The Molecular Biology Of Neurological Disease

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The Molecular Biology of Neurological Disease

Author : Roger N. Rosenberg
Publisher : Butterworth-Heinemann
ISBN 13 : 148316330X
Total Pages : 277 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis The Molecular Biology of Neurological Disease by : Roger N. Rosenberg

Download or read book The Molecular Biology of Neurological Disease written by Roger N. Rosenberg and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

Molecular Biology of Neurodegenerative Diseases: Visions for the Future - Part B

Author :
Publisher : Academic Press
ISBN 13 : 0128241446
Total Pages : 222 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Molecular Biology of Neurodegenerative Diseases: Visions for the Future - Part B by :

Download or read book Molecular Biology of Neurodegenerative Diseases: Visions for the Future - Part B written by and published by Academic Press. This book was released on 2021-01-14 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Part B, Volume 177 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, and more. Includes comprehensive coverage of molecular biology Presents ample use of tables, diagrams, schemata and color figures to enhance the reader's ability to rapidly grasp the information provided Contains contributions from renowned experts in the field

Molecular Biology of Neurodegenerative Diseases

Author : David B. Teplow
Publisher : Academic Press
ISBN 13 : 0123858836
Total Pages : 499 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Molecular Biology of Neurodegenerative Diseases by : David B. Teplow

Download or read book Molecular Biology of Neurodegenerative Diseases written by David B. Teplow and published by Academic Press. This book was released on 2012-04-13 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases result in progressive degeneration and / or death of nerve cells which leads to problems with movement and mental functioning. Examples include Parkinson's, Alzheimer's and Huntington's disease. Much research is taking place to try to identify ways to prevent or lessen the impact of these diseases. This volume reviews the latest research and developments in the molecular biology of neurodegenerative diseases. Contributions from leading authorities Informs and updates on all the latest developments in the field

Molecular Biology of Neuropsychiatric Disorders

Author : Dieter B. Wildenauer
Publisher : Springer Science & Business Media
ISBN 13 : 3540853839
Total Pages : 303 pages
Book Rating : 4.5/5 (48 download)

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Book Synopsis Molecular Biology of Neuropsychiatric Disorders by : Dieter B. Wildenauer

Download or read book Molecular Biology of Neuropsychiatric Disorders written by Dieter B. Wildenauer and published by Springer Science & Business Media. This book was released on 2008-11-28 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is generally accepted that neuropsychiatric disorders have a biological basis. Pathological changes leading to illness have been confirmed for Alzheimer’s (amyloid plaques) and Parkinson’s disease (loss of dopaminergic transmission) and are the foundation for studies on the molecular biology of these disorders. For other neuropsychiatric disorders, in particular for schizophrenic and affective disorders, molecular causes appear to be more complex and therefore remain hypothetical, despite decades of research. Changes in a number of neuronal pathways and structures have been reported to be associated with these disorders and are currently under extensive investigation. The present volume reviews recent knowledge with emphasis on ongoing research findings. Current hypotheses based on these findings are described and discussed.

Molecular Neurology

Author : Stephen Waxman
Publisher : Elsevier
ISBN 13 : 0080546188
Total Pages : 597 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Molecular Neurology by : Stephen Waxman

Download or read book Molecular Neurology written by Stephen Waxman and published by Elsevier. This book was released on 2010-07-26 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology. Describes the newest molecular aspects of neurological disorders Provides an introduction to neurological disorders for basic scientists Updates clinicians and clinical researchers on the most recent developments

The Molecular and Genetic Basis of Neurological Disease

Author : Roger N. Rosenberg
Publisher : Butterworth-Heinemann
ISBN 13 :
Total Pages : 1054 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Molecular and Genetic Basis of Neurological Disease by : Roger N. Rosenberg

Download or read book The Molecular and Genetic Basis of Neurological Disease written by Roger N. Rosenberg and published by Butterworth-Heinemann. This book was released on 1993 with total page 1054 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Molecular Immunology of Neurological Diseases

Author : Sunil Kumar
Publisher : Academic Press
ISBN 13 : 0128232544
Total Pages : 178 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis The Molecular Immunology of Neurological Diseases by : Sunil Kumar

Download or read book The Molecular Immunology of Neurological Diseases written by Sunil Kumar and published by Academic Press. This book was released on 2021-02-16 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular Immunology of Neurological Diseases provides a comprehensive review of current updates in molecular immunogenetics of different neurological diseases. Readers will learn about the role of immune cells and their modulation strategies to help in the development of therapeutic approaches for both acute and chronic neurodegenerative disorders. There is no other book available on the topic. It has long been thought that the brain is an immune-privilege organ with very limited immune response. However recent studies have made clear that both systemic 'brain' and peripheral 'blood' immune cell responses play key roles in determining brain pathology in neurodegenerative disorders. This book summarizes the role of immune cell activation in the central nervous system microenvironment in acute and chronic neurodegenerative disorders. In addition, it discusses the key role of immune cells and their modulation strategies for the development of current therapeutic approaches. Discusses the molecular immunogenetics of different neurological diseases Covers strategies for the development of therapeutic approaches Encompasses both acute and chronic neurogenerative disorders Describes the molecular pathogenesis of viral genes in various diseases Features chapters on migraine, muscular dystrophy and cancer

Biology of Brain Disorders

Author : Daniela Tropea
Publisher : Frontiers Media SA
ISBN 13 : 2889453804
Total Pages : 586 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Biology of Brain Disorders by : Daniela Tropea

Download or read book Biology of Brain Disorders written by Daniela Tropea and published by Frontiers Media SA. This book was released on 2018-01-31 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain disorders, including neurological and neuropsychiatric conditions, represent a challenge for public health systems and society at large. The limited knowledge of their biology hampers the development of diagnostic tools and effective therapeutics. A clear understanding of the mechanisms that underlie the onset and progression of brain disorders is required in order to identify new avenues for therapeutic intervention. Overlapping genetic risk factors across different brain disorders suggest common linkages and pathophysiological mechanisms that underlie brain disorders. Methodological and technological advances are leading to new insights that go beyond traditional hypotheses. Taking account of underlying molecular, cellular and systems biology underlying brain function will play an important role in the classification of brain disorders in future. In this Research Topic, the latest advances in our understanding of biological mechanisms across different brain disorders are presented. The areas covered include developments in neurogenetics, epigenetics, plasticity, glial cell biology, neuroimmune interactions and new technologies associated with the study of brain function. Examples of how understanding of biological mechanisms are translating into research strategies that aim to advance diagnoses and treatment of brain disorders are discussed.

The Molecular and Cellular Basis of Neurodegenerative Diseases

Author : Michael S. Wolfe
Publisher : Academic Press
ISBN 13 : 0128113057
Total Pages : 561 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Molecular and Cellular Basis of Neurodegenerative Diseases by : Michael S. Wolfe

Download or read book The Molecular and Cellular Basis of Neurodegenerative Diseases written by Michael S. Wolfe and published by Academic Press. This book was released on 2018-03-29 with total page 561 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Molecular Biology of Neurodegenerative Diseases: Visions for the Future

Author :
Publisher : Academic Press
ISBN 13 : 9780128178744
Total Pages : 0 pages
Book Rating : 4.1/5 (787 download)

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Book Synopsis Molecular Biology of Neurodegenerative Diseases: Visions for the Future by :

Download or read book Molecular Biology of Neurodegenerative Diseases: Visions for the Future written by and published by Academic Press. This book was released on 2019-11-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of Neurodegenerative Diseases: Visions for the Future, Volume 168 in the Progress in Molecular Biology and Translational Science series, provides the most topical, informative and exciting monographs available on a wide variety of research topics. The series includes in-depth knowledge on the molecular biological aspects of organismal physiology, with this release including chapters on Alzheimer's disease, Prion-like propagation of alpha-synuclein, What - if anything - can we learn about neurodegenerative diseases from yeast?, Mitochondrial rejuvenation and replacement as a novel strategy for treatment of age-related neurodegenerative diseases, Propagation and removal of cerebral amyloid angiopathy, and much more.

The Molecular and Genetic Basis of Neurologic and Psychiatric Disease

Author : Roger N. Rosenberg
Publisher : Butterworth-Heinemann
ISBN 13 :
Total Pages : 898 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Molecular and Genetic Basis of Neurologic and Psychiatric Disease by : Roger N. Rosenberg

Download or read book The Molecular and Genetic Basis of Neurologic and Psychiatric Disease written by Roger N. Rosenberg and published by Butterworth-Heinemann. This book was released on 2003 with total page 898 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inside the third edition of this reference, the reader will find thorough and authoritative discussions of all of these developments and their implications for clinical practice. It includes a major new section on Psychiatric Diseases; descriptions of the molecular and genetic basis of the spongiform encephalopathies as well as the expression of the prion gene under physiologic and pathologic conditions; additional coverage examines the human genome project and neurologic disease; and coverage on alzheimer's disease and related dementias.

The Molecular and Clinical Pathology of Neurodegenerative Disease

Author : Patrick A. Lewis
Publisher : Academic Press
ISBN 13 : 0128110708
Total Pages : 276 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis The Molecular and Clinical Pathology of Neurodegenerative Disease by : Patrick A. Lewis

Download or read book The Molecular and Clinical Pathology of Neurodegenerative Disease written by Patrick A. Lewis and published by Academic Press. This book was released on 2018-11-16 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular and Clinical Pathology of Neurodegenerative Disease brings together in one volume our current understanding of the molecular basis of neurodegeneration in humans, targeted at neuroscientists and graduate students in neuroscience, and the biomedical and biological sciences. Bringing together up-to-date molecular biology data with clinical evidence, this book sheds a light on common molecular mechanisms that underlie many different neurodegenerative diseases and addresses the molecular pathologies in each. The combined research and clinical background of the authors provides a unique perspective in relating clinical experiences with the molecular understanding needed to examine these diseases and is a must-read for anyone who wants to learn more about neurodegeneration. Provides an up-to-date summary of neurodegeneration at a molecular, cellular, and tissue level for the most common human disorders Describes the clinical background and underlying molecular processes for Alzheimer’s disease, Parkinson’s, Prion, Motor Neuron, Huntington’s, and Multiple Sclerosis Highlights the state-of-the-art treatment options for each disorder Details examples of relevant cutting edge experimental systems, including genome editing and human pluripotent stem cell-derived neuronal models

Alzheimer's Disease

Author : Sangram S. Sisodia
Publisher : Springer Science & Business Media
ISBN 13 : 0387351353
Total Pages : 291 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Alzheimer's Disease by : Sangram S. Sisodia

Download or read book Alzheimer's Disease written by Sangram S. Sisodia and published by Springer Science & Business Media. This book was released on 2007-02-16 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.

Molecular Biology of the Neuron

Author : R. W. Davies
Publisher : OUP Oxford
ISBN 13 : 0191585831
Total Pages : 500 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Molecular Biology of the Neuron by : R. W. Davies

Download or read book Molecular Biology of the Neuron written by R. W. Davies and published by OUP Oxford. This book was released on 2004-04-08 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nerve cells - neurons - are arguably the most complex of all cells. From the action of these cells comes movement, thought and consciousness. It is a challenging task to understand what molecules direct the various diverse aspects of their function. This has produced an ever-increasing amount of molecular information about neurons, and only in Molecular Biology of the Neuron can a large part of this information be found in one source. In this book, a non-specialist can learn about the molecules that control information flow in the brain or the progress of brain disease in an approachable format, while the expert has access to a wealth of detailed information from a wide range of topics impacting on his or her field of endeavour. The text is designed to achieve a balance of accessibility and broad coverage with up-to-date molecular detail. In the six years since the first edition of Molecular Biology of the Neuron there has been an explosion in the molecular information about neurons that has been discovered, and this information is incorporated into this second edition. Entirely new chapters have been introduced where recent advances have made a new aspect of neuronal function more comprehensible at the molecular level. Written by leading researchers in the field, the book provides an essential overview of the molecular structure and function of neurons, and will be an invaluable tool to students and researchers alike.

Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders

Author : Akhlaq A. Farooqui
Publisher : Academic Press
ISBN 13 : 0128217014
Total Pages : 404 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders by : Akhlaq A. Farooqui

Download or read book Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders written by Akhlaq A. Farooqui and published by Academic Press. This book was released on 2020-09-07 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Aspects of Neurodegeneration, Neuroprotection, and Regeneration in Neurological Disorders presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of neurological disorders. The book covers information on signal transduction processes associated with neurochemistry of neurological disorders, including neurodegenerative, neurotraumatic, and neuropsychiatric disorders. The book also discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential treatments of neurological disorders. The comprehensive information in this monograph may not only help in early detection of various neurological disorders, but will also promote the discovery of new drugs. Provides a comprehensive overview of the molecular aspects of neurodegeneration, neuroprotection, and neuro-regeneration, along with therapeutic strategies for various types of neurological disorders Provides cutting-edge research information on the signal transduction processes associated with the neurochemistry of neurological disorders Discusses risk factors, symptoms, pathogenesis, biomarkers, and the potential for treatments of neurological disorders

Gene Therapy for Neurological Disorders

Author : Fredric P. Manfredsson
Publisher : Humana
ISBN 13 : 9781493932702
Total Pages : 0 pages
Book Rating : 4.9/5 (327 download)

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Book Synopsis Gene Therapy for Neurological Disorders by : Fredric P. Manfredsson

Download or read book Gene Therapy for Neurological Disorders written by Fredric P. Manfredsson and published by Humana. This book was released on 2015-11-26 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a clear and detailed roadmap of how to design and execute a gene therapy experiment in order to obtain consistent results. Chapters in this book disseminate bits of unknown information that are important to consider during the course of experimentation and will answer questions such as: What delivery vehicle do you use?; How will you ensure that your vector retains stability?; What expression system best fits your needs?; What route will you choose to deliver your gene therapy agent?; How will you model the neurodegenerative disorder that you aim to investigate and what are the proven methods to treat these disorders in preclinical models? Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and thorough, Gene Therapy for Neurological Disorders: Methods and Protocols, is a compilation of protocols and instructive chapters intended to give researchers, clinicians, and students of all levels, a foundation upon which future gene therapy experiments can be designed.

Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease

Author : Roger N. Rosenberg
Publisher : Academic Press
ISBN 13 : 012813867X
Total Pages : 830 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease by : Roger N. Rosenberg

Download or read book Rosenberg's Molecular and Genetic Basis of Neurological and Psychiatric Disease written by Roger N. Rosenberg and published by Academic Press. This book was released on 2020-06-24 with total page 830 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rosenberg’s Molecular and Genetic Basis of Neurologic and Psychiatric Disease, Sixth Edition: Volume Two provides a comprehensive introduction and reference to the foundations and practical aspects relevant to the majority of neurologic and psychiatric disease. This updated volume focuses on degenerative disorders, movement disorders, neuro-oncology, neurocutaneous disorders, epilepsy, white matter diseases, neuropathies and neuronopathies, muscle and neuromuscular junction disorders, stroke, psychiatric disease, and a neurologic gene map. A favorite of over three generations of students, clinicians and scholars, this new edition retains and expands on the informative, concise and critical tone of the first edition. This is an essential reference for general medical practitioners, neurologists, psychiatrists, geneticists, related professionals, and for the neuroscience and neurology research community at large. The content covers all aspects essential to the practice of neurogenetics to inform clinical diagnosis, treatment and genetic counseling. Provides comprehensive coverage on the neurogenetic foundation of neurological and psychiatric disease Presents detailed coverage of genomics, animal models and diagnostic methods, with new coverage on evaluating patients with biochemical abnormalities or gene mutations Includes new chapters on the pharmacogenomics of epilepsy and the most recent updates in molecular genetics, focusing on neurodegenerative and psychiatric diseases