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The Regulation Of Glucose Synthesis By Rat Liver
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Book Synopsis The Regulation of Glucose Synthesis by Rat Liver by : Carlo Marcello Veneziale
Download or read book The Regulation of Glucose Synthesis by Rat Liver written by Carlo Marcello Veneziale and published by . This book was released on 1969 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dietary Regulation of Glucose-6-phosphate and 6-phosphogluconate Dehydrogenase Synthesis in Rat Liver by : Larry Keith Winberry
Download or read book Dietary Regulation of Glucose-6-phosphate and 6-phosphogluconate Dehydrogenase Synthesis in Rat Liver written by Larry Keith Winberry and published by . This book was released on 1976 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dietary Regulation of the Synthesis of Glucose-6-phosphate Dehydrogenase in Rat Liver by : James Dean Sun
Download or read book Dietary Regulation of the Synthesis of Glucose-6-phosphate Dehydrogenase in Rat Liver written by James Dean Sun and published by . This book was released on 1978 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Regulation of Glucose-6-phosphate Dehydrogenase in Serum-free Cultures of Primary Adult Rat Hepatocytes by : Patricia Manos
Download or read book The Regulation of Glucose-6-phosphate Dehydrogenase in Serum-free Cultures of Primary Adult Rat Hepatocytes written by Patricia Manos and published by . This book was released on 1987 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of Glucose Metabolism in Rat Liver and Hepatomas by : Francis A. Farina
Download or read book Regulation of Glucose Metabolism in Rat Liver and Hepatomas written by Francis A. Farina and published by . This book was released on 1970 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Integration of Hormonal Effects (insulin, Glucagon and Leptin) on Key Metabolic Pathways Through a Computational Perfused Fed and Fasted Rat Liver Model by : Tania Habib
Download or read book Integration of Hormonal Effects (insulin, Glucagon and Leptin) on Key Metabolic Pathways Through a Computational Perfused Fed and Fasted Rat Liver Model written by Tania Habib and published by . This book was released on 2019 with total page 151 pages. Available in PDF, EPUB and Kindle. Book excerpt: A mechanistic model of the perfused rat liver was developed, integrating the hormonal regulation by insulin, glucagon, and leptin; under various nutritional states. This work is based on the recent model of Chalhoub E. et al. and Fayad R. et al., which included the detailed metabolic pathway, compartmentation between cytosol and mitochndria, shuttling mechanisms, and perfusion of different gluconeogenic substrates. The model was enhanced by including the glycogen metabolism, through the addition of GS and GP kinetic rates. It also included the activation and inhibitory effects of insulin, glucagon, and leptin, or a combination of them; on several key metabolic enzymes. The kinetic rate expressions are developed based on Michaelis-Menten, accounting for Haldane relation for reversible reactions, and modulation by ADP/ATP and/or NADH/NAD+. The regulatory effects of hormones were modeled based on a combination of Michaelis-Menten and Hill equations. Under fasted state, the model was fitted to several experiments of rat livers perfused with alanine in combination with insulin and leptin. In addition, during the fed state, the model was fitted to perfused rat liver experimental data of glucagon or glucagaon in combination with leptin or insulin; with no gluconeogenic precursors. The simulated model results are found in good agreement with experimental ones. The fasted liver model, under the perfusion of alanine with insulin, portrays a decrease in glucose production, lactate formation and urea synthesis by 32.3%, 49.2% and 78% respectively. Under perfusion of alanine with leptin, a decrease of 37.5, 23.571%, 40.09% was achieved for the rates of glucose, urea and lactate respectively. The simulation of glucagon in the fed rat liver model; in the absence of gluconeogenic precursors, promoted a rapid increase in hepatic glycogenolysis and glucose production by a rate of 55-52.35% and 90.6% respectively. Computational in silico models complement in vitro and in vivo tests to minimize the need for animal testing and decrease the cost and time for experimental procedures, in addition to the unique advantage of testing drugs and chemicals before they are synthesized. The model paves a way to study and analyse the distribution of key-regulatory enzymes to the alteration of physiological hormonal stimuli (such as insulin, leptin and glucagon) which allows for quantifying the contribution of these hormones in the liver. The future of computational hepatic metabolism modeling holds exciting opportunities as one of the ambitious aims of researchers is to have 90% of the human body computationally modeled by 2038.
Book Synopsis Acute Control of Rat Hepatic Glucose-6-phosphatase and Glucokinase Activities During the Fasting to Feeding Transition by : Nora Mary O'Brien
Download or read book Acute Control of Rat Hepatic Glucose-6-phosphatase and Glucokinase Activities During the Fasting to Feeding Transition written by Nora Mary O'Brien and published by . This book was released on 1987 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies of the Fasted to Fed Transition in Isolated Rat Hepatocytes with Respect to the Glucose Paradox, Glucokinase, and Glucose-6-phosphatase by : Leslie Jo Marden
Download or read book Studies of the Fasted to Fed Transition in Isolated Rat Hepatocytes with Respect to the Glucose Paradox, Glucokinase, and Glucose-6-phosphatase written by Leslie Jo Marden and published by . This book was released on 1986 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Relationship Between the Amino Acid, Glucose and Insulin Concentration in Control of Gluconeogenesis in the Perfused Rat Liver by : Celia Davis Sladek
Download or read book The Relationship Between the Amino Acid, Glucose and Insulin Concentration in Control of Gluconeogenesis in the Perfused Rat Liver written by Celia Davis Sladek and published by . This book was released on 1971 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Regulation of Rat Liver 6-phosphogluconate Dehydrogenase by : Dana Allen Procsal
Download or read book The Regulation of Rat Liver 6-phosphogluconate Dehydrogenase written by Dana Allen Procsal and published by . This book was released on 1974 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies on the Regulation of Triacylglycerol Synthesis in Rat Liver by : Pieter Declercq
Download or read book Studies on the Regulation of Triacylglycerol Synthesis in Rat Liver written by Pieter Declercq and published by . This book was released on 1983 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Control of Glucose-6-phosphate Dehydrogenase and 6-phosphogluconate Dehydrogenase in Culture Rat Hepatocytes by : Randil Lee Clark
Download or read book The Control of Glucose-6-phosphate Dehydrogenase and 6-phosphogluconate Dehydrogenase in Culture Rat Hepatocytes written by Randil Lee Clark and published by . This book was released on 1982 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Study of Some Aspects of the Metabolic Control and Physiological Significance of Rat Liver Glucokinase by : Monica David Blumenthal
Download or read book A Study of Some Aspects of the Metabolic Control and Physiological Significance of Rat Liver Glucokinase written by Monica David Blumenthal and published by . This book was released on 1962 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Glucose Production by Liver Cells by : Ronald Webster Brosemer
Download or read book Mechanisms of Glucose Production by Liver Cells written by Ronald Webster Brosemer and published by . This book was released on 1960 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies on the Turnover of Rat Liver Glucose-6-phosphate Dehydrogenase by : Daniel Edgar Peavy
Download or read book Studies on the Turnover of Rat Liver Glucose-6-phosphate Dehydrogenase written by Daniel Edgar Peavy and published by . This book was released on 1976 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Shawn Scott Donkin Publisher :Ann Arbor, Mich. : University Microfilms International ISBN 13 : Total Pages :424 pages Book Rating :4.:/5 (89 download)
Book Synopsis Direct Regulation of Gluconeogenesis in Bovine Liver by Insulin and Glucagon by : Shawn Scott Donkin
Download or read book Direct Regulation of Gluconeogenesis in Bovine Liver by Insulin and Glucagon written by Shawn Scott Donkin and published by Ann Arbor, Mich. : University Microfilms International. This book was released on 1992 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms of Insulin Action by : Alan R. Saltiel
Download or read book Mechanisms of Insulin Action written by Alan R. Saltiel and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.