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Author : Leslie Jo Willmert
Publisher :
ISBN 13 :
Total Pages : 288 pages
Book Rating : 4.E/5 ( download)
Download or read book The Retinoic Acid Receptors and Cellular Retinoic Acid Binding Protein II written by Leslie Jo Willmert and published by . This book was released on 2006 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anuradha Samantha Budhu
Publisher :
ISBN 13 :
Total Pages : 366 pages
Book Rating : 4.E/5 ( download)
Download or read book The Retinoid Receptors and Cellular Retinoic Acid Binding Proteins written by Anuradha Samantha Budhu and published by . This book was released on 2002 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ding Dong
Publisher :
ISBN 13 :
Total Pages : 222 pages
Book Rating : 4.E/5 ( download)
Download or read book Retinoid Receptors and Cellular Retinoic Acid Binding Proteins written by Ding Dong and published by . This book was released on 2000 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Richard J. Sessler
Publisher :
ISBN 13 :
Total Pages : 162 pages
Book Rating : 4.E/5 ( download)
Download or read book Studies on the Mechanisms of Ligand-induced Nuclear Localization of Cellular Retinoic Acid Binding Protein Type II written by Richard J. Sessler and published by . This book was released on 2006 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Academic Press
ISBN 13 : 0128201479
Total Pages : 612 pages
Book Rating : 4.1/5 (282 download)
Download or read book Retinoid Signaling Pathways written by and published by Academic Press. This book was released on 2020-04-29 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Retinoid Signaling Pathways, Volume 637, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Sections in this release include The chemistry and biochemistry of Vitamin A and its natural derivative, Biosynthesis of retinoic acids, Biodegration of retinoic acids mediated by retinoid binding proteins, Retinoic acid homeostasis, Cryo Electron Microscopy to study retinol update via the STRA6 receptor, Immuno-detection of retinoic acid synthesis enzymes in the brain, classical pathway of gene regulation by retinoids, Protein-protein interactions in the regulation of retinoid acid receptors activity, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Methods in Enzymology series Includes the latest information on retinoid signaling pathways
Author : Xiaofei Jia
Publisher :
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.3/5 (129 download)
Download or read book X-ray Crystallographic Studies of Cellular Retinoic Acid-binding Protein II Mutants Designed as Rhodopsin Mimics written by Xiaofei Jia and published by . This book was released on 2008 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mary Ann Asson-Batres
Publisher : Springer
ISBN 13 : 9402409459
Total Pages : 267 pages
Book Rating : 4.4/5 (24 download)
Download or read book The Biochemistry of Retinoid Signaling II written by Mary Ann Asson-Batres and published by Springer. This book was released on 2016-11-09 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The role of vitamin A in living organisms has been known throughout human history. In the last 100 years, the biochemical nature of vitamin A and its active derivative, retinoic acid, its physiological impact on growth processes, and the essential details of its mechanism of action have been revealed by investigations carried out by researchers using vertebrate and more recently invertebrate models to study a multiplicity of processes and conditions, encompassing embryogenesis, postnatal development to old age. A wealth of intercellular interactions, intracellular signaling systems, and molecular mechanisms have been described and the overall conclusion is that retinoic acid is essential for life. This book series, with chapters authored by experts in every aspect of this complex field, unifies the knowledge base and mechanisms currently known in detailed, engaging, well-illustrated, focused chapters that synthesize information for each specific area. In view of the recent information explosion in this field, it is timely to publish a contemporary, comprehensive, book series recapitulating the most exciting developments in the field and covering fundamental research in molecular mechanisms of vitamin A action, its role in physiology, development, and continued well-being, and the potential of vitamin A derivatives and synthetic mimetics to serve as therapeutic treatments for cancers and other debilitating human diseases. Volume II is divided into nine chapters contributed by prominent experts in their respective fields. Each chapter starts with the history of the area of research. Then, the key findings that contributed to development of the field are described, followed by a detailed look at key findings and progress that are being made in current, ongoing research. Each chapter is concluded with a discussion of the relevance of the research and a perspective on missing pieces and lingering gaps that the author recommends will be important in defining future directions in vitamin A research.
Author : Esther Ruberte
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (49 download)
Download or read book RETINOIC ACID RECEPTORS AND CELLULAR RETINOID BINDING PROTEINS written by Esther Ruberte and published by . This book was released on 1992 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: NOUS AVONS ETUDIE LA DISTRIBUTION DES ARN MESSAGERS CODANT POUR LES RECEPTEURS DE L'ACIDE RETINOIQUE ET POUR LES PROTEINES CYTOPLASMIQUES LORS DE L'EMBRYOGENESE DE LA SOURIS EN UTILISANT LA TECHNIQUE D'HYBRIDATION IN SITU. NOS RESULTATS MONTRENT QUE LES RECEPTEURS NUCLEAIRES ET LES PROTEINES CYTOPLASMIQUES ONT DES DISTRIBUTIONS SPECIFIQUES DANS LES TISSUS ET LES ORGANES EMBRYONNAIRES A DES MOMENTS OU LEUR DEVELOPPEMENT EST ALTERE PAR DES TAUX ANORMAUX DE RETINOIDES. LA CORRELATION DE CES DOMAINES D'EXPRESSION AVEC LES EFFETS MORPHOGENETIQUES DE LA VITAMINE A SUGGERENT QUE LA CELLULAR RETINOL BINDING PROTEIN EST IMPLIQUEE DANS LE PROCES DE TRANSFORMATION DU RETINOL EN ACIDE RETINOIQUE ET QUE LES CELLULAR RETINOIC ACID BINDING PROTEINS SONT RESPONSABLES DU CONTROLE DES TAUX D'ACIDE RETINOIQUE LIBRE DANS LES CELLULES. LE RECEPTEUR GAMMA POURRAIT JOUER UN ROLE SPECIFIQUE LORS DE LA CHONDROGENESE ET DE LA FORMATION DES EPITHELIUMS KERATINISES TANDIS QUE LE RECEPTEUR BETA AURAIT DES FONCTIONS PARTICULIERES AU COURS DU DEVELOPPEMENT DU SYSTEME NERVEUX ET DES EPITHELIUMS DES MUQUEUSES RESPIRATOIRES ET DIGESTIVES.
Author : Amanda C Vreeland
Publisher :
ISBN 13 :
Total Pages : 126 pages
Book Rating : 4.:/5 (96 download)
Download or read book Cellular Retinoic Acid-binding Protein 2 Cooperates with HuR to Stabilize RNA and Inhibit Tumor Growth written by Amanda C Vreeland and published by . This book was released on 2015 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular retinoic acid-binding protein 2 (CRABP2) enhances the transcriptional activation of the nuclear receptors termed retinoic acid receptors (RARs) by transporting retinoic acid (RA) from the cytosol to the nucleus and directly "channeling" it to RARs. One outcome of this cooperation is that CRABP2 enhances the RAR-mediated anti-carcinogenic activity of RA.Interestingly, it has been reported that CRABP2 also regulates the expression of some genes and displays pro-apoptotic activities in the absence of RA, using a mechanism that does not involve RAR. These observations suggest a novel function for the protein. The goal of this work was to determine the molecular mechanism by which apo-CRABP2 exerts its RA-independent activity and to examine whether it contributes to the tumor suppressive function of the protein. We found that apo-CRABP2 cooperates with the RNA-binding and stabilizing protein HuR to upregulate and stabilize mRNAs. CRABP2 directly interacts with HuR and enhances its affinity for target mRNAs. We found further that some transcripts that are co-regulated by CRABP2 and HuR include mRNAs for cancer-related proteins such as apoptotic peptidase activating factor-1, caspase 7, BRCA1, and BRCA2. Additional studies revealed that both functions of CRABP2 respectively mediated by RAR and by HuR contribute to the tumor suppressive activity of the protein.
Author : Ulf Eriksson
Publisher :
ISBN 13 :
Total Pages : 48 pages
Book Rating : 4.:/5 (34 download)
Download or read book Functional Studies of Intracellular Retinoid Binding Proteins written by Ulf Eriksson and published by . This book was released on 1984 with total page 48 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.:/5 (644 download)
Download or read book Cellular Retinoic Acid Binding Protein and Breast Cancer written by and published by . This book was released on 2004 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt: In attempts to understand how the signaling by retinoic acid (the active vitamin A metabolite) is regulated we have been studying the retinoic acid binding protein called CRABP-II. These studies revealed that CRABP-II acts to enhance the transcriptional activities of RA and that it does so by directly delivering the hormone to its cognate transcription factor, RAR. Consequently CRABP-II dramatically sensitized cultured mammary carcinoma cells to RA-induced growth inhibition. Similarly, over-expression of CRABP-II inhibited mammary tumor growth in two different mouse models of cancer. CRABP-II may be a novel target for therapeutic and preventive strategies for retinoid-treatment of breast cancer. This project aims to delineate the mechanism by which CRABP-II modulates RA activity, especially as related to its ability to enhance the anti-proliferative action of the ligand. The first aim is to determine the extent to which CRABP-II acts in activating different isotypes of RAR. The second aim is to dissect the mechanism by which RA-induced growth inhibition is mediated. This will then allow for closer inspection of particular target genes that are under such control. The third aim is to understand the basis for RA-resistance of mammary carcinoma cells and how CRABP-II functions to overcome this resistance.
Author : Lincong Wang
Publisher :
ISBN 13 :
Total Pages : 478 pages
Book Rating : 4.3/5 (129 download)
Download or read book Biochemical and NMR Studies of Human Cellular Retinoic Acid Binding Proteins written by Lincong Wang and published by . This book was released on 1998 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul Douglas Fiorella
Publisher :
ISBN 13 :
Total Pages : 472 pages
Book Rating : 4.:/5 (335 download)
Download or read book Expression, Purification and Characterization of Cellular Retinoic Acid Binding Protein Types I and II. A Role in Vitamin A Metabolism written by Paul Douglas Fiorella and published by . This book was released on 1995 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Montserrat Rabago-Smith
Publisher :
ISBN 13 :
Total Pages : 806 pages
Book Rating : 4.3/5 (129 download)
Download or read book Studies on 15-15'--carotene Dioxygenase and Reengineering Cellular Retinoic Acid Binding Protein II Into a Retinal Binding Protein and Its Interaction with Retinal Mimics written by Montserrat Rabago-Smith and published by . This book was released on 2006 with total page 806 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pascal Dollé
Publisher : John Wiley & Sons
ISBN 13 : 1118627989
Total Pages : 631 pages
Book Rating : 4.1/5 (186 download)
Download or read book The Retinoids written by Pascal Dollé and published by John Wiley & Sons. This book was released on 2015-06-15 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives. The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy. Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.
Author : BAERT ET BAERT ET AL
Publisher : Academic Press
ISBN 13 : 1483296377
Total Pages : 463 pages
Book Rating : 4.4/5 (832 download)
Download or read book The Retinoids: v. 2 written by BAERT ET BAERT ET AL and published by Academic Press. This book was released on 2014-06-28 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Retinoids: v. 2
Author : KATHRYN JEAN KEHOE
Publisher :
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.3/5 (91 download)
Download or read book THE EFFECT OF AGENT INDUCED DIFFERENTIATION ON CELLULAR RETINOIC ACID BINDING PROTEIN IN PRIMARY RAT KERATINOCYTE CULTURES. written by KATHRYN JEAN KEHOE and published by . This book was released on 1990 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: this process.
