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The Effect Of A Simulated Subarachnoid Hemorrhage On Cerebral Blood Flow In The Monkey
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Book Synopsis The Effect of a Simulated Subarachnoid Hemorrhage on Cerebral Blood Flow in The Monkey by : A. N. Martins
Download or read book The Effect of a Simulated Subarachnoid Hemorrhage on Cerebral Blood Flow in The Monkey written by A. N. Martins and published by . This book was released on 1976 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hydrogen clearance method was used to measure local and total cerebral blood flow (CBF) in the rhesus monkey before and for 5 hours after a simulated subarachnoid hemorrhage (SAH). CBF remained stable after SAH unless SAH was associated with a fall in cerebral perfusion pressure. In addition, cerebrovascular resistance did not increase after SAH. These results suggest that vasoactive agents in fresh whole blood, and the arterial spasm they produce when added to cerebrospinal fluid, play only a limited role in the pathogenesis of ischemic encephalopathy that follows an SAH. (Author).
Book Synopsis The Effect of Intracisternal Phentolamine on Cerebral Blood Flow After Simulated Subarachnoid Hemorrhage by : A. N. Martins
Download or read book The Effect of Intracisternal Phentolamine on Cerebral Blood Flow After Simulated Subarachnoid Hemorrhage written by A. N. Martins and published by . This book was released on 1975 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hydrogen clearance method was used to measure total and focal blood flow (CBF) in the monkey before and for 5 hours after a simulated subarachnoid hemorrhage (SAH). Some monkeys also received 0.2-1.0 mg/kg phentolamine intracisternally 3 hours after SAH. SAH did not change cerebrovascular resistance, but as cerebral perfusion pressure decreased, CBF fell transiently. Phentolamine injected intracisternally 3 hours after SAH produced a significant fall in arterial blood pressure; cerebrovascular resistance did not change but CBF decreased significantly. These data indicate that, contrary to expectation, intracisternal phentolamine cannot be considered potentially useful to treat ischemic encephalopathy after SAH. (Author).
Book Synopsis Regional Cerebral Blood Flow Autoregulation and Cerebral Vasospasm in Monkeys with Subarachnoid Hemorrhage by : Donald P. J. Boisvert
Download or read book Regional Cerebral Blood Flow Autoregulation and Cerebral Vasospasm in Monkeys with Subarachnoid Hemorrhage written by Donald P. J. Boisvert and published by . This book was released on 1978 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regional cerebral blood flow measurements (intra-arterial Xenon technique) and cerebral angiography were performed in two series of macaque monkeys. Cerebral blood flow autoregulatory and arterial caliber responses to increases in mean arterial blood pressure (MaBP) were studied before and during the acute period following induced subarachnoid hemorrhage or mock subarachnoid hemorrhage (subarachnoid injection of artificial cerebrospinal fluid) in rhesus monkeys. A comparative study of the acute effects of subarachnoid injections of artificial cerebrospinal fluid, serotonin and blood on regional cerebral blood flow, cerebral arterial caliber, neurological status and cerebral vessel ultrastructure was carried out in cynmolgous monkeys. Regional cerebral blood flow autoregulatory responses to increases in MaBP were impaired following subarachnoid hemorrhage. Autoregulatory impairment was associated with loss of cerebral arterial vasomotor tone. Mock subarachnoid hemorrhage had no effect on autoregulation or vasomotor tone. Subarachnoid injection of blood in cynmolgous monkeys caused a decrease in cerebral blood flow lasting less than one hour and moderate vasospasm which lasted at least three hours. In contrast, subarachnoid injection of artificial cerebrospinal fluid had no effect on these parameters. Subarachnoid injection of a serotonin solution at physiological concentrations (as determined by in-vitro bioassay) was also made without effect on cerebral blood flow or arterial caliber. Higher (lOx) serotonin concentrations caused a cerebral blood flow response similar to that obtained with blood. However, the cerebral vasospasm induced was of shorter duration than that obtained with blood. No significant neurological effect of these subarachnoid injections was observed during the 16 to 18 hour period following reversal of anesthesia. Animals with moderate vasospasm demonstrated no ultrastructural changes in cerebral arteries, arterioles and capillaries. These results support the following conclusions: (1) Cerebral flow regulatory mechanisms play an important role in determining cerebral perfusion status following subarachnoid hemorrhage. (2) Moderate vasospasm does not impair cerebral perfusion in the presence of normal cerebral perfusion pressure and arterial blood gases. (3) Unphysiologically high concentrations of serotonin are required to produce significant effects on the cerebral ci rcu'l at ion. (4) Development of post-SAH cerebral edema is at least partly due to the duration of intracranial hypertension which occurs during hemorrhage from a ruptured cerebral aneurysm.
Book Synopsis The Pathophysiology and Treatment of Subarachnoid Hemorrhage in the Cynomolgus Monkey by : William Legget Richie
Download or read book The Pathophysiology and Treatment of Subarachnoid Hemorrhage in the Cynomolgus Monkey written by William Legget Richie and published by . This book was released on 1979 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The effect of a treatment regime comprising hypertension induced with dopamine/ volume expansion using autologous blood and human serum albumin, and ventilatory support on the pathophysiology of subarachnoid hemorrhage (SAH) in a cynomolgus monkey model has been studied. Two experimental groups, a pilot group and main treatment group with a total of 22 monxeys are reported. The animals from the main treatment group with SAH are compared with a comparable group of 5 animals previously studied in this laboratory. Cerebral blood flow (CBF)# vessel calibre, intracranial pressure (ICP) and other pertinent physiologic parameters has been measured during all experiments. Besults reveal a significant improvement in morbidity and mortality of the animals treated post-SAH compared to the untreated group. The improved survival is associated with return of CBF and vessel calibre towards pre-SAH levels. The contribution of each treatment parameter to the overall efficacy of the treatment regime is not demonstrated in the study. Linear regression analysis of vessel calibre in relation to CBF reveals a poor fit, despite adjusting for changes in blood pressure, central venous pressure, and ICP. This supports the hypothesis that microvascular changes have a major role in the control of CBF post-SAH when moderate vasospasm (30 - 35%) is present. Despite the increased CBF in the treatment group compared to the ''control" group* an increase in cerebral perfusion pressure with treatment compared to the "control" group jls not seen. This suggest that the benefit of the treatment regime may be the result of positive inotropic effects on the heart or a local effect on the cerebra-i vasculature. The significant contribution of ventilation to the overall survival is acknowledged.
Download or read book Cerebrovascular Bibliography written by and published by . This book was released on 1976-04 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Intracranial Aneurysms by : J.L. Fox
Download or read book Intracranial Aneurysms written by J.L. Fox and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 913 pages. Available in PDF, EPUB and Kindle. Book excerpt: Professor Fox has undertaken the monumental In his Preface, Dr. Fox has quoted Cannon task of compiling the available data on intracra and Rosenblueth in questioning where to stop nial arterial aneurysms. The magnitude and ex the record. One can only document progress tent of the undertaking attest to the tremen to date-and certainly the advances in this field dous amount of information which has are noteworthy-and then make some cau accumulated in the past few decades and to tious predictions for the future. They have cor the accelerated pace at which the field has ex rectly made note that the overall morbidity panded, particularly since the end of World and mortality of these aneurysm patients re War II. mains unacceptably high, largely as a result of Our heritage can be traced to many sources, the secondary complications of the subarach among whom should be mentioned such nota noid hemorrhage itself. More attention should bles as Willis, Quincke, Blackall, Moniz, Dott, be directed in the future to the recognition of Dandy, Hounsfield, and others. The modern era those patients with unruptured aneurysms and includes a number of investigators and clini those with minimal bleeds. Hopefully infor cians, some of whom have contributed to this mation will be forthcoming as to which indi magnificent tome. The bibliography of over viduals are at risk because of some unusual con 4000 references represents the increasing in genital, metabolic, or acquired defect.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1840 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Vascular Mechanisms in CNS Trauma by : Eng H. Lo
Download or read book Vascular Mechanisms in CNS Trauma written by Eng H. Lo and published by Springer Science & Business Media. This book was released on 2013-11-04 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: While there are a number of books on the market that deal with neuronal mechanisms and targets, the proposed book will be the only one to cover the vascular aspects of CNS trauma. The contributing authors will present basic mechanisms, explain cutting-edge experimental models and techniques, and provide several clinical chapters that provide treating physicians with some insight on the cases that they see in the ICU. The table of contents is diverse and comprehensive with chapters on molecular mechanisms, physiology, pharmacology, stem cells, genomics and proteomics, in vivo MRI and PET, as well as the clinical management of vascular parameters.
Book Synopsis Nuclear medicine by : United States. Department of Energy. Technical Information Center
Download or read book Nuclear medicine written by United States. Department of Energy. Technical Information Center and published by . This book was released on 1980 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Annual Research Report 1 July 1974-30 June 1975 by : ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD.
Download or read book Annual Research Report 1 July 1974-30 June 1975 written by ARMED FORCES RADIOBIOLOGY RESEARCH INST BETHESDA MD. and published by . This book was released on 1975 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: ;Contents: Mitigation of graft versus host disease in lethally irradiated mice grafted with spleen cells adherent to glass beads; Studies on the distribution and metabolism of cyclotrimethylene-trinitramine in the rat and in the miniature swine; Serum protein-bound carbohydrates and neurogenic tumors; A method of localization for radionuclide bone imaging in the mandible; Acute radiation sickness--The prodromal syndrome. An annotated bibliography; The effect of a simulated subarachnoid hemorrhage on cerebral blood flow in the monkey; Kinematics of knee motion during a simulated car crash; Immunoenhancement and neural oncogenesis; Depression of dopamine release during the ethanol withdrawal syndrome; Nonexchangeable water in rat skeletal muscle; Monkey brain damage from radiation in the therapeutic range.
Book Synopsis An Introductory Guide to EC Competition Law and Practice by : Valentine Korah
Download or read book An Introductory Guide to EC Competition Law and Practice written by Valentine Korah and published by . This book was released on 1994 with total page 2354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Government Reports Announcements & Index by :
Download or read book Government Reports Announcements & Index written by and published by . This book was released on 1976 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis JNM. Journal of Nuclear Medicine by :
Download or read book JNM. Journal of Nuclear Medicine written by and published by . This book was released on 1976 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Neurocardiology by : Ralph Hudson Johnson
Download or read book Neurocardiology written by Ralph Hudson Johnson and published by W.B. Saunders Company. This book was released on 1984 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book ERDA Energy Research Abstracts written by and published by . This book was released on 1977 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :United States. Energy Research and Development Administration. Technical Information Center Publisher : ISBN 13 : Total Pages :1680 pages Book Rating :4.3/5 (129 download)
Book Synopsis ERDA Energy Research Abstracts by : United States. Energy Research and Development Administration. Technical Information Center
Download or read book ERDA Energy Research Abstracts written by United States. Energy Research and Development Administration. Technical Information Center and published by . This book was released on 1977 with total page 1680 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research Awards Index written by and published by . This book was released on 1987 with total page 834 pages. Available in PDF, EPUB and Kindle. Book excerpt:
