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The Origin And Evolution Of Alpha Catenin In Epithelial Cell Polarity
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Book Synopsis The Origin and Evolution of Alpha-catenin in Epithelial Cell Polarity by : Daniel James Dickinson
Download or read book The Origin and Evolution of Alpha-catenin in Epithelial Cell Polarity written by Daniel James Dickinson and published by Stanford University. This book was released on 2011 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fundamental characteristic of metazoans is the formation of a simple, polarized epithelium. In higher animals, the structural integrity and functional polarization of simple epithelia require a cell-cell adhesion complex containing a classical cadherin, the Wnt-signaling protein β-catenin and the actin-binding protein α-catenin. I have investigated the evolutionary origins of epithelial cell polarity and of the cadherin-catenin complex. I show that the non-metazoan Dictyostelium discoideum forms a polarized epithelium that is essential for multicellular development. Although D. discoideum lacks a cadherin homolog, I have identified and characterized an α-catenin ortholog that binds a β-catenin-related protein. Both proteins are essential for formation of the epithelium, polarized protein secretion and proper multicellular morphogenesis. Thus the organizational principles of metazoan multicellularity may be more ancient than previously recognized, and the role of the catenins in cell polarity predates the evolution of Wnt signaling and classical cadherins.
Book Synopsis The Origin and Evolution of Alpha-catenin in Epithelial Cell Polarity by : Daniel James Dickinson
Download or read book The Origin and Evolution of Alpha-catenin in Epithelial Cell Polarity written by Daniel James Dickinson and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A fundamental characteristic of metazoans is the formation of a simple, polarized epithelium. In higher animals, the structural integrity and functional polarization of simple epithelia require a cell-cell adhesion complex containing a classical cadherin, the Wnt-signaling protein [Beta]-catenin and the actin-binding protein [Alpha]-catenin. I have investigated the evolutionary origins of epithelial cell polarity and of the cadherin-catenin complex. I show that the non-metazoan Dictyostelium discoideum forms a polarized epithelium that is essential for multicellular development. Although D. discoideum lacks a cadherin homolog, I have identified and characterized an [Alpha]-catenin ortholog that binds a [Beta]-catenin-related protein. Both proteins are essential for formation of the epithelium, polarized protein secretion and proper multicellular morphogenesis. Thus the organizational principles of metazoan multicellularity may be more ancient than previously recognized, and the role of the catenins in cell polarity predates the evolution of Wnt signaling and classical cadherins.
Book Synopsis Origin and Evolution of Metazoan Cell Types by : Sally Leys
Download or read book Origin and Evolution of Metazoan Cell Types written by Sally Leys and published by CRC Press. This book was released on 2021-05-23 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evolution of animal diversity is strongly affected by the origin of novel cell and tissue types and their interactions with each other. Understanding the evolution of cell types will shed light on the evolution of novel structures, and in turn highlight how animals diversified. Several cell types may also have been lost as animals simplified – for example did sponges have nerves and lose them? This book reveals the interplay between gains and losses and provides readers with a better grasp of the evolutionary history of cell types. In addition, the book illustrates how new cell types allow a better understanding permitting the discrimination between convergence and homology.
Book Synopsis Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease by : Venkataramana K Sidhaye
Download or read book Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease written by Venkataramana K Sidhaye and published by Academic Press. This book was released on 2017-03-09 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences
Book Synopsis Cell Polarity in Development and Disease by :
Download or read book Cell Polarity in Development and Disease written by and published by Elsevier. This book was released on 2023-04-28 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Polarity in Development and Disease, Volume 154 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Cell polarity in the protist-to-animal transition, Polarized actin networks in development: Case studies from Drosophila, Protein clustering and cell polarization, Polarity in the Drosophila female germline, Context Matters: Mechanisms governing epithelial polarization in C. elegans, Epithelial polarity in the fly: Principles and diversity, Polarizing epithelial expulsion and expulsion driven by mispolarization, The Role of Apical-Basal Polarization in the Mammalian First Cell Fate Decision, and much more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Methods in Cell Biology series - Updated release includes the latest information on Cell Polarity in Development and Disease
Book Synopsis Functional Organization of Vertebrate Plasma Membrane by :
Download or read book Functional Organization of Vertebrate Plasma Membrane written by and published by Elsevier. This book was released on 2013-11-05 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes is targeted toward scientists and researchers in biochemistry and molecular and cellular biology, providing the necessary membrane research to assist them in discovering the current state of a particular field and in learning where that field is heading. This volume covers recent breakthroughs in understanding the molecular and cellular basis for patterning vertebrate plasma membranes. A special emphasis is placed on physiological function with chapters covering signaling in the nervous system and heart, vision, and the immune system. consolidates subjects normally dispersed in the literature presents in one volume a subject that has undergone a recent molecular revolution authors are primary contributors and in some cases the founding figures in their fields
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Molecular Biology of Cadherins by :
Download or read book The Molecular Biology of Cadherins written by and published by Academic Press. This book was released on 2013-03-08 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Progress in Molecular Biology and Translational Science focuses on the most recent research surrounding Cadherins from top experts in the field. - Contributions from leading authorities - Informs and updates on all the latest developments in the field
Book Synopsis Interrelationships of the Platyhelminthes by : D T J Littlewood
Download or read book Interrelationships of the Platyhelminthes written by D T J Littlewood and published by CRC Press. This book was released on 2014-04-21 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interrelationships of the Platyhelminthes elucidates the role of the flatworms in the animal kingdom. It brings together results from an international group of experts, spanning many disciplines, who give evidence for the phylogeny of flatworms and constituent major taxa. A combined approach, using traditional comparative techniques along with the modern techniques of molecular phylogeny, is utilized to show that the monophyly of the phylum is not fully established, and that the phylum may in fact consist of two groups: the acoels and their relatives, which are basal metazoans, and the Rhabditophora, which is a more derived group.
Book Synopsis The Choanoflagellates by : Barry S. C. Leadbeater
Download or read book The Choanoflagellates written by Barry S. C. Leadbeater and published by Cambridge University Press. This book was released on 2015-01-08 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unique account of the biology, ecology and evolution of choanoflagellates - the closest, known, living, unicellular relatives of animals.
Book Synopsis Plasticity of cell polarity across scales in development and disease by : Eurico Morais-de-Sá
Download or read book Plasticity of cell polarity across scales in development and disease written by Eurico Morais-de-Sá and published by Frontiers Media SA. This book was released on 2023-10-27 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Molecular Biology of Cadherins by :
Download or read book The Molecular Biology of Cadherins written by and published by Academic Press. This book was released on 2013-04-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Progress in Molecular Biology and Translational Science focuses on the most recent research surrounding Cadherins from top experts in the field.
Book Synopsis Extracellular and Intracellular Signaling by : James D. Adams
Download or read book Extracellular and Intracellular Signaling written by James D. Adams and published by Royal Society of Chemistry. This book was released on 2011 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
Download or read book Embryology written by Scott F. Gilbert and published by Sinauer Associates Incorporated. This book was released on 1997-01-01 with total page 537 pages. Available in PDF, EPUB and Kindle. Book excerpt: A textbook for a laboratory-based, sophomore-level course. Discusses species the development of which is little understood on a cellular or molecular level as well as the conventional examples used in developmental biology courses. Emphasizes both the similarities between groups of organisms and the differences that make each group unique. Annotation copyrighted by Book News, Inc., Portland, OR
Download or read book Cell Polarity 1 written by Klaus Ebnet and published by Springer. This book was released on 2015-03-04 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides a state-of-the art overview on the most relevant aspects of cell polarity. Volume 1 addresses cell polarity and cell migration (front-rear polarity), cell polarity and barrier formation (apico-basal polarity) and neuronal polarity. It particularly focuses on cell polarity at the molecular level and the underlying molecular mechanisms. It also elaborates the common principles and mechanisms that regulate cellular polarization in different cell types and contexts. Both volumes are intended for professors, group leaders and researchers in cell biology as well as medical professionals in the fields of anatomy, cell biology, physiology, pathology and tumor biology.
Book Synopsis The Actin Cytoskeleton by : Brigitte M. Jockusch
Download or read book The Actin Cytoskeleton written by Brigitte M. Jockusch and published by Springer. This book was released on 2017-01-03 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Actin is one of the most abundant proteins and ubiquitously expressed in all eukaryotes. In recent years, the analysis of structure and function of such complexes has shed new light on actin's role in cellular and tissue morphogenesis, locomotion and various forms of intracellular motility, but also on its role in nuclear processes like chromatin architecture and transcription. Progress in understanding these different physiological phenomena, but also in unravelling the basis of actin-based pathophysiological processes has been made by combining video microscopy, molecular biology, genetics and biochemistry. Thus, the current research on actin, as ongoing in many international laboratories, is a "hot spot" in basic and translational research in life sciences. In this book on "The Actin Cytoskeleton", twelve internationally renowned authors present specific chapters that cover their recent work concerned with the various roles of actin mentioned above. This comprehensive volume is therefore an attractive handbook for teachers and students in many fields of medicine and pharmacology.
Book Synopsis Cellular Adhesion in Development and Disease by :
Download or read book Cellular Adhesion in Development and Disease written by and published by Academic Press. This book was released on 2015-03-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell adhesion is a fundamental determinant of embryonic development and organogenesis. Cellular Adhesion in Development and Disease, volume 112 in Current Topics in Developmental Biology, comprehensively surveys current developments in understanding how adhesion systems affect organismal development. Topics covered include nectins, nectin-like molecules, and afadin in development; cadherin adhesion, signaling, and morphogenesis; endothelial cell junctions; epidermal development and barrier formation; and more.
