The Role Of The Cd11c Cells Tsc1 Mtorc1 Nutrient Sensing Pathway In Metabolic Homeostasis

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The Role of the CD11c+ Cells Tsc1-mTORC1 Nutrient Sensing Pathway in Metabolic Homeostasis

Author : Danai Nyasha Chagwedera
Publisher :
ISBN 13 : 9780438778283
Total Pages : 100 pages
Book Rating : 4.7/5 (782 download)

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Book Synopsis The Role of the CD11c+ Cells Tsc1-mTORC1 Nutrient Sensing Pathway in Metabolic Homeostasis by : Danai Nyasha Chagwedera

Download or read book The Role of the CD11c+ Cells Tsc1-mTORC1 Nutrient Sensing Pathway in Metabolic Homeostasis written by Danai Nyasha Chagwedera and published by . This book was released on 2018 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alterations in host metabolic state have been reported to drastically alter gut microbial communities and influence host immune responses. While much attention has been paid to how the gut microbiome affects immune cell response, the reverse is understudied: how do immune cells influence the gut microbiome and in turn, regulate host metabolic state? CD11c+ cells are well known for their critical role in bridging innate and adaptive immune responses and are resident cells of almost all tissues in the body. In the gut, CD11c+ cells are located in the lamina propria and have been shown to play a key role in maintaining gut immune homeostasis. The tuberous sclerosis 1---mechanistic target of rapamycin complex 1 (Tsc1-mTORC1) pathway is a cell's major nutrient-sensing pathway and functions to assess nutrient availability and determine whether energy-intensive processes, such as protein translation, should take place. Specifically, Tsc1 is a negative regulator of mTORC1 and inhibits mTOR activity under conditions of low nutrient availability. Given this knowledge, we asked whether perturbing nutrient sensing in CD11c+ cells would alter the gut microbiome to ultimately influence host systemic metabolism. We generated CD11c Cre x Tsc1flox/flox mice (C57BL/6J background), where Tsc1 was specifically deleted in all CD11c expressing cells. Tsc1flox/flox ("control; CTRL") and CD11cCre x Tsc1 flox/flox ("knockout; KO") mice were housed under thermoneutral (30 °C) and sub-thermoneutral conditions (22 °C), and placed on normal chow diet (NCD) or high-fat diet (HFD). Weight gain, glucose and insulin sensitivity, and food intake were monitored over time. Additionally stool was collected for 16S rRNA gene sequencing. First, we determined how nutrient sensing by immune cells regulates body weight, adiposity and insulin action. Under all housing conditions, KO mice exhibited reduced weight gain as compared to CTRL mice. This decrease in body weight was not due to growth or birth defects and persisted with age. Analysis of food intake uncovered a reduction in overall food consumption. There were no differences in metabolic rate or physical activity between the groups. Interestingly, on a HFD protection from insulin resistance only occurred under thermoneutral conditions. In addition, we have investigated the microbial and immunologic mechanisms by which alterations in nutrient sensing in immune cells regulates weight gain. Flow cytometric analyses of immune cell populations in the small intestine and colon revealed differences in IgA binding. Co-housing experiments identified KO as capable of gaining weight in the presence of the CTRL mouse microbiome. Conclusions: We show that activation of nutrient sensing pathways in CD11c+ cells is sufficient to modulate systemic metabolism through alterations in the gut microbiome and that housing temperature conditions affects insulin and the microbiome. This project furthers our understanding of the role immune cells play in regulating systemic metabolism and has immediate translational implications for the treatment of metabolic disorders.

Essential Aspects of Immunometabolism in Health and Disease

Author : Niels Olsen Saraiva Camara
Publisher :
ISBN 13 : 9783030866853
Total Pages : 0 pages
Book Rating : 4.8/5 (668 download)

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Book Synopsis Essential Aspects of Immunometabolism in Health and Disease by : Niels Olsen Saraiva Camara

Download or read book Essential Aspects of Immunometabolism in Health and Disease written by Niels Olsen Saraiva Camara and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunometabolism has emerged as an intersectional crossroad between metabolism and immune response. Over the past decade, it has become clear that most - if not all - immune cell functions are not separated from cellular metabolism. Although seminal works have addressed the metabolic fate of immune cells during differentiation and function, the physiological status of a given tissue is also dependent on the cell metabolism. The dialogue between immune cells and their microenvironment can also modulate cellular metabolism, which can trigger the onset and progression of a multitude of inflammation-mediated diseases. Thus, uncovering the specific characteristics of the metabolism in different immune cells types and in different conditions, can shed light into the molecular mechanisms of disease and help develop new drugs and therapeutic strategies to treat immune diseases. The edited volume Essentials aspects of Immunometabolism will give the readers a broad view on how metabolic pathways can influence many types of immune cells during activation, differentiation and function, in health and disease. Of note, the structure of the book was created thinking not only on the experienced immunologist but also on undergraduate and graduate students, physicians, and all members of the scientific community interested in this exciting field of research.

Chromatin Signaling and Diseases

Author : Olivier Binda
Publisher : Academic Press
ISBN 13 : 012802609X
Total Pages : 468 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Chromatin Signaling and Diseases by : Olivier Binda

Download or read book Chromatin Signaling and Diseases written by Olivier Binda and published by Academic Press. This book was released on 2016-08-06 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatin Signaling and Diseases covers the molecular mechanisms that regulate gene expression, which govern everything from embryonic development, growth, and human pathologies associated with aging, such as cancer. This book helps researchers learn about or keep up with the quickly expanding field of chromatin signaling. After reading this book, clinicians will be more capable of explaining the mechanisms of gene expression regulation to their patients to reassure them about new drug developments that target chromatin signaling mechanisms. For example, several epigenetic drugs that act on chromatin signaling factors are in clinical trials or even approved for usage in cancer treatments, Alzheimer's, and Huntington's diseases. Other epigenetic drugs are in development to regulate various class of chromatin signaling factors. To keep up with this changing landscape, clinicians and doctors will need to stay familiar with genetic advances that translate to clinical practice, such as chromatin signaling. Although sequencing of the human genome was completed over a decade ago and its structure investigated for nearly half a century, molecular mechanisms that regulate gene expression remain largely misunderstood. An emerging concept called chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these, is reviewed in Chromatin Signaling and Diseases. Finally, the impact of gene expression defects associated with malfunctioning chromatin signaling is also explored. Explains molecular mechanisms that regulate gene expression, which governs everything from embryonic development, growth, and human pathologies associated with aging Educates clinicians and researchers about chromatin signaling, a molecular mechanism that is changing our understanding of human pathology Explores the addition and removal of chemical modifications on histones, the proteins that specifically recognize these, and the impact of gene expression defects associated with malfunctioning chromatin signaling Helps researchers learn about the quickly expanding field of chromatin signaling

Genetics, Neurology, Behavior, and Diet in Parkinson's Disease

Author : Colin R Martin
Publisher : Academic Press
ISBN 13 : 0128159510
Total Pages : 764 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Genetics, Neurology, Behavior, and Diet in Parkinson's Disease by : Colin R Martin

Download or read book Genetics, Neurology, Behavior, and Diet in Parkinson's Disease written by Colin R Martin and published by Academic Press. This book was released on 2020-08-13 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics, Neurology, Behavior, and Diet in Parkinson's Disease: The Neuroscience of Parkinson’s Disease, Volume 2 provides a single source of material covering different scientific domains of neuropathology underlying this condition. The book covers a wide range of subjects and unravels the complex relationships between genetics, molecular biology, pharmaceutical chemistry, neurobiology, imaging, assessments, and treatment regimens. It fills a much-needed gap as a "one-stop" synopsis of everything to do with the neurology and neuroscience related to Parkinson’s disease—from chemicals and cells to individuals. It is an invaluable resource for neuroscientists, neurologists, and anyone in the field. Offers the most comprehensive coverage of a broad range of topics related to Parkinson's disease Serves as a foundational collection for neuroscientists and neurologists on the biology of disease and brain dysfunction Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Features preclinical and clinical studies to help researchers map out key areas for research and further clinical recommendations Serves as a "one-stop" source for everything you need to know about Parkinson’s disease

Principles & Practice of Neuro-Oncology

Author :
Publisher : Demos Medical Publishing
ISBN 13 : 1617050148
Total Pages : 967 pages
Book Rating : 4.6/5 (17 download)

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Book Synopsis Principles & Practice of Neuro-Oncology by :

Download or read book Principles & Practice of Neuro-Oncology written by and published by Demos Medical Publishing. This book was released on 2010-10-21 with total page 967 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuro-oncologic (brain and spine) cancers account for 19,000 new cases and 13,000 deaths per year. The early and proper diagnosis of these virulent cancers is critical to patient outcomes and diagnosis and treatment strategies are continually evolving. The multidisciplinary team that manages these patients involves medical and radiation oncology, neurosurgery, neuroimaging, nurses and therapists. Principles and Practices of Neuro-Oncology establishes a new gold standard in care through a comprehensive, multidisciplinary text covering all aspects of neuro-oncology. Six major sections cover all topics related to epidemiology and etiology, molecular biology, clinical features and supportive care, imaging, neuroanatomy and neurosurgery, medical oncology and targeted therapies, and radiation oncology for adult and pediatric cancers. Expert contributors from multiple disciplines provide detailed and in-depth discussions of the entire field of neuro-oncology including histopathologic harmonization, neurosurgical techniques, quality of life and cognitive functions, and therapeutic changes in terms of combined modality treatments, advanced radiation techniques, the advent of new drugs, especially targeted agents, and the tantalizing early promise of personalized therapeutic approaches. With contributions from over 180 authors, numerous diagrams, illustrations and tables, and a 48 page color section, Principles and Practice of Neuro-Oncology reflects the breadth and depth of this multi-faceted specialty.

Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

Author : M. A. Hayat
Publisher : Academic Press
ISBN 13 : 0128094273
Total Pages : 431 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging by : M. A. Hayat

Download or read book Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging written by M. A. Hayat and published by Academic Press. This book was released on 2016-12-28 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is an eleven volume series that discusses in detail all aspects of autophagy machinery in the context of health, cancer, and other pathologies. Autophagy maintains homeostasis during starvation or stress conditions by balancing the synthesis of cellular components and their deregulation by autophagy. This series discusses the characterization of autophagosome-enriched vaccines and its efficacy in cancer immunotherapy. Autophagy serves to maintain healthy cells, tissues, and organs, but also promotes cancer survival and growth of established tumors. Impaired or deregulated autophagy can also contribute to disease pathogenesis. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward-thinking, these books offer a valuable guide to cellular processes while also inciting researchers to explore their potentially important connections. Presents the most advanced information regarding the role of the autophagic system in life and death Examines whether autophagy acts fundamentally as a cell survivor or cell death pathway or both Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death, providing information that will aid in preventing detrimental inflammation Features recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, including atherosclerosis and CNS tumors, and their development and treatment Includes chapters authored by leaders in the field around the globe—the broadest, most expert coverage available

Two Faces of Evil: Cancer and Neurodegeneration

Author : Thomas Curran
Publisher : Springer Science & Business Media
ISBN 13 : 3642166024
Total Pages : 171 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Two Faces of Evil: Cancer and Neurodegeneration by : Thomas Curran

Download or read book Two Faces of Evil: Cancer and Neurodegeneration written by Thomas Curran and published by Springer Science & Business Media. This book was released on 2010-12-16 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. For the most part, the topics have been viewed as distinct and rarely do opportunities arise for transdisciplinary discussions among experts in both fields. However, cancer and neurodegeneration represent yin-yang counterpoints in the regulation of cell growth, and it is reasonable to hypothesize that key regulatory events mediated by oncogenes and tumor suppressor genes in cancer may also affect neurodegenerative processes

The Smallest Biomolecules: Diatomics and their Interactions with Heme Proteins

Author : Abhik Ghosh
Publisher : Elsevier
ISBN 13 : 0080556329
Total Pages : 627 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Smallest Biomolecules: Diatomics and their Interactions with Heme Proteins by : Abhik Ghosh

Download or read book The Smallest Biomolecules: Diatomics and their Interactions with Heme Proteins written by Abhik Ghosh and published by Elsevier. This book was released on 2011-10-13 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is not a book on NO biology, nor about hemoglobin, nor about heme-based sensors per se. Of course, it covers all these topics and more, but above all, it aims at providing a truly multidisciplinary perspective of heme-diatomic interactions. The overarching goal is to build bridges among disciplines, to bring about a meeting of minds. The contributors to this book hail from diverse university departments and disciplines – chemistry, biochemistry, molecular biology, microbiology, zoology, physics, medicine and surgery, bringing with them very different views of heme-diatomic interactions. The hope is that the juxtaposition of this diversity will lead to increased exchanges of ideas, approaches, and techniques across traditional disciplinary boundaries. The authors represent a veritable Who’s Who of heme protein research and include John Olson, Tom Spiro, Walter Zumft, F. Ann Walker, Teizo Kitagawa, W. Robert Scheidt, Pat Farmer, Marie-Alda Gilles-Gonzalez, and many other equally distinguished scientists. Extremely distinguished list of authors Multidisciplinary character – equally suitable for chemists and biochemists Covers the hottest topics in heme protein research: sensors, NO biology, new roles of hemoglobin, etc.

Textbook of Energy Balance, Neuropeptide Hormones, and Neuroendocrine Function

Author : Eduardo A. Nillni
Publisher : Springer
ISBN 13 : 9783319895055
Total Pages : 378 pages
Book Rating : 4.8/5 (95 download)

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Book Synopsis Textbook of Energy Balance, Neuropeptide Hormones, and Neuroendocrine Function by : Eduardo A. Nillni

Download or read book Textbook of Energy Balance, Neuropeptide Hormones, and Neuroendocrine Function written by Eduardo A. Nillni and published by Springer. This book was released on 2018-08-06 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook presents for the first time a comprehensive body of the latest knowledge in the field of neuropeptides and their action on energy balance. It contains a detailed and comprehensive account of the specific hypothalamic peptides in regards to their roles in energy balance, food intake control and co-morbidities, to better understand the patho-physiology of obesity. The textbook includes an examination the history of the evolution of human society from a thin to the obese phenotype and, within that context, how modern society habits and industrial food production did not respect the evolutionary trait resulting in changes in the energy balance set point. It provides a novel conceptualization of the problem of obesity when considering the biochemistry of peptide hormones and entertaining novel ideas on multiple approaches to the problems of energy balance, as well as demonstrates and explains why alterations in pro-hormone processing are paramount to understand metabolic disease. This text is excellent material for teaching graduate and medical school courses, as well as a valuable resource for researchers in biochemistry, cell, and molecular biology, neuroscientists, physician endocrinologists, and nutritionists.

Immunology for Pharmacy - E-Book

Author : Dennis Flaherty
Publisher : Elsevier Health Sciences
ISBN 13 : 0323291112
Total Pages : 272 pages
Book Rating : 4.3/5 (232 download)

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Book Synopsis Immunology for Pharmacy - E-Book by : Dennis Flaherty

Download or read book Immunology for Pharmacy - E-Book written by Dennis Flaherty and published by Elsevier Health Sciences. This book was released on 2014-06-25 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a new pharmacy-specific approach to immunology, Immunology for Pharmacy prepares pharmacists for practice by providing a complete understanding of the basis of immunology and the consequences of either suppressing or enhancing immune function. It covers key subjects such as prophylaxis and vaccination, antibodies as therapeutic and diagnostic agents, biological modifiers, and the rationale for use and mechanisms of therapeutic agents. Written by experienced author and educator Dennis Flaherty, this book presents topics with a logical, step-by-step approach, explaining concepts and their practical application. A companion Evolve website reinforces your understanding with flashcards and animations. Pharmacy-specific coverage narrows the broad field of immunology to those areas most pertinent and clinically relevant to pharmacy students. 165 full-color illustrations help to illuminate difficult concepts. Factors That Influence the Immune Response chapter covers biological agents including bacteria, viruses, and fungi, and their related toxins and how they relate to the immune system. Three chapters on vaccinations prepare you for this important part of the pharmacist's role by discussing cancer treatment with whole tumor vaccines, cell vaccines, and viral vector vaccines, describing other vaccines such as recombinant vaccines and plant vaccines, and examining how diseases such as diphtheria, whooping cough, and tetanus respond to vaccinations. A summary of drugs used in treating each condition helps you understand typical treatments and their immunological mechanisms, so you can choose proper treatments. Integrated information makes it easier to understand how various parts of the immune system work together, leading to a better understanding of immunology as a whole. A unique focus on practical application and critical thinking shows the interrelationship of concepts and makes it easier to apply theory to practice. Information on AIDS covers the identification and treatment of both strains of HIV as well as AIDS, preparing you for diseases you will see in practice. Unique student-friendly features simplify your study with learning objectives and key terms at the beginning of each chapter, bulleted summaries and self-assessment questions at the end of each chapter, and a glossary at the back of the book. Over 60 tables summarize and provide quick reference to important material. A companion Evolve website includes animations and pharmacy terminology flashcards.

Hormone Metabolism and Signaling in Plants

Author : Jiayang Li
Publisher : Academic Press
ISBN 13 : 0128115637
Total Pages : 618 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Hormone Metabolism and Signaling in Plants by : Jiayang Li

Download or read book Hormone Metabolism and Signaling in Plants written by Jiayang Li and published by Academic Press. This book was released on 2017-04-19 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Hormones: Biosynthesis and Mechanisms of Action is based on research funded by the Chinese government’s National Natural Science Foundation of China (NSFC). This book brings a fresh understanding of hormone biology, particularly molecular mechanisms driving plant hormone actions. With growing understanding of hormone biology comes new outlooks on how mankind values and utilizes the built-in potential of plants for improvement of crops in an environmentally friendly and sustainable manner. This book is a comprehensive description of all major plant hormones: how they are synthesized and catabolized; how they are perceived by plant cells; how they trigger signal transduction; how they regulate gene expression; how they regulate plant growth, development and defense responses; and how we measure plant hormones. This is an exciting time for researchers interested in plant hormones. Plants rely on a diverse set of small molecule hormones to regulate every aspect of their biological processes including development, growth, and adaptation. Since the discovery of the first plant hormone auxin, hormones have always been the frontiers of plant biology. Although the physiological functions of most plant hormones have been studied for decades, the last 15 to 20 years have seen a dramatic progress in our understanding of the molecular mechanisms of hormone actions. The publication of the whole genome sequences of the model systems of Arabidopsis and rice, together with the advent of multidisciplinary approaches has opened the door to successful experimentation on plant hormone actions. Offers a comprehensive description of all major plant hormones including the recently discovered strigolactones and several peptide hormones Contains a chapter describing how plant hormones regulate stem cells Offers a fresh understanding of hormone biology, particularly molecular mechanisms driving plant hormone actions Discusses the built-in potential of plants for improvement of crops in an environmentally friendly and sustainable manner

Annual Review of Genomics and Human Genetics

Author : Eric Lander
Publisher : Annual Reviews
ISBN 13 : 9780824337018
Total Pages : 0 pages
Book Rating : 4.3/5 (37 download)

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Book Synopsis Annual Review of Genomics and Human Genetics by : Eric Lander

Download or read book Annual Review of Genomics and Human Genetics written by Eric Lander and published by Annual Reviews. This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Oncological Functional Nutrition

Author : Maira Rubi Segura Campos
Publisher : Academic Press
ISBN 13 : 012819829X
Total Pages : 210 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Oncological Functional Nutrition by : Maira Rubi Segura Campos

Download or read book Oncological Functional Nutrition written by Maira Rubi Segura Campos and published by Academic Press. This book was released on 2021-08-20 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncological Functional Nutrition: Phytochemicals and Medicinal Plants presents the anticancer activities, metabolism, mechanism of action, doses, and sources of various phytochemicals and medicinal plants. Broken into five parts, this book addresses cancer epidemiology, molecular and therapeutic bases of cancer, macro and micronutrients in cancer prevention and treatment, phytochemicals in the cancer treatment, and medical plants as potential functional foods or resources for the obtention of metabolites with anticancer activity. Written for nutritionists, food scientists, health professionals, oncologists, endocrinologists, natural product chemists, ethnobotanists, chemists, pharmacists, biochemists, and students studying relating fields, Oncological Functional Nutrition: Phytochemicals and Medicinal Plants will be a useful reference for those interested in learning more about functional nutrition and cancer. Discusses functional nutrition as alternative therapy Provides recommendations and intervention strategies related to the consumption of phytochemicals, food, and medicinal plants Addresses cancer epidemiology, the molecular and therapeutic bases of cancer, phytochemicals in the cancer treatment, and medical plants

Genomics and Personalized Medicine

Author : Michael Snyder
Publisher : Oxford University Press
ISBN 13 : 0190234784
Total Pages : 185 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis Genomics and Personalized Medicine by : Michael Snyder

Download or read book Genomics and Personalized Medicine written by Michael Snyder and published by Oxford University Press. This book was released on 2016-02-09 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2001 the Human Genome Project succeeded in mapping the DNA of humans. This landmark accomplishment launched the field of genomics, the integrated study of all the genes in the human body and the related biomedical interventions that can be tailored to benefit a person's health. Today genomics, part of a larger movement toward personalized medicine, is poised to revolutionize health care. By cross-referencing an individual's genetic sequence -- their genome -- against known elements of "Big Data," elements of genomics are already being incorporated on a widespread basis, including prenatal disease screening and targeted cancer treatments. With more innovations soon to arrive at the bedside, the promise of the genomics revolution is limitless. This entry in the What Everyone Needs to Know series offers an authoritative resource on the prospects and realities of genomics and personalized medicine. As this science continues to alter traditional medical paradigms, consumers are faced with additional options and more complicated decisions regarding their health care. This book provides the essential information everyone needs.

Urologic Surgical Pathology E-Book

Author : Liang Cheng
Publisher : Elsevier Health Sciences
ISBN 13 : 0323076149
Total Pages : 1037 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Urologic Surgical Pathology E-Book by : Liang Cheng

Download or read book Urologic Surgical Pathology E-Book written by Liang Cheng and published by Elsevier Health Sciences. This book was released on 2008-06-25 with total page 1037 pages. Available in PDF, EPUB and Kindle. Book excerpt: Completely revised with practical guidance in daily urological pathology sign-out and the latest recommended diagnostic approaches, the new edition of this comprehensive reference equips you to accurately diagnose specimens of the entire urinary tract and male reproductive system plus the adrenal glands. It begins with a look at normal anatomy and histology for each organ system...followed by discussions of the pathology of congenital anomalies, inflammations, non-neoplastic diseases and neoplasia. An emphasis on clinicopathologic and radiographic-pathologic correlations makes this a true diagnostic decision-making guide. A consistent format enables you to locate critical information quickly, and morethan 1500 high-quality illustrations — most in full color — make diagnosis even easier. Presents the practice-proven experience of today’s authorities to enable you to diagnose with confidence. Limits coverage of general mechanisms of disease and anatomy to the most relevant information needed to fully comprehend the clinical picture. Includes boxed lists of types and causes of diseases, differential diagnosis, characteristic features of diseases, complications, classifications, and staging that help you quickly locate the specific information you need. Presents two brand-new chapters covering urinary cytology and fine needle aspiration to keep you up to date. Covers newly described entities and application of ancillary study for precise diagnosis. Features integration of new molecular techniques and immunohistochemical analysis for differential diagnosis. Equips you with the latest recommended diagnostic approaches help you make the most informed decisions. Provides you with a critical review of the current classifications of cancer and disease. Features more than 1500 high-quality illustrations-in full color—providing a complete visual perspective of the conditions encountered in pathology.

Patterning and Cell Type Specification in the Developing CNS and PNS

Author :
Publisher : Academic Press
ISBN 13 : 0123973481
Total Pages : 993 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Patterning and Cell Type Specification in the Developing CNS and PNS by :

Download or read book Patterning and Cell Type Specification in the Developing CNS and PNS written by and published by Academic Press. This book was released on 2013-05-06 with total page 993 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems. Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop Features leading experts in various subfields as Section Editors and article Authors All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship Volume 1 sections include coverage of mechanisms which: control regional specification, regulate proliferation of neuronal progenitors and control differentiation and survival of specific neuronal subtypes, and controlling development of non-neural cells

Elsevier's Integrated Review Biochemistry

Author : John W. Pelley, PhD
Publisher : Elsevier Health Sciences
ISBN 13 : 0323074464
Total Pages : 254 pages
Book Rating : 4.3/5 (23 download)

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Book Synopsis Elsevier's Integrated Review Biochemistry by : John W. Pelley, PhD

Download or read book Elsevier's Integrated Review Biochemistry written by John W. Pelley, PhD and published by Elsevier Health Sciences. This book was released on 2011-11-30 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Effectively merge basic science and clinical skills with Elsevier's Integrated Review Biochemistry, by John W. Pelley, PhD. This concise, high-yield title in the popular Integrated Review Series focuses on the core knowledge in biochemistry while linking that information to related concepts from other basic science disciplines. Case-based questions at the end of each chapter enable you to gauge your mastery of the material, and a color-coded format allows you to quickly find the specific guidance you need. Online access via www.studentconsult.com - included with your purchase - allows you to conveniently access the book's complete text and illustrations online as well as relevant content from other Student Consult titles. This concise and user-friendly reference provides crucial guidance for the early years of medical training and USMLE preparation. Spend more time reviewing and less time searching thanks to an extremely focused, "high-yield" presentation. Gauge your mastery of the material and build confidence with both case-based, andUSMLE-style questions that provide effective chapter review and quick practice for your exams. Access the full contents online at www.studentconsult.com where you'll find the complete text and illustrations, "Integration Links" to bonus content in other Student Consult titles, an interactive community center with a wealth of additional resources, and much more! Grasp and retain vital concepts more easily thanks to a color-coded format, succinct,text, key concept boxes, and dynamic illustrations that facilitate learning in a highly visual approach. Effectively review for problem-based courses with the help of text boxes that help you clearly see the clinical relevance of the material. Great for visual learners!