DNA Repair in Cancer Therapy

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Publisher : Academic Press
ISBN 13 : 0128035994
Total Pages : 466 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis DNA Repair in Cancer Therapy by : Mark R. Kelley

Download or read book DNA Repair in Cancer Therapy written by Mark R. Kelley and published by Academic Press. This book was released on 2016-06-07 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair and Cancer Therapy: Molecular Targets and Clinical Applications, Second Edition provides a comprehensive and timely reference that focuses on the translational and clinical use of DNA repair as a target area for the development of diagnostic biomarkers and the enhancement of cancer treatment. Experts on DNA repair proteins from all areas of cancer biology research take readers from bench research to new therapeutic approaches. This book provides a detailed discussion of combination therapies, in other words, how the inhibition of repair pathways can be coupled with chemotherapy, radiation, or DNA damaging drugs. Newer areas in this edition include the role of DNA repair in chemotherapy induced peripheral neuropathy, radiation DNA damage, Fanconi anemia cross-link repair, translesion DNA polymerases, BRCA1-BRCA2 pathway for HR and synthetic lethality, and mechanisms of resistance to clinical PARP inhibitors. - Provides a comprehensive overview of the basic and translational research in DNA repair as a cancer therapeutic target - Includes timely updates from the earlier edition, including Fanconi Anemia cross-link repair, translesion DNA polymerases, chemotherapy induced peripheral neuropathy, and many other new areas within DNA repair and cancer therapy - Saves academic, medical, and pharma researchers time by allowing them to quickly access the very latest details on DNA repair and cancer therapy - Assists researchers and research clinicians in understanding the importance of the breakthroughs that are contributing to advances in disease-specific research

Marine Compounds and Cancer

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Publisher : MDPI
ISBN 13 : 3038427659
Total Pages : 119 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Marine Compounds and Cancer by : Friedemann Honecker

Download or read book Marine Compounds and Cancer written by Friedemann Honecker and published by MDPI. This book was released on 2018-06-26 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Marine Compounds and Cancer" that was published in Marine Drugs

Trabectedin, Lurbinectedin, and Other Marine-Derived Anticancer Alkaloids on Solid Cancer: Mechanisms of Action, Clinical Impact, and Future Perspectives

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Publisher : Frontiers Media SA
ISBN 13 : 2832516297
Total Pages : 96 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Trabectedin, Lurbinectedin, and Other Marine-Derived Anticancer Alkaloids on Solid Cancer: Mechanisms of Action, Clinical Impact, and Future Perspectives by : Alberto Zambelli

Download or read book Trabectedin, Lurbinectedin, and Other Marine-Derived Anticancer Alkaloids on Solid Cancer: Mechanisms of Action, Clinical Impact, and Future Perspectives written by Alberto Zambelli and published by Frontiers Media SA. This book was released on 2023-03-02 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Index Medicus

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Publisher :
ISBN 13 :
Total Pages : 1940 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1940 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Encyclopedia of Marine Biotechnology

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Publisher : John Wiley & Sons
ISBN 13 : 1119143799
Total Pages : 3632 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Encyclopedia of Marine Biotechnology by : Se-Kwon Kim

Download or read book Encyclopedia of Marine Biotechnology written by Se-Kwon Kim and published by John Wiley & Sons. This book was released on 2020-08-04 with total page 3632 pages. Available in PDF, EPUB and Kindle. Book excerpt: A keystone reference that presents both up-to-date research and the far-reaching applications of marine biotechnology Featuring contributions from 100 international experts in the field, this five-volume encyclopedia provides comprehensive coverage of topics in marine biotechnology. It starts with the history of the field and delivers a complete overview of marine biotechnology. It then offers information on marine organisms, bioprocess techniques, marine natural products, biomaterials, bioenergy, and algal biotechnology. The encyclopedia also covers marine food and biotechnology applications in areas such as pharmaceuticals, cosmeceuticals, and nutraceuticals. Each topic in Encyclopedia of Marine Biotechnology is followed by 10-30 subtopics. The reference looks at algae cosmetics, drugs, and fertilizers; biodiversity; chitins and chitosans; aeroplysinin-1, toluquinol, astaxanthin, and fucoxanthin; and algal and fish genomics. It examines neuro-protective compounds from marine microorganisms; potential uses and medical management of neurotoxic phycotoxins; and the role of metagenomics in exploring marine microbiomes. Other sections fully explore marine microbiology, pharmaceutical development, seafood science, and the new biotechnology tools that are being used in the field today. One of the first encyclopedic books to cater to experts in marine biotechnology Brings together a diverse range of research on marine biotechnology to bridge the gap between scientific research and the industrial arena Offers clear explanations accompanied by color illustrations of the techniques and applications discussed Contains studies of the applications of marine biotechnology in the field of biomedical sciences Edited by an experienced author with contributions from internationally recognized experts from around the globe Encyclopedia of Marine Biotechnology is a must-have resource for researchers, scientists, and marine biologists in the industry, as well as for students at the postgraduate and graduate level. It will also benefit companies focusing on marine biotechnology, pharmaceutical and biotechnology, and bioenergy.

Fluid Resuscitation

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Publisher : National Academies Press
ISBN 13 : 0309172799
Total Pages : 207 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Fluid Resuscitation by : Institute of Medicine

Download or read book Fluid Resuscitation written by Institute of Medicine and published by National Academies Press. This book was released on 1999-10-05 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Historically, 20% of all injured combatants die on the battlefield before they can be evacuated to a field hospital. Blood lossâ€"hemorrhageâ€"is the single major cause of death among those killed in action whose lives might otherwise be saved. Fluid resuscitation and the treatment of hypovolemia (the abnormally decreased volume of circulating fluid in the body) offer the greatest opportunity for reducing mortality and morbidity associated with battlefield casualties. In Fluid Resuscitation, a committee of experts assess current resuscitation fluids and protocols for the treatment of combat casualties and make recommendations for future research. Chapters focus on the pathophysiology of acute hemorrhagic shock, experience with and complications of fluid resuscitation, novel approaches to the treatment of shock, protocols of care at the site of injury, and future directions for research. The committee explicitly describes the similarities and differences between acute medical care during combat and civilian emergency trauma care. Fluid Resuscitation should help energize and focus research in both civilian and military emergency care and help save the lives of citizens and soldiers alike.

Cell Death

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Publisher : CRC Press
ISBN 13 : 1420038893
Total Pages : 354 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Cell Death by : Csaba Szabo

Download or read book Cell Death written by Csaba Szabo and published by CRC Press. This book was released on 2000-06-22 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Poly (ADP-ribose) polymerase (PARP), also termed poly (ADP-ribose) synthetase (PARS) is a nuclear enzyme with a wide range of functions, including regulation of DNA repair, cell differentiation, and gene expression. More than a decade after the identification of PARP-like enzymatic activities in mammalian cells, a novel role was proposed for this e

Handbook of Anticancer Drugs from Marine Origin

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Author :
Publisher : Springer
ISBN 13 : 3319071459
Total Pages : 801 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Handbook of Anticancer Drugs from Marine Origin by : Se-Kwon Kim

Download or read book Handbook of Anticancer Drugs from Marine Origin written by Se-Kwon Kim and published by Springer. This book was released on 2014-11-27 with total page 801 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely desk reference focuses on marine-derived bioactive substances which have biological, medical and industrial applications. The medicinal value of these marine natural products are assessed and discussed. Their function as a new and important resource in novel, anticancer drug discovery research is also presented in international contributions from several research groups. For example, the potential role of Spongistatin, Apratoxin A, Eribulin mesylate, phlorotannins, fucoidan, as anticancer agents is explained. The mechanism of action of bioactive compounds present in marine algae, bacteria, fungus, sponges, seaweeds and other marine animals and plants are illustrated via several mechanisms. In addition, this handbook lists various compounds that are active candidates in chemoprevention and their target actions. The handbook also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.

The DNA Damage Response: Implications on Cancer Formation and Treatment

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Publisher : Springer Science & Business Media
ISBN 13 : 9048125618
Total Pages : 450 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis The DNA Damage Response: Implications on Cancer Formation and Treatment by : Kum Kum Khanna

Download or read book The DNA Damage Response: Implications on Cancer Formation and Treatment written by Kum Kum Khanna and published by Springer Science & Business Media. This book was released on 2009-09-18 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ?eld of cellular responses to DNA damage has attained widespread recognition and interest in recent years commensurate with its fundamental role in the ma- tenance of genomic stability. These responses, which are essential to preventing cellular death or malignant transformation, are organized into a sophisticated s- tem designated the “DNA damage response”. This system operates in all living organisms to maintain genomic stability in the face of constant attacks on the DNA from a variety of endogenous by-products of normal metabolism, as well as exogenous agents such as radiation and toxic chemicals in the environment. The response repairs DNA damage via an intricate cellular signal transduction network that coordinates with various processes such as regulation of DNA replication, tr- scriptional responses, and temporary cell cycle arrest to allow the repair to take place. Defects in this system result in severe genetic disorders involving tissue degeneration, sensitivity to speci?c damaging agents, immunode?ciency, genomic instability, cancer predisposition and premature aging. The ?nding that many of the crucial players involved in DNA damage response are structurally and functionally conserved in different species spurred discoveries of new players through similar analyses in yeast and mammals. We now understand the chain of events that leads to instantaneous activation of the massive cellular responses to DNA lesions. This book summarizes several new concepts in this rapidly evolving ?eld, and the advances in our understanding of the complex network of processes that respond to DNA damage.

Biodiversity of Marine Microbes

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Publisher : MDPI
ISBN 13 : 3036510524
Total Pages : 104 pages
Book Rating : 4.0/5 (365 download)

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Book Synopsis Biodiversity of Marine Microbes by : Savvas Genitsaris

Download or read book Biodiversity of Marine Microbes written by Savvas Genitsaris and published by MDPI. This book was released on 2021-08-31 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book entitled “Biodiversity of Marine Microbes” aims at highlighting the significance of marine microbes as primary producers, their contribution in complex ecological processes and their roles in biogeochemical cycles and ecosystem functioning. The book includes five research papers covering the diversity and composition of marine microbial communities representing all three domains of life in various marine environments, including coastal eutrophic areas, ice waters, and lagoons. One paper examines the diversity and succession of bacterial and archaeal communities from coastal waters in mesocosm experiments. The combination of classical tools with novel technological advances implemented in the methods of the papers offered an opportunity to answer fundamental questions and shed light on the complex and diverse life of marine microbes.

Advanced Healthcare Materials

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Publisher : John Wiley & Sons
ISBN 13 : 1118773683
Total Pages : 421 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Advanced Healthcare Materials by : Ashutosh Tiwari

Download or read book Advanced Healthcare Materials written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2014-05-09 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a comprehensive and interdisciplinary view of cutting-edge research on advanced materials for healthcare technology and applications Advanced healthcare materials are attracting strong interest in fundamental as well as applied medical science and technology. This book summarizes the current state of knowledge in the field of advanced materials for functional therapeutics, point-of-care diagnostics, translational materials, and up-and-coming bioengineering devices. Advanced Healthcare Materials highlights the key features that enable the design of stimuli-responsive smart nanoparticles, novel biomaterials, and nano/micro devices for either diagnosis or therapy, or both, called theranostics. It also presents the latest advancements in healthcare materials and medical technology. The senior researchers from global knowledge centers have written topics including: State-of-the-art of biomaterials for human health Micro- and nanoparticles and their application in biosensors The role of immunoassays Stimuli-responsive smart nanoparticles Diagnosis and treatment of cancer Advanced materials for biomedical application and drug delivery Nanoparticles for diagnosis and/or treatment of Alzheimers disease Hierarchical modelling of elastic behavior of human dental tissue Biodegradable porous hydrogels Hydrogels in tissue engineering, drug delivery, and wound care Modified natural zeolites Supramolecular hydrogels based on cyclodextrin poly(pseudo)rotaxane Polyhydroxyalkanoate-based biomaterials Biomimetic molecularly imprinted polymers

Plant-derived Natural Products

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Publisher : Springer Science & Business Media
ISBN 13 : 0387854983
Total Pages : 588 pages
Book Rating : 4.3/5 (878 download)

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Book Synopsis Plant-derived Natural Products by : Anne E. Osbourn

Download or read book Plant-derived Natural Products written by Anne E. Osbourn and published by Springer Science & Business Media. This book was released on 2009-07-07 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.

Natural Products as Anticancer Agents

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Author :
Publisher : Elsevier
ISBN 13 : 0323997112
Total Pages : 444 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Natural Products as Anticancer Agents by : Bimal Krishna Banik

Download or read book Natural Products as Anticancer Agents written by Bimal Krishna Banik and published by Elsevier. This book was released on 2023-11-21 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Products as Anticancer Agents introduces the different types of natural products that have been used for cancer treatment. Divided into four parts, covering anticancer agents derived from terrestrial plants, anticancer agents derived from the marine environment, and anticancer agents derived from microorganisms, as well as evaluation of new anticancer agents, each part includes discussion of the properties, synthesis/extraction, storage, mechanism of action, and usage of the molecules. Discussion of the future prospects in anticancer natural products—including several new trends and an indication of where research in this area is likely to go in the future—is also included. - Assists in the identification of risk factors associated with the drug development process - Includes process diagrams detailing the procedure for the isolation and purification of molecules - Covers cost-effective green approaches in the development of anticancer drugs

Mechanisms of Cell Death

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Author :
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Mechanisms of Cell Death by : Zahra Zakeri

Download or read book Mechanisms of Cell Death written by Zahra Zakeri and published by . This book was released on 1999 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains papers from a July 1998 conference held at the Queens College Campus of the City University of New York. Papers are arranged in sections on mechanisms and general considerations, programmed (developmental) cell death, and cell death and pathological and clinical situations. Specific topics

Breeding Plantation Tree Crops: Tropical Species

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Publisher : Springer Science & Business Media
ISBN 13 : 0387712011
Total Pages : 654 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Breeding Plantation Tree Crops: Tropical Species by : Shri Mohan Jain

Download or read book Breeding Plantation Tree Crops: Tropical Species written by Shri Mohan Jain and published by Springer Science & Business Media. This book was released on 2008-10-08 with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tree species are indispensable to support human life. Due to their long life cycle and environmental sensitivity, breeding trees to suit day-to-day human needs is a formidable challenge. Whether they are edible or industrial crops, improving yield under optimal, sub-optimal and marginal areas calls for uni?ed efforts from the s- entistsaroundtheworld. Whiletheuniquenessofcoconutaskalpavriksha(Sanskr- meaning tree-of-life) marks its presence in every continent from Far East to South America, tree crops like cocoa, oil palm, rubber, apple, peach, grapes and walnut prove their environmental sensitivity towards tropical, sub-tropical and temperate climates. Desert climate is quintessential for date palm. Thus, from soft drinks to breweries to beverages to oil to tyres, the value addition offers a spectrum of pr- ucts to human kind, enriched with nutritional, environmental, ?nancial, social and trade related attributes. Taxonomically, tree crops do not con?ne to a few families, but spread across a section of genera, an attribute so unique that contributes immensely to genetic biodiversity even while cultivated at the commercial scale. Many of these species in?uence other ?ora to nurture in their vicinity, thus ensuring their integrity in p- serving the genetic biodiversity. While wheat, rice, maize, barley, soybean, cassava andbananamakeup themajorfoodstaples,manyfruittreespeciescontributegreatly tonutritionalenrichment inhumandiet. Theediblepartofthesespeciesisthesource of several nutrients that makes additives for the daily diet of humans, for example, vitamins, sugars, aromas and ?avour compounds, and raw material for food proce- ing industries. Tree crops face an array of agronomic and horticultural problems in propagation, yield, appearance, quality, diseases and pest control, abiotic stresses and poor shelf-life.

Chemical Biomarkers in Aquatic Ecosystems

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Publisher : Princeton University Press
ISBN 13 : 1400839106
Total Pages : 417 pages
Book Rating : 4.4/5 (8 download)

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Book Synopsis Chemical Biomarkers in Aquatic Ecosystems by : Thomas S. Bianchi

Download or read book Chemical Biomarkers in Aquatic Ecosystems written by Thomas S. Bianchi and published by Princeton University Press. This book was released on 2011-02-28 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a unique and thorough look at the application of chemical biomarkers to aquatic ecosystems. Defining a chemical biomarker as a compound that can be linked to particular sources of organic matter identified in the sediment record, the book indicates that the application of these biomarkers for an understanding of aquatic ecosystems consists of a biogeochemical approach that has been quite successful but underused. This book offers a wide-ranging guide to the broad diversity of these chemical biomarkers, is the first to be structured around the compounds themselves, and examines them in a connected and comprehensive way. This timely book is appropriate for advanced undergraduate and graduate students seeking training in this area; researchers in biochemistry, organic geochemistry, and biogeochemistry; researchers working on aspects of organic cycling in aquatic ecosystems; and paleoceanographers, petroleum geologists, and ecologists. Provides a guide to the broad diversity of chemical biomarkers in aquatic environments The first textbook to be structured around the compounds themselves Describes the structure, biochemical synthesis, analysis, and reactivity of each class of biomarkers Offers a selection of relevant applications to aquatic systems, including lakes, rivers, estuaries, oceans, and paleoenvironments Demonstrates the utility of using organic molecules as tracers of processes occurring in aquatic ecosystems, both modern and ancient

Prokaryotic Metabolism and Physiology

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Publisher : Cambridge University Press
ISBN 13 : 1107171733
Total Pages : 509 pages
Book Rating : 4.1/5 (71 download)

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Book Synopsis Prokaryotic Metabolism and Physiology by : Byung Hong Kim

Download or read book Prokaryotic Metabolism and Physiology written by Byung Hong Kim and published by Cambridge University Press. This book was released on 2019-05-16 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive and up-to-date review of key metabolic processes in bacteria and archaea and how metabolism is regulated under various conditions.