The Role Of The Magnetic Resonance Imaging For The Accurate Management Of Focal Therapy With High Intensity Focused Ultrasound For The Localized Prostate Cancer

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The Role of the Magnetic Resonance Imaging for the Accurate Management of Focal Therapy with High-Intensity Focused Ultrasound for the Localized Prostate Cancer

Author : Sunao Shoji
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (115 download)

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Book Synopsis The Role of the Magnetic Resonance Imaging for the Accurate Management of Focal Therapy with High-Intensity Focused Ultrasound for the Localized Prostate Cancer by : Sunao Shoji

Download or read book The Role of the Magnetic Resonance Imaging for the Accurate Management of Focal Therapy with High-Intensity Focused Ultrasound for the Localized Prostate Cancer written by Sunao Shoji and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of the currently attracted focal therapy is to treat clinical significant cancer with minimal invasion of health-related functions such as urethra, sphincter, neurovascular bundle, and bladder neck. The patients' criteria have been decided with pathologic tumor features characterized according to a combination of cancer core length and Gleason grade with prostate biopsy. Because the area involved in a single treatment using high-intensity focused ultrasound (HIFU) is extremely small, only minor temperature changes are observed outside of the focal zone. HIFU has been considered as an attractive therapeutic modality for the focal treatment of the prostate with the aim of curing the cancer while preserving continence and erectile function. Clinical trials of focal ablation of prostate cancer with HIFU have been reported. In our protocol, magnetic resonance imaging (MRI) has played a major role in the diagnosis of the spatial location of the significant cancer, treatment planning, and the evaluation of the treatment efficacy and recurrence after the treatment. In the chapter in "MR Imaging," we want to present the role of MRI in the accurate management of focal therapy with HIFU for the localized prostate cancer.

Technical Aspects of Focal Therapy in Localized Prostate Cancer

Author : Eric Barret
Publisher : Springer
ISBN 13 : 2817804848
Total Pages : 252 pages
Book Rating : 4.8/5 (178 download)

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Book Synopsis Technical Aspects of Focal Therapy in Localized Prostate Cancer by : Eric Barret

Download or read book Technical Aspects of Focal Therapy in Localized Prostate Cancer written by Eric Barret and published by Springer. This book was released on 2015-01-29 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focal therapy is a promising option for selected patients who have localized low or intermediate-risk prostate cancer, providing a compelling alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible. Numerous cohort studies have already investigated multiple focal techniques, such as cryotherapy, high-intensity focused ultrasound, brachytherapy, photodynamic therapy, laser therapy, irreversible electroporation and cyberknife methods, all of which have demonstrated positive oncological outcomes with 70 to 90 % negative follow-up biopsy. These various ablative techniques have produced only minor side-effects concerning urinary function, a low rate of erectile dysfunction, and have demonstrated a limited rectal toxicity. As a result, the primary end-point has now shifted and a new strategy needs to be established for patient follow-up and for defining treatment failure. Written by international experts in the field, this book is mainly focused on new techniques, all of which are amply illustrated. Technical Aspects of Focal Therapy in Localized Prostate Cancer will be of great practical value to all urologists and oncologists.

High-Resolution Neuroimaging

Author : Ahmet Mesrur Halefoğlu
Publisher : BoD – Books on Demand
ISBN 13 : 9535138650
Total Pages : 176 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis High-Resolution Neuroimaging by : Ahmet Mesrur Halefoğlu

Download or read book High-Resolution Neuroimaging written by Ahmet Mesrur Halefoğlu and published by BoD – Books on Demand. This book was released on 2018-03-14 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Ahmet Mesrur Halefoğlu mostly deals with research fields in body imaging and neuroradiology with multidetector computed tomography and high-resolution magnetic resonance imaging. He has served as postdoctoral research fellow at Johns Hopkins Hospital. Currently, he is working as an associate professor of radiology in Istanbul, Turkey. He has more than 50 high-impact-factor publications and has written 3 book chapters. He is a member of Turkish Society of Radiology and European Society of Radiology. During the recent years, there have been major breakthroughs in MRI due to developments in scanner technology and pulse sequencing. These important achievements have led to remarkable improvements in neuroimaging and advanced techniques, including diffusion imaging, diffusion tensor imaging, perfusion imaging, magnetic resonance spectroscopy, and functional MRI. These advanced neuroimaging techniques have enabled us to achieve invaluable insights into tissue microstructure, microvasculature, metabolism, and brain connectivity.

Imaging and Focal Therapy of Early Prostate Cancer

Author : Thomas J. Polascik
Publisher : Springer
ISBN 13 : 3319499114
Total Pages : 475 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Imaging and Focal Therapy of Early Prostate Cancer by : Thomas J. Polascik

Download or read book Imaging and Focal Therapy of Early Prostate Cancer written by Thomas J. Polascik and published by Springer. This book was released on 2017-02-22 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text encompass an up-to-date, comprehensive review of the state-of-the-art for gland preserving therapies. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, is discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on patient selection and outcomes utilizing both advanced imaging techniques and pathologic evaluation. Current and new approaches to image cancer foci within the prostate (multiparametric ultrasonography, multiparametric magnetic resonance image, etc) are presented along with various biopsy techniques, including robotics to map prostate cancer. Patient selection based on imaging and genomic classification, adjuvants to enhance therapy, treatment strategy, outcomes and patient centered concerns is discussed, providing an acceptable balance between cancer control and improved quality of life for patients. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer, Second Edition is designed as a comprehensive resource for urologists, radiation oncologists, medical oncologists, radiologists, uropathologists, molecular biologists, biomedical engineers, other clinicians –- residents, fellows, nurses and allied professionals -- and researchers with an interest in the diagnosis and novel treatment of prostate cancer. It will provide insight into the latest research and clinical applications of image-guided diagnosis and minimally invasive focal, gland-preserving treatment for prostate cancer.

Focal Therapy in Prostate Cancer

Author : Hashim Uddin Ahmed
Publisher : John Wiley & Sons
ISBN 13 : 1405196491
Total Pages : 213 pages
Book Rating : 4.4/5 (51 download)

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Book Synopsis Focal Therapy in Prostate Cancer by : Hashim Uddin Ahmed

Download or read book Focal Therapy in Prostate Cancer written by Hashim Uddin Ahmed and published by John Wiley & Sons. This book was released on 2011-12-27 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews the potential of focal therapy and discusses why the changing face of prostate cancer warrants a change in the way we treat men with the disease. It deals with the mechanisms by which disease can be localized within the gland and then the different technologies used for focal ablation. Bringing together eminent contributors in one accessible reference, this book introduces focal therapy to all urologists, oncologists, and radiologists who are involved in the treatment of men with prostate cancer.

MRI-Guided Focused Ultrasound Surgery

Author : Ferenc A. Jolesz
Publisher : CRC Press
ISBN 13 : 1420019937
Total Pages : 217 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis MRI-Guided Focused Ultrasound Surgery by : Ferenc A. Jolesz

Download or read book MRI-Guided Focused Ultrasound Surgery written by Ferenc A. Jolesz and published by CRC Press. This book was released on 2007-09-26 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: MRI-Guided Focused Ultrasound Surgery will be the first publication on this new technology, and will present a variety of current and future clinical applications in tumor ablation treatment. This source helps surgeons and specialists evaluate, analyze, and utilize MRI-guided focused ultrasound surgery - bridging the gap between phase 3 clinical tr

Focal Therapy of Prostate Cancer

Author : Stefan Thüroff
Publisher : Springer
ISBN 13 : 3319141600
Total Pages : 144 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Focal Therapy of Prostate Cancer by : Stefan Thüroff

Download or read book Focal Therapy of Prostate Cancer written by Stefan Thüroff and published by Springer. This book was released on 2015-03-20 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a 2015 state of the art update on the hot topic of focal prostate cancer therapy, which offers a means of preserving the prostate and avoiding major side-effects associated with conventional treatment strategies. In so doing, focal therapy meets the desire of many patients, especially those with low-risk disease, to avoid or postpone radical therapies in order to preserve quality of life. A wide range of aspects are covered, including the role of imaging-guided targeted biopsies, the pros and cons of surveillance in comparison with focal therapy, focal hemiablation and focal salvage therapy, multifocal therapies, focal cryotherapy. The potential role of various new diagnostic technologies as well as specific therapeutic devices as "Focal.One" robotic high-intensity focused ultrasound are explained. The authors are all international experts who are long-term proponents of non-invasive treatment of prostate cancer. "Focal Therapy of Prostate Cancer" will be an invaluable source of information for urologists, oncologists, radiation oncologists, and general practitioners, and also for patients wishing to learn more about this new treatment option.

Image-Guided Cancer Therapy

Author : Damian E. Dupuy
Publisher : Springer
ISBN 13 : 9781441907509
Total Pages : 0 pages
Book Rating : 4.9/5 (75 download)

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Book Synopsis Image-Guided Cancer Therapy by : Damian E. Dupuy

Download or read book Image-Guided Cancer Therapy written by Damian E. Dupuy and published by Springer. This book was released on 2013-08-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Image-Guided Cancer Therapy: A Multidisciplinary Approach provides clinicians with in-depth coverage of the growing, dynamic field of interventional oncology. Combining the knowledge of expert editors and authors into one powerhouse reference, this book looks at tumor ablation, HIFU, embolic therapies, emerging technologies, and radiation therapy throughout the body (liver, bone, breast, gynecologic and prostate cancers, to name just a few) , and includes discussion of different imaging modalities. In the words of Peter Mueller, MD, author of the book’s Foreword: “... The senior authors are all world renowned experts in interventional oncology, which is another example of the high quality authorship and experience that is brought to this book. The later chapters discuss therapies that are simply not covered in any other source. Everyone who is doing or wants to do ablation therapies and interventional oncology will face a time when they will be asked to use their expertise in less used and less investigated areas. There is nowhere else where the reader can get information on the prostate, breast, and gynecologic areas, and especially pediatrics....This book is an outstanding contribution to the literature and will become a ‘must read’ for all physicians who are interested in Interventional Oncology.”

Focal Therapy in Prostate Cancer

Author : Hashim Uddin Ahmed
Publisher : John Wiley & Sons
ISBN 13 : 1444346873
Total Pages : 213 pages
Book Rating : 4.4/5 (443 download)

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Book Synopsis Focal Therapy in Prostate Cancer by : Hashim Uddin Ahmed

Download or read book Focal Therapy in Prostate Cancer written by Hashim Uddin Ahmed and published by John Wiley & Sons. This book was released on 2011-10-19 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively reviews the potential of focal therapy and discusses why the changing face of prostate cancer warrants a change in the way we treat men with the disease. It deals with the mechanisms by which disease can be localized within the gland and then the different technologies used for focal ablation. Bringing together eminent contributors in one accessible reference, this book introduces focal therapy to all urologists, oncologists, and radiologists who are involved in the treatment of men with prostate cancer.

Active Surveillance for Localized Prostate Cancer

Author : Laurence Klotz
Publisher : Humana
ISBN 13 : 9783319873756
Total Pages : 0 pages
Book Rating : 4.8/5 (737 download)

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Book Synopsis Active Surveillance for Localized Prostate Cancer by : Laurence Klotz

Download or read book Active Surveillance for Localized Prostate Cancer written by Laurence Klotz and published by Humana. This book was released on 2018-08-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer. The book reviews new data about molecular characteristics of the disease, profiles the new grading system for prostate cancer introduced in 2015, and provides new perspectives about imaging of prostate cancer, as well as the role of targeted biopsies. The text summarizes the role of biomarkers and MRI in patient selection and management and details the world wide results of active surveillance. Specific chapters address communication and ethical issues, QOL outcomes, economic aspects, and psycho-social aspects of surveillance. The role of focal therapy for low risk disease is summarized, and the data supporting preventive interventions during surveillance reviewed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in this common malignancy, as it provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.

Diagnostic Accuracy of Multiparametric Magnetic Resonance Imaging and Prostate-specific Antigen Levels for Prediction of Treatment Failure After Local Therapy of Prostate Cancer with High-intensity Focused Ultrasound

Download Diagnostic Accuracy of Multiparametric Magnetic Resonance Imaging and Prostate-specific Antigen Levels for Prediction of Treatment Failure After Local Therapy of Prostate Cancer with High-intensity Focused Ultrasound PDF Online Free

Author : Julia Bruhin
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (115 download)

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Book Synopsis Diagnostic Accuracy of Multiparametric Magnetic Resonance Imaging and Prostate-specific Antigen Levels for Prediction of Treatment Failure After Local Therapy of Prostate Cancer with High-intensity Focused Ultrasound by : Julia Bruhin

Download or read book Diagnostic Accuracy of Multiparametric Magnetic Resonance Imaging and Prostate-specific Antigen Levels for Prediction of Treatment Failure After Local Therapy of Prostate Cancer with High-intensity Focused Ultrasound written by Julia Bruhin and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Correlation of Imaging and Pathology to Advance the Study of Prostate Cancer Focal Therapy

Author : Alan Martin Priester
Publisher :
ISBN 13 :
Total Pages : 183 pages
Book Rating : 4.:/5 (15 download)

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Book Synopsis Correlation of Imaging and Pathology to Advance the Study of Prostate Cancer Focal Therapy by : Alan Martin Priester

Download or read book Correlation of Imaging and Pathology to Advance the Study of Prostate Cancer Focal Therapy written by Alan Martin Priester and published by . This book was released on 2017 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer, a disease diagnosed in approximately 220,000 men in the U.S. annually, has historically been treated through extirpation of the entire gland. Unfortunately, whole-gland interventions exact a heavy toll, often resulting in incontinence and impotence. One proposed alternative is focal therapy, wherein MR-visible tumor foci are treated locally while sparing the majority of healthy tissue. This approach has great potential to deliver curative treatment while reducing costs and risks. In order to demonstrate the safety, efficacy, and practicality of focal therapy, several key questions remain: 1. How reliably can tumor location be distinguished? 2. What treatment margins are necessary? 3. Can treatment be delivered safely in a clinic setting? This thesis presents a concerted effort to answer these questions, guided by the central hypothesis that focal therapy can be made safe and effective by registering MRI with ultrasound, pathology, and thermal data. To this end, we characterized and clinically implemented a means of accurately correlating MRI with histopathology. We discovered that many tumors extend far beyond the confines of MR-visibility, and the average tumor was three times its predicted volume. Isotropic margins in excess of 1 cm would have been necessary to treat the majority of focal therapy eligible men. However, by registering tracked biopsy data with MRI, we demonstrated that patient-specific treatment margins can greatly improve cancer prediction. We performed clinical trials investigating the safety of focal laser ablation (FLA) of prostate cancer, a modality wherein an interstitial laser delivers thermal energy and induces coagulative necrosis. Through analysis of MRI thermometry data, we found that thermal damage could be predicted with less than 15% volumetric error (0.5 cc). In a second clinical trial, FLA was performed under the guidance of MRI-US fusion imaging. This trial demonstrated that focal therapy could be performed safely, in a clinic setting, and without risk of incontinence or impotence. Furthermore, clinically significant cancer was eliminated from 60% of men, demonstrating the potential efficacy of localized treatment. Future work is necessary to refine all aspects of prostate focal therapy. However, this thesis lays a foundation for safe and effective treatment of localized prostate cancer.

Dynamic Contrast-Enhanced MRI Atlas of Prostate Cancer

Author : Robert L. Bard
Publisher : Springer Science & Business Media
ISBN 13 : 3540784233
Total Pages : 179 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Dynamic Contrast-Enhanced MRI Atlas of Prostate Cancer by : Robert L. Bard

Download or read book Dynamic Contrast-Enhanced MRI Atlas of Prostate Cancer written by Robert L. Bard and published by Springer Science & Business Media. This book was released on 2009-04-05 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: MRI Atlas of Prostate Cancer analyses high-resolution MRI scanning and dynamic contrast-enhanced (DCE) MRI. This combination improves the diagnosis and staging of prostate cancer and may soon replace PSA testing and digital rectal examination. The first two chapters focus on normal anatomy, anatomic variations, benign disease and intraprostatic tumors. The subsequent chapters on MRI of extracapsular disease create a useful atlas of pathologic anatomy. This is the first text of its kind to show color-coded DCE-MRI scans of prostate cancer and to correlate these imaging findings with tumor grading. The chapters on the post-treatment prostate clearly display the increasing incidence of post-therapy recurrences. This book is intended for internists, radiologists, radiotherapists, oncologists, urologists, family practitioners, and general surgeons. Ultrasound, MRI, and radiotherapy technicians will find it extremely useful as a reference guide.

Image Guided Prostate Cancer Treatments

Author : Robert L. Bard
Publisher : Springer Science & Business Media
ISBN 13 : 3642404294
Total Pages : 269 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Image Guided Prostate Cancer Treatments by : Robert L. Bard

Download or read book Image Guided Prostate Cancer Treatments written by Robert L. Bard and published by Springer Science & Business Media. This book was released on 2013-11-18 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Image-Guided Prostate Cancer Treatments is a comprehensive reference and practical guide on the technology and application of ultrasound and MRI in the male pelvis, with special attention to the prostate. The book is organized into three main sections, the first of which is devoted to general aspects of imaging and image-guided treatments. The second section provides a systematic overview of the application of ultrasound and MRI to the diagnosis and treatment of diseases of the lower urinary tract. Performance of the ultrasound and MRI studies is explained, and the normal and abnormal pathological anatomy is reviewed. Correlation with the ultrasound in the same plane is provided to assist in understanding the MRI sequences. Biopsy and interventional procedures, ultrasound-MRI fusion techniques, and image-guided therapies, including focused ultrasound, photodynamic therapy, microwave and laser ablation, are all fully covered. The third section focuses on securing treatment effectiveness and the use of follow-up imaging to ensure therapeutic success and detect tumor recurrence at an early stage, which is vital given that prompt focal treatment of recurrence is very successful. Here, particular attention is paid to the role of Doppler ultrasound and DCE-MRI technologies. This book, containing a wealth of high-quality illustrations based on high-end equipment, will acquaint beginners with the basics of prostate ultrasound and MRI, while more advanced practitioners will learn new skills, means of avoiding pitfalls, and ways of effectively relating the imaging and image-guided treatments to the clinical situation. The information provided will permit a tailored approach in dealing with specific pathologic issues.

Mathematics and Physics of Emerging Biomedical Imaging

Author : Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging
Publisher : National Academies Press
ISBN 13 : 0309552923
Total Pages : 261 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Mathematics and Physics of Emerging Biomedical Imaging by : Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging

Download or read book Mathematics and Physics of Emerging Biomedical Imaging written by Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging and published by National Academies Press. This book was released on 1996-03-13 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cross-disciplinary book documents the key research challenges in the mathematical sciences and physics that could enable the economical development of novel biomedical imaging devices. It is hoped that the infusion of new insights from mathematical scientists and physicists will accelerate progress in imaging. Incorporating input from dozens of biomedical researchers who described what they perceived as key open problems of imaging that are amenable to attack by mathematical scientists and physicists, this book introduces the frontiers of biomedical imaging, especially the imaging of dynamic physiological functions, to the educated nonspecialist. Ten imaging modalities are covered, from the well-established (e.g., CAT scanning, MRI) to the more speculative (e.g., electrical and magnetic source imaging). For each modality, mathematics and physics research challenges are identified and a short list of suggested reading offered. Two additional chapters offer visions of the next generation of surgical and interventional techniques and of image processing. A final chapter provides an overview of mathematical issues that cut across the various modalities.

Salvage Therapy for Prostate Cancer

Author : Sanchia S. Goonewardene
Publisher : Springer Nature
ISBN 13 : 3030571815
Total Pages : 273 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Salvage Therapy for Prostate Cancer by : Sanchia S. Goonewardene

Download or read book Salvage Therapy for Prostate Cancer written by Sanchia S. Goonewardene and published by Springer Nature. This book was released on 2020-11-23 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively covers application of salvage therapy in reccurrent prostate cancer. Chapters focus on specific issues associated with a range of surgical and oncological management techniques and strategies including hormone therapy, lymphnode dissection, robotic prostatectomy and salvage reirradiation after locoregional failure. Learning objectives, and definitions of keywords are provided to aid the reader develop a thorough understanding of the topic and reinforce the key points covered in each chapter. Salvage Therapy for Prostate Cancer provides a detailed practically applicable guide on how salvage therapy can be utilised in the treatment of prostate cancer. It represents a valuable resource for trainee and practicing urologists, oncologists, and specialist nurses.

Fast Facts: Prostate Cancer

Author : Roger S. Kirby
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 1910797375
Total Pages : 138 pages
Book Rating : 4.9/5 (17 download)

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Book Synopsis Fast Facts: Prostate Cancer by : Roger S. Kirby

Download or read book Fast Facts: Prostate Cancer written by Roger S. Kirby and published by Karger Medical and Scientific Publishers. This book was released on 2017-03-08 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is unusual among solid tumors in that the majority of affected men die with, rather than of, the disease. This presents many challenges to healthcare professionals and patients in terms of deciding if, when and how to intervene in order to control tumor growth and spread, thereby extending survival but without compromising quality of life. This is the ninth edition of 'Fast Facts: Prostate Cancer' since 1996, testament to the rapid changes in the field and the steadily improving outlook for patients. This new edition provides many key updates: • the Gleason grade grouping, which has valuable prognostic value • nomograms to evaluate risk • our rapidly expanding understanding of the genetics and underlying pathogenesis of prostate cancer and the development of genomic tests to help identify those at greatest risk of developing clinically significant disease • the continuing debate about the role of PSA in the screening, detection and monitoring of prostate cancer • advances in imaging techniques, particularly multiparametric MRI, which is improving the accuracy of biopsy and reducing the numbers of negative biopsies • the roles of drugs, surgery and radiotherapy in the treatment of prostate cancer at different stages, and our ever-improving understanding of when and how best to intervene, aided by improving understanding of the risk factors for disease progression. Primarily intended for primary care providers, specialist nurses, junior doctors and allied healthcare professionals, this highly readable resource provides a comprehensive overview of prostate cancer, enabling fully informed discussions with patients about this complex disease. Contents: • Epidemiology and pathophysiology • Diet, lifestyle and chemoprevention • Screening and early detection • Diagnosis, staging and prognostic indicators • Management of clinically localized disease • Managing recurrence after initial therapy • Management of metastatic prostate cancer • Management of castrate-resistant prostate cancer • Survivorship and treatment complications