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Author : Thomas Yao-Chung Ting
Publisher :
ISBN 13 :
Total Pages : 116 pages
Book Rating : 4.:/5 (15 download)
Download or read book The Conformational Stability of Proteins in Aqueous Solution written by Thomas Yao-Chung Ting and published by . This book was released on 1965 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John F. Carpenter
Publisher : Springer Science & Business Media
ISBN 13 : 1461505577
Total Pages : 218 pages
Book Rating : 4.4/5 (615 download)
Download or read book Rational Design of Stable Protein Formulations written by John F. Carpenter and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recombinant proteins and polypeptides continue to be the most important class of biotechnology-derived agents in today's pharmaceutical industry. Over the past few years, our fundamental understanding of how proteins degrade and how stabilizing agents work has made it possible to approach formulation of protein pharmaceuticals from a much more rational point of view. This book describes the current level of understanding of protein instability and the strategies for stabilizing proteins under a variety of stressful conditions.
Author : Vladimir N. Uversky
Publisher : Nova Publishers
ISBN 13 : 9781600217043
Total Pages : 414 pages
Book Rating : 4.2/5 (17 download)
Download or read book Methods in Protein Structure and Stability Analysis: Conformational stability, size, shape, and surface of protein molecules written by Vladimir N. Uversky and published by Nova Publishers. This book was released on 2007 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein research is a frontier field in science. Proteins are widely distributed in plants and animals and are the principal constituents of the protoplasm of all cells, and consist essentially of combinations of a-amino acids in peptide linkages. Twenty different amino acids are commonly found in proteins, and serve as enzymes, structural elements, hormones, immunoglobulins, etc., and are involved throughout the body, and in photosynthesis. This book gathers new leading-edge research from throughout the world in this exciting and exploding field of research.
Author : Roger Gregory
Publisher : CRC Press
ISBN 13 : 9780824792398
Total Pages : 596 pages
Book Rating : 4.7/5 (923 download)
Download or read book Protein-Solvent Interactions written by Roger Gregory and published by CRC Press. This book was released on 1995-01-04 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work covers advances in the interactions of proteins with their solvent environment and provides fundamental physical information useful for the application of proteins in biotechnology and industrial processes. It discusses in detail structure, dynamic and thermodynamic aspects of protein hydration, as well as proteins in aqueous and organic solvents as they relate to protein function, stability and folding.
Author : Bradley Allen Rogers
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (113 download)
Download or read book Conformational and Colloidal Stability of Macromolecules in Aqueous Salt Solutions written by Bradley Allen Rogers and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The conformational and colloidal stability of proteins in aqueous solutions are critical to the function of biological cells and the shelf-life of biopharmaceutical drug products. These properties of protein macromolecules are strongly influenced by cosolutes in the solution, including inorganic salt ions and non-ionic crowding agents. The intrinsic and cosolute-modulated properties of proteins are governed by specific interactions between proteins, water, and cosolutes. Herein, the non-covalent interactions that drive two phenomena are explored, including anion-induced denaturation of proteins and the liquid-liquid phase separation of therapeutic antibody solutions. In the first aim, protein folding is mimicked by thermoresponsive polymers model systems that undergo hydrophobic collapse upon heating. A combination of light scattering measurements as well as vibrational and nuclear magnetic resonance spectroscopies on these thermoresponsive polymers reveal that the structure of water-water hydrogen bonding at hydrophobic surfaces can modulate the binding affinity of weakly hydrated anions over several orders of magnitude. In the second aim, the colloidal phase separation of concentrated antibody formulations is imaged by dark-field microscopy on a temperature gradient microfluidics platform. This platform facilitates high-throughput measurements of phase separation across a range of temperatures and solution conditions, simultaneously. Analysis of the dark-field images over time reveals that the phase separation is a multistep reaction. Collectively, this work provides novel insights into the conformational and colloidal stability of proteins, which advance the current understanding of protein behavior in biological and biotechnological solutions.
Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470514159
Total Pages : 282 pages
Book Rating : 4.4/5 (75 download)
Download or read book Protein Conformation written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: How the amino acid sequence of a protein determines its three-dimensional structure is a major problem in biology and chemistry. Leading experts in the fields of NMR spectroscopy, X-ray crystallography, protein engineering and molecular modeling offer provocative insights into current views on the protein folding problem and various aspects for future progress.
Author : David S. Eisenberg
Publisher :
ISBN 13 : 9780120342464
Total Pages : 334 pages
Book Rating : 4.3/5 (424 download)
Download or read book Protein Stability written by David S. Eisenberg and published by . This book was released on 1995 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: The topics covered by this volume include: protein destabilization at low temperatures; engineering the stability and function of Gene V Protein; free energy balance in protein folding; modelling protein stability as a heteropolymer collapse; stability of alpha helices; protein stability with T4 Lysozyme.
Author : Kozo Hamaguchi
Publisher : Springer
ISBN 13 :
Total Pages : 274 pages
Book Rating : 4.F/5 ( download)
Download or read book The Protein Molecule written by Kozo Hamaguchi and published by Springer. This book was released on 1992-11-25 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: The functions of proteins are closely related to their conformations - the aspect on which this book primarily concentrates on. It further treats the stability and folding of proteins and discribes the molecular basis of protein functions. The book is useful not only for protein engineers whowant to improve protein functions and stability but also for biochemistswho want to understand the protein functions on the basis of the physicochemical properties of the protein molecule.
Author : Kenneth P. Murphy
Publisher : Springer Science & Business Media
ISBN 13 : 1592591930
Total Pages : 258 pages
Book Rating : 4.5/5 (925 download)
Download or read book Protein Structure, Stability, and Folding written by Kenneth P. Murphy and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Protein Structure, Stability, and Folding, Kenneth P. Murphy and a panel of internationally recognized investigators describe some of the newest experimental and theoretical methods for investigating these critical events and processes. Among the techniques discussed are the many methods for calculating many of protein stability and dynamics from knowledge of the structure, and for performing molecular dynamics simulations of protein unfolding. New experimental approaches presented include the use of co-solvents, novel applications of hydrogen exchange techniques, temperature-jump methods for looking at folding events, and new strategies for mutagenesis experiments. Unique in its powerful combination of theory and practice, Protein Structure, Stability, and Folding offers protein and biophysical chemists the means to gain a more comprehensive understanding of some of this complex area by detailing many of the major techniques in use today.
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : F. Hirata
Publisher : Springer Science & Business Media
ISBN 13 : 1402025904
Total Pages : 366 pages
Book Rating : 4.4/5 (2 download)
Download or read book Molecular Theory of Solvation written by F. Hirata and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Theory of Solvation presents the recent progress in the statistical mechanics of molecular liquids applied to the most intriguing problems in chemistry today, including chemical reactions, conformational stability of biomolecules, ion hydration, and electrode-solution interface. The continuum model of "solvation" has played a dominant role in describing chemical processes in solution during the last century. This book discards and replaces it completely with molecular theory taking proper account of chemical specificity of solvent. The main machinery employed here is the reference-interaction-site-model (RISM) theory, which is combined with other tools in theoretical chemistry and physics: the ab initio and density functional theories in quantum chemistry, the generalized Langevin theory, and the molecular simulation techniques. This book will be of benefit to graduate students and industrial scientists who are struggling to find a better way of accounting and/or predicting "solvation" properties.
Author : Heinz Fabian
Publisher : Springer Science & Business Media
ISBN 13 : 3642222307
Total Pages : 257 pages
Book Rating : 4.6/5 (422 download)
Download or read book Protein Folding and Misfolding written by Heinz Fabian and published by Springer Science & Business Media. This book was released on 2011-09-18 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infrared spectroscopy is a new and innovative technology to study protein folding/misfolding events in the broad arsenal of techniques conventionally used in this field. The progress in understanding protein folding and misfolding is primarily due to the development of biophysical methods which permit to probe conformational changes with high kinetic and structural resolution. The most commonly used approaches rely on rapid mixing methods to initiate the folding event via a sudden change in solvent conditions. Traditionally, techniques such as fluorescence, circular dichroism or visible absorption are applied to probe the process. In contrast to these techniques, infrared spectroscopy came into play only very recently, and the progress made in this field up to date which now permits to probe folding events over the time scale from picoseconds to minutes has not yet been discussed in a book. The aim of this book is to provide an overview of the developments as seen by some of the main contributors to the field. The chapters are not intended to give exhaustive reviews of the literature but, instead to illustrate examples demonstrating the sort of information, which infrared techniques can provide and how this information can be extracted from the experimental data. By discussing the strengths and limitations of the infrared approaches for the investigation of folding and misfolding mechanisms this book helps the reader to evaluate whether a particular system is appropriate for studies by infrared spectroscopy and which specific advantages the techniques offer to solve specific problems.
Author : Bret A. Shirley
Publisher : Taylor & Francis US
ISBN 13 : 9780896033016
Total Pages : 392 pages
Book Rating : 4.0/5 (33 download)
Download or read book Protein Stability and Folding written by Bret A. Shirley and published by Taylor & Francis US. This book was released on 1995-03-24 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Protein Stability and Folding: Theory and Practice, world-class scientists present in a single volume a comprehensive selection of hands-on recipes for all of the major techniques needed to understand the conformational stability of proteins, as well as their three-dimensional folding. The distinguished contributors provide clear, step-by-step instructions along with many troubleshooting tips, alternative procedures, and informative explanations about why certain steps are necessary. Even highly skilled researchers will find many time-saving methods. Among the techniques discussed are fluorescent, ultraviolet, and infrared spectroscopy; HPLC peptide mapping; differential scanning calorimetry; and hydrogen exchange. Shirley's Protein Stability and Folding: Theory and Practice will ensure a significant difference in the outcome of your experiments, producing the result desired even for beginners.
Author : Werner Kunz
Publisher : World Scientific
ISBN 13 : 9814271586
Total Pages : 347 pages
Book Rating : 4.8/5 (142 download)
Download or read book Specific Ion Effects written by Werner Kunz and published by World Scientific. This book was released on 2010 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Specific ion effects are important in numerous fields of science and technology. This book summarizes the main ideas that came up over the years. It presents the efforts of theoreticians and supports it by the experimental results stemming from various techniques.
Author : Alex I. Käiväräinen
Publisher : Springer Science & Business Media
ISBN 13 : 9400951973
Total Pages : 302 pages
Book Rating : 4.4/5 (9 download)
Download or read book Solvent-Dependent Flexibility of Proteins and Principles of Their Function written by Alex I. Käiväräinen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular biology has now advanced to the point where it is no longer possible to give a complete review of the available data on the conformational features of proteins. New data keep streaming in, and there is obviously an urgent need for some sort of general treatment of the subject. A systematic treatment of the large amount of data obtained by a great variety of methods on a great variety of objects must be based on the use of models; these should be as simple as possible, should conform to well-established scien tific laws, and at the same time be sufficiently flexible. The validity of the models finally arrived at is then confirmed or otherwise by testing the conclusions arrived at with their aid by means of experiment. After a suitable model has been adopted, it can be used in analyzing the experimental data. Such an analysis may result in one of three possible situations: neither the experi mental results nor their interpretation contradict the proposed model; the experimental results do not contradict the proposed model but their interpretation by the authors does; finally, both the experimental results and their interpretation may be found to be incompatible with the fundamental principles underlying the proposed model. The first situation is clearly the most desirable, and presents no difficulties.
Author : Adrian M. Gospodarek
Publisher :
ISBN 13 :
Total Pages : 138 pages
Book Rating : 4.:/5 (642 download)
Download or read book Local Conformational Stability of Model Proteins in Solution and on Hydrophobic Interaction Chromatography Surfaces written by Adrian M. Gospodarek and published by . This book was released on 2009 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Eshel Faraggi
Publisher : BoD – Books on Demand
ISBN 13 : 9535105558
Total Pages : 412 pages
Book Rating : 4.5/5 (351 download)
Download or read book Protein Structure written by Eshel Faraggi and published by BoD – Books on Demand. This book was released on 2012-04-20 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the dawn of recorded history, and probably even before, men and women have been grasping at the mechanisms by which they themselves exist. Only relatively recently, did this grasp yield anything of substance, and only within the last several decades did the proteins play a pivotal role in this existence. In this expose on the topic of protein structure some of the current issues in this scientific field are discussed. The aim is that a non-expert can gain some appreciation for the intricacies involved, and in the current state of affairs. The expert meanwhile, we hope, can gain a deeper understanding of the topic.
