-21 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to that at present, the majority of diseases are associated with alterations in oxidative stress and inflammatory processes, and in that Nrf-2 is a modulator of these processes; knowing how this transcriptional factor functions and is regulated opens a therapeutic window to diverse diseases. Therefore, the efforts of various investigation groups are centered on finding activators and/or inhibitors of Nrf-2 to prevent or control diverse diseases, for example, cancer, where it would be important to regulate Nrf-2 in order for it to activate apoptosis pathways in cancerogenous cells, or in neurodegenerative diseases where cell death is predominant, it would be important for Nrf-2 to activate antiapoptotic pathways.

Redox Biochemistry

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Author : Ruma Banerjee
Publisher : John Wiley & Sons
ISBN 13 : 9780470177327
Total Pages : 350 pages
Book Rating : 4.1/5 (773 download)

Book Synopsis Redox Biochemistry by : Ruma Banerjee

Download or read book Redox Biochemistry written by Ruma Banerjee and published by John Wiley & Sons. This book was released on 2007-12-04 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the premier, single-source reference on redox biochemistry, a rapidly emerging field. This reference presents the basic principles and includes detailed chapters focusing on various aspects of five primary areas of redox biochemistry: antioxidant molecules and redox cofactors; antioxidant enzymes; redox regulation of physiological processes; pathological processes related to redox; and specialized methods. This is a go-to resource for professionals in pharmaceuticals, medicine, immunology, nutrition, and environmental fields and an excellent text for upper-level students.

Modulators of Oxidative Stress

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Author : Hande Gurer-Orhan
Publisher : MDPI
ISBN 13 : 9783039432288
Total Pages : 298 pages
Book Rating : 4.4/5 (322 download)

Book Synopsis Modulators of Oxidative Stress by : Hande Gurer-Orhan

Download or read book Modulators of Oxidative Stress written by Hande Gurer-Orhan and published by MDPI. This book was released on 2020-11-03 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book starts with the editors' preface summarizing the contributions of each of the following thirteen articles dealing with chemical and pharmacological aspects of the molecular modulators of the oxidative stress in regard to various therapeutic approaches in cardiovascular and neurodegenerative diseases, cancer, and diabetes. The seven articles present data from original research studies enlightening the roles and mechanisms of action of small molecular weight compounds (natural and synthetic; ascorbic acid/vitamin C, deferoxamine, N-acetylcysteine, MitoVitE, α-tocopherol, trolox, and ezetimibe) or proteins (SIRT3) in modulation of oxidative stress. In the six review papers, the authors present and discuss the possible therapeutic potential of novel approaches and compounds that are promising and deserve further investigation, in modulation of oxidative stress.

Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches

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Author : Javier Egea
Publisher : Frontiers Media SA
ISBN 13 : 2889633160
Total Pages : 257 pages
Book Rating : 4.8/5 (896 download)

Book Synopsis Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches by : Javier Egea

Download or read book Role of Nrf2 in Disease: Novel Molecular Mechanisms and Therapeutic Approaches written by Javier Egea and published by Frontiers Media SA. This book was released on 2020-01-02 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Redox Proteomics

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Author : Isabella Dalle-Donne
Publisher : John Wiley & Sons
ISBN 13 : 0471973114
Total Pages : 978 pages
Book Rating : 4.4/5 (719 download)

Book Synopsis Redox Proteomics by : Isabella Dalle-Donne

Download or read book Redox Proteomics written by Isabella Dalle-Donne and published by John Wiley & Sons. This book was released on 2006-08-11 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methodology and applications of redox proteomics The relatively new and rapidly changing field of redox proteomics has the potential to revolutionize how we diagnose disease, assess risks, determine prognoses, and target therapeutic strategies for people with inflammatory and aging-associated diseases. This collection brings together, in one comprehensive volume, a broad array of information and insights into normal and altered physiology, molecular mechanisms of disease states, and new applications of the rapidly evolving techniques of proteomics. Written by some of the finest investigators in this area, Redox Proteomics: From Protein Modifications to Cellular Dysfunction and Diseases examines the key topics of redox proteomics and redox control of cellular function, including: * The role of oxidized proteins in various disorders * Pioneering studies on the development of redox proteomics * Analytical methodologies for identification and structural characterization of proteins affected by oxidative/nitrosative modifications * The response and regulation of protein oxidation in different cell types * The pathological implications of protein oxidation for conditions, including asthma, cardiovascular disease, diabetes, preeclampsia, and Alzheimer's disease Distinguished by its in-depth discussions, balanced methodological approach, and emphasis on medical applications and diagnosis development, Redox Proteomics is a rich resource for all professionals with an interest in proteomics, cellular physiology and its alterations in disease states, and related fields.

Taurine 10

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Author : Dong-Hee Lee
Publisher : Springer
ISBN 13 : 9402410791
Total Pages : 1181 pages
Book Rating : 4.4/5 (24 download)

Book Synopsis Taurine 10 by : Dong-Hee Lee

Download or read book Taurine 10 written by Dong-Hee Lee and published by Springer. This book was released on 2017-08-28 with total page 1181 pages. Available in PDF, EPUB and Kindle. Book excerpt: Taurine 10 contains original articles and critical reviews based on the oral and poster presentations of XX International Taurine Meeting held in Seoul, Korea in May 2016. The purpose of the book is to present current ideas, new avenues and research regarding biological functions and clinical applications of taurine and taurine derivatives. It focuses on all aspects of taurine research including the cardiovascular system, the immune system, diabetes, the central nervous system, endocrine system and the role of taurine supplements in nutrition. It also includes presentations of novel animal experimental models using Cdo1 and CSAD knock-out mice.

Comprehensive Clinical Plasma Medicine

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Author : Hans-Robert Metelmann
Publisher : Springer
ISBN 13 : 331967627X
Total Pages : 512 pages
Book Rating : 4.3/5 (196 download)

Book Synopsis Comprehensive Clinical Plasma Medicine by : Hans-Robert Metelmann

Download or read book Comprehensive Clinical Plasma Medicine written by Hans-Robert Metelmann and published by Springer. This book was released on 2018-05-04 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the state of the art in clinical plasma medicine and outlines translational research strategies. Written by an international group of authors, it is divided into four parts. Part I is a detailed introduction and includes basic and recent research information on plasma sciences, plasma devices and mechanisms of biological plasma effects. Parts II and III provide valuable clinical insights f.e. into the treatment of superficial contaminations, ulcerations, wounds, treatment of cells in cancer, special indications like in heart surgery, dentistry, palliative treatment in head and neck cancer or the use of plasma in hygiene. Part IV offers information on how and where to qualify in plasma medicine and which companies produce and supply medical devices and is thus of particular interest to medical practitioners. This comprehensive book offers a sciences based practical to the clinical use of plasma and includes an extended selection of scientific medical data and translational literature.

Advances in Nutrition and Cancer 2

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Author : Vincenzo Zappia
Publisher : Springer Science & Business Media
ISBN 13 : 1475732309
Total Pages : 313 pages
Book Rating : 4.4/5 (757 download)

Book Synopsis Advances in Nutrition and Cancer 2 by : Vincenzo Zappia

Download or read book Advances in Nutrition and Cancer 2 written by Vincenzo Zappia and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume includes contributions presented at the Second International Sym posium on Nutrition and Cancer, held in Naples, Italy, in October 1998 at the National Tumor Institute "Fondazione Pascale." During the Conference, experts from different disciplines discussed pivotal and timely subjects on the interactions between human nutrition and the development of malignancies. Comparing the themes of this Meeting with those discussed at the First Sympo sium in 1992, the major scientific advancements certainly derive from the extensive use of molecular approaches to perform research in nutrition. Moreover, the fundamental observation of R. Doll and R. Peto (1981), which suggested that at least 35% of all cancers (with large differences among different tumors) might be prevented by dietary regimens, has been definitively confirmed by epidemiological studies. On the other hand, the relationships between diet and cancer are quite intricate and complex; it is difficult, and at the same time not methodologically correct, to reduce them to simple terms. Metabolic and hormonal factors, contaminants and biological agents, and deficiency of specific protective nutrients are all pieces of the same puzzle.

Ferroptosis in Health and Disease

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Author : Daolin Tang
Publisher : Springer Nature
ISBN 13 : 3030267806
Total Pages : 320 pages
Book Rating : 4.0/5 (32 download)

Book Synopsis Ferroptosis in Health and Disease by : Daolin Tang

Download or read book Ferroptosis in Health and Disease written by Daolin Tang and published by Springer Nature. This book was released on 2019-10-10 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book sheds new light on ferroptosis, as an only recently recognised form of regulated cell death. Its respective chapters address the numerous implications that ferroptosis can have for virtually all aspects of metabolism. They also share insights on the morphological characterisation of ferroptosis and highlight the different pathways of induction. Accordingly, the book offers a unique perspective on a mechanism that is involved in a multitude of pathologies, including cancer cell death, neurotoxicity, neurodegenerative diseases, acute renal failure, drug-induced hepatotoxicity, tissue ischemia/reperfusion injury, and T cell immunity. Readers will learn in which cell types this form of regulated cell death is likely to occur, and how it can be pharmacologically influenced, making the book a fascinating and informative read not only for scientists working in cell biology, but also for clinicians in the field of cancer research.

Current Aspects of Flavonoids: Their Role in Cancer Treatment

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Author : Hardeep Singh Tuli
Publisher : Springer
ISBN 13 : 9811358745
Total Pages : 191 pages
Book Rating : 4.8/5 (113 download)

Book Synopsis Current Aspects of Flavonoids: Their Role in Cancer Treatment by : Hardeep Singh Tuli

Download or read book Current Aspects of Flavonoids: Their Role in Cancer Treatment written by Hardeep Singh Tuli and published by Springer. This book was released on 2019-05-21 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book comprehensively introduces readers to various aspects of flavonoids, a category of natural metabolites that exhibits various pharmacological effects. It discusses their chemistry, absorption and metabolism, mechanisms of action and toxicology as well as future perspectives for clinical applications, and also provides detailed insights into their anti-cancer properties, since flavonoids are known to modulate tumor-associated intracellular as well as extracellular signaling pathways. The book also highlights the current research on the health effects of selected flavonoids, and their various roles in cancer prevention and treatment. Lastly, the book elucidates nanotechnology-mediated tools to enhance the bioavailability and solubility of flavonoids to improve their bioactivity and pharmacokinetic parameters.

Edible Medicinal and Non-Medicinal Plants

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Author : T. K. Lim
Publisher : Springer
ISBN 13 : 3319260650
Total Pages : 702 pages
Book Rating : 4.3/5 (192 download)

Book Synopsis Edible Medicinal and Non-Medicinal Plants by : T. K. Lim

Download or read book Edible Medicinal and Non-Medicinal Plants written by T. K. Lim and published by Springer. This book was released on 2016-02-11 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers such plants with edible modified storage subterranean stems (corms, rhizomes, stem tubers) and unmodified subterranean stem stolons, above ground swollen stems and hypocotyls, storage roots (tap root, lateral roots, root tubers), and bulbs, that are eaten as conventional or functional food as vegetables and spices, as herbal teas, and may provide a source of food additive or neutraceuticals. This volume covers selected plant species with edible modified stems, roots and bulbs in the families Iridaceae, Lamiaceae, Marantaceae, Nelumbonaceae, Nyctaginaceae, Nymphaeaceae, Orchidaceae, Oxalidaceae, Piperaceae, Poaceae, Rubiaceae and Simaroubaceae. The edible species dealt with in this work include wild and underutilized crops and also common and widely grown ornamentals. To help in identification of the plant and edible parts coloured illustrations are included. As in the preceding ten volumes, topics covered include: taxonomy (botanical name and synonyms); common English and vernacular names; origin and distribution; agro-ecological requirements edible plant parts and uses; plant botany; nutritive, medicinal and pharmacological properties with up-to-date research findings; traditional medicinal uses; other non-edible uses; and selected/cited references for further reading. This volume has separate indices for scientific and common names; and separate scientific and medical glossaries.

Oxygen-Ozone Therapy

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Author : V. Bocci
Publisher : Springer Science & Business Media
ISBN 13 : 9401599521
Total Pages : 446 pages
Book Rating : 4.4/5 (15 download)

Book Synopsis Oxygen-Ozone Therapy by : V. Bocci

Download or read book Oxygen-Ozone Therapy written by V. Bocci and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: When I was about fifteen, my Biological Seiences teacher, Prof. N. Benacchio, lent me a book by Paul de Kruif "The Microbe Hunters" and I remained fascinated by infectious diseases. I was intrigued by the potency of virulent bacteria which are constantly trying to invade our bodies and often overcome what today we call innate and adoptive immunity. Indeed, shortly after that, I was struck by his tragic death due to peritonitis. Later, while studying medicine (although medical knowledge in the 1950s was almost primordial compared with today), I soon realised how the various biological systems were wonderfully organised but at the same time frail and how our life could end in a few minutes. Slowly it became obvious that our "wellness" was the result of a dynamic and very unstable equilibrium between health and disease. This unstable equilibrium could be broken forever if the body's response could not reverse the pathological state. I stuck a sort ofposter on the wall ofmy room with these three words and connecting arrows: HEALTH~-? DISEASE -? DEATH As I don't believe in another world after death, it became obvious to me that we should make every possible effort not only to delay death, but to try always to shift the equilibrium to the left. In this book, I will try to show that this can be achieved, as a last resort, even with ozonetherapy.

Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide

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Author : Philip K. Moore
Publisher : Springer
ISBN 13 : 3319181440
Total Pages : 384 pages
Book Rating : 4.3/5 (191 download)

Book Synopsis Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide by : Philip K. Moore

Download or read book Chemistry, Biochemistry and Pharmacology of Hydrogen Sulfide written by Philip K. Moore and published by Springer. This book was released on 2015-07-10 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book puts hydrogen sulfide in context with other gaseous mediators such as nitric oxide and carbon monoxide, reviews the available mechanisms for its biosynthesis and describes its physiological and pathophysiological roles in a wide variety of disease states. Hydrogen sulfide has recently been discovered to be a naturally occurring gaseous mediator in the body. Over a relatively short period of time this evanescent gas has been revealed to play key roles in a range of physiological processes including control of blood vessel caliber and hence blood pressure and in the regulation of nerve function both in the brain and the periphery. Disorders concerning the biosynthesis or activity of hydrogen sulfide may also predispose the body to disease states such as inflammation, cardiovascular and neurological disorders. Interest in this novel gas has been high in recent years and many research groups worldwide have described its individual biological effects. Moreover, medicinal chemists are beginning to synthesize novel organic molecules that release this gas at defined rates with a view to exploiting these new compounds for therapeutic benefit.

RNA-Seq Analysis: Methods, Applications and Challenges

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Author : Filippo Geraci
Publisher : Frontiers Media SA
ISBN 13 : 2889637050
Total Pages : 169 pages
Book Rating : 4.8/5 (896 download)

Book Synopsis RNA-Seq Analysis: Methods, Applications and Challenges by : Filippo Geraci

Download or read book RNA-Seq Analysis: Methods, Applications and Challenges written by Filippo Geraci and published by Frontiers Media SA. This book was released on 2020-06-08 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Endoplasmic Reticulum

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Author : A. Benedetti
Publisher : IOS Press
ISBN 13 : 9781586034740
Total Pages : 172 pages
Book Rating : 4.0/5 (347 download)

Book Synopsis Endoplasmic Reticulum by : A. Benedetti

Download or read book Endoplasmic Reticulum written by A. Benedetti and published by IOS Press. This book was released on 2005 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endoplasmic reticulum is a continuous membrane network in the cytosol, which encloses its internal compartment, the endoplasmic reticulum lumen. Several metabolic pathways are compartmentalised within the ER lumen, for example hydrolysis of glucose 6-phosphate, glucuronidation of endo- xenobiotics, posttranslational modification of proteins including redox reactions required for oxidative folding, oxidoreduction of steroid hormones, synthesis of ascorbate. Therefore, enzyme activities of these pathways depend on the special luminal microenvironment, on access to substrates and on release of products. However, in spite of great efforts, the molecular mechanism for the generation and maintenance of this special microenvironment still remains to be elucidated. Beside the well-known functions of the endoplasmic reticulum, such as calcium signaling and the synthesis of secretory proteins, recent findings underlined the importance of the intraluminal redox biochemistry and the role of membrane transporters. The field is currently undergoing extensive reappraisal, new transporters have been identified either molecular or functional level.The local synthesis and the membrane transport of redox active compounds (pro- and antioxidants) seem to be important not only in the disulfide bond formation, but also in the generation of intracellular proliferative/apoptotic signals. The different points of views in this publication help highlight the potential importance of several recently described phenomena, whose significance needs elucidation.

Inflammation and Immunity in Cancer

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Author : Tsukasa Seya
Publisher : Springer
ISBN 13 : 4431553274
Total Pages : 270 pages
Book Rating : 4.4/5 (315 download)

Book Synopsis Inflammation and Immunity in Cancer by : Tsukasa Seya

Download or read book Inflammation and Immunity in Cancer written by Tsukasa Seya and published by Springer. This book was released on 2015-03-26 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book overviews cancer immunity from broad scientific fields, based on the concept that cancer is a sort of by-product of infection, inflammation, and host immune response. The innate and acquired arms of the immune system mainly participate in tumor immune surveillance, and their activation is critically modulated by the situation of the tumor microenvironment. Many types of immune cells join the formation of the microenvironment. In particular, macrophages and dendritic cells enter the tumor mass to be main players in the inflammatory milieu of tumors. After introducing these topics, the book discusses immunotherapy for cancer patients as an outgrowth of this concept of infection and inflammation. With the contributions of leading scientists actively involved in the field of antitumor immunity study, this book encourages readers to understand the mechanism of general cancers based on inflammation and will facilitate prevention and the development of therapeutics for cancer.

The Rate of Living

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Author : Raymond Pearl
Publisher :
ISBN 13 :
Total Pages : 220 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis The Rate of Living by : Raymond Pearl

Download or read book The Rate of Living written by Raymond Pearl and published by . This book was released on 1928 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: