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The Interleukin Revolution
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Book Synopsis The Interleukin Revolution by : Kendall Smith
Download or read book The Interleukin Revolution written by Kendall Smith and published by . This book was released on 2023-05-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immune system has only been understood by immunologists since 1980, and most of us never had a course in immunology while in school. Trying to grasp the complexities of the dangers of Covid and the rationale of the public health policies has been daunting. This book, a memoir of Smith's first twenty years as a young scientist at Dartmouth Medical School, chronicles the revolution that has occurred in our understanding of how the immune system is regulated. This revolution has been made possible by pioneering experiments that Smith and his team accomplished in the 1970s and '80s, and by many others who have since followed their leads. The keys that unlocked the mysteries of cellular behaviors was the discovery of new molecules that direct and dictate immune responses to microbial infections. It was necessary to coin a new name for these molecules, interleukins, because they had been totally unrecognized. The most important aspect of these new molecules was the startling revelation that they function like classic hormones, and they comprise an immunoendocrine system. Like neurotransmitters in the nervous system, they convey information by interacting with receptors that appear on immune system cells. The excitement and euphoria of discovery of new knowledge in this book are unparalleled.Kendall Smith, a physician scientist for more than fifty years, is Cornell University Professor Emeritus of Medicine and Immunology at Weill Cornell Medicine in New York. He graduated from Denison University, and summa cum laude from The Ohio State College of Medicine. He then trained at Yale New Haven Hospital, The National Cancer Institute, and L'Institut de Cancerologie et d'Immunogenetique in Villejuif, France. He has published articles in more than 200 medical and scientific journals, including Nature, Science, Journal of Experimental Medicine, Proceedings of the National Academy of Sciences, Journal of Immunology, and was founding editor of Frontiers in Immunology. He is the editor of Interleukin-2, and author of The Quantal Theory of Immunity: The Molecular Basis of Autoimmunity and Leukemia, and Molecular Immunity: A Chronology of 60 Years of Discovery.
Book Synopsis A Revolution in Biotechnology by : Jean L. Marx
Download or read book A Revolution in Biotechnology written by Jean L. Marx and published by Cambridge University Press. This book was released on 1989-03-16 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heredity, genes and DNA. Synthesis without cells. Microorganisms as producers of feedstock chemicals. Gene cloning opens up a new frontier in health. The microbial production of biochemicals. Single-cell proteins. Bacterial leaching and biomining. Bacteria and the environment. Biological nitrogen fixation. Plant cell and tissue culture. Improving crop plants by the introduction of isolated genes. Monoclonal antibodies and their applications. Site-directed antibodies in biology and medicine. New methods for the diagnosis of genetic diseases. The prospect of gene therapy for human hereditary diseases. Biotechnology, international competition and regulatory strategies.
Book Synopsis The Optimal Health Revolution by : Duke Johnson
Download or read book The Optimal Health Revolution written by Duke Johnson and published by BenBella Books. This book was released on 2009-04-14 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutting-edge science is coming to a startling realization. The bulk of our most lethal diseases have a common underlying cause: persistent inflammation, an over-active reaction of our natural immune system function resulting in cell and tissue destruction. This persistent inflammation is triggered by our industrial lifestyles, including exposure to chemicals, synthetic food ingredients, pollution and processed foods. "Researchers are linking inflammation to an ever-wider array of chronic illnesses," reports Newsweek's Anne Underwood. "Suddenly medical puzzles seem to be fitting together, such as why hypertension puts patients at increased risk of Alzheimer's, or why rheumatoid-arthritis sufferers have higher rates of sudden cardiac death. They're all connected on some fundamental level." But inflammation, and the risks of chronic diseases it brings, can be managed. Lifestyle and nutritional change is part of the answer. But the other part of the answer lies with ground-breaking information from the newest field of science—nutrigenomics. Nutrigenomics is the science of how your genes interact with nutrients. It is the study of how DNA and the genetic code affect a person's need for certain nutrients and help maintain optimal health throughout life. The Optimal Health Revolution combines leading-edge science — including 600 scientific references — with an easy to read, conversational writing style that make this critical information accessible to every reader. Relevant to both the researcher and medical doctor interested in the latest science and the casual reader looking to improve his or her health, The Optimal Health Revolution makes a critical contribution to our understanding of health.
Download or read book Interleukin 2 written by Kendall A. Smith and published by . This book was released on 1984 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Interleukins written by Steven Gillis and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Investigations of the activation, proliferation, and, in some cases, differentia tion of mononuclear cells involved in the immune response are proceeding rapidly. These studies have resulted in the discovery of several factors that promote these cellular events, some of which have been characterized biochemically to various extents. Because of the considerable interest in understanding these cellular changes at the molecular level, we chose to produce the first thematic volume for Contemporary Topics in Molecular Immunology; the theme deals with certain regulatory factors that promote proliferation and differentiation. We have com piled contributions from numerous scientists well known for their work with several regulatory factors. In the following paragraphs, the reader will find an overview of the contents of this volume. Greene and Robb review data they have generated over the past 2-3 years with respect to characterization of hormone-specific Interleukin-2 (IL-2) recep tors on the surface of activated T cells. Their chapter traces the development of a quantitative assay for assessment of IL-2 receptors based on the preparation and use of radiolabeled IL-2 prepared biosynthetically with the aid of IL-2-pro ducer leukemic cells. The authors then describe an alternate approach, the prep aration of a monoclonal antibody previously determined to be directed against a T -cell-activation antigen. This so-called anti-Tac antibody was later found to recognize a determinant on or near the IL-2 receptor.
Book Synopsis Interleukin-10 in Health and Disease by : Simon Fillatreau
Download or read book Interleukin-10 in Health and Disease written by Simon Fillatreau and published by Springer. This book was released on 2014-07-08 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date.
Book Synopsis Interleukin-10 by : Jan Egbert De Vries
Download or read book Interleukin-10 written by Jan Egbert De Vries and published by R G Landes Company. This book was released on 1995 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the structure and the in vitro and in vivo biological characterization of a recently discovered cytokine: interleukin - 10 (IL-10). The information collected in this volume is a state-of-the-art summary of the pleiotropic effects of IL-10 in vitro and in vivo and significantly contributes to our understanding of the role of IL-10 in the immune system and its potential clinical utility in the near future.
Book Synopsis Nutrition and Integrative Medicine by : Aruna Bakhru
Download or read book Nutrition and Integrative Medicine written by Aruna Bakhru and published by CRC Press. This book was released on 2018-08-06 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: While medical professionals continue to practice traditional allopathic medicine, the public has turned toward nutritional and integrative medical therapies, especially for addressing the proliferation of chronic diseases. Written by leaders in the academic and scientific world, Nutrition and Integrative Medicine: A Primer for Clinicians presents various modalities to help restore health. This book provides users with a guide to evaluating and recommending nutritional and integrative therapies. The book offers insights on the microbiome of the human body, examines the relationship of human health to the microbiome of the food we ingest, and introduces the concept of "food as information." It provides enlightenment on anti-aging and healing modalities, mind–body medicine, and an investigation of psychological trauma as related to disease causation. Integrative therapies, including water, light, and sound therapy, are explored, and information on healing chronic disease through nutrition, the tooth–body connection, the role of toxins in disease causation, and electromagnetic field hypersensitivity, as well as its management, is presented.
Book Synopsis Interleukin-6-type Cytokines by : Andrzej Mackiewicz
Download or read book Interleukin-6-type Cytokines written by Andrzej Mackiewicz and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Cytokine Factsbook by : Robin E. Callard
Download or read book The Cytokine Factsbook written by Robin E. Callard and published by . This book was released on 1994 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact? The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalogue of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common, easy-to-follow format. Taken together they compile everything you wanted to know about proteins but were too busy to look for. More than 45 entries on human and murine cytokines and their receptors, including: * Cytokine receptor superfamilies * Interleukins 1-15 * Other cytokines * Additional information is provided on: * Alternative nomenclature * Cross reactivity * Sources * Bio assays * Physicochemical properties of the cytokines and their receptors * 3-D structure * Gene structure and chromosomal localisation * Amino acid sequences of the cytokines and their receptors * Receptors * Receptor distribution * Signal transduction * Chromosomal location of the receptors * References
Download or read book Interleukins written by and published by Elsevier. This book was released on 2011-08-09 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines.
Book Synopsis Interleukin-2 and Killer Cells in Cancer by : Eva Lotzova
Download or read book Interleukin-2 and Killer Cells in Cancer written by Eva Lotzova and published by CRC Press. This book was released on 1989-12-21 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first-and only-publication available which provides the most recent information in this particular field of biomedicine. Interleukin-2 (IL-2) and IL-2 activated killer cells have been shown to have a potential in the treatment of a variety of human malignant diseases. This work comprehensively summarizes basic aspects of IL-2 as well as its clinical application, therefore making all these aspects easily accessible to the readers. Because of the clinical significance of this molecule in the treatment of cancer, the basic and clinical investigations in the IL-2 field are rapidly expanding, together with the interest of the scientific and medical community. This book is an excellent educational and teaching tool for scientists, clinicians, and students. Those who already have expertise in research in the IL-2 area will find this reference indispensible.
Book Synopsis Cytokine Storm Syndrome by : Randy Q. Cron
Download or read book Cytokine Storm Syndrome written by Randy Q. Cron and published by Springer Nature. This book was released on 2019-09-09 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals. A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.
Download or read book A Cure Within written by Neil Canavan and published by . This book was released on 2018 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer. There are few words in the English language having such a visceral, personal impact. Cancer patient. Cancer survivor. Pretty much anyone over the age of 30 knows one. A family member. A friend. Someone lost too soon. Someone forever changed. But we don't really like to talk about it, because there's really not much we can do. We fight cancer, sure, but we rarely win. Defeating cancer is one of medical science's greatest challenges. So when a novel approach to treatment seems promising, there is an intense interest in its progress and those who are making it. This book is about both - the progress and the pioneers - and its focus is the revolutionary science of something called cancer immunotherapy. This medical marvel, cancer immunotherapy - also called immuno-oncology - is still in its infancy. Yet, mobilizing the immune system to recognize and attack cancer has long been imagined, and occasionally attempted, for more than 100 years: It is only just recently that significant - in fact, unprecedented - progress has been made. With the use of newly approved immunotherapy treatments, there are now reports of hundreds, if not thousands of cancer patients with advanced disease living years beyond all prior expectation. Some of these once-terminally ill patients are now called "cured." This has never happened before. As Dr. Jill O'Donnell-Tormey comments in the Foreword, "It has taken decades of basic research and billions of dollars of investment to build the foundation upon which today's lifesaving treatments are based. This book offers a uniquely entertaining yet inspiring glimpse into the lives and minds of the academic and industry pioneers who forged this new field. It is a story of how an obscure and oft-derided field of cancer research - and the tenacious few scientists who refused to abandon it - came from behind to become the new 'darling of oncology.'" The book's author, Neil Canavan, is an experienced commentator on new developments in medical science. His portraits of 25 of the pioneers in immunotherapy are the culmination of two years of travel to laboratories, offices, and conferences around the world and countless hours of conversation with individuals immersed in a vitally important, promising assault on a dread disease that kills more than eight million people each year worldwide. -- from dust jacket.
Book Synopsis Cytokine Storm Syndrome by : Randy Q. Cron
Download or read book Cytokine Storm Syndrome written by Randy Q. Cron and published by Springer Nature. This book was released on with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neo-adjuvant Chemotherapy by : Claude Jacquillat
Download or read book Neo-adjuvant Chemotherapy written by Claude Jacquillat and published by John Libbey Eurotext. This book was released on 1988 with total page 1066 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the Proceedings of the Second International Congress on Neo-Adjuvant Chemotherapy which took place on 19 to 21 February 1988 in Paris.
Book Synopsis The Beautiful Cure by : Daniel M. Davis
Download or read book The Beautiful Cure written by Daniel M. Davis and published by University of Chicago Press. This book was released on 2021-03-19 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Visceral.”—Wall Street Journal “Illuminating.”—Publishers Weekly “Heroic.”—Science The immune system holds the key to human health. In The Beautiful Cure, leading immunologist Daniel M. Davis describes how the scientific quest to understand how the immune system works—and how it is affected by stress, sleep, age, and our state of mind—is now unlocking a revolutionary new approach to medicine and well-being. The body’s ability to fight disease and heal itself is one of the great mysteries and marvels of nature. But in recent years, painstaking research has resulted in major advances in our grasp of this breathtakingly beautiful inner world: a vast and intricate network of specialist cells, regulatory proteins, and dedicated genes that are continually protecting our bodies. Far more powerful than any medicine ever invented, the immune system plays a crucial role in our daily lives. We have found ways to harness these natural defenses to create breakthrough drugs and so-called immunotherapies that help us fight cancer, diabetes, arthritis, and many age-related diseases, and we are starting to understand whether activities such as mindfulness might play a role in enhancing our physical resilience. Written by a researcher at the forefront of this adventure, The Beautiful Cure tells a dramatic story of scientific detective work and discovery, of puzzles solved and mysteries that linger, of lives sacrificed and saved. With expertise and eloquence, Davis introduces us to this revelatory new understanding of the human body and what it takes to be healthy.
