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The Predictive Value Of Short Term Screening Tests In Carcinogenicity Evaluation
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Book Synopsis The Predictive Value of Short-term Screening Tests in Carcinogenicity Evaluation by : Gary M. Williams
Download or read book The Predictive Value of Short-term Screening Tests in Carcinogenicity Evaluation written by Gary M. Williams and published by North Holland. This book was released on 1980-01-01 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Predictive Value of Short-term Screening Tests in Carcinogenicity Evaluation by :
Download or read book The Predictive Value of Short-term Screening Tests in Carcinogenicity Evaluation written by and published by . This book was released on 1980 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Volume 3: The Predictive Value of Short-Term Screening Tests in Carcinogenicity Evaluation by : GM Williams (Ed)
Download or read book Volume 3: The Predictive Value of Short-Term Screening Tests in Carcinogenicity Evaluation written by GM Williams (Ed) and published by . This book was released on 1980 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Predictive Value of Short-term Screening Tests in Carcinogenicity Evaluation by :
Download or read book The Predictive Value of Short-term Screening Tests in Carcinogenicity Evaluation written by and published by Elsevier-North-Holland Biomedical Press. This book was released on 1980 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Predicitive of Short-term Screening Tests in Carcinogenicity Evaluation by :
Download or read book The Predicitive of Short-term Screening Tests in Carcinogenicity Evaluation written by and published by . This book was released on 1980 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Predictive Value of Carcinogenicity Testing in Drug Evaluation by : Nordic Council on Medicines
Download or read book Predictive Value of Carcinogenicity Testing in Drug Evaluation written by Nordic Council on Medicines and published by . This book was released on 1987 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Carcinogens and Anticarcinogens in the Human Diet by : National Research Council
Download or read book Carcinogens and Anticarcinogens in the Human Diet written by National Research Council and published by National Academies Press. This book was released on 1996-02-12 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens provides a readable overview of issues and addresses critical questions: Does diet contribute to an appreciable proportion of human cancer? Are there significant interactions between carcinogens and anticarcinogens in the diet? The volume discusses the mechanisms of carcinogenic and anticarcinogenic properties and considers whether techniques used to evaluate the carcinogenic potential of synthetics can be used with naturally occurring chemicals. The committee provides criteria for prioritizing the vast number of substances that need to be tested. Carcinogens and Anticarcinogens clarifies the issues and sets the direction for further investigations into diet and cancer. This volume will be of interest to anyone involved in food and health issues: policymakers, regulators, researchers, nutrition professionals, and health advocates.
Book Synopsis Review of Short-term Screening Tests for Mutagens, Toxigens, and Carcinogens by : Heath J. Carney
Download or read book Review of Short-term Screening Tests for Mutagens, Toxigens, and Carcinogens written by Heath J. Carney and published by . This book was released on 1979 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Short-Term Test Systems for Detecting Carcinogens by : K.H. Norpoth
Download or read book Short-Term Test Systems for Detecting Carcinogens written by K.H. Norpoth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: The varying cancer incidence from country to country and region to region suggests that en vironmental factors play a considerable role in the aetiology of cancer. Whether these factors in the environment moderate the effect of car cinogenic chemicals or whether they might them selves be carcinogenic is not known at the present time. What is known is that there are various chemicals, both naturally occurring and man-made, which can induce cancer in man. In the Western world estimates vary as to how much cancer is occupational in origin; the figures range from 1% to 40%. It is our feeling that probably about 10% of cancer has a direct oc cupational origin. Nevertheless this number is considerable and it behoves us therefore to identify those chemicals which are carcinogenic and to reduce human exposure. Recent work on the mode of action of carcinogenic chemicals suggests that the majority exert their effect through an activation step to give elec trophilic metabolites. Such metabolites have as a common feature the ability to react with cel lular nucleophiles to give covalently bound products. Such reaction will occur after carcino gen treatment of animals with nucleic acids par ticularly in target organs. It is reaction with nucleic acids that provides the basis of a num ber of short-term tests for carcinogens, since the basic composition of DNA is similar in micro-organisms and in human cells.
Book Synopsis Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III by : Michael D. Waters
Download or read book Short-Term Bioassays in the Analysis of Complex Environmental Mixtures III written by Michael D. Waters and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the four years since the 1978 Symposium on the Application of Short-Term Bioassays in the Fractionation and Analysis of Complex Environmental Mixtures the use of short-term bioassays to evaluate potential health hazards of complex environmental mixtures has substantially increased. Increased research activity has been particularly noticeable in mobile source emissions, where initial observations on the mutagenic activity of diesel particulate extracts reported at the 1978 symposium stimulated the development of major research programs in government and industry. In the absence of appropriate reference materials, the U.S. Environmental Protection Agency initiated comparative genotoxicity studies to determine the relative mutagenic and carcinogenic activity and, ultimately, the potential human health risk due to exposure to various complex emission products. Among the materials investigated were those of known health risk, such as coke oven and roofing tar emissions and cigarette smoke condensates, and those of unknown hazard, such as exhaust from diesel-and gasoline-powered vehicles. Studies on diesel emission products proved useful in short term bioassay development, as the diesel exhaust extracts were genetically active with low cellular toxicity and could be obtained in relatively large quantities. Availability of such samples aided chemical characterization, and it was eventually determined that the nitro-polynuclear aromatic hydrocarbons were among the mutagenic components of diesel exhaust particulate.
Book Synopsis Five Year Report by : United States-Japan Cooperative Medical Science Program
Download or read book Five Year Report written by United States-Japan Cooperative Medical Science Program and published by . This book was released on 1985 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Issues in Risk Assessment by : National Research Council
Download or read book Issues in Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 1993-02-01 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume. The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures. The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.
Book Synopsis Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards by : H.C. Grice
Download or read book Interpretation and Extrapolation of Chemical and Biological Carcinogenicity Data to Establish Human Safety Standards written by H.C. Grice and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The International Life Sciences Institute (lLSI) is a scientific foundation wh ich addresses critical health and safety issues of national and international concern. ILSI promotes international cooperation by pro viding the mechanism for scientists from government, industry and universities to work together on cooperative programs to generate and disseminate scientific data. The members and trustees of the Institute believe that questions regarding health and safety are best resolved when scientists can ex amine and discuss issues, as an independent body, se~arate from the political pressures of individual countries and the economic concerns of individual companies. Frequently, meaningful assessment of the risk of a test substance is hindered by the inherent inconsistencies in the system. The development and refinement of methods and systems to evaluate the safety of chemicals have evolved in a rapid and largely unplanned fashion. Attempts to improve the system have largely been directed toward broad general concerns, with little attention being given to specific problems or issues. A failure to resolve these problems has frequently resulted in increased testing costs and complications in the assessment and extrapolation of the results. Publicity surrounding toxicologic issues has created chronic public apprehension about the ability of science and government to deal effectively with these problems. In response to these difficulties, ILSI has assembled highly qualified and renowned scientists from research institutes, universities, government and industry, with relevant scientific knowledge and expertise regarding the issues that complicate risk assessment procedures.
Book Synopsis Journal of the National Cancer Institute by :
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1992 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genotoxicology of N-Nitroso Compounds by : T. Rao
Download or read book Genotoxicology of N-Nitroso Compounds written by T. Rao and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toph's in Chemical Mutagenesis is a new series dedicated to studies in the areas of environmental chemical mutagenesis and genetic toxicology. In this series we will explore some of many topics that are emerging in these rapidly developing fields. The purpose of the present volume is to attempt to organize and compare the genotoxic properties of the N-nitroso compounds. This is a particularly interesting class of compounds because of the problems encountered with the Salmonella assay of Ames in generating both false positive and false negative results. The battery approach using a number of assay systems seems more appropriate to evaluate chemicals in this class. Topics to be discussed in other volumes in this series include single-cell mutation monitoring systems, the detection of genetic damage in mammalian germ cells, the mutagenicity of pesticides, problems in monitoring human populations in genetic toxicology, and a glossary of terms in genetic toxicology. All of these books are in various stages of development and should appear within the next few years. Frederick J. de Serres Series Editor vii Preface During the past ten years there has been an explosive development in the number of short-term tests to predict the biological risks, especially risks of cancer, in exposure to xenobiotic chemicals. The number of published articles in this area has reached many thousands a year and there are several new journals devoted almost entirely to the presentation of the results obtained in these tests.
Book Synopsis Environmental Health Perspectives by :
Download or read book Environmental Health Perspectives written by and published by . This book was released on 2000 with total page 1724 pages. Available in PDF, EPUB and Kindle. Book excerpt:
