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The Mechano Energetics Of The Heart
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Book Synopsis The Mechano-energetics of the Heart by : Lauren Dupuis
Download or read book The Mechano-energetics of the Heart written by Lauren Dupuis and published by . This book was released on 2014 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: To determine the mechanical and energetic properties of the heart, experiments are commonly performed on both the whole organ and cardiac trabeculae. In both of these models, the sarcomere is the fundamental contractile unit of muscle, and is activated by calcium. Although the role of calcium in muscle contraction has been well characterised, there are currently no experimental data or computational models which describe its behavior during a work-loop. In this study, the ter Keurs calcium model was successfully paired with the Rice-Tran cross-bridge model. This allowed me to explore the behavior of the free cytosolic calcium concentration during the contractile cycle as well as to study more accurately the mechano-energetic behavior of sarcomere dynamics. The results made clear that as the force developed by the sarcomere waned during the relaxation phase of the twitch (in response to the decline of the calcium transient), Troponin-C released a portion of its bound Ca2+, thus producing a second surge in free cytosolic calcium. Such behaviour has been repeatedly observed in isometric, but not work-loop, contractions. Given the successful performance of the integrated cellular model, I implemented it within an existing model of the left ventricle. Simulations qualitatively reproduced general trends seen experimentally. Most importantly, pressure-volume loops produced by the 3-D, whole-heart model matched experimental data.
Download or read book Cardiac Energetics written by R. Jacob and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assessment of cardiac energetics at the level of ATP-synthesis, chemomechanical energy transformation and whole organ dynamics as a function of haemodynamic load, ventricular configuration and oxygen- and substrates supply is basic to understanding cardiac function under physiological and pathophysiological (hypertrophy, hypoxia, ischaemia and heart failure) conditions. Moreover, cardiac energetics should be an important consideration in the choice and application of drugs especially in the case of vasodilators, inotropic agents and in cardioprotective measures. Only by considering energetics at the subcellular, cellular, and whole-heart level we can arrive at a better understanding of cardiac performance and ultimately better clinical judgement and drug therapy. Quantification of myocardial energetics will also help to determine the optimal time for surgical interventions such as valvular replacement or aneurysm resection. The present volume is the outcome of an international symposium on cardiac energetics held in Gargellen/Montafon (Austria), June 1986. The contributions will certainly help bridge the existing gap between basic research involving isolated structures and that involving the whole organ, on the one hand, and render the results derived from basic research applicable to clinical problems, on the other hand.
Book Synopsis Modelling Cardiac Mechano-Energetics by : Megan Guidry
Download or read book Modelling Cardiac Mechano-Energetics written by Megan Guidry and published by . This book was released on 2016 with total page 75 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis focuses on the computationally efficient, mechanistically detailed modelling of cardiac cross-bridge cycling and the benefit of incorporating such a model into tissue-level cardiac models. A zero --dimensional (0D) model of excitation-contraction was constructed via coupling of the Rice-Tran cross-bridge, Hinch Ca2+, and Rogers action potential models, resulting in the generation of the combined Hinch-Rogers-Tran model (HRT). The capabilities of the combined model were tested, with the HRT model successfully replicating isometric and quick-release experimental data. Success in reproducing experimental observations demonstrates the validity of the HRT model. Knowing that the HRT model can replicate physiological trends, it is then used to study more complex cross-bridge cycling dynamics. The combined model produced force-length work-loops, subtle trends in end-systolic behaviour, and force-calcium loops. By using the HRT model, events and mechanistic details beyond the scope of current experimental technologies were explored. With the HRT model capable of performing 0D work-loops, it is intended that future research projects will use the model within tissue-level or ventricular-level models. Using the HRT as a subcomponent would allow researchers to generate tissue or organ models that have independently functioning cells, a novel concept that allows for the exploration of tissue heterogeneity.
Book Synopsis The Heart's Code by : Paul P. Pearsall
Download or read book The Heart's Code written by Paul P. Pearsall and published by Harmony. This book was released on 1999-03-10 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fascinating synthesis of ancient wisdom, modern medicine, scientific research, and personal experiences that proves that the human heart, not the brain, holds the secrets that link body, mind, and spirit. You know that the heart loves and feels, but did you know that the heart also thinks, remembers, communicates with other hearts, helps regulate immunity, and contains stored information that continually pulses through your body? In The Heart's Code, Dr. Paul Pearsall explains the theory and science behind energy cardiology, the emerging field that is uncovering one of the most significant medical, social, and spiritual discoveries of our time: The heart is more than just a pump; it conducts the cellular symphony that is the very essence of our being. Full of amazing anecdotes and data, The Heart's Code presents the latest research on cellular memory and the power of the heart's energy and explores what these breakthroughs mean about how we should live our lives. By unlocking the heart's code we can discover new ways of understanding human healing and consciousness and create a new model for living that leads to better health, happiness, and self-knowledge.
Book Synopsis Cardiac Energetics by : Robert Jacob
Download or read book Cardiac Energetics written by Robert Jacob and published by Springer Verlag. This book was released on 1987 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechano-Calcium, Mechano-Electric, and Mechano-Metabolic Feedback Loops: Contribution to the Myocardium Contraction in Health and Diseases by : Leonid Katsnelson
Download or read book Mechano-Calcium, Mechano-Electric, and Mechano-Metabolic Feedback Loops: Contribution to the Myocardium Contraction in Health and Diseases written by Leonid Katsnelson and published by Frontiers Media SA. This book was released on 2021-06-01 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cardiac Energy Metabolism in Health and Disease by : Gary D. Lopaschuk
Download or read book Cardiac Energy Metabolism in Health and Disease written by Gary D. Lopaschuk and published by Springer. This book was released on 2014-08-22 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in this energy supply can seriously compromise cardiac function. It has emerged that alterations in cardiac energy metabolism are a major contributor to the development of a number of different forms of heart disease. It is also now known that optimizing energy metabolism in the heart is a viable and important approach to treating various forms of heart disease. Cardiac Energy Metabolism in Health and Disease describes the research advances that have been made in understanding what controls cardiac energy metabolism at molecular, transcriptional and physiological levels. It also describes how alterations in energy metabolism contribute to the development of heart dysfunction and how optimization of energy metabolism can be used to treat heart disease. The topics covered include a discussion of the effects of myocardial ischemia, diabetes, obesity, hypertrophy, heart failure, and genetic disorders of mitochondrial oxidative metabolism on cardiac energetics. The treatment of heart disease by optimizing energy metabolism is also discussed, which includes increasing overall energy production as well as increasing the efficiency of energy production and switching energy substrate preference of the heart. This book will be a valuable source of information to graduate students, postdoctoral fellows, and investigators in the field of experimental cardiology as well as biochemists, physiologists, pharmacologists, cardiologists, cardiovascular surgeons and other health professionals.
Book Synopsis Cardiac Energetics by : Robert Jacob
Download or read book Cardiac Energetics written by Robert Jacob and published by Springer. This book was released on 1987-01-01 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Christian J.F. Holubarsch Publisher :Springer Science & Business Media ISBN 13 :1461508797 Total Pages :219 pages Book Rating :4.4/5 (615 download)
Book Synopsis Mechanics and Energetics of the Myocardium by : Christian J.F. Holubarsch
Download or read book Mechanics and Energetics of the Myocardium written by Christian J.F. Holubarsch and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: During several decades of this century, the classical physiological studies on the cardiovascular system have greatly improved our knowledge on the function of this system under normal and pathological conditions. This knowledge was the basis of the breakthrough for diagnostic techniques like the Swan-Ganz catheter, coronary arteriography, left and right heart biopsies, and invasive measurements of contractility, as well as therapeutic tools including aortocoronary bypass surgery, percutanous transluminal coronary angioplasty, and a broad field of pharmacological interventions for the whole spectrum of cardiovascular diseases, especially chronic heart failure. It was during the last decade that the scientific world focused on the evolution of molecular biology of the cardiovascular system so that cardiovascular physiology seemed to become less important. Regarding the myocardium, molecular alterations of important functional proteins (phenotype changes), as well as signal transduction pathways of contractility and cardiac growth have been elucidated. The functional importance of a number of genes has undoubtedly been proven with the help of transgenic animals. Mechanics and Energetics of the Myocardium provides an overview for those researchers and practioners interested in the broad field of molecular biology and physiology of the cardiovascular system.
Book Synopsis Cardiac Mechanics and Function in the Normal and Diseased Heart by : Masatsugu Hori
Download or read book Cardiac Mechanics and Function in the Normal and Diseased Heart written by Masatsugu Hori and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular dynamics is a field in which modelling and systems analysis have formed an extremely important discipline. For example, understanding of even such a fundamental function of the circulation as the relationship between central venous pressure apd cardiac output has required evolution of a pertinent model based on years of exhaustive ex perimental investigations by Starling, Starr, and Guyton. Hemodynamic analyses of pulsatile pressures and flows in the arteries and veins have been a continuing challenge taken up by champions of fluid dynamics such as Frank, Wetterer, Taylor, and Wormersley, just to mention a few names, and some kind of model was always proposed as a conceptual framework. An even greater challenge to cardiovascular dynamicists was how to analyze the intermittent coupling of the ventricle and the arterial or venous vasculature through the valve. The availability of numerical solutions by computer and the recently evolved ventricular model with a time-varying elastance and a pressure-dependent internal resistance opened the way to analysis of this coupling. The ever increasing speed of computers has also facilitated trips between the fre quency and the time domain, even on-line for some experimental studies. This book contains many analyses dedicated to the interactions between the heart and the vasculature, providing the reader with findings at the cutting edge of current research in this field.
Book Synopsis Regulation of Cardiac Myofilament Mechano-energetics by G-protein Signaling by : Susan Vahebi
Download or read book Regulation of Cardiac Myofilament Mechano-energetics by G-protein Signaling written by Susan Vahebi and published by . This book was released on 2005 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Insight Into the Heart by : Samuel Sideman
Download or read book Insight Into the Heart written by Samuel Sideman and published by . This book was released on 2005 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cardiac Mechano-electric Coupling: Acute Effects of Mechanical Stimulation on Heart Rate and Rhythm by : T. Alexander Quinn
Download or read book Cardiac Mechano-electric Coupling: Acute Effects of Mechanical Stimulation on Heart Rate and Rhythm written by T. Alexander Quinn and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: The heart is vital for biological function in almost all chordates, including humans. It beats continually throughout our life, supplying the body with oxygen and nutrients while removing waste products. If it stops, so does life. The heartbeat involves precise coordination of the activity of billions of individual cells, as well as their swift and well-coordinated adaption to changes in physiological demand. Much of the vital control of cardiac function occurs at the level of individual cardiac muscle cells, including acute beat-by-beat feedback from the local mechanical environment to electrical activity (as opposed to longer term changes in gene expression and functional or structural remodeling). This process is known as mechano-electric coupling (MEC). In the current review, we present evidence for, and implications of, MEC in health and disease in human; summarize our understanding of MEC effects gained from whole animal, organ, tissue, and cell studies; identify potential molecular mediators of MEC responses; and demonstrate the power of computational modeling in developing a more comprehensive understanding of "what makes the heart tick.ˮ
Book Synopsis Cardiac Energetics by : Martin M Lewinter
Download or read book Cardiac Energetics written by Martin M Lewinter and published by . This book was released on 1995-10-31 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modulation of Determinants of Myocardial Function and Energetics by Stunning and Heart Failure by : Dongsheng Fan
Download or read book Modulation of Determinants of Myocardial Function and Energetics by Stunning and Heart Failure written by Dongsheng Fan and published by . This book was released on 1996 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cardiac Energetics in the Isolated Heart by NMR Spectroscopy and Mathematical Modeling by : Ming Lu
Download or read book Cardiac Energetics in the Isolated Heart by NMR Spectroscopy and Mathematical Modeling written by Ming Lu and published by . This book was released on 2010 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Inotropic Stimulation and Myocardial Energetics by : H. Just
Download or read book Inotropic Stimulation and Myocardial Energetics written by H. Just and published by . This book was released on 2014-01-15 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
