The Extracellular Matrix and Ground Regulation

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Publisher : North Atlantic Books
ISBN 13 : 1556436882
Total Pages : 233 pages
Book Rating : 4.5/5 (564 download)

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Book Synopsis The Extracellular Matrix and Ground Regulation by : Alfred Pischinger

Download or read book The Extracellular Matrix and Ground Regulation written by Alfred Pischinger and published by North Atlantic Books. This book was released on 2007-07-17 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: The workings of the suitable environment for cells—called the extracellular matrix (ECM) and ground regulation—has occupied the European medical tradition since the early part of the 20th century. As it has become more clear that the origin of disease and its first signals register in the connective tissue, or myofascia, cellular pathologists and biochemists have sought to circumscribe networks of cell communication and microcirculation in the ECM. Alfred Pischinger (1899-1982) continued this line of work by further studying, in work published from 1926 through the late seventies, the connections of the ECM to the hormonal and autonomic systems. In the last twenty years Professor and Doctor of Natural Sciences Hartmut Heine and his colleagues have carried on Pischinger’s work, here summarized in one volume. Part One encompasses theoretical underpinnings; Parts Two and Three address applications and directions for further research. This updated English-language translation not only is an account of the work of Pischinger’s successors—Heine, Otto Bergsmann, and Felix Perger, (the three editors of this volume) and their many colleagues—but notes the positive development of complementary therapies based on this understanding of histology. Acupuncture is referenced directly. Both in Europe and the States the work of manual therapists, including Rolfers, cranio- sacral therapists, and other somatic disciplines have been informed for many years by Pischinger’s outsider model of how changes in the EMC register in the central nervous system and the brain, and are conveyed back to the periphery and connected organs. Heine’s exciting recent work shows that the regulation and construction of the ECM have relationships to cybernetic non-linear systems and phase transitions.

The Extracellular Matrix: an Overview

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Publisher : Springer Science & Business Media
ISBN 13 : 3642165559
Total Pages : 429 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis The Extracellular Matrix: an Overview by : Robert Mecham

Download or read book The Extracellular Matrix: an Overview written by Robert Mecham and published by Springer Science & Business Media. This book was released on 2011-02-16 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Extracellular Matrix

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Publisher : CRC Press
ISBN 13 : 9783718658428
Total Pages : 494 pages
Book Rating : 4.6/5 (584 download)

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Book Synopsis Extracellular Matrix by : W.D. Comper

Download or read book Extracellular Matrix written by W.D. Comper and published by CRC Press. This book was released on 1996-06-30 with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt: Looking at the area of the extracellular matrix of connective tissue, including the results and concepts which have recently been generated, this text describes the structural characteristics of extracellular molecules and discusses the interaction between the cell and the extracellular matrix.

The Extracellular Matrix: an Overview

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Publisher : Springer
ISBN 13 : 9783642165566
Total Pages : 426 pages
Book Rating : 4.1/5 (655 download)

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Book Synopsis The Extracellular Matrix: an Overview by : Robert Mecham

Download or read book The Extracellular Matrix: an Overview written by Robert Mecham and published by Springer. This book was released on 2011-03-25 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Molecular Biology of the Cell

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Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Extracellular Matrix

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Publisher : Elsevier
ISBN 13 : 0323150411
Total Pages : 437 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Extracellular Matrix by : Susan Hawkes

Download or read book Extracellular Matrix written by Susan Hawkes and published by Elsevier. This book was released on 2012-12-02 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular Matrix contains the proceedings of the symposium ""The Extracellular Matrix,"" sponsored by the Michigan Molecular Institute and held in Midland, Michigan, on June 28-July 2, 1982. The papers explore the role played by the extracellular matrix (ECM) in the physiology of a cell, particularly in the regulation of cellular phenotypes, differentiation, and proliferation. The progress made in isolating and defining the chemistry and functional interactions of the ECM components is discussed, along with the biology of the ECM. This book is comprised of 52 chapters and begins with an introduction to the ECM, with emphasis on the question of whether the malignant process can be defined in a cell culture model, and in particular, whether the pericellular matrix is characteristically altered in cancer. The discussion then turns to the structure of the heparan sulfate proteoglycans and the molecular mechanisms responsible for the association of these molecules with the surfaces of cultured cells. Subsequent chapters focus on the chemistry of ECM components such as collagen, glycosaminoglycans, and adhesive glycoproteins, along with their functional interactions, biosynthesis, turnover, and degradation. The final section is devoted to the diseased states of ECM. This monograph should serve as a valuable reference for biochemists as well as undergraduate and graduate students of biochemistry.

Holistic Medicine and the Extracellular Matrix

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Publisher : Simon and Schuster
ISBN 13 : 1644112957
Total Pages : 315 pages
Book Rating : 4.6/5 (441 download)

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Book Synopsis Holistic Medicine and the Extracellular Matrix by : Matthew Wood

Download or read book Holistic Medicine and the Extracellular Matrix written by Matthew Wood and published by Simon and Schuster. This book was released on 2021-09-28 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: • Examines the function of the extracellular matrix, the inner ocean that unifies all our cells and controls them in a coordinated and integrated fashion • Explores how the extracellular matrix builds and repairs itself and how holistic therapy can be applied based on this knowledge • Introduces new and old holistic and herbal protocols for treatment of the matrix The cells in our bodies are not independent units. They do not control their own feeding, elimination, migration, or reproduction; they are controlled by signals from the extracellular matrix (ECM) that surrounds them. This all-encompassing inner ocean unifies all our cells and controls them in a coordinated and integrated fashion. Revealing the stunning implications of the extracellular matrix, Matthew Wood shows how it clearly explains the actions and efficacy of holistic therapies. He explores the groundbreaking research of Alfred Pischinger, who discovered the ECM in 1975, as well as the role of the matrix in transmitting and enacting the genetic code, including the roles of the mitochondria, the nucleus, and ribosomes. Wood explains how modern drugs, directed at specific receptors on the cell membrane, interfere with bodily self-regulation. He details how holistic therapies modify the environment of the cell and strengthen the whole, bringing the body back to homeostasis and consequently offering true healing.

Extracellular Matrix: Pathobiology and Signaling

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Author :
Publisher : Walter de Gruyter
ISBN 13 : 3110258773
Total Pages : 940 pages
Book Rating : 4.1/5 (12 download)

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Book Synopsis Extracellular Matrix: Pathobiology and Signaling by : Nikos Karamanos

Download or read book Extracellular Matrix: Pathobiology and Signaling written by Nikos Karamanos and published by Walter de Gruyter. This book was released on 2012-08-31 with total page 940 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last decades cell biology and biological chemistry have increasingly turned their attention to the space between cells and revealed an elaborate network of macromolecules essential for structural support, cell adhesion and signaling. This comprehensive handbook of the extracellular matrix will give an overview of the current state of knowledge of matrix components (structure and function), their role in heath and disease (matrix pathobiology) and new aspects related to pharmacological targeting. It will provide an introduction to the extracellular matrix and detailed sections and chapters on: Importance of extracellular matrix in health and disease Matrix proteoglycans (aggrecan, versican, perlecan, SLRPs, syndecans, glypicans, serglycin) Matrix proteinases (remodeling, would healing, regulatory roles in health and disease, metalloproteinases, cystein proteases, plasmin and plasminogen activator system) Glycobiology (hyaluronan and sulfated glycosaminoglycans in cancer, inflammation and metabolic control) Collagens (supramolecular assembly, proteins binding collagen, scaffolds, bacterial and mutated collagens, procollagen proteinases) Cell surface receptors (integrins, syndecans, mechanical strain and TGFb, CD44 and DDR). Biotechnological and pharmacological outlook (matrix regulation by growth factors, hyaluronidases, pathobiology, disease targeting, delivery systems, EMT and proteomics). "The book Extracellular Matrix: Pathobiology and Signaling provides a comprehensive and up to date collection of very relevant topics for understanding the various facets of extracellular matrix and its interactions with cells in normal tissue as well as in disease. It represents the current front-line and will serve as a reference for extracellular matrix and posttranslational modifications." Dick Heinegård, Department of Clinical Sciences Lund, Section Rheumatology, Lund University, Sweden

Extracellular Matrix Degradation

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Publisher : Springer Science & Business Media
ISBN 13 : 3642168612
Total Pages : 262 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Extracellular Matrix Degradation by : William C. Parks

Download or read book Extracellular Matrix Degradation written by William C. Parks and published by Springer Science & Business Media. This book was released on 2011-04-07 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regulated turnover of extracellular matrix (ECM) is an important component of tissue homeostasis. In recent years, the enzymes that participate in, and control ECM turnover have been the focus of research that touches on development, tissue remodeling, inflammation and disease. This volume in the Biology of Extracellular Matrix series provides a review of the known classes of proteases that degrade ECM both outside and inside the cell. The specific EMC proteases that are discussed include cathepsins, bacterial collagenases, matrix metalloproteinases, meprins, serine proteases, and elastases. The volume also discusses the domains responsible for specific biochemical characteristics of the proteases and the physical interactions that occur when the protease interacts with substrate. The topics covered in this volume provide an important context for understanding the role that matrix-degrading proteases play in normal tissue remodeling and in diseases such as cancer and lung disease.

Composition and Function of the Extracellular Matrix in the Human Body

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 9535124153
Total Pages : 376 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Composition and Function of the Extracellular Matrix in the Human Body by : Francesco Travascio

Download or read book Composition and Function of the Extracellular Matrix in the Human Body written by Francesco Travascio and published by BoD – Books on Demand. This book was released on 2016-06-15 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.

Organization of the Extracellular Matrix

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Publisher : CRC Press
ISBN 13 : 1351083732
Total Pages : 295 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Organization of the Extracellular Matrix by : Laszlo Modis

Download or read book Organization of the Extracellular Matrix written by Laszlo Modis and published by CRC Press. This book was released on 2018-05-04 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes analysis techniques and results of topics such as physical backgrounds, chemical backgrounds, and principal methods of topo-optical reactions used in ultrastructure research of the ECM; orientation patterns of GAGs and collagen in different tissues/cartilage, cornea, kidney basement membranes, and skin; factors involved in the formation of submicroscopically ordered matrix structure; and cell-matrix interactions, including cytoskeleton-cell-membrane-matrix relationships. A summarization of the advantages and limitations of polarization microscopy compared to electron microscopy in ultracellular research is also included. Cell biologists, histologists, pathologists, and biochemists in connective tissue research will find this book to be an invaluable reference tool.

Extracellular Matrix Protocols

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Publisher : Springer Science & Business Media
ISBN 13 : 1592590632
Total Pages : 370 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Extracellular Matrix Protocols by : Charles Streuli

Download or read book Extracellular Matrix Protocols written by Charles Streuli and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now widely accepted that much of the dynamic function of cells and tissues is regulated from outside the cell by the extracellular matrix. In ad- tion to its conventional role in providing a scaffold for building tissues, the extracellular matrix acts as a directional highway for cellular movement and provides instructional information for promoting survival, proliferation, and differentiation. Indeed, the extracellular matrix is beginning to take a starring role in the choreography of cell and tissue function. The diverse roles of the extracellular matrix are reflected in its highly complicated structure, consisting of an ever increasing number of components. Yet the mechanisms of extracellular matrix assembly and how they influences cell behavior are only just beginning to be understood. In order to solve these problems new methodologies are, of necessity, being developed. Many of these technologies are highly sophisticated and are currently available only in a ha- ful of laboratories. However, we believe that they can readily be transported and established by other researchers. Thus, the purpose of Extracellular Matrix Protocols is to present some of these complicated techniques in a style that is relatively easy to reproduce.

Neuropeptides

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Publisher : MIT Press
ISBN 13 : 9780262194075
Total Pages : 678 pages
Book Rating : 4.1/5 (94 download)

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Book Synopsis Neuropeptides by : Fleur L. Strand

Download or read book Neuropeptides written by Fleur L. Strand and published by MIT Press. This book was released on 1999 with total page 678 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. In recent years there has been increasing interest and, subsequently, active research in neuropeptides. These neuroactive molecules coordinate, integrate, and regulate physiological processes in all organisms, throughout all phases of development. Acting as neurohormones, neurotransmitters, and/or neuromodulators, they maintain physiological homeostasis and influence important behavioral patterns. This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner. The book is divided into two parts. In Part I the author defines the basic principles of neuropeptide action, including their biosynthesis, processing, transport, distribution, and interactions with receptors and second messenger systems. Strand also discusses the intimate interaction between the neuropeptides, stress, and the immune system. In Part II she discusses the regulatory functions of the families of neuropeptide in sufficient detail to provide both the advanced student and senior investigator with a thorough understanding of the most important neuropeptides. The text also contains a complete and up-to-date reference/reading list.

Extracellular Matrix Influences on Gene Expression

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Publisher :
ISBN 13 :
Total Pages : 888 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Extracellular Matrix Influences on Gene Expression by : Harold C. Slavkin

Download or read book Extracellular Matrix Influences on Gene Expression written by Harold C. Slavkin and published by . This book was released on 1975 with total page 888 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular matrix influences on gene expression; Chromosomal and extrachromosomal influences upon transcription; Translational and post-translational regulation during development; Regulation of extracellular matrix macromolecular biosynthesis; Regulation of tissue-specific collagen synthesis; Extracellular matrix macromolecules; Outer cell surface specificities and cell interactions; Epithelial-mesenchymal interactions; Extracellular matrix influences on gene expression; Matrix-cell and cell-matrix interactions and mineralization processes; Aberrations in developmental processes.

Evolution of Extracellular Matrix

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Publisher : Springer Science & Business Media
ISBN 13 : 3642360025
Total Pages : 297 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Evolution of Extracellular Matrix by : Fred W. Keeley

Download or read book Evolution of Extracellular Matrix written by Fred W. Keeley and published by Springer Science & Business Media. This book was released on 2013-03-15 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function. This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed.

Cell Shape & Integrins

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Publisher :
ISBN 13 :
Total Pages : 432 pages
Book Rating : 4.:/5 (375 download)

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Book Synopsis Cell Shape & Integrins by : Christopher Sao Bing Chen

Download or read book Cell Shape & Integrins written by Christopher Sao Bing Chen and published by . This book was released on 1997 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Anatomy and Physiology

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Publisher :
ISBN 13 : 9781947172807
Total Pages : 0 pages
Book Rating : 4.1/5 (728 download)

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Book Synopsis Anatomy and Physiology by : J. Gordon Betts

Download or read book Anatomy and Physiology written by J. Gordon Betts and published by . This book was released on 2013-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: