Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
The Jnk Signaling Pathway
Download The Jnk Signaling Pathway full books in PDF, epub, and Kindle. Read online The Jnk Signaling Pathway ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis The JNK Signaling Pathway by : Anning Lin
Download or read book The JNK Signaling Pathway written by Anning Lin and published by CRC Press. This book was released on 2006-02-15 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction is one of the most exciting research areas in modern biology as it deals with how information flows from the extracellular environment into a living cell to change its metabolism, genotype and phenotype. With the completion of the genomes of human and several other species, it becomes even more important to elucidate the molecul
Book Synopsis Characterization of the Biological Roles of the JNK MAPK Pathways in Mammalian Cells by : Helen Le-Niculescu
Download or read book Characterization of the Biological Roles of the JNK MAPK Pathways in Mammalian Cells written by Helen Le-Niculescu and published by . This book was released on 2000 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of MAPK/JNK Signaling Pathway and TGF-beta Signaling Pathway by Axin by : Hongliang Rui
Download or read book Regulation of MAPK/JNK Signaling Pathway and TGF-beta Signaling Pathway by Axin written by Hongliang Rui and published by . This book was released on 2004 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Targeting Cell Survival Pathways to Enhance Response to Chemotherapy by :
Download or read book Targeting Cell Survival Pathways to Enhance Response to Chemotherapy written by and published by Academic Press. This book was released on 2018-03-28 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy. Presents cutting-edge agents and approaches with proved success in different model systems that can be translated to a different type of cancer Brings updated information to be used to propose new clinical trials investigating innovative strategies for improving responses to chemotherapy Provides mechanistic details to help guide the design of laboratory studies associated with clinical trials
Book Synopsis Cellular and Molecular Basis of Regeneration by : Patrizia Ferretti
Download or read book Cellular and Molecular Basis of Regeneration written by Patrizia Ferretti and published by . This book was released on 1998-05-29 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an extensive overview of the fundamental issues of regeneration, and surveys selected models throughout phylogenesis. Eighteen contributions integrate information obtained from anatomical and experimental embryology studies with that derived from cellular and molecular approaches, and genetics. The emphasis throughout is on how information accumulating from each of the models discussed is shedding light both on the mechanisms underlying regeneration, and on whether and how this could be translated into clinical practice. Annotation copyrighted by Book News, Inc., Portland, OR
Book Synopsis Stress-Activated Protein Kinases by : Francesc Posas
Download or read book Stress-Activated Protein Kinases written by Francesc Posas and published by Springer Science & Business Media. This book was released on 2008-01-24 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book leading researchers in the field discuss the state-of-the-art of many aspects of SAPK signaling in various systems from yeast to mammals. These include various chapters on regulatory mechanisms as well as the contribution of the SAPK signaling pathways to processes such as gene expression, metabolism, cell cycle regulation, immune responses and tumorigenesis. Written by international experts, the book will appeal to cell biologists and biochemists.
Book Synopsis Computational and Biochemical Exploration of Interactions in the Human JNK Signal Transduction Pathway by : Thomas Craig Whisenant
Download or read book Computational and Biochemical Exploration of Interactions in the Human JNK Signal Transduction Pathway written by Thomas Craig Whisenant and published by . This book was released on 2010 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein kinases make up a major component of the enzymes present in eukaryotic cells. One subgroup, the mitogen-activated protein kinase (MAPK) family, are Ser/Thr protein kinases responsible for regulating cellular processes such as division, differentiation, survival, and death. The c-Jun N-terminal kinase (JNK) MAPK pathway is primarily responsive to stress signals like UV radiation and inflammatory cytokines and its activation can be pro-survival or pro-apoptotic depending on cell type, stimulus, duration of activation, and/or crosstalk with other signaling pathways. Its deregulation has been implicated in diseases like cancer, obesity, Parkinson's, muscular dystrophy, rheumatoid arthritis and aging. How do MAPKs recognize their substrates and regulators? A recognition mechanism, characterized by specific interaction at a so-called docking site (D-site), exists for JNK interacting proteins. The linear JNK docking sites share a core consensus sequence and due to the conservation of the D-site sequence and its importance in mediating interactions with the MAPKs, a protein database was searched for novel JNK D-sites using a hybrid algorithm called D-finder. Following in silico validation, in vitro validation by peptide macroarray, and biochemical workup, functional D-sites were identified in multiple proteins. GLI3 and its human hedgehog transcription factor paralog, GLI1, were identified as JNK substrates where the D-site mediated phosphoacceptor sites were also characterized. These findings are the first to identify a link between the Hedgehog and MAPK signaling pathways which has implications in various types of cancer. The functionally uncharacterized protein Smoothelin Like 2, SMTNL2, also had a D-finder predicted JNK D-site that was biochemically validated. Mass Spectrometry and subsequent biochemical validation were able to identify a subset of these residues that underwent D-site mediated phosphorylation. Furthermore, in a cell based assay, these sites also underwent D-site mediated phosphorylation. Based on high throughput datasets and RT-PCR analysis SMTNL2 is expressed in adult skeletal muscle as well as a mouse skeletal muscle cell line. The potential JNK interaction with SMTNL2 in skeletal muscle has implications for understanding the mechanism of myogenesis as well as muscle associated diseases such as muscular dystrophy and insulin resistance associated type 2 diabetes.
Book Synopsis Role of the JNK Signal Transduction Pathway in Cell Survival by : Jennifer Ann Lamb
Download or read book Role of the JNK Signal Transduction Pathway in Cell Survival written by Jennifer Ann Lamb and published by . This book was released on 2004 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Leucine-Rich Repeat Kinase 2 (LRRK2) by : Hardy J. Rideout
Download or read book Leucine-Rich Repeat Kinase 2 (LRRK2) written by Hardy J. Rideout and published by Springer. This book was released on 2017-03-28 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to assemble the leading researchers in the field of LRRK2 biology and neurology and provide a snapshot of the current state of knowledge, encompassing all major aspects of its function and dysfunction. The contributors are experts in cell biology and physiology, neurobiology, and medicinal chemistry, bringing a multidisciplinary perspective on the gene and its role in disease. The book covers the identification of LRRK2 as a major contributor to the pathogenesis of Parkinson's Disease. It also discusses the current state of the field after a decade of research, putative normal physiological roles of LRRK2, and the various pathways that have been identified in the search for the mechanism(s) of its induction of neurodegeneration.
Book Synopsis JNK signal transduction pathway by : Rastislav Tamaskovic
Download or read book JNK signal transduction pathway written by Rastislav Tamaskovic and published by . This book was released on 2000 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis JNK Signal Transduction Pathway: from Accurate Measurement of Kinase Activity to the Role in G2/M Checkpoint and Apoptosis by : Rastislav Tamaskovic
Download or read book JNK Signal Transduction Pathway: from Accurate Measurement of Kinase Activity to the Role in G2/M Checkpoint and Apoptosis written by Rastislav Tamaskovic and published by . This book was released on 2000 with total page 67 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Encyclopedia of Inflammatory Diseases by :
Download or read book Encyclopedia of Inflammatory Diseases written by and published by Birkhäuser. This book was released on 2016-09-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Inflammation has become one of the most exciting and rewarding areas of medical research. Recent years have seen a revolution in our understanding of how blood and tissue cells interact and of the intracellular mechanisms controlling their activation. This has revealed the underlying inflammatory pathology of many diseases and provided multiple new targets for anti-inflammatory and immunomodulatory therapy. The Encyclopedia of Inflammatory Diseases will cover the following areas: Inflammatory Processes and Cells Inflammatory Diseases Mediators of Inflammation Pharmacology of Inflammation Since inflammatory diseases and their therapy cover a broad range of scientific and medical fields, the encyclopedia will be co-edited by four international experts, a clinician and three researchers from the disciplines of immunology, biochemistry, and pharmacology, in this way providing students, basic and clinical scientists and practitioners in academia, hospitals and industry with valuable interlinked information. This living project will serve as a reliable and comprehensive data pool for everybody working in inflammation research. Owing to its dynamic nature, it will grow with time and future editions, becoming an indispensible source of information for academia, clinical practitioners and industry.
Book Synopsis Origin and Evolution of the Vertebrate Immune System by : L. Du Pasquier
Download or read book Origin and Evolution of the Vertebrate Immune System written by L. Du Pasquier and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The comparative approach to immunology can be traced to the era of Pasteur and Metchnikov in which observations regarding foreign recognition in invertebrates was a factor in the develop ment of the principal concepts that created the foundation of what now is the broad field of immunology. With each major experimental and conceptual breakthrough, the classical, albeit essential, question has been asked "are the immune systems of phylogenetically primitive vertebrates and invertebrates similar to that of mammals?" Somewhat surprisingly for the jawed verte brates, the general answer has been a qualified form of "yes", whereas for agnathans and invertebrate phyla it has been "no" so far. The apparent abruptness in the appearance of the immune system of vertebrates is linked to the introduction of the somatic generation of the diversity of its antigen specific receptors. Therefore the questions regarding the origin and evolution of the specific immune system revolve around this phenomenon. With respect to the origin of the system (aside from the or igin of the rearranging machinery itself, the study of which is still in its infancy) one can ask questions about the cellular and mo lecular contexts in which the mechanism was introduced.
Book Synopsis Disease Pathways by : Anastasia P. Nesterova
Download or read book Disease Pathways written by Anastasia P. Nesterova and published by Elsevier. This book was released on 2019-10-18 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disease Pathways: An Atlas of Human Disease Signaling Pathways is designed to fill a void of illustrated reviews about the cellular mechanisms of human diseases. It covers 42 of the most common non-oncologic diseases and illustrates the connections between the molecular causes of the disease and its symptoms. This resource provides readers with detailed information about the disease molecular pathways, while keeping the presentation simple. Pathway models that aggregate the knowledge about protein–protein interactions have become indispensable tools in many areas of molecular biology, pharmacology, and medicine. In addition to disease pathways, the book includes a comprehensive overview of molecular signaling biology and application of pathway models in the analysis of big data for drug discovery and personalized medicine. This is a must-have reference for general biologists, biochemists, students, medical workers, and everyone interested in the cellular and molecular mechanisms of human disease. Over 145 full-color illustrations of the molecular and cellular cascades underlying the disease pathology. Disease pathways are based on computational models from Elsevier’s Disease Pathway Collection, published for the first time outside of Pathway Studio® commercial software. Each relationship on the pathway models is supported by references to scientific articles and can be examined at freely available online resources.
Book Synopsis Drosophila melanogaster: Practical Uses in Cell and Molecular Biology by :
Download or read book Drosophila melanogaster: Practical Uses in Cell and Molecular Biology written by and published by Academic Press. This book was released on 1995-01-25 with total page 789 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drosophila melanogaster: Practical Uses in Cell and Molecular Biology is a compendium of mostly short technical chapters designed to provide state-of-the art methods to the broad community of cell biologists, and to put molecular and cell biological studies of flies into perspective. The book makes the baroque aspects of genetic nomenclature and procedure accessible to cell biologists. It also contains a wealth of technical information for beginning or advanced Drosophila workers. Chapters, written within a year of publication, make this topical volume a valuable laboratory guide today and an excellent general reference for the future. Key Features* Collection of ready-to-use, state-of-the art methods for modern cell biological and related research using Drosophila melanogaster* Accessible to both experienced Drosophila researchers and to others who wish to join in at the cutting edge of this system * Drosophila offers an easily managed life cycle, inexpensive lifestyle, extraordinarily manipulable molecular and classical genetics, now combined with powerful new cell biology techniques * Introduction and overview sections orient the user to the Drosophila literature and lore * Six full-color plates and over 100 figures and tables enhance the understanding of these cell biology techniques
Book Synopsis Mechanisms of Actomyosin Activation Pathway in Regulating JNK Signaling Activity by : Yisha Lin
Download or read book Mechanisms of Actomyosin Activation Pathway in Regulating JNK Signaling Activity written by Yisha Lin and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Crosstalk Between LXR and JNK Pathways by : Kader Çavusoglu
Download or read book The Crosstalk Between LXR and JNK Pathways written by Kader Çavusoglu and published by . This book was released on 2013 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: This project was carried out in the Cell Signaling Research Group headed by Dr. Carme Caelles at IRB Barcelona. As a part of the research-line that deals with physiological and pharmacological (anti-inflammatory and/or anti-diabetic) actions conducted by some nuclear receptor (NR) ligands through negative interference with the c-Jun N-terminal kinase (JNK) signaling pathway, this project was focused on studying the mechanism of cross-talk between those pathways. The results of the study show the ligand-dependent LXR inhibition of the LPS-activated SAPK (JNK and p38MAPK) pathways. Moreover, PP5, a serine/threonine phosphatase previously shown to regulate MAPK pathways, is suggested as a novel target of LXR that negatively regulates LPS-induced activation of SAPK pathways. Furthermore, it is proposed that through the inhibition of SAPK activity, and thereby cJun/AP-1 activity, PP5 is mediating negative regulation of LPS-induced Mmp13 gene expression by LXR in murine primary macrophages.
