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The Role Of Dual Specificity Phosphatase 1 In The Anti Inflammatory Effects Of The Glucocorticoid Receptor
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Book Synopsis The Role of Dual Specificity Phosphatase 1 in the Anti-inflammatory Effects of the Glucocorticoid Receptor by : Marie-Eugénie Joanny
Download or read book The Role of Dual Specificity Phosphatase 1 in the Anti-inflammatory Effects of the Glucocorticoid Receptor written by Marie-Eugénie Joanny and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Dual Specificity Phosphatase 1 in the Anti-inflammatory Effects of the Glucocorticoid Receptor by : Marie-Eugénie Joanny
Download or read book The Role of Dual Specificity Phosphatase 1 in the Anti-inflammatory Effects of the Glucocorticoid Receptor written by Marie-Eugénie Joanny and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of Dual Specificity Phosphatase 1 Gene Expression by Glucocorticoids by :
Download or read book Regulation of Dual Specificity Phosphatase 1 Gene Expression by Glucocorticoids written by and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dual Specificity Phosphatases by : Rafael Pulido
Download or read book Dual Specificity Phosphatases written by Rafael Pulido and published by MDPI. This book was released on 2019-11-28 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dual specificity phosphatases (DUSPs) constitute a heterogeneous group of protein tyrosine phosphatases with the ability to dephosphorylate Ser/Thr and Tyr residues from proteins, as well as from other non-proteinaceous substrates including signaling lipids. DUSPs include, among others, MAP kinase (MAPK) phosphatases (MKPs) and small-size atypical DUSPs. MKPs are enzymes specialized in regulating the activity and subcellular location of MAPKs, whereas the function of small-size atypical DUSPs seems to be more diverse. DUSPs have emerged as key players in the regulation of cell growth, differentiation, stress response, and apoptosis. DUSPs regulate essential physiological processes, including immunity, neurobiology and metabolic homeostasis, and have been implicated in tumorigenesis, pathological inflammation and metabolic disorders. Accordingly, alterations in the expression or function of MKPs and small-size atypical DUSPs have consequences essential to human disease, making these enzymes potential biological markers and therapeutic targets. This Special Issue covers recent advances in the molecular mechanisms and biological functions of MKPs and small-size atypical DUSPs, and their relevance in human disease.
Book Synopsis Glucocorticoids in Immunity and Inflammation by : Emira Ayroldi
Download or read book Glucocorticoids in Immunity and Inflammation written by Emira Ayroldi and published by Frontiers Media SA. This book was released on 2021-11-30 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Recent Advances in Glucocorticoid Receptor Action by : A. Cato
Download or read book Recent Advances in Glucocorticoid Receptor Action written by A. Cato and published by Springer Science & Business Media. This book was released on 2002-09-12 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: The long-term use of glucocorticoids is associated with several deleterious effects. Attempts to separate the beneficial from the adverse effects of these compounds have met with varying degrees of difficulty. The discovery of distinct modes of action of the glucocorticoid receptor, the protein that mediates glucocorticoid action has opened up many possibilities for improving glucocorticoid therapy. This book provides an in-depth overview of the molecular actions of the glucocorticoid receptor and discusses the chances of an imminent identification of selective glucocorticoid agonists. Such componds should fulfill all the criteria of a glucocorticoid but should lack the sideeffects so far linked with classical glucocorticoids.
Book Synopsis Recent Developments in Anti-Inflammatory Therapy by : Parteek Prasher
Download or read book Recent Developments in Anti-Inflammatory Therapy written by Parteek Prasher and published by Academic Press. This book was released on 2023-02-17 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Anti-inflammatory Therapy explores the cutting-edge in anti-inflammation therapy in clear and concise language, with insights from academia and industry. Sections cover key regulatory pathways that mediate acute and chronic inflammation and disease onset. Further chapters are devoted to advanced anti-inflammatory pharmaceuticals, including chemical moieties, pharmacophores, APIs, natural products, herbal therapies, molecular nanomedicine and advanced drug delivery vectors. Systematically planned chapters and illustrations enable potential readers to gain essential insights on the most recent advancements in the field. Arranged with systematic chapters covering a broad range of inflammatory diseases, discussions on past, current and future therapeutics and advanced anti-inflammatory pharmaceuticals, this book will be useful to a wide range of researchers, especially medicinal chemists, drug design experts, and biological and translational researchers working in the field of inflammation. Identifies recent developments and current trends in anti-inflammation therapy Discusses advanced chemotherapeutics, SAR analysis of novel pharmacophores and natural products Outlines the pathophysiology of inflammatory pathways in the pathogenesis of disease onset, including strategies to counter these intricacies Contains a blend of editors from both academia and industry
Book Synopsis The Resolution of Inflammation by : Adriano Rossi
Download or read book The Resolution of Inflammation written by Adriano Rossi and published by Springer Science & Business Media. This book was released on 2008-03-17 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with an up-to-date and comprehensive view on the resolution of inflammation and on new developments in this area, including pro-resolution mediators, apoptosis, macrophage clearance of apoptotic cells, possible novel drug developments.
Book Synopsis From Molecular to Modular Tumor Therapy: by : Albrecht Reichle
Download or read book From Molecular to Modular Tumor Therapy: written by Albrecht Reichle and published by Springer Science & Business Media. This book was released on 2010-09-09 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting a holistic and abstract perspective of tumors, this volume aims to provide personalized diagnostic and therapeutic strategies for the control of metastatic tumor disease. Readers will find ways to record tumor biology that are based on different sciences, in addition to other strategies.
Download or read book Severe Asthma written by Kian Fan Chung and published by European Respiratory Society. This book was released on 2019-06-01 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.
Book Synopsis Immunopharmacology and Inflammation by : Carlo Riccardi
Download or read book Immunopharmacology and Inflammation written by Carlo Riccardi and published by Springer. This book was released on 2018-06-09 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of the current research on inflammation and immunopharmacology, with particular attention to the use of anti-inflammatory drugs, this book discusses future trends in this area of pharmacological research. It addresses an audience with basic knowledge in the inflammatory process, immune system and pharmacology. The book meets the needs of graduate students, junior and senior researchers and is useful as a source of the most current information for those already working in these fields.
Book Synopsis Effects of Novel Anti-inflammatory Glucocorticoid Receptor Ligands on Receptor Localization and Gene Regulation by : Elaheh Karbassi
Download or read book Effects of Novel Anti-inflammatory Glucocorticoid Receptor Ligands on Receptor Localization and Gene Regulation written by Elaheh Karbassi and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Glucocorticoids are steroid hormones that are used synthetically for their anti-inflammatory and immunosuppressive effects. However, treatment can result in unwanted side effects, such as insulin resistance, osteoporosis, and muscle atrophy. The effects of glucocorticoids are mediated through an intracellular glucocorticoid receptor (GR). The wanted anti-inflammatory effects of synthetic glucocorticoids, like dexamethasone (DEX), occur through gene repression by indirect GR association with NF-[kappa]B and AP-1 transcription factors while the side effects are associated with gene activation. In the pharmaceutical field, it would be ideal to find a GR modulator that can distinguish between transactivation and transrepression in both tissue-specific and promoter-specific contexts. Muscle atrophy can be triggered by different conditions--disease, nutritional deprivation, and altered hormone levels--and has been associated with increased proteasome activity. The MuRF1 and MAFbx genes were found to be upregulated in different atrophy-inducing conditions, including DEX treatment, and serve as key atrophy markers. In MuRF1 and MAFbx knockout mice, significant muscle mass sparing was observed. In efforts to discover novel GR ligands with selective effects, a series of drugs (NSR compounds) were created, displaying promising results in distinguishing repression of NF-[kappa]B and AP-1 dependent promoters from activation of GRE-containing promoters in transfected reporter gene assays and GR target cells. Previously, our lab studied the effects NSR1, NSR2, and NSR5 in the C2C12 mouse skeletal cell line. While these compounds efficiently suppressed pro-inflammatory IL-6 expression, they poorly regulated the levels of MuRF1 and MAFbx induction. NSR1 had weak or no effects in the upregulation of endogenous MuRF1 and transfected MuRF1 promoter-containing or MuRF1 GRE-containing reporter genes. We found that the NSR compounds induced myotube atrophy to similar degrees as measured MuRF1 and MAFbx expression levels, with NSR1 resulting in minimal atrophy. Additionally, the NSR compounds were effective at resulting in nuclear translocation of the GR. Attention was given to NSR1, which suppressed IL-6 expression but weakly upregulated MuRF1 and MAFbx expression, thus a potential GR ligand. NSR1 weakly activated glucocorticoid-responsive genes due to poor association of the GR to GRE-containing promoters. Our studies have demonstrated the complexity of GR gene regulation, which is cell-specific and promoter-specific.
Book Synopsis Goldman-Cecil Medicine E-Book by : Lee Goldman
Download or read book Goldman-Cecil Medicine E-Book written by Lee Goldman and published by Elsevier Health Sciences. This book was released on 2023-07-15 with total page 4183 pages. Available in PDF, EPUB and Kindle. Book excerpt: For more than 95 years, Goldman-Cecil Medicine has been the authoritative source for internal medicine and the care of adult patients. Every chapter is written by acclaimed experts who, with the oversight of our editors, provide definitive, unbiased advice on the diagnosis and treatment of thousands of common and uncommon conditions, always guided by an understanding of the epidemiology and pathobiology, as well as the latest medical literature. But Goldman-Cecil Medicine is not just a textbook. It is designed to optimize electronic searches that will rapidly take you to exactly the information you are seeking. Throughout the lifetime of each edition, periodic updates continually include the newest information from a wide range of journals. Furthermore, Goldman-Cecil Medicine is available for all users of ClinicalKey, Elsevier’s full library of subspecialty textbooks that can be accessed by readers who may want even more in-depth information. More than 400 chapters authored by a veritable "Who’s Who" of modern medicine A practical, templated organization with an emphasis on up-to-date, evidence-based references New chapters on Population Health, Effects of Climate Change on Health, Bradycardias, Transgender Medicine, Whipple Disease, Covid-19 Virology and Pathobiology, Covid-19 Epidemiology/Clinical Manifestations/Diagnosis/Community Prevention, COVID-19 Treatment and Vaccination, Polyomaviruses, and more Thousands of algorithms, figures, and tables that make its information readily accessible Over 100 supplementary videos, heart sounds, and key references Available in print and on a variety of electronic devices Continuously updated by Lee Goldman, MD
Author :Andrea Giustina Publisher :Karger Medical and Scientific Publishers ISBN 13 :3805572964 Total Pages :213 pages Book Rating :4.8/5 (55 download)
Book Synopsis Glucocorticoid-induced Osteoporosis by : Andrea Giustina
Download or read book Glucocorticoid-induced Osteoporosis written by Andrea Giustina and published by Karger Medical and Scientific Publishers. This book was released on 2002 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoporosis is one of the most clinically relevant disabling chronic disease encountered in clinical practice. A common cause of osteoporosis is glucocorticoid excess, as glucocorticoids may increase bone resorption, inhibit bone formation, have indirect actions on bone by decreasing intestinal calcium absorption and induce hypercalciuria. This book presents a comprehensive overview of the effects of glucocorticoids on bone metabolism and structure and on the diagnosis and treatment of glucocorticoid-induced osteoporosis. It aims at providing updated information on the pathogenesis, diagnosis and treatment of this often dramatic complication of glucocorticoid excess. Being one of the few publications completely devoted to glucocorticoid-induced osteoporosis it will heighten the awareness of specialists who prescribe glucocorticoids of the clinical relevance of this treatment complication. 'Glucocorticoid-Induced Osteoporosis' is addressed to clinical experts as well as to general practitioners who will both benefit from the comprehensive and integrative view of the management of patients exposed to glucocorticoids.
Book Synopsis Glucocorticoid Signaling by : Jen-Chywan Wang
Download or read book Glucocorticoid Signaling written by Jen-Chywan Wang and published by Springer. This book was released on 2015-07-27 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.
Book Synopsis Goldman-Cecil Medicine E-Book by : Lee Goldman
Download or read book Goldman-Cecil Medicine E-Book written by Lee Goldman and published by Elsevier Health Sciences. This book was released on 2019-08-16 with total page 2972 pages. Available in PDF, EPUB and Kindle. Book excerpt: To be the best doctor you can be, you need the best information. For more than 90 years, what is now called Goldman-Cecil Medicine has been the authoritative source for internal medicine and the care of adult patients. Every chapter is written by acclaimed experts who, with the oversight of our editors, provide definitive, unbiased advice on the diagnosis and treatment of thousands of common and uncommon conditions, always guided by an understanding of the epidemiology and pathobiology, as well as the latest medical literature. But Goldman-Cecil Medicine is not just a textbook. Throughout the lifetime of each edition, periodic updates continually include the newest information from a wide range of journals. Furthermore, Goldman-Cecil Medicine is available for all users of ClinicalKey, Elsevier’s full library of subspecialty textbooks that can be accessed by readers who may want even more in-depth information. More than 400 chapters authored by a veritable "Who’s Who" of modern medicine A practical, templated organization with an emphasis on evidence-based references Thousands of algorithms, figures, and tables that make its information readily accessible Supplemented by over 1500 board-style questions and answers to help you prepare for certification and recertification examinations
Book Synopsis Encyclopedia of Endocrine Diseases by :
Download or read book Encyclopedia of Endocrine Diseases written by and published by Academic Press. This book was released on 2018-09-12 with total page 4225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Endocrine Diseases, Second Edition, Five Volume Set comprehensively reviews the extensive spectrum of diseases and disorders that can occur within the endocrine system. It serves as a useful and comprehensive source of information spanning the many and varied aspects of the endocrine end metabolic system. Students will find a concise description of the physiology and pathophysiology of endocrine and metabolic functions, as well as their diseases. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers, from advanced undergraduate students, to research professionals. Chapters explore the latest advances and hot topics that have emerged in recent years, such as the molecular basis of endocrine and metabolic diseases (mutations, epigenetics, signaling), the pathogenesis and therapy of common endocrine diseases (e.g. diabetes and endocrine malignancies), new technologies in endocrine research, new methods of treatment, and endocrine toxicology/disruptors. Covers all aspects of endocrinology and metabolism Incorporates perspectives from experts working within the domains of biomedicine (e.g. physiology, pharmacology and toxicology, immunology, genetics) and clinical sciences to provide readers with reputable, multi-disciplinary content from domain experts Provides a ‘one-stop’ resource for access to information as written by world-leading scholars in the field, with easy cross-referencing of related articles to promote understanding and further research
