The Osmotic Second Virial Coefficient As A Predictor Of Protein Stability

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The Osmotic Second Virial Coefficient as a Predictor of Protein Stability

Author : Kusum S. Verma
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (428 download)

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Book Synopsis The Osmotic Second Virial Coefficient as a Predictor of Protein Stability by : Kusum S. Verma

Download or read book The Osmotic Second Virial Coefficient as a Predictor of Protein Stability written by Kusum S. Verma and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of protein containing therapeutic drugs is growing day by day. Lack of proper storage conditions can cause protein degradation or aggregation. The osmotic second virial coefficient, B22, is a thermodynamic parameter, which can predict protein interaction with other proteins and solvent molecules. B22 has been successfully used as predictor of crystallization conditions for a protein in the solution, and in this study an attempt has been made to relate B22 as a predictor of stability of the protein. Static light scattering was used to measure B22 in our studies. B22 and the solubility of three proteins were measured in several excipient solutions. George et al. in 1997 related the osmotic second virial coefficient with the solubility of protein in a solution. In this study we have attempted to relate solubility with B22 and stability of lysozyme, human serum albumin, and ovalbumin in buffer solutions containing various excipients.

The Osmotic Second Virial Coefficient As A Predictor Of Protein Stability

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (654 download)

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Book Synopsis The Osmotic Second Virial Coefficient As A Predictor Of Protein Stability by :

Download or read book The Osmotic Second Virial Coefficient As A Predictor Of Protein Stability written by and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The number of protein containing therapeutic drugs is growing day by day. Lack of proper storage conditions can cause protein degradation or aggregation. The osmotic second virial coefficient, B22, is a thermodynamic parameter, which can predict protein interaction with other proteins and solvent molecules. B22 has been successfully used as predictor of crystallization conditions for a protein in the solution, and in this study an attempt has been made to relate B22 as a predictor of stability of the protein. Static light scattering was used to measure B22 in our studies. B22 and the solubility of three proteins were measured in several excipient solutions. George et al. in 1997 related the osmotic second virial coefficient with the solubility of protein in a solution. In this study we have attempted to relate solubility with B22 and stability of lysozyme, human serum albumin, and ovalbumin in buffer solutions containing various excipients.

The Second Virial Coefficient of Proteins in Aqueous Solutions and Its Relationship to Protein Solubility and Long-term Aggregation Stability

Download The Second Virial Coefficient of Proteins in Aqueous Solutions and Its Relationship to Protein Solubility and Long-term Aggregation Stability PDF Online Free

Author : Harminder Bajaj
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (628 download)

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Book Synopsis The Second Virial Coefficient of Proteins in Aqueous Solutions and Its Relationship to Protein Solubility and Long-term Aggregation Stability by : Harminder Bajaj

Download or read book The Second Virial Coefficient of Proteins in Aqueous Solutions and Its Relationship to Protein Solubility and Long-term Aggregation Stability written by Harminder Bajaj and published by . This book was released on 2005 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Aggregation of Therapeutic Proteins

Author : Wei Wang
Publisher : John Wiley & Sons
ISBN 13 : 1118043588
Total Pages : 400 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Aggregation of Therapeutic Proteins by : Wei Wang

Download or read book Aggregation of Therapeutic Proteins written by Wei Wang and published by John Wiley & Sons. This book was released on 2010-12-28 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives pharmaceutical scientists an up-to-date resource on protein aggregation and its consequences, and available methods to control or slow down the aggregation process. While significant progress has been made in the past decade, the current understanding of protein aggregation and its consequences is still immature. Prevention or even moderate inhibition of protein aggregation has been mostly experimental. The knowledge in this book can greatly help pharmaceutical scientists in the development of therapeutic proteins, and also instigate further scientific investigations in this area. This book fills such a need by providing an overview on the causes, consequences, characterization, and control of the aggregation of therapeutic proteins.

Continuous Biopharmaceutical Processes

Author : David Pfister
Publisher : Cambridge University Press
ISBN 13 : 1108349781
Total Pages : 349 pages
Book Rating : 4.1/5 (83 download)

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Book Synopsis Continuous Biopharmaceutical Processes by : David Pfister

Download or read book Continuous Biopharmaceutical Processes written by David Pfister and published by Cambridge University Press. This book was released on 2018-10-11 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This innovative reference provides a coherent and critical view on the potential benefits of a transition from batch to continuous processes in the biopharmaceutical industry, with the main focus on chromatography. It also covers the key topics of protein stability and protein conjugation, addressing the chemical reaction and purification aspects together with their integration. This book offers a fine balance between theoretical modelling and illustrative case studies, between fundamental concepts and applied examples from the academic and industrial literature. Scientists interested in the design of biopharmaceutical processes will find useful practical methodologies, in particular for single-column and multi-column chromatographic processes.

Protein-Solvent Interactions

Author : Roger Gregory
Publisher : CRC Press
ISBN 13 : 9780824792398
Total Pages : 596 pages
Book Rating : 4.7/5 (923 download)

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Book Synopsis Protein-Solvent Interactions by : Roger Gregory

Download or read book Protein-Solvent Interactions written by Roger Gregory and published by CRC Press. This book was released on 1995-01-04 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work covers advances in the interactions of proteins with their solvent environment and provides fundamental physical information useful for the application of proteins in biotechnology and industrial processes. It discusses in detail structure, dynamic and thermodynamic aspects of protein hydration, as well as proteins in aqueous and organic solvents as they relate to protein function, stability and folding.

Analysis of Aggregates and Particles in Protein Pharmaceuticals

Author : Hanns-Christian Mahler
Publisher : John Wiley & Sons
ISBN 13 : 0470497181
Total Pages : 480 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Analysis of Aggregates and Particles in Protein Pharmaceuticals by : Hanns-Christian Mahler

Download or read book Analysis of Aggregates and Particles in Protein Pharmaceuticals written by Hanns-Christian Mahler and published by John Wiley & Sons. This book was released on 2012-01-24 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes how to address the analysis of aggregates and particles in protein pharmaceuticals, provides a comprehensive overview of current methods and integrated approaches used to quantify and characterize aggregates and particles, and discusses regulatory requirements. Analytical methods covered in the book include separation, light scattering, microscopy, and spectroscopy.

Fundamentals and Practice in Statistical Thermodynamics

Author : Jianzhong Wu
Publisher : John Wiley & Sons
ISBN 13 : 1394161425
Total Pages : 773 pages
Book Rating : 4.3/5 (941 download)

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Book Synopsis Fundamentals and Practice in Statistical Thermodynamics by : Jianzhong Wu

Download or read book Fundamentals and Practice in Statistical Thermodynamics written by Jianzhong Wu and published by John Wiley & Sons. This book was released on 2024-08-20 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridge the gap between thermodynamic theory and engineering practice with this essential textbook Thermodynamics is a discipline which straddles the fields of chemistry, physics, and engineering, and has long been a mainstay of undergraduate and graduate curricula. Conventional thermodynamics courses, however, often ignore modern developments in statistical mechanics, such as molecular simulation methods, cooperative phenomena, phase transitions, universality, as well as liquid-state and polymer theories, despite their close relevance to both fundamental research and engineering practice. Fundamentals and Practice in Statistical Thermodynamics fills this gap with an essential book that applies up-to-date statistical-mechanical techniques to address the most crucial thermodynamics problems found in chemical and materials systems. It is ideally suited to introduce a new generation of researchers and molecular engineers to modern thermodynamic topics with numerous cutting-edge applications. From Fundamentals and Practice in Statistical Thermodynamics readers will also find: An introduction to statistical-mechanical methods including molecular dynamics simulation, Monte Carlo simulation, as well as the molecular theories of phase transitions, classical fluids, electrolyte solutions, polymeric materials, and more Illustrative examples and exercise problems with solutions to facilitate student understanding Supplementary online materials covering the basics of quantum mechanics, density functional theory, variational principles of classical mechanics, intermolecular interactions, and many more subjects Fundamentals and Practice in Statistical Thermodynamics is ideal for graduate and advanced undergraduate students in chemical engineering, biomolecular engineering, environmental engineering, materials science and engineering, and all related scientific subfields of physics and chemistry.

Therapeutic Proteins and Peptides

Author :
Publisher : Academic Press
ISBN 13 : 012814341X
Total Pages : 410 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Therapeutic Proteins and Peptides by :

Download or read book Therapeutic Proteins and Peptides written by and published by Academic Press. This book was released on 2018-04-18 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Therapeutic Proteins and Peptides, Volume 112 in an ongoing series promotes further research in the discovery of new therapeutic targets that can be affected by therapeutic proteins and peptides to cure or manage symptoms of human diseases, with this release focusing on the Rational Design of Stable Liquid Formulations of Biopharmaceuticals, Formulation strategies for peptides, proteins and antibodies using nanotechnology, the Solution structural dynamics of therapeutic peptides and their adsorption on plasmonic nanoparticles, Enzymatic approaches of protein-polymer conjugation, Chimeric small antibody fragments as a strategy to deliver therapeutic payloads, Smart cell-penetrating peptide-based techniques for cytoplasmic delivery of therapeutic macromolecules, and more. Describes advances in the discovery and application of therapeutic proteins/peptides which allow better targeting to the site of treatment and cause fewer adverse effects when compared to chemical compounds used for disease treatment Targeted to a very wide audience of specialists, researchers and students Written by well-renown authorities in their field Includes a number of high quality illustrations, figures and tables

Biophysical Methods for Biotherapeutics

Author : Tapan K. Das
Publisher : John Wiley & Sons
ISBN 13 : 0470938439
Total Pages : 380 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Biophysical Methods for Biotherapeutics by : Tapan K. Das

Download or read book Biophysical Methods for Biotherapeutics written by Tapan K. Das and published by John Wiley & Sons. This book was released on 2014-04-28 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development. • Helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods • Chapters organized according to the sequential nature of the drug development process • Helps formulation, analytical, and bioanalytical scientists in pharma and biotech better understand and usestrengths and limitations of biophysical methods • Explains how to use biophysical methods, the information obtained, and what needs to be presented in a regulatory filing, assess impact on quality and immunogenicity • With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.

High-Throughput Formulation Development of Biopharmaceuticals

Author : Vladimir I. Razinkov
Publisher : Woodhead Publishing
ISBN 13 : 190881876X
Total Pages : 133 pages
Book Rating : 4.9/5 (88 download)

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Book Synopsis High-Throughput Formulation Development of Biopharmaceuticals by : Vladimir I. Razinkov

Download or read book High-Throughput Formulation Development of Biopharmaceuticals written by Vladimir I. Razinkov and published by Woodhead Publishing. This book was released on 2016-09-29 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: High Throughput Formulation Development of Biopharmaceuticals: Practical Guide to Methods and Applications provides the latest developments and information on the science of stable and safe drug product formulations, presenting a comprehensive review and detailed description of modern methodologies in the field of formulation development, a process starting with candidate and pre-formulation screening in its early development phase and then progressing to the refinement of robust formulations during commercialization in the later phases of development. The title covers topics such as experiment design, automation of sample preparation and measurements, high-throughput analytics, stress-inducing methods, statistical analysis of large amounts of formulation study data, emerging technologies, and the presentation of several case studies, along with a concluding summary. Presents applications of high-throughput methodologies to accelerate drug formulation development Provides the latest technologies in the field Includes key statistical approaches, such as design of experiment and multivariate data analysis Written by highly respected formulation development experts

Analytical Ultracentrifugation

Author : Susumu Uchiyama
Publisher : Springer
ISBN 13 : 443155985X
Total Pages : 520 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Analytical Ultracentrifugation by : Susumu Uchiyama

Download or read book Analytical Ultracentrifugation written by Susumu Uchiyama and published by Springer. This book was released on 2016-05-13 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces analytical ultracentrifugation (AUC) as a whole, covering essential theoretical and practical aspects as well as its applications in both biological and non-biological systems. Comprehensive characterizations of macromolecules in a solution are now routinely required not only for understanding the solution system but also for producing a solution with better properties. Analytical ultracentrifugation is one of most powerful and reliable techniques for studying the biophysical behavior of solutes in solution. In the last few years, there have been steady advances made in hardware, software, and applications for AUC. This book provides chapters that cover everything essential for beginners to the most advanced users and also offer updated knowledge of the field on advances in hardware, software, and applications. Recent development of hardware described in this book covers new detection systems that give added dimensions to AUC. Examples of data analysis with essential theoretical explanations for advanced and recently updated software are also introduced. Besides AUC of biological systems including membrane proteins and biopharmaceuticals, AUC applications for non-biological questions are included. AUC studies under non-ideal conditions such as highly concentrated solutions and solutions with high salt concentration are also included. The contributors to this book are leading researchers in the fields of solution biophysics and physical chemistry who extensively employ AUC analysis for their research. From this published work, one can gain new and comprehensive knowledge of recent AUC analysis.

Approaches to the Conformational Analysis of Biopharmaceuticals

Author : Roger L. Lundblad
Publisher : CRC Press
ISBN 13 : 1439807817
Total Pages : 370 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Approaches to the Conformational Analysis of Biopharmaceuticals by : Roger L. Lundblad

Download or read book Approaches to the Conformational Analysis of Biopharmaceuticals written by Roger L. Lundblad and published by CRC Press. This book was released on 2009-12-15 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The activity of many biopharmaceutical polymers is dependent on conformation, and the next several years will see increased interest in the conformational analysis of these polymers resulting from the development of biosimilar or "follow-on" biological products. While a wide variety of approaches to analysis exists, finding the most viable ones wou

Physicochemical Measurement by Gas Chromatography

Author : John R. Conder
Publisher : John Wiley & Sons
ISBN 13 :
Total Pages : 660 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Physicochemical Measurement by Gas Chromatography by : John R. Conder

Download or read book Physicochemical Measurement by Gas Chromatography written by John R. Conder and published by John Wiley & Sons. This book was released on 1979 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Smart Colloidal Materials

Author : Walter Richtering
Publisher : Springer
ISBN 13 : 3540327029
Total Pages : 192 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Smart Colloidal Materials by : Walter Richtering

Download or read book Smart Colloidal Materials written by Walter Richtering and published by Springer. This book was released on 2006-08-29 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains selected papers presented at the 42nd Biennial Meeting of the Kolloid-Gesellschaft held at the RWTH Aachen University September 26-28, 2005. The contributions in this volume represent the diversity of research topics in colloid and polymer science. They include the investigation of synthesis and properties of advanced temperature sensitive particles and their biomedical applications, drug delivery systems, foams, capsules, vesicles and gels, polyelectrolytes, nanoparticles surfactants and hybrid materials.

Biopolymers in Food Colloids: Thermodynamics and Molecular Interactions

Author : Maria Germanovna Semenova
Publisher : CRC Press
ISBN 13 : 1466562056
Total Pages : 369 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Biopolymers in Food Colloids: Thermodynamics and Molecular Interactions by : Maria Germanovna Semenova

Download or read book Biopolymers in Food Colloids: Thermodynamics and Molecular Interactions written by Maria Germanovna Semenova and published by CRC Press. This book was released on 2010-01-13 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: The theme and contents of this book have assumed a new significance in the light of recent ideas on nanoscience and nanotechnology, which are now beginning to influence developments in food research and food processing. The fabrication of nanoscale structures for food use relies on an in-depth understanding of thermodynamically driven interactions

Biothermodynamics

Author : Urs von Stockar
Publisher : CRC Press
ISBN 13 : 1466582162
Total Pages : 632 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Biothermodynamics by : Urs von Stockar

Download or read book Biothermodynamics written by Urs von Stockar and published by CRC Press. This book was released on 2013-05-30 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the fundamentals of the rapidly growing field of biothermodynamics, showing how thermodynamics can best be applied to applications and processes in biochemical engineering. It describes the rigorous application of thermodynamics in biochemical engineering to rationalize bioprocess development and obviate a substantial fraction of this need for tedious experimental work. As such, this book will appeal to a diverse group of readers, ranging from students and professors in biochemical engineering, to scientists and engineers, for whom it will be a valuable reference.