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Author : Liqian Zhang
Publisher :
ISBN 13 :
Total Pages : 240 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Regulation of the Expression of Human Interleukin-2 Gene written by Liqian Zhang and published by . This book was released on 1993 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Kendall A Smith
Publisher : Elsevier
ISBN 13 : 0323139949
Total Pages : 334 pages
Book Rating : 4.3/5 (231 download)
Download or read book Interleukin 2 written by Kendall A Smith and published by Elsevier. This book was released on 2012-12-02 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interleukin 2 focuses on interleukin 2 (IL-2) and its impact on immunology. Topics covered include IL-2's mechanism of action, the structure of the IL-2 receptor, the characteristics of natural and recombinant human IL-2, regulation of IL-2 production by the T cell antigen receptor, how IL-2 binding induces the transcription of a novel set of genes, and the pathological roles of IL-2 receptor inducers in adult T cell leukemia. This book is comprised of 12 chapters and begins with a historical overview of IL-2, from the discovery of soluble mitogenic factors in culture media of stimulated lymphocytes to the discovery of IL-2 as the molecule responsible for stimulating T cell proliferation. The physicochemical and biological properties of purified recombinant IL-2 are then described, paying particular attention to natural IL-2 derived from human peripheral blood leukocytes. The chapters that follow discuss the different techniques used to gain insight into the functionally important regions of IL-2, the role of the T cell antigen receptor in regulating the production of IL-2, and the structure of the human high-affinity IL-2 receptor. The book also describes transmembrane signaling by IL-2, IL-2-inducible gene expression in T lymphocytes, abnormal IL-2 receptor expression in adult T cell leukemia, the use of IL-2 receptors in immunosuppressive therapy, and the use of IL-2 as a pharmacologic reagent. This book will be of interest to students and researchers in immunology and biochemistry.
Author : Donald Frederick Robinson
Publisher :
ISBN 13 :
Total Pages : 292 pages
Book Rating : 4.:/5 (299 download)
Download or read book Use of the Human Interleukin-2 Gene Regulatory Sequences and Amber Suppression for Transcriptional and Post-transcriptional Control Over Expression of a Potent Toxin Gene written by Donald Frederick Robinson and published by . This book was released on 1993 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Janet Valentine
Publisher :
ISBN 13 :
Total Pages : 396 pages
Book Rating : 4.:/5 (222 download)
Download or read book Regulation of Human Interleukin-5 Gene Expression written by Janet Valentine and published by . This book was released on 1995 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Fiona Rolfe
Publisher :
ISBN 13 :
Total Pages : 458 pages
Book Rating : 4.:/5 (222 download)
Download or read book Transcriptional and Post-transcriptional Regulation of Human Interleukin 5 Gene Expression written by Fiona Rolfe and published by . This book was released on 1996 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Milena Iacobelli Martinez
Publisher :
ISBN 13 :
Total Pages : 206 pages
Book Rating : 4.:/5 (318 download)
Download or read book Transcriptional Regulation of the Human IL-2 Gene written by Milena Iacobelli Martinez and published by . This book was released on 2000 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interleukin 2 (IL-2) is produced by optimally stimulated T cells and is the major growth factor for T cells. Quiescent T cells do not synthesize IL-2, but upon stimulation, IL-2 is quickly expressed due to the coordinate binding of transcription factors within a 300 base pair promoter. Activation of the transcription factors involved in IL-2 transcription is highly dependent on proper stimulation through the T cell receptor (TCR) as well as a co-stimulatory molecule such as the CD28 receptor. TCR-induced signals are necessary to induce the binding of most, but not all, factors to the IL-2 promoter. CD28 stimulation synergizes with the TCR to activate many of these factors, but is also responsible for the induced binding of a novel complex to a region of the IL-2 promoter known as the CD28 responsive element (CD28RE). Determination of the proteins which function at this site was investigated. Functional studies led to the discovery that the CD28RE forms a composite element with a proximal AP-1 site. Together, the CD28RE/AP-1 sequences bind a complex that contains c-Rel, c-Fos, c-Jun, and the novel protein p21 SNFT in Jurkat T cells. Further analysis of p21SNFT indicates that it inhibits IL-2 promoter activity due to its ability to repress AP-1-associated enhancers required for transcription. Functional and binding studies using nuclear extracts and purified proteins suggest that p21 SNFT competes with Fos proteins for Jun binding, thereby effectively decreasing the numbers of transcriptionally active AP-1 heterodimers that form. While much is known about transactivation requirements for IL-2 expression, less is known about the inhibitory processes that shut down or prevent IL-2 transcription. Therefore, the identity of a novel protein that represses IL-2 promoter activity may help in our understanding of the mechanisms involved in the silencing of the IL-2 gene in situations such as in sub-optimally stimulated T cells, anergic T cells, or during T cell differentiation.
Author : Tarra Lea McDowell
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (278 download)
Download or read book Regulation of Human Interleukin 1 Alpha Gene Expression written by Tarra Lea McDowell and published by . This book was released on 1995 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anish D. Singh
Publisher :
ISBN 13 :
Total Pages : 240 pages
Book Rating : 4.:/5 (155 download)
Download or read book Studies on the Transcriptional Regulation of Human Interleukin 5 written by Anish D. Singh and published by . This book was released on 2000 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Grant E. Gallagher
Publisher :
ISBN 13 :
Total Pages : 176 pages
Book Rating : 4.:/5 (773 download)
Download or read book Expression and Regulation of Human Interleukin-19 written by Grant E. Gallagher and published by . This book was released on 2011 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ajay Nirula
Publisher :
ISBN 13 :
Total Pages : 282 pages
Book Rating : 4.:/5 (413 download)
Download or read book Regulation of Interleukin-2 Gene Expression by the Cellular Protein, Interleukin Enhancer Binding Factor written by Ajay Nirula and published by . This book was released on 1997 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Beatrice Hoyos
Publisher :
ISBN 13 :
Total Pages : 260 pages
Book Rating : 4.:/5 (891 download)
Download or read book Transcriptional Regulation of Interleukin-2 Gene Expression Through NF-kB and RW-Bf written by Beatrice Hoyos and published by . This book was released on 1993 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Forest Rohwer
Publisher :
ISBN 13 :
Total Pages : 384 pages
Book Rating : 4.:/5 (318 download)
Download or read book Interleukin-2 Activation of Intracellular Signaling Pathways written by Forest Rohwer and published by . This book was released on 1997 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: During an immune reaction, T cell clones must be expanded by mitogenic cytokines such as interleukin-2 (IL-2). IL-2 is able to induce proliferation, protection from apoptosis, and differentiation of T cells. These cellular phenomena are mediated through signaling events initiated at the IL-2 receptor (IL-2R) and are associated with changes in the mRNA levels that encode necessary proteins. The following work examined the molecular signals initiated at the IL-2R and sought to understand their linkage to increases in mRNA levels and subsequent cellular responses, such as proliferation and protection from apoptosis. Understanding these links is vital to understanding the molecular events that control the immune response, as well as providing insight into the cell cycle and activated transcription. To study this problem, an IL-2 responsive system based on thymic blast cells (TBCs) was developed and characterized. This system has the advantage of yielding a large number of IL-2 responsive cells from primary human tissue. Using the TBCs it was shown that transcription of important cell cycle genes is linked to the IL-2R via the c-Ras/MAPK pathway. Additionally, this pathway is responsible for IL-2 mediated proliferation. A second pathway, mediated through PKC, is responsible for upregulation of anti-apoptosis genes and protection from apoptosis. TBCs were also used to show that IL-2 can increase mRNA levels of specific genes by releasing transcriptional attenuation. Together these results show that specific signaling pathways can be linked to increases in specific mRNAs and suggest at least one mechanism of this upregulation. These results also show that increased expression of certain mRNAs may explain specific cellular responses. Finally, this work provides direction for future research that should yield more interesting insights into IL-2 mediated control of transcription.
Author : Z. Kmiec
Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.6/5 (425 download)
Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.
Author : Heather Margaret Pringle
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (181 download)
Download or read book Regulation of Expression of the Interleukin-2 Receptor Alpha Chain (CD25) in Human Tonsillar B Lymphocytes written by Heather Margaret Pringle and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mary Mann-Jong Chang
Publisher :
ISBN 13 :
Total Pages : 354 pages
Book Rating : 4.:/5 (59 download)
Download or read book Regulation of Interleukin-8 Gene Expression in Airway Epithelium written by Mary Mann-Jong Chang and published by . This book was released on 1999 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Regulation of Interleukin-2 Gene Expression in T Lymphocytes by Tumour Necrosis Factor-Alpha written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher : Birkhäuser
ISBN 13 : 9783764385309
Total Pages : 0 pages
Book Rating : 4.3/5 (853 download)
Download or read book Encyclopedia of Inflammatory Diseases written by and published by Birkhäuser. This book was released on 2016-09-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation has become one of the most exciting and rewarding areas of medical research. Recent years have seen a revolution in our understanding of how blood and tissue cells interact and of the intracellular mechanisms controlling their activation. This has revealed the underlying inflammatory pathology of many diseases and provided multiple new targets for anti-inflammatory and immunomodulatory therapy. The Encyclopedia of Inflammatory Diseases will cover the following areas: Inflammatory Processes and Cells Inflammatory Diseases Mediators of Inflammation Pharmacology of Inflammation Since inflammatory diseases and their therapy cover a broad range of scientific and medical fields, the encyclopedia will be co-edited by four international experts, a clinician and three researchers from the disciplines of immunology, biochemistry, and pharmacology, in this way providing students, basic and clinical scientists and practitioners in academia, hospitals and industry with valuable interlinked information. This living project will serve as a reliable and comprehensive data pool for everybody working in inflammation research. Owing to its dynamic nature, it will grow with time and future editions, becoming an indispensible source of information for academia, clinical practitioners and industry.
