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The Opiate Receptors
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Book Synopsis Opioids and Their Receptors by : Mariana Spetea
Download or read book Opioids and Their Receptors written by Mariana Spetea and published by MDPI. This book was released on 2020-12-18 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistry and pharmacology of new ligands targeting the opioid receptors as effective and safe therapeutics for human diseases. Furthermore, it draws a special attention to advancing concepts and strategies in opioid drug discovery to mitigate opioid liabilities. The diversity among the discussed topics is a testimony to the complexity of the opioid system, which results from the expression, regulation, and functional role of ligands and receptors. The array of multidisciplinary research areas illustrates the rapidly developing basic research and translational activities in opioid drug discovery. This book will serve as a useful reference while also stimulating continued research in the chemistry and pharmacology of opioids and their receptors, with the prospect of developing improved therapies for human diseases, but also improving health and quality of life in general.
Book Synopsis The Opiate Receptors by : Gavril W. Pasternak
Download or read book The Opiate Receptors written by Gavril W. Pasternak and published by Springer Science & Business Media. This book was released on 2010-11-30 with total page 519 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition covers the latest knowledge on opiate receptors and related receptor subtypes. It discusses many topics pertaining to the unique integrated approach of correlating the biochemical, physiological and pharmacological aspects of opiate reaction.
Book Synopsis The Opiate Receptors by : Gavril Pasternak
Download or read book The Opiate Receptors written by Gavril Pasternak and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The growth of the opiate field over the past decade has been enor mous. Initial interest focused upon the strategic clinical impor tance of morphine and its analogs, but the discovery of the enkephalins and the other endogenous opioid peptides with their widespread actions within brain has expanded the field to investi gators in almost all areas of neuroscience as well as pharmacol ogy. Unfortunately, this field of research with its vast literature has become progressively more complex. The receptors are no longer limited to opiates, but include many subtypes selective for the opioid peptides. Indeed, they might be better termed opioid, rather than opiate, receptors. Many controversies have emerged and been settled; others remain. Early studies must now be inter preted on the basis of current information. Thousands of papers examining various aspects of opiates and the endogenous opioids present separate pieces of a large puzzle. The goal of this volume is to put the pieces together to give a coherent overview of opiate receptor pharmacology and to provide insights into both the mo lecular and classical pharmacology of opiates and the opioid pep tides. The issue of multiple classes of opiate and opioid peptide re ceptors and their importance in understanding mechanisms of ac tion provides the major focus of the book. The study of opiates and opioid peptides provides a unique research opportunity in the neuropharmacology of drug receptors.
Download or read book Itch written by E. Carstens and published by CRC Press. This book was released on 2014-02-25 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in itch research have elucidated differences between itch and pain but have also blurred the distinction between them. There is a long debate about how somatic sensations including touch, pain, itch, and temperature sensitivity are encoded by the nervous system. Research suggests that each sensory modality is processed along a fixed, direct-line communication system from the skin to the brain. Itch: Mechanisms and Treatment presents a timely update on all aspects of itch research and the clinical treatment of itch that accompanies many dermatological conditions including psoriasis, neuropathic itch, cutaneous t-cells lymphomas, and systemic diseases such as kidney and liver disease and cancer. Composed of contributions from distinguished researchers around the world, the book explores topics such as: Neuropathic itch Peripheral neuronal mechanism of itch The role of PAR-2 in neuroimmune communication and itch Mrgprs as itch receptors The role of interleukin-31 and oncostatin M in itch and neuroimmune communication Spinal coding of itch and pain Spinal microcircuits and the regulation of itch Examining new findings on cellular and molecular mechanisms, the book is a compendium of the most current research on itch, its prevalence in society, and the problems associated with treatment.
Book Synopsis The Essence of Analgesia and Analgesics by : Raymond S. Sinatra
Download or read book The Essence of Analgesia and Analgesics written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2010-10-14 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
Book Synopsis Opioid Sensitivity of Chronic Noncancer Pain by : Eija Kalso
Download or read book Opioid Sensitivity of Chronic Noncancer Pain written by Eija Kalso and published by Progress in Pain Research and. This book was released on 1999 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains papers from the first international research symposium of the International Association for the Study of Pain, held in Helsinki, Finland, Fall 1998. Focus is on opioid responsiveness to neuropathic pain. Papers are arranged in sections on function and dysfunction of opioid receptors, clinical pharmacology of opioids, understanding and improving opioid sensitivity, and opioid sensitivity of different chronic pain states. Specific topics include targeting of opioid receptors to presynaptic sites, route of opioid administration, phenotypic changes induced in dorsal root ganglion neurons by nerve injury, and opioids in headache. Kalso is currently affiliated with the Karolinska Institute in Sweden. IASP member price, $44.85. Annotation copyrighted by Book News, Inc., Portland, OR.
Author :World Health Organization. Department of Mental Health and Substance Abuse Publisher :World Health Organization ISBN 13 :9241547545 Total Pages :133 pages Book Rating :4.2/5 (415 download)
Book Synopsis Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence by : World Health Organization. Department of Mental Health and Substance Abuse
Download or read book Guidelines for the Psychosocially Assisted Pharmacological Treatment of Opioid Dependence written by World Health Organization. Department of Mental Health and Substance Abuse and published by World Health Organization. This book was released on 2009 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: "These guidelines were produced by the World Health Organization (WHO), Department of Mental Health and Substance Abuse, in collaboration with the United Nations Office on Drugs and Crime (UNODC) a Guidelines Development Group of technical experts, and in consultation with the International Narcotics Control Board (INCB) secretariat and other WHO departments. WHO also wishes to acknowledge the financial contribution of UNODC and the Joint United Nations Programme on HIV/AIDS (UNAIDS) to this project. " - p. iv
Book Synopsis Opioids in Non-Cancer Pain by : Catherine F. Stannard
Download or read book Opioids in Non-Cancer Pain written by Catherine F. Stannard and published by Oxford University Press. This book was released on 2013-03-21 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: This pocketbook summarizes the recent developments in this important and controversial aspect of pain management, looking at the benefits and adverse effects of opioids in non-cancer pain.
Book Synopsis The Kappa Opioid Receptor by : Lee-Yuan Liu-Chen
Download or read book The Kappa Opioid Receptor written by Lee-Yuan Liu-Chen and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest knowledge in structure, signaling, and biochemical pharmacology of KOR as well as preclinical research and clinical applications (including clinical phase studies and approved for human use) of KOR compounds. It is divided up into the three parts: Molecular aspects of KOR, Preclinical research on pharmacology of KOR agonists and antagonists in animals and KOR agonists and antagonists in clinical use and in past and present clinical trials. The chapters "Biosensors monitor ligand-selective effects at kappa opioid receptors" and "The role of dynorphin and the kappa opioid receptor in schizophrenia and major depressive disorder: a translational approach" of this book are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Book Synopsis Opiate Receptors and Antagonists by : Reginald Dean
Download or read book Opiate Receptors and Antagonists written by Reginald Dean and published by Springer Science & Business Media. This book was released on 2009-03-12 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive and authoritative, Opioid Receptors and Antagonists: From Bench to Clinic offers neuroscientists, pharmacologists and interested clinicians a unique survey of the extensive and diverse research efforts currently employed with opioid antagonists to develop novel innovative drug therapies. Summarizes the present understanding of the chemistry, pharmacology and molecular biology of opioid receptors and their subtypes Highlights differences and similarities between the opioid pharmacology of animals and human Describes current and potential therapeutic areas for opioid antagonists, including substance abuse, alcohol and ingestive behaviors, behavioral disorders and other medical indications, supported by nonclinical and clinical evidence Focuses on the development of exciting and innovative drug delivery approaches that are being used with opioid antagonists for the above medical indications
Download or read book The Opiate Receptors written by and published by . This book was released on 2011-04-11 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Anesthesiology In-Training Exam Review by : Ratan K. Banik
Download or read book Anesthesiology In-Training Exam Review written by Ratan K. Banik and published by Springer. This book was released on 2022-01-18 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focused on rotations in regional anesthesia and chronic pain, this book provides a structured review of the concepts covered in the American Board of Anesthesiology in-training exam. The first section of the book covers regional anesthesia with dedicated chapters on basic science, acute postoperative pain, and nerve blocks for neuraxial, lower and upper extremity blocks, and head and neck. The second section on chronic pain includes chapters on basic science and common pain conditions - including craniofacial pain, CRPS, neuropathic pain, and cancer pain. This section closes on multimodal analgesia and other treatment approaches. Each chapter presents a common clinical topic and is organized by indications, preparation, technique, complication, prevention, clinical pearls, and related ABA key points. Highlights must-know information in bold throughout the text. Concise, practical, and easy-to-read, this book will aid anesthesiology residents, certified nurse anesthetists, and medical students in their study regarding patient care practices on regional anesthesia and chronic pain. The book will also be useful to residents going into regional anesthesia and pain medicine subspecialties during the year of their anesthesiology training.
Book Synopsis Veterinary Anesthesia and Analgesia by : Kurt A. Grimm
Download or read book Veterinary Anesthesia and Analgesia written by Kurt A. Grimm and published by John Wiley & Sons. This book was released on 2015-05-11 with total page 1072 pages. Available in PDF, EPUB and Kindle. Book excerpt: Veterinary Anesthesia and Analgesia: the Fifth Edition of Lumb and Jones is a reorganized and updated edition of the gold-standard reference for anesthesia and pain management in veterinary patients. Provides a thoroughly updated edition of this comprehensive reference on veterinary anesthesia and analgesia, combining state-of-the-art scientific knowledge and clinically relevant information Covers immobilization, sedation, anesthesia, and analgesia of companion, wild, zoo, and laboratory animals Takes a body systems approach for easier reference to information about anesthetizing patients with existing conditions Adds 10 completely new chapters with in-depth discussions of perioperative heat balance, coagulation disorders, pacemaker implantation, cardiac output measurement, cardiopulmonary bypass, shelter anesthesia and pain management, anesthetic risk assessment, principles of anesthetic pharmacology, and more Now printed in color, with more than 400 images
Book Synopsis In Situ Hybridization Histochemistry by : Marie-Francoise Chesselet
Download or read book In Situ Hybridization Histochemistry written by Marie-Francoise Chesselet and published by CRC Press. This book was released on 1990-07-03 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of this fascinating new book is to review the diversity of methods available to apply in situ hybridization histochemistry (ISHH) to a variety of experimental questions. This work includes topics such as synthesis and use of nick-translated DNA probes for ISHH, synthesis and use of oligomeric DNA probes for ISHH, and synthesis and use of RNA probes for ISHH. These interesting chapters describe the preparation of different radiolabeled probes for ISHH. They also discuss their respective advantages and limitations, and describe current results based on the use of these various probes. Sections of the text highlight low and high resolution autoradiography for ISHH, the use of biotin-labeled probes for ISHH, as well as the use of ISHH in combination with established anatomical techniques. In Situ Hybridization Histochemistry answers all of your questions regarding the quantification of ISHH. It also provides a practical description of typical protocols, both from molecular biology and histology. Investigators will understand and value this useful, powerful tool-whatever their backgrounds might be.
Book Synopsis Opioids in Cancer Pain by : Mellar P. Davis
Download or read book Opioids in Cancer Pain written by Mellar P. Davis and published by Oxford University Press, USA. This book was released on 2005 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a great deal of interest in the effective use of opioids for cancer pain due to concerns from both clinicians and patients about addiction. When used correctly, opioids are capable of relieving pain in more than 90% of cancer patients. In reality, patients world-wide continue to endure pain usually due to irrational fears about using them. Fear of addiction is fed by outdated knowledge about opioids and the unintended effects of the war on drugs. However, new research shows that using opioids appropriately for pain management is effective, safe, and has an extremely low potential to produce addiction. This book provides evidence (on which guidelines can be based) from an international group of editors and contributors on opioids in cancer pain management, aimed at palliative care doctors, pharmacists, pain specialists, and oncologists. It includes information on opioid pharmacokinetics as a basis for understanding opioid analgesia, dosing schedule, polymorphisms of analgesic receptors in relationship to tolerance, and intrinsic efficacy. The main body of the book covers individual opioids. Topics within each chapter include structure, pharmacokinetics, pharmacodynamics, routes of administration, toxicity, drug interactions and influences of dosing and kinetics related to organ function. A chapter is dedicated to the WHO analgesic guidelines and opioid choices.
Book Synopsis Fundamentals of Anaesthesia by : Colin Pinnock
Download or read book Fundamentals of Anaesthesia written by Colin Pinnock and published by Cambridge University Press. This book was released on 2002-12 with total page 990 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Fundamentals of Anaesthesia builds upon the success of the first edition, and encapsulates the modern practice of anaesthesia in a single volume. Written and edited by a team of expert contributors, it provides a comprehensive but easily readable account of all of the information required by the FRCA Primary examination candidate and has been expanded to include more detail on all topics and to include new topics now covered in the examination. As with the previous edition, presentation of information is clear and concise, with the use of lists, tables, summary boxes and line illustrations where necessary to highlight important information and aid the understanding of complex topics. Great care has been taken to ensure an unrivalled consistency of style and presentation throughout.
Book Synopsis Opioid Receptors: Advances in Research and Application: 2011 Edition by :
Download or read book Opioid Receptors: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Opioid Receptors: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Opioid Receptors. The editors have built Opioid Receptors: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Opioid Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Opioid Receptors: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
