Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
The Genetics Of The Mouse
Download The Genetics Of The Mouse full books in PDF, epub, and Kindle. Read online The Genetics Of The Mouse ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Genetics of the Mouse by : Jean Louis Guénet
Download or read book Genetics of the Mouse written by Jean Louis Guénet and published by Springer. This book was released on 2014-11-29 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.
Author :Professor of Molecular Biology Lee M Silver, Professor Dr Publisher :Oxford University Press on Demand ISBN 13 :9780195075540 Total Pages :362 pages Book Rating :4.0/5 (755 download)
Book Synopsis Mouse Genetics by : Professor of Molecular Biology Lee M Silver, Professor Dr
Download or read book Mouse Genetics written by Professor of Molecular Biology Lee M Silver, Professor Dr and published by Oxford University Press on Demand. This book was released on 1995 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mouse Genetics offers for the first time in a single comprehensive volume a practical guide to mouse breeding and genetics. Nearly all human genes are present in the mouse genome, making it an ideal organism for genetic analyses of both normal and abnormal aspects of human biology. Written as a convenient reference, this book provides a complete description of the laboratory mouse, the tools used in analysis, and procedures for carrying out genetic studies, along with background material and statistical information for use in ongoing data analysis. It thus serves two purposes, first to provide students with an introduction to the mouse as a model system for genetic analysis, and to give practicing scientists a detailed guide for performing breeding studies and interpreting experimental results. All topics are developed completely, with full explanations of critical concepts in genetics and molecular biology. As investigators around the world are rediscovering both the heuristic and practical value of the mouse genome, the demand for a succinct introduction to the subject has never been greater. Mouse Genetics is intended to meet the needs of this wide audience.
Book Synopsis Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes by : Wim E. Crusio
Download or read book Behavioral Genetics of the Mouse: Volume 1, Genetics of Behavioral Phenotypes written by Wim E. Crusio and published by Cambridge University Press. This book was released on 2013-04-25 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.
Download or read book Mouse Genetics written by Shree Ram Singh and published by Humana. This book was released on 2016-09-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mouse Genetics: Methods and Protocols provide selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish the manipulation of genes of interest, tracing cell lineages and modeling human diseases. Composed in the highly successful Methods in Molecular Biology series format, each chapter contains a brief introduction, a list of necessary materials, systematic, readily reproducible methods and a notes section, which shares tips on troubleshooting in order to avoid known pitfalls. Comprehensive and authoritative, Mouse Genetics: Methods and Protocols promises to deliver fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students and postdoctoral fellows working in the various disciplines of mouse biology and modeling human disease.
Book Synopsis Microbial and Phenotypic Definition of Rats and Mice by : National Research Council
Download or read book Microbial and Phenotypic Definition of Rats and Mice written by National Research Council and published by National Academies Press. This book was released on 1999-08-26 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: US-Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US-Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic of Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes published in 1991. In addition to these publications, these meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats.
Book Synopsis The Mouse in Animal Genetics and Breeding Research by : Eugene J. Eisen
Download or read book The Mouse in Animal Genetics and Breeding Research written by Eugene J. Eisen and published by World Scientific. This book was released on 2005 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics research has made enormous contributions to the understanding of basic genetics, human genetics, and livestock genetics and breeding. The wide-ranging topics in the book include the mouse genome sequencing effort, molecular dissection of quantitative traits, embryo biotechnology, ENU mutagenesis, and genetics of disease resistance, and have been written by experts in their respective fields.Chapter 1: The Beginnings - Ode To A Wee Mouse (58 KB)
Book Synopsis The Genetics of the Mouse by : Hans Grüneberg
Download or read book The Genetics of the Mouse written by Hans Grüneberg and published by CUP Archive. This book was released on 1952 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Mouse in Animal Genetics and Breeding Research by : Eugene J. Eisen
Download or read book The Mouse in Animal Genetics and Breeding Research written by Eugene J. Eisen and published by World Scientific. This book was released on 2005 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics research has made enormous contributions to the understanding of basic genetics, human genetics, and livestock genetics and breeding. The wide-ranging topics in the book include the mouse genome sequencing effort, molecular dissection of quantitative traits, embryo biotechnology, ENU mutagenesis, and genetics of disease resistance, and have been written by experts in their respective fields.Chapter 1: The Beginnings - Ode To A Wee Mouse (58 KB)
Book Synopsis Cells and Surveys by : National Research Council
Download or read book Cells and Surveys written by National Research Council and published by National Academies Press. This book was released on 2001-01-19 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: What can social science, and demography in particular, reasonably expect to learn from biological information? There is increasing pressure for multipurpose household surveys to collect biological data along with the more familiar interviewer-respondent information. Given that recent technical developments have made it more feasible to collect biological information in non-clinical settings, those who fund, design, and analyze survey data need to think through the rationale and potential consequences. This is a concern that transcends national boundaries. Cells and Surveys addresses issues such as which biologic/genetic data should be collected in order to be most useful to a range of social scientists and whether amassing biological data has unintended side effects. The book also takes a look at the various ethical and legal concerns that such data collection entails.
Book Synopsis The Coat Colors of Mice by : W.K. Silvers
Download or read book The Coat Colors of Mice written by W.K. Silvers and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many investigators seem to be fascinated by the coat colors of the mam mals with which they work. This seems to be the case particularly for those utilizing isogenic strains of mice, not only because such strains display wide ly different phenotypes, but because scientists, by definition, are an inquisi tive lot and it is sometimes difficult for the uninitiated to comprehend how such phenotypes are produced. This bewilderment becomes even more ap parent if the investigator happens to be involved in breeding studies and a number of attractively colored animals, quite different from the original stocks, appear. Thus I can recall numerous occasions when my colleagues, frequently working in areas completely unrelated to any aspect of genetics, have come to me with an attractively pigmented animal or, more likely, with a popUlation of segregating coat color types (usually because they have not tended their animals properly and have ended up with a cage full of F 2S displaying a number of different colors). How, they ask, do such colors come about? While in some cases it is easy to take chalk in hand and explain what has been going on (segregating) and why, in other cases it is virtually impossible. It is extremely difficult because while the interactions of many coat-color factors obey the simple laws of heredity and of predictable gene interactions, others do not.
Book Synopsis The Children of Atomic Bomb Survivors by : National Research Council
Download or read book The Children of Atomic Bomb Survivors written by National Research Council and published by National Academies Press. This book was released on 1991-02-01 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Do persons exposed to radiation suffer genetic effects that threaten their yet-to-be-born children? Researchers are concluding that the genetic risks of radiation are less than previously thought. This finding is explored in this volume about the children of atomic bomb survivors in Hiroshima and Nagasakiâ€"the population that can provide the greatest insight into this critical issue. Assembled here for the first time are papers representing more than 40 years of research. These documents reveal key results related to radiation's effects on pregnancy termination, sex ratio, congenital defects, and early mortality of children. Edited by two of the principal architects of the studies, J. V. Neel and W. J. Schull, the volume also offers an important comparison with studies of the genetic effects of radiation on mice. The wealth of technical details will be immediately useful to geneticists and other specialists. Policymakers will be interested in the overall conclusions and discussion of future studies.
Book Synopsis Systems Genetics by : Florian Markowetz
Download or read book Systems Genetics written by Florian Markowetz and published by Cambridge University Press. This book was released on 2015-07-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Whereas genetic studies have traditionally focused on explaining heritance of single traits and their phenotypes, recent technological advances have made it possible to comprehensively dissect the genetic architecture of complex traits and quantify how genes interact to shape phenotypes. This exciting new area has been termed systems genetics and is born out of a synthesis of multiple fields, integrating a range of approaches and exploiting our increased ability to obtain quantitative and detailed measurements on a broad spectrum of phenotypes. Gathering the contributions of leading scientists, both computational and experimental, this book shows how experimental perturbations can help us to understand the link between genotype and phenotype. A snapshot of current research activity and state-of-the-art approaches to systems genetics are provided, including work from model organisms such as Saccharomyces cerevisiae and Drosophila melanogaster, as well as from human studies.
Book Synopsis Model Behavior by : Nicole C. Nelson
Download or read book Model Behavior written by Nicole C. Nelson and published by University of Chicago Press. This book was released on 2018-04-04 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mice are used as model organisms across a wide range of fields in science today—but it is far from obvious how studying a mouse in a maze can help us understand human problems like alcoholism or anxiety. How do scientists convince funders, fellow scientists, the general public, and even themselves that animal experiments are a good way of producing knowledge about the genetics of human behavior? In Model Behavior, Nicole C. Nelson takes us inside an animal behavior genetics laboratory to examine how scientists create and manage the foundational knowledge of their field. Behavior genetics is a particularly challenging field for making a clear-cut case that mouse experiments work, because researchers believe that both the phenomena they are studying and the animal models they are using are complex. These assumptions of complexity change the nature of what laboratory work produces. Whereas historical and ethnographic studies traditionally portray the laboratory as a place where scientists control, simplify, and stabilize nature in the service of producing durable facts, the laboratory that emerges from Nelson’s extensive interviews and fieldwork is a place where stable findings are always just out of reach. The ongoing work of managing precarious experimental systems means that researchers learn as much—if not more—about the impact of the environment on behavior as they do about genetics. Model Behavior offers a compelling portrait of life in a twenty-first-century laboratory, where partial, provisional answers to complex scientific questions are increasingly the norm.
Book Synopsis Contributions to Behavior-genetic Analysis by : Gardner Lindzey
Download or read book Contributions to Behavior-genetic Analysis written by Gardner Lindzey and published by Ardent Media. This book was released on 1970 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Transgenic Mouse Methods and Protocols by : Marten H. Hofker
Download or read book Transgenic Mouse Methods and Protocols written by Marten H. Hofker and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.
Book Synopsis Scientific Frontiers in Developmental Toxicology and Risk Assessment by : National Research Council
Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-11-21 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
Download or read book Mouse Genetics written by Lee M. Silver and published by . This book was released on 1995 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
