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Author : Nazish Malik
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (129 download)
Download or read book The Complement System and Invariant Natural Killer T (iNKT) Cell Responses written by Nazish Malik and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chaohong Liu
Publisher : Humana
ISBN 13 : 9781071617748
Total Pages : 195 pages
Book Rating : 4.6/5 (177 download)
Download or read book Invariant Natural Killer T-Cells written by Chaohong Liu and published by Humana. This book was released on 2021-10-16 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book focuses on various aspects of Invariant Natural Killer T-Cells (iNKT), which are known to contribute to homeostasis and autoimmunity and can also cause various pathological responses such as allergy, infection, excessive autoimmune response, and cancer. The volume explores techniques for identification and isolation of iNKT cells, iNKT cell activation and transformation, as well as proliferation and differentiation and much more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Invariant Natural Killer T-Cells: Methods and Protocols is an ideal guide for researchers working with and studying iNKT cells, perhaps to provide a deeper knowledge of the human immune system.
Author : Masaki Terabe
Publisher : Springer Science & Business Media
ISBN 13 : 1461406137
Total Pages : 212 pages
Book Rating : 4.4/5 (614 download)
Download or read book Natural Killer T cells written by Masaki Terabe and published by Springer Science & Business Media. This book was released on 2011-09-22 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will cover primary roles of NKT cells in immunity to cancer, in both mouse tumor models and cancer patients. There are several chapters describing general aspects of NKT cells.
Author : Nathan V. Fournier
Publisher : Nova Publishers
ISBN 13 : 9781604562873
Total Pages : 222 pages
Book Rating : 4.5/5 (628 download)
Download or read book Natural Killer T-cells written by Nathan V. Fournier and published by Nova Publishers. This book was released on 2008 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer (NK) cells. Many of these cells recognize the non-polymorphic CD1d molecule, an antigen-presenting molecule that binds self- and foreign lipids and glycolipids. Upon activation, NK T cells are able to produce large quantities of interferon-gamma, IL-4, and granulocyte-macrophage colony-stimulating factor, as well as multiple other cytokines and chemokines (such as IL-2 and TNF-alpha). NKT cells seem to be essential for several aspects of immunity because their dysfunction or deficiency has been shown to lead to the development of autoimmune diseases (such as diabetes or atherosclerosis) and cancers. NKT cells have recently been implicated in the disease progression of human asthma. The clinical potential of NKT cells lies in the rapid release of cytokines (such as IL-2, IFN-gamma, TNF-alpha, and IL-4) that promote or suppress different immune responses.
Author : Alysia Marie Birkholz
Publisher :
ISBN 13 : 9781321648997
Total Pages : 133 pages
Book Rating : 4.6/5 (489 download)
Download or read book Immune and Structural Studies of Synthetic Invariant Natural Killer T Cell Glycosphingolipid Activators written by Alysia Marie Birkholz and published by . This book was released on 2015 with total page 133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Invariant Natural Killer T (iNKT) cells comprise a small fraction of immune cells capable of responding within hours when stimulated by glycosphingolipid (GSL) antigens (Ags) and can impact the immune system months later. These iNKT cells respond to GSLs that are presented by the antigen presenting molecule CD1d. The iNKT cell driven immune cytokine response can alter depending on the GSL that is presented by CD1d. The GSL can lead to the production of a T helper type 1 (Th1) or a T helper type 2 (Th2) response characterized by IFN-gamma and IL-4 cytokines. Many synthetic GSL analogs of the most common iNKT cell antigen, alpha-Galactosylceramide (aGalCer) were used in this study to determine immunological and biochemical properties of Ags capable of activating iNKT cells. Studies consisted of in vitro Ag binding models, crystallographic structural models and in vivo immunological studies. Ags that are categorized as Th1 iNKT cell cytokine skewers have properties correlated with this response. The Th1 Ags studied are presented by CD1d on dendritic antigen presenting cells (APCs) and the CD1d and GSL seem to form more contacts according to structural studies and the CD1d-GSL complexes are more biologically stable in vivo. The work from these studies adds the to growing information in the field regarding the nature of iNKT cell immune system skewing.
Author : Akshat Sharma
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (18 download)
Download or read book The Innate Effector Programmes of Invariant Natural Killer T-cells written by Akshat Sharma and published by . This book was released on 2018 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: T-cell effector functions exemplify adaptive immunity in that they 'adapt' to the threat at hand via a programme of antigen recognition, clonal expansion and subsequent contraction, and the generation of long-lived memory cells as insurance against subsequent insult. Invariant Natural Killer T (iNKT) cells are a lipid-reactive lineage of T-lymphocyte which, via an invariant T-cell receptor and epigentically 'poised effector' status, combine both the specificity of adaptive immunity as well as the rapid 'trained' responses of innate immunity. While a lot has been written about adaptive, antigen-specific or TCR-driven mechanisms of iNKT functionality, less is known about non-TCR or innate cues that drive iNKT responses. This disquisition aims to explore the same via enquiring after the functional consequences of having unusually high cell-surface expression of the integrin and co-stimulatory molecule Leucocyte Function-associated Antigen-1 (LFA-1) as well as the means by which iNKT cells serve as cellular adjuvants in a humanised mouse model of EBV-driven lymphomagenesis. For the former, we stimulated clonal or short-term polyclonal lines of human iNKT cells with plate-bound ICAM-1-Fc in the absence of antigen-presenting cells, but in the presence or absence of exogenous IL-12p70 to investigate the role that LFA-1:ICAM-1 interactions play in co-stimulating TCR-independent means of cell responsiveness. Surprisingly, we found that ICAM-1-fc alone is sufficient to drive IFNg from iNKT cells, and does not require concurrent TCR or pro-inflammatory cytokine cues. Immunotherapy work was performed within an in vivo model of EBV-driven lymphomagenesis using humanised mice. iNKT cells appear to promote tumour clearance via the activation of endogenous MHC-restricted T-cells. Whether or not the iNKT-TCR is involved in potentiating this programme of adjuvanticity will be a topic for future experiments. Ultimately, the work curated here builds a case for the versatility of iNKT cells via their ability to be sensitive to changes in their milieu that do not always involve direct antigen presentation. This ability to 'stay current' is what posits iNKT cells as a vital conduit, bridging the 'communication gaps' between classically innate and adaptive immune responses.
Author : Nadia Rachel Cohen
Publisher :
ISBN 13 :
Total Pages : 402 pages
Book Rating : 4.:/5 (11 download)
Download or read book Invariant Natural Killer T Cell Activation by Fungi written by Nadia Rachel Cohen and published by . This book was released on 2011 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: Invariant Natural Killer T (iNKT) cells are innate-like T lymphocytes recognizing self and foreign lipid antigens presented by CD1d, a trans-membrane glycoprotein closely related to MHC molecules. iNKT cells become rapidly activated during infection and play an important role in immunity against a spectrum of microbes. Unlike MHC-restricted T cells, however, iNKT cells express a semi-clonal T cell receptor (TCR) repertoire, comprised of a canonical V[alpha] chain paired with a limited set of V[beta] chains. Furthermore, in contrast to MHC, CD1d is non-polymorphic. This suggests that the diversity of antigens that can be presented to and recognized by iNKT cells may be limited. Clarifying the mechanisms allowing iNKT cells to respond to different microbes is central to understanding the biology of these and other innate-like lymphocytes with restricted receptor diversity. In this dissertation, we address this question in the context of infection with fungi, a neglected class of pathogens with increasing clinical significance.
Author : Victoria DeVault
Publisher :
ISBN 13 :
Total Pages : 396 pages
Book Rating : 4.:/5 (19 download)
Download or read book Regulation of Natural Killer T Cell Subset Development and Function by Slam Family Receptors written by Victoria DeVault and published by . This book was released on 2019 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Semi-invariant natural killer T (iNKT) cells are critical components of the host immune response in peripheral tissues such as the lung, liver, and gut, and they play important roles in cancer, bacterial infections, autoimmunity, wound repair, and atherosclerosis. Tissue-resident iNKT cells exert their effects early in the developing immune response by rapidly producing a wide variety of cytokines and chemokines, and it was recently discovered that different tissues possess iNKT cell subsets that preferentially produce IFN-[Gamma] (NKT1), IL-4 (NKT2), or IL-17 (NKT17). Despite their critical role in the immune response, the mechanisms that regulate iNKT cell function in the periphery remain unclear. Signaling lymphocyte activation marker (SLAM) proteins are cell surface-expressed molecular switches that are expressed on all hematopoietic cells. The nine SLAM family receptors serve a variety of functions including promotion of cell-cell adhesion, regulation of cytokine production, co-stimulation, and inhibition. Importantly, SLAM family receptors are critical for the development of iNKT cells. Yet, numerous efforts to ascribe discrete roles of SLAM family receptors in iNKT cell function has proven difficult. We conducted a comprehensive analysis of SLAM family receptor co-expression on iNKT cell subsets in the lung, spleen, liver, and thymus and identified co-expression profiles that varied in a tissue and strain-dependent manner. Interestingly, we found that SLAM family receptor expression profiles varied among different iNKT cell subsets. In particular, we noted a close association of SLAMf6 expression with the NKT2 and NKT17 subsets in both the periphery and in the thymus. Further investigation using SLAMf6-deficient mice revealed a critical role for SLAMf6 in NKT2 and NKT17 subset development, and in iNKT IL-4 and IL-17 cytokine production in the periphery. This investigation also revealed that the SLAMf6 [superscript "high"] NKT2 and NKT17 subsets exhibited significantly higher proliferative capacity than the NKT1 subset and the NKT2 and NKT17 proliferation was dependent, in part, on SLAMf6 expression. Since Slam family genes are highly polymorphic, we next investigated whether these polymorphisms regulated iNKT function. We employed a B6.129 congenic mouse exhibiting impaired NKT cell function, in which a 6.6 Mbp 129/SvJ locus encompassing Slam genes was introgressed onto the C57BL/6 background. To test the hypothesis that Slam gene polymorphisms regulate iNKT cell function, we refined this genetic interval by generating B6.129 subcongenic lines and assessing iNKT cell function. Unexpectedly, we found that while Slam gene polymorphisms in this model do regulate iNKT cell function, the dominant regulator was in a 0.14 Mbp interval centromeric to the Slam genes. Further experimentation revealed that impaired iNKT cell development and function was associated with changes in the expression of Fcgr3 (Fc gamma receptor III) on iNKT cells, suggesting it as a novel candidate gene regulating iNKT cell function. Taken together, these data reveal for the first time a specific role for SLAMf6 on NKT2 and NKT17 subset development and function. In addition, these data identify Fcgr3 as a novel candidate gene that regulates iNKT cell subset development and cytokine production. Cumulatively, these data reveal the presence of discrete regulatory mechanisms at work in different iNKT subsets, a finding that has broad implications for our understanding of iNKT-cell mediated immunity.
Author : M. Eric Gershwin
Publisher : Springer Science & Business Media
ISBN 13 : 331902096X
Total Pages : 482 pages
Book Rating : 4.3/5 (19 download)
Download or read book Liver Immunology written by M. Eric Gershwin and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver Immunology: Principles and Practice, Second Edition begins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters that provide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediated liver disease helps provide context for how these diseases affect the patient overall. In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases -- primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome – are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others. This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients. Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Edition will again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases. This volume will again be a must-read for clinicians at all levels, investigators and students.
Author : Kazuya Iwabuchi
Publisher : Frontiers Media SA
ISBN 13 : 2889631222
Total Pages : 429 pages
Book Rating : 4.8/5 (896 download)
Download or read book Role of CD1- and MR1-restricted T cells in Immunity and Disease written by Kazuya Iwabuchi and published by Frontiers Media SA. This book was released on 2019-10-18 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: CD1 and MR1 are major histocompatibility complex (MHC) class I-related proteins that bind and present non-peptide antigens to subsets of T cells with specialized functions. CD1 proteins typically present lipid antigens to CD1-restricted T cells, whereas MR1 presents vitamin B-based ligands and a variety of drugs and drug-like molecules to MR1-restricted T cells. The CD1 family of antigen presenting molecules has been divided into two groups: Group 1 contains CD1a, CD1b and CD1c, and Group 2 contains CD1d. Additionally, CD1e is expressed intracellularly and is involved in the loading of lipid antigens onto Group 1 CD1 proteins. Humans express both Groups 1 and 2 CD1 proteins, whereas mice only express CD1d. Group 1 CD1 proteins present lipid antigens to T cells that generally express diverse T cell receptors (TCRs) and exhibit adaptive-like functions, whereas CD1d presents lipid antigens to subsets of T cells that express either diverse or highly restricted TCRs and exhibit innate-like functions. CD1d-restricted T cells are called natural killer T (NKT) cells, which includes Type I or invariant NKT (iNKT) cells expressing semi-invariant TCRs, and Type II NKT cells expressing more diverse TCRs. CD1-restricted T cells have been implicated in a wide variety of diseases, including cancer, infections, and autoimmune, inflammatory and metabolic diseases. Additionally, NKT cells have been targeted for immunotherapy of disease with ligands such as α-galactosylceramide for iNKT cells, or sulfatide for Type II NKT cells. Like iNKT cells, MR1-restricted T cells express semi-invariant TCRs and display innate-like functions. MR1-restricted T cells, also called mucosal-associated invariant T (MAIT) cells, have been implicated in immune responses against a variety of pathogens such as Mycobacterium tuberculosis, Pseudomonas aeruginosa, Helicobacter pylori, hepatitis C virus and influenza virus. Moreover, these cells contribute to autoimmune and inflammatory diseases, including colitis, rheumatoid arthritis, psoriasis, lupus, and diabetes.
Author : Manzoor M. Khan
Publisher : Springer Science & Business Media
ISBN 13 : 0387779760
Total Pages : 275 pages
Book Rating : 4.3/5 (877 download)
Download or read book Immunopharmacology written by Manzoor M. Khan and published by Springer Science & Business Media. This book was released on 2008-12-19 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decades, with the introduction of the recombinant DNA, hybridoma and transgenic technologies there has been an exponential evolution in understanding the pathogenesis, diagnosis and treatment of a large number of human diseases. The technologies are evident with the development of cytokines and monoclonal antibodies as therapeutic agents and the techniques used in gene therapy. Immunopharmacology is that area of biomedical sciences where immunology, pharmacology and pathology overlap. It concerns the pharmacological approach to the immune response in physiological as well as pathological events. This goals and objectives of this textbook are to emphasize the developments in immunology and pharmacology as they relate to the modulation of immune response. The information includes the pharmacology of cytokines, monoclonal antibodies, mechanism of action of immune-suppressive agents and their relevance in tissue transplantation, therapeutic strategies for the treatment of AIDS and the techniques employed in gene therapy. The book is intended for health care professional students and graduate students in pharmacology and immunology.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1490107223
Total Pages : 1232 pages
Book Rating : 4.4/5 (91 download)
Download or read book Issues in Immunology Research: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-05-01 with total page 1232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Issues in Immunology Research / 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Immunochemistry. The editors have built Issues in Immunology Research: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Immunochemistry in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Immunology Research / 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author : Abul K. Abbas
Publisher : Elsevier Health Sciences
ISBN 13 : 0323523234
Total Pages : 579 pages
Book Rating : 4.3/5 (235 download)
Download or read book Cellular and Molecular Immunology written by Abul K. Abbas and published by Elsevier Health Sciences. This book was released on 2017-03-10 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: The top required and recommended immunology text worldwide, Cellular and Molecular Immunology by Drs. Abul K. Abbas, Andrew H. H. Lichtman, and Shiv Pillai, is a clear, well-written, and superbly illustrated introduction to the field. The 9th Edition retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area. Highlights the implications of immunologic science for the management of human disease, emphasizing clinical relevance throughout. Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program. Helps readers grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions. Includes summary boxes that assist with rapid review and mastery of key material. Features updates from cover to cover, including tumor immunity (tumor antigens, cancer immunotherapy), immune checkpoints, cytosolic sensors for DNA, non-canonical inflammasomes, prionization as a signaling mechanism, monogenic defects in immunity, and more.
Author : S.M. Mansour Haeryfar
Publisher : Frontiers Media SA
ISBN 13 : 2889197506
Total Pages : 191 pages
Book Rating : 4.8/5 (891 download)
Download or read book CD1- and MR1-restricted T Cells in Antimicrobial Immunity written by S.M. Mansour Haeryfar and published by Frontiers Media SA. This book was released on 2016-01-21 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell-mediated immunity to extracellular and intracellular microbes has been traditionally linked to CD4+ and CD8+ T cells that recognize pathogen-derived peptides in the context of major histocompatibility complex (MHC) class II and class I molecules, respectively. Recent progress in our understanding of early host defense mechanisms has brought ‘unconventional’, innate-like T cells into the spotlight. These are a heterogeneous population of non-MHC-restricted T cells that exhibit ‘memory-like’ properties and mount emergency responses to infection. They may directly detect and destroy infected cells, but are best known for their ability to regulate downstream effector cells including but not limited to conventional T cells. Innate-like T cells include among others CD1-restricted natural killer T (NKT) cells and MR1-restricted mucosa-associated invariant T (MAIT) cells. NKT cells recognize lipid antigens, and MAIT cells were recently demonstrated to respond to microbe-derived vitamin B metabolites. However, much remains to be learned about the antigen specificity range of these cells, their activation mode and their true potentials in immunotherapeutic applications. Like in many other areas of biology, uncertainties and controversies surrounding these cells and some of the experimental models, techniques and reagents employed to study them have brought about excitement and sometimes hot debates. This Special Topic was launched to provide updated reviews on protective and/or pathogenic roles of NKT and MAIT cells during infection. Leading experts discuss current controversies, pressing questions and the challenges that lie ahead for the advancement of this intriguing and rapidly evolving area of immunology. Unlike MHC, CD1 and MR1 display very limited polymorphism. Therefore, NKT and MAIT cells may be considered attractive targets for various diseases in diverse human populations. The potential benefits of NKT cell- and MAIT cell-based vaccination and treatment strategies in infectious diseases is an important subject that is also covered in this Topic.
Author : Ivan Maurice Roitt
Publisher :
ISBN 13 :
Total Pages : 244 pages
Book Rating : 4.:/5 (42 download)
Download or read book Essential Immunology written by Ivan Maurice Roitt and published by . This book was released on 1971 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Abul K. Abbas
Publisher : Elsevier Health Sciences
ISBN 13 : 0323757502
Total Pages : 603 pages
Book Rating : 4.3/5 (237 download)
Download or read book Cellular and Molecular Immunology E-Book written by Abul K. Abbas and published by Elsevier Health Sciences. This book was released on 2021-02-19 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Well-written, readable, and superbly illustrated, Cellular and Molecular Immunology, 10th Edition, continues the tradition of excellence established through multiple editions of this bestselling text. Offering an unparalleled introduction to this complex field, it retains a practical, clinical focus while updating and revising all content to ensure clarity and comprehension, bringing readers fully up to date with new and emerging information in this challenging area. It’s an ideal resource for medical, graduate, and undergraduate students, as well as a trusted reference for physicians and scientists. Highlights the implications of immunologic science for the management of human disease, emphasizing clinical relevance throughout. Employs a highly accessible writing style that makes difficult concepts easier to understand, and provides clear implications of immunologic science to the management of human disease and clinical practice. Features updates from cover to cover, including new information on intracellular sensors of innate immunity, therapeutic use of monoclonal antibodies, regulation of migration events during T cell-B cell interactions, regulatory and transcriptional events in germinal center formation, immunology of infectious diseases including coronaviruses, human immunodeficiency disorders, and immunology of HIV. Provides a highly visual, full-color description of the key immunologic and molecular processes with a fully updated, comprehensive, and consistent art program, including many new and extensively revised illustrations. Helps readers grasp the details of experimental observations that form the basis for the science of immunology at the molecular, cellular, and whole-organism levels and draw the appropriate conclusions. Includes summary boxes that assist with rapid review and mastery of key material. Evolve Instructor site with an image and test bank is available to instructors through their Elsevier sales rep or via request at https://evolve.elsevier.com.
Author : Carlo Perricone
Publisher : Academic Press
ISBN 13 : 012814307X
Total Pages : 728 pages
Book Rating : 4.1/5 (281 download)
Download or read book Mosaic of Autoimmunity written by Carlo Perricone and published by Academic Press. This book was released on 2019-02-15 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases describes the multifactorial origin and diversity of expression of autoimmune diseases in humans. The term implies that different combinations of factors in autoimmunity produce varying and unique clinical pictures in a wide spectrum of autoimmune diseases. Most of the factors involved in autoimmunity can be categorized into four groups: genetic, immune defects, hormonal and environmental factors. In this book, the environmental factors are reviewed, including infectious agents, vaccines as triggers of autoimmunity, smoking and its relationship with rheumatoid arthritis, systemic lupus erythematosus, thyroid disease, multiple sclerosis and inflammatory bowel diseases. An entirely new syndrome, the autoimmune/inflammatory syndrome induced by adjuvants (ASIA), is also included, along with other diseases that are now recognized as having an autoimmune etiopathogenesis. Highlights the concept of the mosaic of autoimmune manifestations Includes new visions on unsuspected molecules Provides updated knowledge to physicians helping patients with autoimmune diseases Presents thorough, up-to-date information on specific diseases, along with clinical applications
