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The Identification Of The Genetic Components Of Autism Spectrum Disorders 2017
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Book Synopsis The Identification of the Genetic Components of Autism Spectrum Disorders 2017 by : Merlin G. Butler
Download or read book The Identification of the Genetic Components of Autism Spectrum Disorders 2017 written by Merlin G. Butler and published by MDPI. This book was released on 2018-06-27 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "The Identification of the Genetic Components of Autism Spectrum Disorders 2017" that was published in IJMS
Book Synopsis The Identification of the Genetic Components of Autism Spectrum Disorders 2017 by :
Download or read book The Identification of the Genetic Components of Autism Spectrum Disorders 2017 written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation This textbook is dedicated to the study of genetic factors contributing to autism and includes a collection of original research and review articles related to this topic. Autism spectrum disorders (ASD) include a collection of neurodevelopmental disorders characterized by three recognized behavioral domains involving difficulties in communication, social interaction and repetitive behavior. ASD affects 1 to 2 percent of children and is on the increase worldwide. Significant genetic contributions and mechanisms underlie the causation of ASD. Advances in genetic technology and better awareness have led to a diagnosis of 50 to 70 percent of individuals with ASD primarily due to chromosomal abnormalities, submicroscopic deletions or duplications now identified with high-resolution microarray analysis, next-generation DNA (exome) sequencing of gene variants or mutations, recognized single gene disorders or metabolic disturbances. Through discovery by searching genomic databases and peer-reviewed research articles, nearly 800 genes have been identified to contribute to ASD. Highlights in the field of autism research, discovery and identification of genetic components with characterization will be addressed. Furthermore, reviews of current understanding of the causes and diagnostic approaches for ASD and related syndromes will be presented along with discussion of psychiatric/behavior comorbidities and related features, environmental risk factors, parental attitudes and treatment.
Book Synopsis The Identification of the Genetic Components of Autism Spectrum Disorders 2017 by : Merlin G. Butler (Ed.)
Download or read book The Identification of the Genetic Components of Autism Spectrum Disorders 2017 written by Merlin G. Butler (Ed.) and published by . This book was released on 2017 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is dedicated to the study of genetic factors contributing to autism and includes a collection of original research and review articles related to this topic. Autism spectrum disorders (ASD) include a collection of neurodevelopmental disorders characterized by three recognized behavioral domains involving difficulties in communication, social interaction and repetitive behavior. ASD affects 1 to 2 percent of children and is on the increase worldwide. Significant genetic contributions and mechanisms underlie the causation of ASD. Advances in genetic technology and better awareness have led to a diagnosis of 50 to 70 percent of individuals with ASD primarily due to chromosomal abnormalities, submicroscopic deletions or duplications now identified with high-resolution microarray analysis, next-generation DNA (exome) sequencing of gene variants or mutations, recognized single gene disorders or metabolic disturbances. Through discovery by searching genomic databases and peer-reviewed research articles, nearly 800 genes have been identified to contribute to ASD. Highlights in the field of autism research, discovery and identification of genetic components with characterization will be addressed. Furthermore, reviews of current understanding of the causes and diagnostic approaches for ASD and related syndromes will be presented along with discussion of psychiatric/behavior comorbidities and related features, environmental risk factors, parental attitudes and treatment.
Book Synopsis Autism Spectrum Disorders by : Andreas M. Grabrucker
Download or read book Autism Spectrum Disorders written by Andreas M. Grabrucker and published by . This book was released on 2021 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism spectrum disorders are developmental disorders. Individuals with autism spectrum disorders develop differently. These differences are usually present in social interaction, communication, and sensory processing, and become visible through a wide variety of behavioral responses that differ from individuals without autism spectrum disorders. Despite significant research efforts, the exact causes of autism spectrum disorders remain poorly understood; however, researchers have gained extensive insights into possible pathomechanisms, even at the molecular level of cells. Many diagnostic criteria have been developed, adapted, and improved. The eight chapters in this book highlight the current state-of-the-art in many areas of autism spectrum disorders. Chapter 1 provides an overview of the epidemiology of autism spectrum disorders and the current knowledge of the underlying pathogenic mechanisms. Chapter 2 summarizes the diagnostic criteria and procedures and highlights present and upcoming therapeutic strategies. Chapter 3 reviews the adverse events and trauma in people with autism spectrum disorders. Chapters 4 and 5 focus on atypical sensory processing, and Chapter 6 discusses the genetic overlap of autism spectrum disorders with other neuropsychiatric disorders such as attention deficit hyperactivity disorder (ADHD), depression, and schizophrenia. Chapter 7 focuses on the contribution of abnormalities in mitochondria, and chapter 8 discusses gut-brain interactions and a potential role for microbiota in autism spectrum disorders. This book is aimed primarily at clinicians and scientists, but many areas will also be of interest to the layperson.
Book Synopsis Identification and Characterization of Genetic Components in Autism Spectrum Disorders 2020 by : Merlin G Butler
Download or read book Identification and Characterization of Genetic Components in Autism Spectrum Disorders 2020 written by Merlin G Butler and published by Mdpi AG. This book was released on 2022-04-28 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Identification of the Genetic Components of Autism Spectrum Disorders 2020 will be a useful resource for laboratory and clinical scientists, translational-based researchers, primary healthcare providers and physicians, psychologists/psychiatrists, neurologists, developmental pediatricians, clinical geneticists, teachers, special educators, and caregivers involved with individuals who have autism spectrum disorders (ASD), with the goal to translate information directly to the clinical, education and home settings. Other professionals, students at all levels, and families who are interested in this important neurodevelopmental disorder will find this textbook of value by obtaining a better awareness of the causes, testing, and understanding of genetic components leading to autism, and research that may open avenues for treatment with new approaches. This textbook includes nine chapters divided into three sections (clinical, genetics, other) written by experts in the field dedicated to genetics research and clinical care, description, and treatment by generating reviews for ASD and related disorders. These chapters include information on discoveries, risk factors, causation, diagnosis, treatment, and phenotyping with characterization of genomic or genetic factors and the environment, as genetics play an important role in up to 90% of individuals with autism via over 800 currently recognized genes.
Book Synopsis A Time for Metabolism and Hormones by : Paolo Sassone-Corsi
Download or read book A Time for Metabolism and Hormones written by Paolo Sassone-Corsi and published by Springer. This book was released on 2016-04-04 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen spectacular advances in the field of circadian biology. These have attracted the interest of researchers in many fields, including endocrinology, neurosciences, cancer, and behavior. By integrating a circadian view within the fields of endocrinology and metabolism, researchers will be able to reveal many, yet-unsuspected aspects of how organisms cope with changes in the environment and subsequent control of homeostasis. This field is opening new avenues in our understanding of metabolism and endocrinology. A panel of the most distinguished investigators in the field gathered together to discuss the present state and the future of the field. The editors trust that this volume will be of use to those colleagues who will be picking up the challenge to unravel how the circadian clock can be targeted for the future development of specific pharmacological strategies toward a number of pathologies.
Book Synopsis Identification and Characterization of Genetic Components in Autism Spectrum Disorders 2019 by : Merlin G Butler
Download or read book Identification and Characterization of Genetic Components in Autism Spectrum Disorders 2019 written by Merlin G Butler and published by Mdpi AG. This book was released on 2022-04-26 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Identification of the Genetic Components of Autism Spectrum Disorders 2019 will serve as a resource for laboratory and clinical scientists as well as translational-based researchers, primary healthcare providers or physicians, psychologists/psychiatrists, neurologists, developmental pediatricians, clinical geneticists, and other healthcare providers, teachers, caregivers and students involved in autism spectrum disorders (ASD) with the goal to translate information directly to the clinic, education and home setting. Other professionals, students and families might find this textbook of value based on better awareness, causes and understanding of genetic components leading to autism and open avenues for treatment. Genetics play a role with up to 90% of autism, with over 800 currently recognized genes contributing to causes, clinical presentation, treatment, and counseling of family members. This textbook includes 13 chapters divided into three sections (clinical, genetics, other) written by experts in the field dedicated to research and clinical care, description, treatment and generating relevant reviews for ASD and related disorders impacting gene expression, profiling, and pathways. Identification of potential risk factors will be discussed, including obesity, microbiota, malignancy, and the immune system, as well as their direct or indirect contribution to ASD treatment and causation.
Author :American Psychiatric Association Publisher :American Psychiatric Publishing ISBN 13 :9781955245180 Total Pages : pages Book Rating :4.2/5 (451 download)
Book Synopsis Diagnostic and Statistical Manual of Mental Disorders (DSM-5) by : American Psychiatric Association
Download or read book Diagnostic and Statistical Manual of Mental Disorders (DSM-5) written by American Psychiatric Association and published by American Psychiatric Publishing. This book was released on 2021-09-24 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Autism and Environmental Factors by : Omar Bagasra
Download or read book Autism and Environmental Factors written by Omar Bagasra and published by John Wiley & Sons. This book was released on 2018-05-01 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explores environmental factors during fetal development that may contribute to autism It is well documented that in the majority of the cases, an autistic child's brain has acquired the genetic and organismal abnormalities that were initiated during the first trimester of their gestational period. Yet, scientists still don’t know what is causing these abnormalities; this book explains how the human brain develops and what the critical stages are in which a fetal brain may acquire genetic and developmental abnormalities. It presents scientific data supporting previous anecdotal observations to attempt to understand the complex puzzle that is autism. From chemical fragrances to herbicides, synthetic chemicals are abundant in everyday life and this book examines the evidence surrounding these chemicals and their effects, including on the developing human brain and how that might explain certain characteristics observed in autism. Discussing various aspects of potential ASD causing factors, Autism and Environmental Factors brings together as many pieces of the autism puzzle as possible in one place to begin to clarify the picture and spark discussion to ensure a safe environment for everyone, especially our developing children. Discusses the genetic and environmental factors that may contribute to autism Covers how the human brain develops and the critical stages in which a fetal brain may acquire genetic and developmental abnormalities Describes the rapid proliferation of synthetic chemicals in our modern world and the effects on the developing human brain—endocrine-disturbing chemicals that alter DNA, epigenetics, and hormones Written in a clear and accessible style Autism and Environmental Factors is an important book for researchers and students in neuroscience, neuroanatomy, developmental neurobiology and anyone focusing on autism research.
Book Synopsis An A-Z of Genetic Factors in Autism by : Kenneth Aitken
Download or read book An A-Z of Genetic Factors in Autism written by Kenneth Aitken and published by Jessica Kingsley Publishers. This book was released on 2011-04-15 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the biological bases to the autistic spectrum disorders (ASDs) is advancing rapidly. Over 80 genetic conditions have now been reported in people who have also been diagnosed with ASDs. Many of these conditions have specific implications for the presenting phenotype and for treatment, management, and intervention. If the basis to the presenting behavioural phenotype is not identified, this can result in a sub-optimal level of care, complications, or even permanent damage. Kenneth J. Aitken shows that the notion of a single condition known as 'autism' is no longer tenable, and challenges current trends in the diagnosis and management of these behaviours as a homogenous group by drawing on recent research into brain function, genetics, epidemiology and neurology. This volume explains the biology and genetics of ASD, and provides clinicians and researchers with a comprehensive summary of each genetic factor including the research that links it to ASD, diagnosis and treatment issues, and related animal models, as well as detailing relevant professional organisations and avenues for further research. An A-Z of Genetic Factors in Autism is an essential resource for a wide range of researchers, clinical professionals and students interested in autism spectrum disorders, including clinical and educational psychologists, dieticians, psychiatrists, and neurologists.
Book Synopsis An A-Z of Genetic Factors in Autism by : Kenneth Aitken
Download or read book An A-Z of Genetic Factors in Autism written by Kenneth Aitken and published by Jessica Kingsley Publishers. This book was released on 2011-01-15 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of a single condition known as 'autism' is quickly becoming outdated, and is now understood to be an umbrella term for a variety of predominantly genetic conditions. This can be confusing for parents of children who have been diagnosed as having an 'autism spectrum disorder'. An A-Z of Genetic Factors in Autism provides parents with a complete overview of the main genetic disorders associated with autism, including those linked to growth differences, cardiovascular issues, neurodevelopmental problems, immune dysfunction, gastrointestinal disturbances and epilepsy. Kenneth Aitken demystifies the umbrella term 'autism' by alphabetically listing these conditions along with information about how common they are, their causes, signs, and symptoms, and for many, appropriate methods of treatment and management. Information on support groups and sources of further information are also included to help parents obtain any additional support they need, and keep up to date with new developments in research and practice. This is a must-have book for any parent or carer who feels confused by their child's diagnosis, or who seeks a better understanding of the many genetic conditions linked to autism.
Book Synopsis Autism Spectrum Disorders by : Stephen Deutsch
Download or read book Autism Spectrum Disorders written by Stephen Deutsch and published by BoD – Books on Demand. This book was released on 2011-08-01 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: Estimated prevalence rates of autism spectrum disorders (ASDs) have increased at an alarming rate over the past decade; current estimates stand as high as 1 in 110 persons in the population with a higher ratio of affected males to females. In addition to their emotional impact on the affected persons and their family members (in fact, the latter are often unrecognized unaffected “patients” themselves), the economic and social impacts of ASDs on society are staggering. Persons with ASDs will need interdisciplinary approaches to complex treatment and life planning, including, but not limited to, special education, speech and language therapy, vocational skills training and rehabilitation, social skills training and cognitive remediation, in addition to pharmacotherapy. The current book highlights some of the recent research on nosology, etiology, and pathophysiology. Additionally, the book touches on the implications of new research for treatment and genetic counseling. Importantly, because the field is advancing rapidly, no book can be considered the final word or finished product; thus, the availability of open access rapid publication is a mechanism that will help to assure that readers remain current and up-to-date.
Book Synopsis The Broad Autism Phenotype by : Anthony F. Rotatori
Download or read book The Broad Autism Phenotype written by Anthony F. Rotatori and published by Emerald Group Publishing. This book was released on 2015-03-27 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: This proposed volume will provide in-depth coverage about a construct known as the broad autism phenotype (BAP).
Book Synopsis The Neuroscience of Autism Spectrum Disorders by : Joseph D. Buxbaum
Download or read book The Neuroscience of Autism Spectrum Disorders written by Joseph D. Buxbaum and published by Academic Press. This book was released on 2012-10-25 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autism is no longer considered a rare disease, and the Center for Disease Control now estimates that upwards of 730,000 children in the US struggle with this isolating brain disorder. New research is leading to greater understanding of and ability to treat the disorder at an earlier age. It is hoped that further genetic and imaging studies will lead to biologically based diagnostic techniques that could help speed detection and allow early, more effective intervention. Edited by two leaders in the field, this volume offers a current survey and synthesis of the most important findings of the neuroscience behind autism of the past 20 years. With chapters authored by experts in each topic, the volume explores etiology, neuropathology, imaging, and pathways/models. Offering a broad background of ASDs with a unique focus on neurobiology, the volume offers more than the others on the market with a strictly clinical focus or a single authored perspective that fails to offer expert, comprehensive coverage. Researchers and graduate students alike with an interest in developmental disorders and autism will benefit, as will autism specialists across psychology and medicine looking to expand their expertise. Uniquely explores ASDs from a neurobiological angle, looking to uncover the molecular/cellular basis rather than to merely catalog the commonly used behavioral interventions Comprehensive coverage synthesizes widely dispersed research, serving as one-stop shopping for neurodevelopmental disorder researchers and autism specialists Edited work with chapters authored by leaders in the field around the globe - the broadest, most expert coverage available
Book Synopsis Autism Spectrum Disorders: From Genotypes to Phenotypes by : Valsamma Eapen
Download or read book Autism Spectrum Disorders: From Genotypes to Phenotypes written by Valsamma Eapen and published by Frontiers Media SA. This book was released on 2015-12-10 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic covers the pathogenetic processes in Autism Spectrum Disorder (ASD) that underpin the translation of genetic vulnerability to clinically significant symptoms. Available research data in ASD suggests that it is a neural connectivity disorder and that the social communication and related neurobehavioural symptoms result from reduced synchronization between key "social brain" regions. These interconnected neural systems can be understood through the relationship between functionally relevant anatomic areas and neurochemical pathways, the programming of which are genetically modulated during neurodevelopment and mediated through a range of epigenetic and environmental modulators. Elucidating the underlying molecular mechanisms can provide an invaluable window for understanding the neural wiring that regulates higher brain functions and consequent clinical phenotypes. In keeping with the multi modal and diverse origins of ASD, this Research Topic explores the genetic underpinnings and environmental modulation in the aetiology; neural substrates, biomarkers and endophenotypes that underlie clinical characteristics; as well as neurochemical pathways and pathophysiological mechanisms that pave the way for therapeutic interventions. Furthermore, since genetically mediated deficits and consequent functional impairments involve activity-dependent synapse development that depends on postnatal learning and experience, the trajectory towards the final clinical expression could be modulated by early interventions that exploit the neuronal maturation and brain plasticity. However, identifying these diverse pathogenetic processes and tailoring interventions would require subtyping ASD into homogeneous subgroups. In this regard, this topic covers the current state of evidence in the literature through topic reviews as well as ongoing original work that provides tangible hypotheses and directions for future research.
Book Synopsis Autism Spectrum Disorder by : Jill Boucher
Download or read book Autism Spectrum Disorder written by Jill Boucher and published by SAGE. This book was released on 2017-02-25 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the historical foundations of autism and what precisely is meant by the ′autistic spectrum′? How can we explain behavioural patterns of people with autism, young or old, and what are the major theoretical bases for understanding these? What is the latest thinking regarding diagnosis, and what are the most effective strategies for assessment, education and care for people with this condition? Following on from the popular provocative first edition, the Second Edition answers these questions with the latest research on autistic spectrum disorders, exploring theories at the psychological, neurobiological and ′first cause′ levels to methods of assessment, intervention, education and support. Already popular as an introductory text for those wanting to know more about autism as well as a source of basic information and references for those familiar with the field, this newly updated and enhanced book is invaluable for students, professionals and even families.
Book Synopsis Genomic Rearrangements in Autism Spectrum Disorders: Identification of Novel Candidate Genes by :
Download or read book Genomic Rearrangements in Autism Spectrum Disorders: Identification of Novel Candidate Genes written by and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: There is evidence from family studies for the importance of genetic factors in the development of autism spectrum disorders (ASDs) but the identification of major genes has not been achieved to date. There are several reports of deletions and duplications in individuals with ASDs, some of which are not unique to an individual. In most cases, the frequencies and relevance of these abnormalities are unknown, as they have been identified serendipitously in one or a few individuals. My overall hypothesis was that such rearrangements would facilitate the identification of "culprit" genes associated with ASDs by identifying a small chromosomal region for candidate gene testing. I molecularly characterized two overlapping 2p15-2p16.1 deletions detected in unrelated individuals with confirmed autistic disorder (Subject 1) or autistic features (Subject 2), a 1.4Mb deletion on chromosome Xp22 (Subject 1) and a duplication of chromosome 7q11.23, reciprocal to the Williams-Beuren Syndrome (WBS) deletion, in one individual with an ASD (Subject 3). Using real-time semi-quantitative PCR, I screened a total of 798 individuals with an ASD and 186 healthy controls for the presence of similar abnormalities. No additional cases were identified in either group. Subsequently, I selected 6 genes [Orthodenticle homolog 1 (OTX1), Variable charge, X-linked (VCX), Neuroligin 4, X-linked (NLGN4X), Syntaxin 1A (STX1A), Cytoplasmic linker 2 (CYLN2) and General transcription factor IIi (GTF2i)], based on their function and localization within or in the vicinity of the rearrangements and tested them for association with ASDs. Although there was no evidence for association for any marker or haplotype in most of the genes tested, this was not so for GTF2i. Haplotype transmission disequilibrium testing revealed an increased transmission, from healthy parents to their affected offspring, of the common alleles of one marker and one haplotype in GTF2i (P = 0.0010 and 0.0005, respectively). This gene enc.
