The Developmental Neurotoxicity of Lead

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Publisher : Springer Science & Business Media
ISBN 13 : 9400955944
Total Pages : 161 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis The Developmental Neurotoxicity of Lead by : C. Winder

Download or read book The Developmental Neurotoxicity of Lead written by C. Winder and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two millennia environmental lead levels have risen dramatically (Patterson, 1980). Most of this increase has occurred since the beginning of the present century (Murozami et 01. , 1969), and taken into perspective, a typical individual living in the industrialized world sustains a lead burden 500 times that of his prehistoric ancestors (Patterson, 1983). Lead is unique in being an environmental pollutant where the levels deemed clinically toxic are less than an order of magnitude from those that are normally encountered in the population. The clinical limit for lead exposure, 70 JLg Pb/tOO ml blood, is about three times the 'normal' value (in the range 15-30 JLg Pb/100ml blood). This small difference is remarkable from the toxicological standpoint. The key concept here is control of dis persal. The industrial actions of man bring contact with a wide variety of substances, some of which are poisonous or dangerous. In such cases pro tective measures are taken to keep hazardous exposure to a minimum. In the of lead compounds, stringent regulations are production and distribution enforced. The exception to this is in the dispersal of lead from vehicle exhausts following purchase from the petrol pump. Perhaps man's long standing acquaintance with lead in home and industry is responsible for a complacency which until only recently has been unquestioned. Beginning in the late 1960s, evidence began to accumulate suggesting that lead at relatively low levels of exposure might be causing negative effects on neurobiological function.

Lead Toxicity

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Publisher :
ISBN 13 :
Total Pages : 60 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Lead Toxicity by : Sarah E. Royce

Download or read book Lead Toxicity written by Sarah E. Royce and published by . This book was released on 2000 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Environmental Neurotoxicology

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Publisher : National Academies Press
ISBN 13 : 0309045312
Total Pages : 167 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Environmental Neurotoxicology by : National Research Council

Download or read book Environmental Neurotoxicology written by National Research Council and published by National Academies Press. This book was released on 1992-02-01 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.

Developmental Neurotoxicity of Low Levels of Lead

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Publisher :
ISBN 13 :
Total Pages : 246 pages
Book Rating : 4.:/5 (381 download)

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Book Synopsis Developmental Neurotoxicity of Low Levels of Lead by : Nabil A. Bourjeily

Download or read book Developmental Neurotoxicity of Low Levels of Lead written by Nabil A. Bourjeily and published by . This book was released on 1997 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Developmental Neurotoxicology

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Publisher : Academic Press
ISBN 13 : 0128093943
Total Pages : 618 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Handbook of Developmental Neurotoxicology by : William Slikker Jr.

Download or read book Handbook of Developmental Neurotoxicology written by William Slikker Jr. and published by Academic Press. This book was released on 2018-01-04 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Developmental Neurotoxicology, Second Edition, provides a comprehensive view of the fundamental aspects of neurodevelopment, the pathways and agents that affect them, relevant clinical syndromes, and risk assessment procedures for developmental neurotoxicants. The editors and chapter authors are internationally recognized experts whose collaboration heralds a remarkable advance in the field, bridging developmental neuroscience with the principles of neurotoxicology. The book features eight new chapters with newly recruited authors, making it an essential text for students and professionals in toxicology, neurotoxicology, developmental biology, pharmacology, and neuroscience. Presents a comprehensive, up-to-date resource on developmental neurotoxicology with updated chapters from the first edition Contains new chapters that focus on subjects recent to the field Includes well-illustrated material, with diagrams, charts, and tables Contains compelling case studies and chapters written by world experts

Lead: Its Effects on Environment and Health

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Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110434334
Total Pages : 596 pages
Book Rating : 4.1/5 (14 download)

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Book Synopsis Lead: Its Effects on Environment and Health by : Astrid Sigel

Download or read book Lead: Its Effects on Environment and Health written by Astrid Sigel and published by Walter de Gruyter GmbH & Co KG. This book was released on 2017-04-10 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 17, entitled Lead: Its Effects on Environment and Health of the series Metal Ions in Life Sciences centers on the interrelations between biosystems and lead. The book provides an up-to-date review of the bioinorganic chemistry of this metal and its ions; it covers the biogeochemistry of lead, its use (not only as gasoline additive) and anthropogenic release into the environment, its cycling and speciation in the atmosphere, in waters, soils, and sediments, and also in mammalian organs. The analytical tools to determine and to quantify this toxic element in blood, saliva, urine, hair, etc. are described. The properties of lead(II) complexes formed with amino acids, peptides, proteins (including metallothioneins), nucleobases, nucleotides, nucleic acids, and other ligands of biological relevance are summarized for the solid state and for aqueous solutions as well. All this is important for obtaining a coherent picture on the properties of lead, its effects on plants and toxic actions on mammalian organs. This and more is treated in an authoritative and timely manner in the 16 stimulating chapters of Volume 17, which are written by 36 internationally recognized experts from 13 nations. The impact of this recently again vibrant research area is manifested in nearly 2000 references, over 50 tables and more than 100 illustrations (half in color). Lead: Its Effects on Environment and Health is an essential resource for scientists working in the wide range from material sciences, inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching.

Human Lead Exposure

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Publisher : CRC Press
ISBN 13 : 9780849360343
Total Pages : 314 pages
Book Rating : 4.3/5 (63 download)

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Book Synopsis Human Lead Exposure by : Herbert L. Needleman

Download or read book Human Lead Exposure written by Herbert L. Needleman and published by CRC Press. This book was released on 1991-12-07 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Lead Exposure consists of scientific reviews and important contributions intended to increase the understanding of the legal, social, and economic forces that have delayed effective prevention of lead toxicity. Chapters discuss the history (both ancient and recent) of lead, explore its neurobiology and toxicology, review the sources and routes to humans, and examine evidence that indicates that lead may affect humans at levels previously thought to be harmless. Neurobiologists, epidemiologists, public health officials, and others concerned about the effects of lead on the human population will find a tremendous amount of useful information in this timely volume.

Toxicological Profile for Lead

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Publisher :
ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicological Profile for Lead by :

Download or read book Toxicological Profile for Lead written by and published by . This book was released on 2007 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Methylmercury and Neurotoxicity

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Publisher : Springer Science & Business Media
ISBN 13 : 146142383X
Total Pages : 375 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Methylmercury and Neurotoxicity by : Sandra Ceccatelli

Download or read book Methylmercury and Neurotoxicity written by Sandra Ceccatelli and published by Springer Science & Business Media. This book was released on 2012-03-23 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mercury (Hg) is a global pollutant that knows no environmental boundaries. Even the most stringent control of anthropogenic Hg sources will not eliminate exposure given its ubiquitous presence. Exposure to Hg occurs primarily via the food chain due to MeHg’s accumulation in fish. Latest US statistics indicate that 46 States have fish consumption advisories. In addition, Hg is a common pollutant in hazardous waste sites, with an estimated 3-4 million children living within one mile of at least one of the 1,300+ active hazardous waste sites in the US. The effects on intellectual function in children prenatally exposed to MeHg via maternal fish consumption have been the subject of two on-going major, prospective, longitudinal studies in the Seychelles and the Faroe Islands. It is important to recognize that the risk for MeHg exposure is not limited only to islanders with high fish consumption. This book will provide state-of-the-art information to the graduate student training in toxicology, risk assessors, researchers and medical providers at large. It is aimed to bring the reader up to date on contemporary issues associated with exposure to methylmercury, from its effects on stem cells and neurons to population studies.

Pediatric Neurotoxicology

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Publisher : Springer
ISBN 13 : 331932358X
Total Pages : 205 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Pediatric Neurotoxicology by : Cynthia A. Riccio

Download or read book Pediatric Neurotoxicology written by Cynthia A. Riccio and published by Springer. This book was released on 2016-08-10 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on children and the impact of neurotoxins on the developing brain to guide the practice of psychologists working with children in clinical and school settings. Each chapter covers a distinct neurotoxin or group of neurotoxins, with particular emphasis on the impact of the neurotoxin exposure on the developing brain and long-term cognitive and psychosocial outcomes. This is more complex than studying neurotoxins with adults because of the rapid development occurring in the child's brain. Further, children are more susceptible than adults to the effects of neurotoxins due to their developmental status. Many of the effects discussed in this volume occur in utero, thus setting the stage for an altered developmental trajectory.

Environmental Toxicants

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Publisher : John Wiley & Sons
ISBN 13 : 0470442883
Total Pages : 1189 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Environmental Toxicants by : Morton Lippmann

Download or read book Environmental Toxicants written by Morton Lippmann and published by John Wiley & Sons. This book was released on 2009-03-26 with total page 1189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides the most current information and research available for performing risk assessments on exposed individuals and populations, giving guidance to public health authorities, primary care physicians, and industrial managers Reviews current knowledge on human exposure to selected chemical agents and physical factors in the ambient environment Updates and revises the previous edition, in light of current scientific literature and its significance to public health concerns Includes new chapters on: airline cabin exposures, arsenic, endocrine disruptors, and nanoparticles

Behavioral Measures of Neurotoxicity

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Publisher : National Academies Press
ISBN 13 : 0309040477
Total Pages : 449 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Behavioral Measures of Neurotoxicity by : National Research Council

Download or read book Behavioral Measures of Neurotoxicity written by National Research Council and published by National Academies Press. This book was released on 1990-02-01 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exposure to toxic chemicalsâ€"in the workplace and at homeâ€"is increasing every day. Human behavior can be affected by such exposure and can give important clues that a person or population is in danger. If we can understand the mechanisms of these changes, we can develop better ways of testing for toxic chemical exposure and, most important, better prevention programs. This volume explores the emerging field of neurobehavioral toxicology and the potential of behavior studies as a noninvasive and economical means for risk assessment and monitoring. Pioneers in this field explore its promise for detecting environmental toxins, protecting us from exposure, and treating those who are exposed.

Lead Poisoning in Childhood

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Author :
Publisher : Brookes Publishing Company
ISBN 13 :
Total Pages : 266 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Lead Poisoning in Childhood by : Siegfried M. Pueschel

Download or read book Lead Poisoning in Childhood written by Siegfried M. Pueschel and published by Brookes Publishing Company. This book was released on 1996 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This resource examines the causes and consequences of childhood lead poisoning, offers cost-effective prevention strategies, and explores crucial legislation that can and should protect children at risk. Information on screening tests, nutrition, treatment guidelines, and safe environmental abatement techniques will help pediatricians, physicians, social workers, and nurses understand, treat, and eliminate lead poisoning in children.

Neurobehavioral Toxicity

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Publisher : CRC Press
ISBN 13 : 9781439805480
Total Pages : 418 pages
Book Rating : 4.8/5 (54 download)

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Book Synopsis Neurobehavioral Toxicity by : Bernard Weiss

Download or read book Neurobehavioral Toxicity written by Bernard Weiss and published by CRC Press. This book was released on 1994-06-30 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: In establishing how certain chemicals can cause behavioural disorders, the process of neurotoxicity risk assessment poses significant challenges to every discipline within neuroscience. In this volume, leaders from industrial, academic, and government settings share insights on behavioural measurement in neurotoxicity risk assessment, and address the critical scientific issues arising from the expanding role of neurobehavioral toxicology in public policy development.; The authors set out to provide a comprehensive and authoritative review of current methods in the analysis and interpretation of neurobehavioural toxicology. Coverage begins with a discussion of criteria for determining neurotoxic potential. The next section examines neurobehavioural evaluations in developmental neurotoxicity. Subsequent sections focus on activity and observational data and applications of schedule-controlled operant behaviour in toxicity testing. The contributors address controversies surrounding the suitability and interpretation of procedures designed for neurotoxicological assessments. Some case studies are also included.

Drinking Water and Health,

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Author :
Publisher : National Academies Press
ISBN 13 : 0309036879
Total Pages : 476 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Drinking Water and Health, by : National Research Council

Download or read book Drinking Water and Health, written by National Research Council and published by National Academies Press. This book was released on 1986-02-01 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most recent volume in the Drinking Water and Health series contains the results of a two-part study on the toxicity of drinking water contaminants. The first part examines current practices in risk assessment, identifies new noncancerous toxic responses to chemicals found in drinking water, and discusses the use of pharmacokinetic data to estimate the delivered dose and response. The second part of the book provides risk assessments for 14 specific compounds, 9 presented here for the first time.

Lead Exposure and Child Development

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Publisher : Springer Science & Business Media
ISBN 13 : 9400908474
Total Pages : 516 pages
Book Rating : 4.4/5 (9 download)

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Book Synopsis Lead Exposure and Child Development by : M. Smith

Download or read book Lead Exposure and Child Development written by M. Smith and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book arises out of a workshop on lead exposure and child development which was held at the University of Edinburgh on 8th-12th September 1986. It was organized jointly by the Commission of the European Communities (CEC) and the US Environmental Protection Agency (EPA), in association with the UK Department of the Environment and the Scottish Home and Health Department. It brought together most of the internationally recognized groups working on the effects of lead exposure on child development including child psychologists, psychiatrists, neurologists, epidemiologists, toxicologists, stati sticians, and medical practitioners. One of the unique features of the meeting was that it included workers from initially separate fields of lead research, in particular those undertaking studies in infants and in older children, and those carrying out behavioural research in animals, as well as those undertaking biochemical studies on mechanisms of lead effect. The structure of this book reflects the main elements of the meeting. As such it includes three main sections. The first consists of two major state-of the-art reviews, and two invited introductory papers. The reviews were prepared for the organizers of the conference by two of the Editors. The objectives were to assess critically the state of current knowledge in this field and to provide a scientific basis both for policy decisions and for further research. The review prepared by Marjorie Smith for the Commission of the European Communities focusses on methodological and design issues, and summarizes our present scientific knowledge in this area.

OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 426: Developmental Neurotoxicity Study

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Author :
Publisher : OECD Publishing
ISBN 13 : 9264067396
Total Pages : 26 pages
Book Rating : 4.2/5 (64 download)

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Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 426: Developmental Neurotoxicity Study by : OECD

Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 426: Developmental Neurotoxicity Study written by OECD and published by OECD Publishing. This book was released on 2007-10-15 with total page 26 pages. Available in PDF, EPUB and Kindle. Book excerpt: A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...