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The Future Of Predictive Safety Evaluation
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Book Synopsis The Future of Predictive Safety Evaluation by : D.V. Parke
Download or read book The Future of Predictive Safety Evaluation written by D.V. Parke and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: A. N. WORDEN, D. V. PARKE AND J. MARKS THE BACKGROUND There is nothing new about the fact that chemical substances derived either from natural products or by synthetic means .. can give rise to toxicity in animals and human beings, and that they must be subjected to controls. The earliest writings speak of such toxicity and, from the times of ancient Egypt and in the Old Tes tament, controls have existed[l]. In the Middle Ages Paracelsus (1493-1541) noted that "All things are poisons, for there is nothing without poisonous qualities. It is only the dose which makes a thing a poison", and hence he stressed the importance of dose relative to toxic reactions [ 2] . Most of the early controls concentrated on substances that were to be deliberately administered to the human subject in the form of medicines. Legislation for many centuries was mainly con cerned with regulating the activities of apothecaries and physicians. The Royal College of Physicians, for example, was originally established to control the activities of physicians within London. Among the controls which it exerted was that over the use of medicinal substances. Such controls were, however, poor, based as they were on hearsay evidence of toxicity. For many centuries no means existed for the accurate determination of toxicity.
Book Synopsis The Future of Predictive Safety Evaluation by : A.N. Worden
Download or read book The Future of Predictive Safety Evaluation written by A.N. Worden and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reproduction and fetal development in humans and experimental animals may be adversely affected by a wide range of drugs and environmental agents. They may be toxic in the parental generation leading to impaired germ cell formation, loss of reproductive poten tial and infertility following chronic exposure. Deviant fetal development occurs as a consequence of cellular damage at sensi tive stages in development. Changes seen range from intrauterine mortality and structural malformation to growth retardation with physiological and behavioural defects. Concepts on the mechanism of action of teratogens are discussed with reference to some better-known agents. Presently, regulatory authorities prefer whole animal studies in predictive safety evaluation of substances to which a pregnant woman may be exposed. Tests are conducted over one or more generations and are designed to study the influence of test com pounds upon general reproductive performance, fertility, fetal development and perinatal and postnatal behaviour. Experiments are designed to permit compounds to be tested under conditions resembling expected human exposure. Small rodents and rabbits are preferred species on account of their convenience as laboratory animals and the available knowledge regarding their reproductive behaviour, fetal development and known sensitivity to human teratogens.
Book Synopsis Predictive Safety Analytics by : Robert Stevens
Download or read book Predictive Safety Analytics written by Robert Stevens and published by CRC Press. This book was released on 2023-10-03 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly all our safety data collection and reporting systems are backwardlooking: incident reports; dashboards; compliance monitoring systems; and so on. This book shows how we can use safety data in a forward-looking, predictive sense. Predictive Safety Analytics: Reducing Risk through Modeling and Machine Learning contains real use cases where organizations have reduced incidents by employing predictive analytics to foresee and mitigate future risks. It discusses how Predictive Safety Analytics is an opportunity to break through the plateau problem where safety rate improvements have stagnated in many organizations. The book presents how the use of data, coupled with advanced analytical techniques, including machine learning, has become a proven and successful innovation. Emphasis is placed on how the book can “meet you where you are” by illuminating a path to get there, starting with simple data the organization likely already has. Highlights of the book are the real examples and case studies that will assist in generating thoughts and ideas for what might work for individual readers and how they can adapt the information to their particular situations. This book is written for professionals and researchers in system reliability, risk and safety assessment, quality control, operational managers in selected industries, data scientists, and ML engineers. Students taking courses in these areas will also find this book of interest to them.
Book Synopsis Predictive Safety Analytics by : Robert Stevens (Analytics consultant)
Download or read book Predictive Safety Analytics written by Robert Stevens (Analytics consultant) and published by . This book was released on 2023-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Nearly all our safety data collection and reporting systems are backward-looking: incident reports; dashboards; compliance monitoring systems, and so on. This book shows how we can use safety data in a forward-looking, predictive sense. Predictive Safety Analytics: Reducing Risk through Modeling and Machine Learning contains real use cases where organizations have reduced incidents by employing predictive analytics to foresee and mitigate future risks. It discusses how Predictive Safety Analytics is an opportunity to break through the plateau problem where safety rate improvements have stagnated in many organizations. The book presents how the use of data, coupled with advanced analytical techniques, including machine learning, has become a proven and successful innovation. Emphasis is placed on how the book can "meet you where you are" by illuminating a path to get there, starting with simple data the organization likely already has. A highlight of the book is the real examples and case studies that will assist in generating thoughts and ideas for what might work for individual readers and how they can adapt the information to their particular situations. The book is written for professionals and researchers in system reliability, risk and safety assessment, quality control, operational managers in selected industries, data scientists, and ML engineers. Students taking courses in these areas will also find this book of interest"--
Book Synopsis Predictive Policing and Artificial Intelligence by : John McDaniel
Download or read book Predictive Policing and Artificial Intelligence written by John McDaniel and published by Routledge. This book was released on 2021-02-25 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited text draws together the insights of numerous worldwide eminent academics to evaluate the condition of predictive policing and artificial intelligence (AI) as interlocked policy areas. Predictive and AI technologies are growing in prominence and at an unprecedented rate. Powerful digital crime mapping tools are being used to identify crime hotspots in real-time, as pattern-matching and search algorithms are sorting through huge police databases populated by growing volumes of data in an eff ort to identify people liable to experience (or commit) crime, places likely to host it, and variables associated with its solvability. Facial and vehicle recognition cameras are locating criminals as they move, while police services develop strategies informed by machine learning and other kinds of predictive analytics. Many of these innovations are features of modern policing in the UK, the US and Australia, among other jurisdictions. AI promises to reduce unnecessary labour, speed up various forms of police work, encourage police forces to more efficiently apportion their resources, and enable police officers to prevent crime and protect people from a variety of future harms. However, the promises of predictive and AI technologies and innovations do not always match reality. They often have significant weaknesses, come at a considerable cost and require challenging trade- off s to be made. Focusing on the UK, the US and Australia, this book explores themes of choice architecture, decision- making, human rights, accountability and the rule of law, as well as future uses of AI and predictive technologies in various policing contexts. The text contributes to ongoing debates on the benefits and biases of predictive algorithms, big data sets, machine learning systems, and broader policing strategies and challenges. Written in a clear and direct style, this book will appeal to students and scholars of policing, criminology, crime science, sociology, computer science, cognitive psychology and all those interested in the emergence of AI as a feature of contemporary policing.
Book Synopsis The Future of Pharmaceuticals by : Sarfaraz K. Niazi
Download or read book The Future of Pharmaceuticals written by Sarfaraz K. Niazi and published by CRC Press. This book was released on 2022-03-01 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Before now, biological systems could only be expressed in terms of linear relationships, however, as knowledge grows and new techniques of analysis on biological systems is made available, we are realizing the non-linearity of these systems. The concepts and techniques of nonlinear analysis allow for more realistic and accurate models in science. The Future of Pharmaceuticals: A Nonlinear Analysis provides an opportunity to understand the non-linearity of biological systems and its application in various areas of science, primarily pharmaceutical sciences. This book will benefit professionals in pharmaceutical industries, academia, and policy who are interested in an entirely new approach to how we will treat disease in the future. Key Features: Addresses a new approach of nonlinear analysis. Applies a theory of projection to chalk out the future, instead of basing on linear evolution. Provides an opportunity to better understand the non-linearity in biological systems and its applications in various areas of science, primarily pharmaceutical sciences. Helps change the thought process for those looking for answers to their questions which they do not find in the linear relationship approach. Encourages a broader perspective for the creative process of drug development.
Download or read book ICLAS Bulletin written by and published by . This book was released on 1988 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Predictive Policing by : Walt L. Perry
Download or read book Predictive Policing written by Walt L. Perry and published by Rand Corporation. This book was released on 2013-09-23 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Predictive policing is the use of analytical techniques to identify targets for police intervention with the goal of preventing crime, solving past crimes, or identifying potential offenders and victims. These tools are not a substitute for integrated approaches to policing, nor are they a crystal ball. This guide assesses some of the most promising technical tools and tactical approaches for acting on predictions in an effective way.
Book Synopsis Comprehensive Medicinal Chemistry by :
Download or read book Comprehensive Medicinal Chemistry written by and published by . This book was released on 1990 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Evaluation of the Shreveport Predictive Policing Experiment by : Priscillia Hunt
Download or read book Evaluation of the Shreveport Predictive Policing Experiment written by Priscillia Hunt and published by Rand Corporation. This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Even though there is a growing interest in predictive policing, to date there have been few, if any, formal evaluations of these programs. This report documents an assessment of a predictive policing effort in Shreveport, Louisiana, in 2012, which was conducted to evaluate the crime reduction effects of policing guided by statistical predictions. RAND researchers led multiple interviews and focus groups with the Shreveport Police Department throughout the course of the trial to document the implementation of the statistical predictive and prevention models. In addition to a basic assessment of the process, the report shows the crime impacts and costs directly attributable to the strategy. It is hoped that this will provide a fuller picture for police departments considering if and how a predictive policing strategy should be adopted. There was no statistically significant change in property crime in the experimental districts that applied the predictive models compared with the control districts; therefore, overall, the intervention was deemed to have no effect. There are both statistical and substantive possibilities to explain this null effect. In addition, it is likely that the predictive policing program did not cost any more than the status quo."--"Abstract" on web page.
Download or read book Lethal Laws written by Alix Fano and published by Zed Books. This book was released on 1997-05 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: For the last 150 years, industrial, agricultural and household chemicals have been tested on animals for the alleged purpose of protecting the public from their dangerous effects. Through a meticulous analysis of the technical and scientific problems that have plagued animal tests for decades, this book reveals that using animals as human surrogates is not only unethical, it is bad science.
Book Synopsis Predictive Modeling and Risk Assessment by : Rui Costa
Download or read book Predictive Modeling and Risk Assessment written by Rui Costa and published by Springer Science & Business Media. This book was released on 2008-12-02 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The single most important task of food scientists and the food industry as a whole is to ensure the safety of foods supplied to consumers. Recent trends in global food production, distribution and preparation call for increased emphasis on hygienic practices at all levels and for increased research in food safety in order to ensure a safer global food supply. The ISEKI-Food book series is a collection of books where various aspects of food safety and environmental issues are introduced and reviewed by scientists specializing in the field. In all of the books a special emp- sis was placed on including case studies applicable to each specific topic. The books are intended for graduate students and senior level undergraduate students as well as professionals and researchers interested in food safety and environmental issues applicable to food safety. The idea and planning of the books originates from two working groups in the European thematic network “ISEKI-Food” an acronym for “Integrating Safety and Environmental Knowledge In to Food Studies”. Participants in the ISEKI-Food network come from 29 countries in Europe and most of the institutes and univer- ties involved with Food Science education at the university level are represented. Some international companies and non teaching institutions have also participated in the program. The ISEKI-Food network is coordinated by Professor Cristina Silva at The Catholic University of Portugal, College of Biotechnology (Escola) in Porto. The program has a web site at: http://www. esb. ucp. pt/iseki/.
Author :National Aeronautics and Space Administration (NASA) Publisher :Createspace Independent Publishing Platform ISBN 13 :9781719397322 Total Pages :32 pages Book Rating :4.3/5 (973 download)
Book Synopsis Prospective Safety Analysis and the Complex Aviation System by : National Aeronautics and Space Administration (NASA)
Download or read book Prospective Safety Analysis and the Complex Aviation System written by National Aeronautics and Space Administration (NASA) and published by Createspace Independent Publishing Platform. This book was released on 2018-05-23 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fatal accident rates in commercial passenger aviation are at historic lows yet have plateaued and are not showing evidence of further safety advances. Modern aircraft accidents reflect both historic causal factors and new unexpected "Black Swan" events. The ever-increasing complexity of the aviation system, along with its associated technology and organizational relationships, provides fertile ground for fresh problems. It is important to take a proactive approach to aviation safety by working to identify novel causation mechanisms for future aviation accidents before they happen. Progress has been made in using of historic data to identify the telltale signals preceding aviation accidents and incidents, using the large repositories of discrete and continuous data on aircraft and air traffic control performance and information reported by front-line personnel. Nevertheless, the aviation community is increasingly embracing predictive approaches to aviation safety. The "prospective workshop" early assessment tool described in this paper represents an approach toward this prospective mindset-one that attempts to identify the future vectors of aviation and asks the question: "What haven't we considered in our current safety assessments?" New causation mechanisms threatening aviation safety will arise in the future because new (or revised) systems and procedures will have to be used under future contextual conditions that have not been properly anticipated. Many simulation models exist for demonstrating the safety cases of new operational concepts and technologies. However the results from such models can only be as valid as the accuracy and completeness of assumptions made about the future context in which the new operational concepts and/or technologies will be immersed. Of course that future has not happened yet. What is needed is a reasonably high-confidence description of the future operational context, capturing critical contextual characteristics that modulate both the likelihood of occurrence of hazards, and the likelihood that those hazards will lead to negative safety events. Heuristics extracted from scenarios, questionnaires, and observed trends from scanning the aviation horizon may be helpful in capturing those future changes in a way conducive to safety assessment. What is also needed is a checklist of potential sources of emerging risk that arise from organizational features that are frequently overlooked. The ultimate goal is to develop a pragmatic, workable method for using descriptions of the future aviation context, to generate valid predictions of safety risks. Smith, Brian E. Ames Research Center AIRCRAFT ACCIDENTS; COMMERCIAL AIRCRAFT; AIRCRAFT SAFETY; FLIGHT SAFETY; COMPLEX SYSTEMS; PREDICTIONS; RISK ASSESSMENT; AIR TRAFFIC CONTROL; HEURISTIC METHODS; AIRCRAFT HAZARDS; FLIGHT HAZARDS
Book Synopsis Journal of the Royal Society of Medicine by : Royal Society of Medicine (Great Britain)
Download or read book Journal of the Royal Society of Medicine written by Royal Society of Medicine (Great Britain) and published by . This book was released on 1987 with total page 972 pages. Available in PDF, EPUB and Kindle. Book excerpt: Includes selected papers from meetings of the Society and of its sections.
Book Synopsis Predictive Analytics by : Eric Siegel
Download or read book Predictive Analytics written by Eric Siegel and published by John Wiley & Sons. This book was released on 2016-01-13 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Mesmerizing & fascinating..." —The Seattle Post-Intelligencer "The Freakonomics of big data." —Stein Kretsinger, founding executive of Advertising.com Award-winning | Used by over 30 universities | Translated into 9 languages An introduction for everyone. In this rich, fascinating — surprisingly accessible — introduction, leading expert Eric Siegel reveals how predictive analytics (aka machine learning) works, and how it affects everyone every day. Rather than a “how to” for hands-on techies, the book serves lay readers and experts alike by covering new case studies and the latest state-of-the-art techniques. Prediction is booming. It reinvents industries and runs the world. Companies, governments, law enforcement, hospitals, and universities are seizing upon the power. These institutions predict whether you're going to click, buy, lie, or die. Why? For good reason: predicting human behavior combats risk, boosts sales, fortifies healthcare, streamlines manufacturing, conquers spam, optimizes social networks, toughens crime fighting, and wins elections. How? Prediction is powered by the world's most potent, flourishing unnatural resource: data. Accumulated in large part as the by-product of routine tasks, data is the unsalted, flavorless residue deposited en masse as organizations churn away. Surprise! This heap of refuse is a gold mine. Big data embodies an extraordinary wealth of experience from which to learn. Predictive analytics (aka machine learning) unleashes the power of data. With this technology, the computer literally learns from data how to predict the future behavior of individuals. Perfect prediction is not possible, but putting odds on the future drives millions of decisions more effectively, determining whom to call, mail, investigate, incarcerate, set up on a date, or medicate. In this lucid, captivating introduction — now in its Revised and Updated edition — former Columbia University professor and Predictive Analytics World founder Eric Siegel reveals the power and perils of prediction: What type of mortgage risk Chase Bank predicted before the recession. Predicting which people will drop out of school, cancel a subscription, or get divorced before they even know it themselves. Why early retirement predicts a shorter life expectancy and vegetarians miss fewer flights. Five reasons why organizations predict death — including one health insurance company. How U.S. Bank and Obama for America calculated the way to most strongly persuade each individual. Why the NSA wants all your data: machine learning supercomputers to fight terrorism. How IBM's Watson computer used predictive modeling to answer questions and beat the human champs on TV's Jeopardy! How companies ascertain untold, private truths — how Target figures out you're pregnant and Hewlett-Packard deduces you're about to quit your job. How judges and parole boards rely on crime-predicting computers to decide how long convicts remain in prison. 182 examples from Airbnb, the BBC, Citibank, ConEd, Facebook, Ford, Google, the IRS, LinkedIn, Match.com, MTV, Netflix, PayPal, Pfizer, Spotify, Uber, UPS, Wikipedia, and more. How does predictive analytics work? This jam-packed book satisfies by demystifying the intriguing science under the hood. For future hands-on practitioners pursuing a career in the field, it sets a strong foundation, delivers the prerequisite knowledge, and whets your appetite for more. A truly omnipresent science, predictive analytics constantly affects our daily lives. Whether you are a consumer of it — or consumed by it — get a handle on the power of Predictive Analytics.
Book Synopsis Whitaker's Cumulative Book List by :
Download or read book Whitaker's Cumulative Book List written by and published by . This book was released on 1986 with total page 1436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis World Review of Nutrition and Dietetics by : Artemis P. Simopoulos
Download or read book World Review of Nutrition and Dietetics written by Artemis P. Simopoulos and published by . This book was released on 1959 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
