The Cerebellum as a Neuronal Machine

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 3662131471
Total Pages : 342 pages
Book Rating : 4.6/5 (621 download)

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Book Synopsis The Cerebellum as a Neuronal Machine by : John C. Eccles

Download or read book The Cerebellum as a Neuronal Machine written by John C. Eccles and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has had a three-fold origin, corresponding to the discoveries made by the three authors and their collaborators during the last few years - mostly since 1962. A most fruitful symposium on the cerebellum was held in Tokyo at the time of the International Physiological Congress in September 1965, and there was then formulated the project of writing this book so as to organize all this new knowledge and make it readily available, and to give opportunity for the con ceptual developments that may be seen in Chapters XI, XII and XV in particular. The present account of the physiological properties of the cerebellar cortex is based to a large extent on systematic investigations that were concerned with discovering the mode of operation of the constituent neuronal elements of the cerebellar cortex. This work was carried out in the Physiology Department of the Australian National University from 1963 to 1966 in collaboration with several visiting scientists - initially Drs. ANDERSEN, OscARssaN and VooRHOEVE and later Drs. LuNAs, SAsAKI and STRATA - to all of whom grateful thanks are extended for a great many of the figures, and even more significantly for the original and critical contributions that they made to so many aspects of this exploration into the mode of operation of the neural machinery of the cerebellar cortex.

The Cerebellum: Disorders and Treatment

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Author :
Publisher : Elsevier
ISBN 13 : 0444641904
Total Pages : 442 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis The Cerebellum: Disorders and Treatment by :

Download or read book The Cerebellum: Disorders and Treatment written by and published by Elsevier. This book was released on 2018-06-08 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cerebellum: Disorders and Treatment, Volume 155 updates readers on the latest and clinically relevant advances in the study of cerebellar diseases in children and adults. It is organized into sections detailing: (1) Disorders (starting from the fetal cerebellum, to adult cerebellum) encountered during daily practice, and (2) Therapy (including insights into innovative drug and rehabilitative approaches). The book's innovative structure discusses cerebellar disorders in children and adults as a continuum, with its companion volume, The Cerebellum: From Embryology to Diagnostic Investigations detailing embryology, anatomy, function and diagnostic investigations and neuroimaging, including conventional sequences, diffusion tensor imaging, functional MRI, and connectivity studies. Provides an in-depth understanding of the cerebellum and its involvement in a wide variety of diseases Explores long-term outcome data of pediatric cerebellar diseases and potential problems in adult life for patients with pediatric cerebellar diseases Features chapters co-authored by two experts, combining expertise in both pediatric and adult cerebellar diseases

The Cerebellum

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Author :
Publisher : FT Press
ISBN 13 : 0132623080
Total Pages : 297 pages
Book Rating : 4.1/5 (326 download)

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Book Synopsis The Cerebellum by : Masao Ito

Download or read book The Cerebellum written by Masao Ito and published by FT Press. This book was released on 2011-08-01 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leading neuroscientist Dr. Masao Ito advances a detailed and fascinating view of what the cerebellum contributes to brain function. The cerebellum has been seen as primarily involved in coordination of body movement control, facilitating the learning of motor skills such as those involved in walking, riding a bicycle, or playing a piano. The cerebellum is now viewed as an assembly of numerous neuronal machine modules, each of which provides an implicit learning capability to various types of motor control. The cerebellum enables us to unconsciously learn motor skills through practice by forming internal models simulating control system properties of the body parts. Based on these remarkable advances in our understanding of motor control mechanisms of the cerebellum, Ito presents a still larger view of the cerebellum as serving a higher level of brain functions beyond movements, including the implicit part of the thought and cognitive processes that manipulate knowledge. Ito extends his investigation of the cerebellum to discuss neural processes that may be involved implicitly in such complex mental actions as having an intuition, imagination, hallucination, or delusion.

Essentials of Cerebellum and Cerebellar Disorders

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Author :
Publisher : Springer Nature
ISBN 13 : 3031150708
Total Pages : 694 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Essentials of Cerebellum and Cerebellar Disorders by : Donna L. Gruol

Download or read book Essentials of Cerebellum and Cerebellar Disorders written by Donna L. Gruol and published by Springer Nature. This book was released on 2023-03-20 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph, now in its 2nd edition with 31 new chapters and significant updates, is the first book of its kind written specifically for graduate students and clinicians. The monograph is based on the 4-volume treatise, Handbook of the Cerebellum and Cerebellar Disorders (Springer, 2013; 2nd edition: 2022), the definitive reference for scientists and neurologists in the field of cerebellar neurobiology and related areas. There have been fundamental advances in the basic science and clinical neurology of the cerebellum and its role in sensorimotor function and cognition. Essentials of the Cerebellum and Cerebellar Disorders makes this large and expanding body of knowledge readily accessible to trainees and clinicians alike. It is organized into easy to read and short chapters that are ideal for students and clinicians. The most common cerebellar disorders encountered in the clinic are covered. The editors are world leaders in the field, and the chapters are authored by an international panel of experts drawn from cerebellar laboratories and ataxia clinics throughout North America, Europe and Asia. Essentials provides a solid grounding in the field of cerebellar research and ataxiology from cerebellar cellular biology and circuity to clinical practice, and it serves as a springboard to a deeper appreciation of both the principles and the complexities of cerebellar neurobiology. Clinicians are expected to have a deep appreciation of cerebellar disorders, not only in specialized ataxia clinics but also in adult and pediatric neurology, neurosurgery, psychiatry and neuropsychology practices, and in outpatient and inpatient rehabilitation settings. This book is an indispensable resource for students and practitioners navigating the evolving field of cerebellar motor and cognitive neurology. It also links to the more expansive Handbook for those who need to explore the topics in this monograph in greater depth.

The Cerebellum

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Author :
Publisher : Theclassics.Us
ISBN 13 : 9781230292939
Total Pages : 20 pages
Book Rating : 4.2/5 (929 download)

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Book Synopsis The Cerebellum by : H. Davies

Download or read book The Cerebellum written by H. Davies and published by Theclassics.Us. This book was released on 2013-09 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1898 edition. Excerpt: ... "THE CEREBELLUM." The whole of the Nervous System, including the sympathetic and peripheral nerves, as also various epithelia and structures, --are derived from the first of the three blastodermic layers, --theEpiblast, Mesoblast, and Hypoblast, with which the student of embryology has to become so familiarized. The study of the development of the brain is replete with exceeding interest and charm, and the reward of the diligent inquirer who, commencing at the pre-natal state, recognizes the primitive changes and follows them onward with a growing wonder and increasing apprehension of their eventual modifications and purposes, until the embryo, through all its stages, has been ushered into the light of life and traced progressively through an amazing complexity of relationships, --the reward of such an one is incapable of verbal expression; it is certainly most profound. The principal reason why people who approach the study of the brain and its functions go away disappointed, discouraged, and appalled at the immensity of the subject, is because they allow themselves to be deluded in the first instance into a short but altogether wrong method of research. They begin at the wrong end and fondly hope they will be able to master the subject by taking somewhat of a retrospective view of its tenets, rather than a progressive one. Briefly, the Cerebellum may be described as consisting of two hemispheres or lobes connected centrally by elongated processes termed Versiform. In addition to such connection, there is that of the middle crus--the greater portion of the Pons Varolii being included in it. The remaining adjacent connections are the superior and inferior crura; the former, with theVieussens'Valve, forming a junction with it and the...

Compendium of Regional Diagnosis in Affections of the Brain and Spinal Cord

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Author :
Publisher :
ISBN 13 :
Total Pages : 246 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Compendium of Regional Diagnosis in Affections of the Brain and Spinal Cord by : Robert Bing

Download or read book Compendium of Regional Diagnosis in Affections of the Brain and Spinal Cord written by Robert Bing and published by . This book was released on 1911 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of the Cerebellum and Cerebellar Disorders

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Author :
Publisher : Springer
ISBN 13 : 9789400713321
Total Pages : 0 pages
Book Rating : 4.7/5 (133 download)

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Book Synopsis Handbook of the Cerebellum and Cerebellar Disorders by : Mario Manto

Download or read book Handbook of the Cerebellum and Cerebellar Disorders written by Mario Manto and published by Springer. This book was released on 2012-08-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications.

Handbook of the Cerebellum and Cerebellar Disorders

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Author :
Publisher : Springer
ISBN 13 : 9783030238094
Total Pages : 2737 pages
Book Rating : 4.2/5 (38 download)

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Book Synopsis Handbook of the Cerebellum and Cerebellar Disorders by : Mario U. Manto

Download or read book Handbook of the Cerebellum and Cerebellar Disorders written by Mario U. Manto and published by Springer. This book was released on 2021-12-05 with total page 2737 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our knowledge of cerebellar functions and cerebellar disorders, called ataxias, is increasing considerably. Studies of the cerebellum are now a central focus in neuroscience. During the last four decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and biology of mental processes, behavioral symptoms, and emotion. It is now accepted that the cerebellum acts as a cognitive operator in learning, perception, and attention. Moreover, major improvements in our assessment of in vivo cerebellar architecture using imaging techniques have occurred. A typical example is the accurate description of cerebellar anatomy during fetal development with MRI, a progress which has direct impacts on patient care. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias. More than 20 new genes have been identified these last 10 years. Only for dominant ataxias, more than 30 diseases have now been unravelled. The number of ataxic disorders will increase with aging, the cerebellum being the structure of the brain with the most important loss of neurons with age. More than 300 different cerebellar disorders are encountered during daily practice, but we are missing a single source of information explaining their pathogenesis. Despite the immense amount of knowledge acquired about the cerebellar circuitry these last years, a large book covering the neuroscience of the cerebellum is missing. The goal of this endeavour is to bring up to date information relevant for basic science and also for clinical activities. To reach this goal, the most renowned authors are gathered in a unique and in-depth book with a format of a handbook. We emphasize the connections between molecular findings, imaging features, behavioural/neuropsychological aspects, and clinical implications.

Cerebellar Functions (1912)

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Author :
Publisher :
ISBN 13 : 9781436801683
Total Pages : 228 pages
Book Rating : 4.8/5 (16 download)

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Book Synopsis Cerebellar Functions (1912) by : J. Andre-Thomas

Download or read book Cerebellar Functions (1912) written by J. Andre-Thomas and published by . This book was released on 2008-06-01 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This scarce antiquarian book is a facsimile reprint of the original. Due to its age, it may contain imperfections such as marks, notations, marginalia and flawed pages. Because we believe this work is culturally important, we have made it available as part of our commitment for protecting, preserving, and promoting the world's literature in affordable, high quality, modern editions that are true to the original work.

The Cerebellum in Emotions and Psychopathology

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Publisher : Routledge
ISBN 13 : 1351383744
Total Pages : 156 pages
Book Rating : 4.3/5 (513 download)

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Book Synopsis The Cerebellum in Emotions and Psychopathology by : Dennis J.L.G. Schutter

Download or read book The Cerebellum in Emotions and Psychopathology written by Dennis J.L.G. Schutter and published by Routledge. This book was released on 2020-12-29 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This groundbreaking volume examines the complex role of the cerebellum in emotional regulation and disorders that are insufficiently understood, subverting the widely held belief that the cerebellum is solely involved in balance and motor functions. Beginning with the evolution of the cerebellum toward a structure dedicated to homeostatic regulation and socio-emotional behavior, the book examines the growing body of evidence supporting the importance of the cerebellum in emotions, cognition, and psychopathology. Going on to discuss the implications of cerebellar abnormalities, Schutter analyzes groundbreaking research and explores how cerebellar abnormalities are associated with disruption in associative learning in anxiety, the pathophysiology of depression and cognitive regulation, the synchronization of information processing in schizophrenia, the aberrant connectivity patterns in autism spectrum disorders, and explosive forms of aggressive behavior. Collating pioneering research on the multifaceted role of the cerebellum, this book will be essential reading for students and researchers of neurology and psychopathology.

Cerebellum and Rhythmical Movements

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Author :
Publisher : Springer
ISBN 13 :
Total Pages : 194 pages
Book Rating : 4.:/5 (45 download)

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Book Synopsis Cerebellum and Rhythmical Movements by : I︠U︡riĭ Ilʹich Arshavskiĭ

Download or read book Cerebellum and Rhythmical Movements written by I︠U︡riĭ Ilʹich Arshavskiĭ and published by Springer. This book was released on 1986-10 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: After reading the manuscript, some biologists inquired why, on the basis of the broad experimental material presented in this book, we had not come up with a model describing the operation of the cerebellum. To answer this question, we decided to write a preface to our book. How the nervous system copes with the complexity of the world is one of the central problems of neurophys iology. The question was clearly formulated for the frrst time by N. A. Bernstein. Considering the problem of motor control, he pointed out that the main objective of motor coordination is to overcome the redundant number of degrees of freedom of the motor apparatus or, in other words, to diminish the number of independent variables which control the movement (Bernstein 1967). These I. M. Gelfand and M. L. Zetlin ideas were further developed by (Gelfand and Zetlin 1966). They proposed, in particular, the "non-individualized" ("non-addressed") mode of control in complex systems, where only the highest levels of the system have the full notion about the fmal task while the main "effectors" act on the basis of very limited information. These propositions were made by Gelfand and Zetlin in a very general form, but, nevertheless, proved to be fruitful in determining the direction of experimental research. For instance, the discovery of the "locomotory region" of the brain stem (Shik et al.

The Cerebellum (Classic Reprint)

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Author :
Publisher : Forgotten Books
ISBN 13 : 9780282778316
Total Pages : 68 pages
Book Rating : 4.7/5 (783 download)

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Book Synopsis The Cerebellum (Classic Reprint) by : H. Davies

Download or read book The Cerebellum (Classic Reprint) written by H. Davies and published by Forgotten Books. This book was released on 2017-07-07 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: Excerpt from The Cerebellum The whole of the Nervous System, including the sympathetic and peripheral nerves, as also various epi thelia and structures, - are derived from the first of the three blastodermic layers, - the Epiblast, Mesoblast, and Hypoblast, with which the student of embryology has to become so familiarized. The study of the develop ment of the brain is replete with exceeding interest and charm, and the reward of the diligent inquirer who, commencing at the pre-natal state, recognizes the primitive changes and follows them onward with a growing wonder and increasing apprehension of their eventual modifications and purposes, until the embryo, through all its stages, has been ushered into the light of life and traced progressively through an amazing complexity of relationships, - the reward of such an one is incapable of verbal expression it is certainly most profound. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.

Cerebellum and Rhythmical Movements

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Author :
Publisher : Springer
ISBN 13 : 9783642708282
Total Pages : 0 pages
Book Rating : 4.7/5 (82 download)

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Book Synopsis Cerebellum and Rhythmical Movements by : Y.I. Arshavsky

Download or read book Cerebellum and Rhythmical Movements written by Y.I. Arshavsky and published by Springer. This book was released on 1986 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: After reading the manuscript, some biologists inquired why, on the basis of the broad experimental material presented in this book, we had not come up with a model describing the operation of the cerebellum. To answer this question, we decided to write a preface to our book. How the nervous system copes with the complexity of the world is one of the central problems of neurophys iology. The question was clearly formulated for the frrst time by N. A. Bernstein. Considering the problem of motor control, he pointed out that the main objective of motor coordination is to overcome the redundant number of degrees of freedom of the motor apparatus or, in other words, to diminish the number of independent variables which control the movement (Bernstein 1967). These I. M. Gelfand and M. L. Zetlin ideas were further developed by (Gelfand and Zetlin 1966). They proposed, in particular, the "non-individualized" ("non-addressed") mode of control in complex systems, where only the highest levels of the system have the full notion about the fmal task while the main "effectors" act on the basis of very limited information. These propositions were made by Gelfand and Zetlin in a very general form, but, nevertheless, proved to be fruitful in determining the direction of experimental research. For instance, the discovery of the "locomotory region" of the brain stem (Shik et al.

Neuropedia

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Author :
Publisher : Princeton University Press
ISBN 13 : 0691242186
Total Pages : 176 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis Neuropedia by : Eric H. Chudler

Download or read book Neuropedia written by Eric H. Chudler and published by Princeton University Press. This book was released on 2022-11-22 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fun and fact-filled A–Z treasury for anyone with a head on their shoulders Neuropedia journeys into the mysteries and marvels of the three pounds of tissue between your ears—the brain. Eric Chudler takes you on a breathtaking tour of the nervous system with dozens of entries that explore the structure and function of the brain and cover topics such as the spinal cord and nerve cells, the methods of neuroscientific research, and the visionary scientists who have dedicated their lives to understanding what makes each of us who we are. The brain has fascinated and puzzled researchers, physicians, and philosophers for thousands of years and captivated us with each new discovery. This compendium of neuroscientific wonders is brimming with facts and insights, helping us to make sense of our current understanding of the nervous system while identifying the frontiers in our knowledge that remain unexplored. Chudler guides readers through a variety of rare and common neurological disorders such as alien hand disorder, Capgras syndrome, Alzheimer’s disease, Parkinson’s disease, and stroke, and discusses the latest brain-imaging methods used to diagnose them. He discusses neurochemicals, neurotoxins, and lifesaving drugs, and offers bold perspectives on human consciousness that enable us to better appreciate our place in nature. With marvelous illustrations by Kelly Chudler, Neuropedia is an informative and entertaining trip into the inner world of the brain.

The Human Brain and Spinal Cord

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1468401505
Total Pages : 396 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis The Human Brain and Spinal Cord by : Lennart Heimer

Download or read book The Human Brain and Spinal Cord written by Lennart Heimer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was written to serve both as a guide for the dissection of the human brain and as an illustrated compendium of the functional anatomy of the brain and spinal cord. In this sense, the book represents an updated and expanded version of the book The Human Brain and Spinal Cord written by the author and published in Swedish by Scandinavian University Books in 1961. The complicated anatomy of the brain can often be more easily appreciated and understood in relation to its development. Some insight about the coverings of the brain will also make the brain dissections more meaningful. Introductory chapters on these subjects constitute Part I of the book. Part 2 is composed of the dissection guide, in which text and illustrations are juxtaposed as much as possible in order to facilitate the use of the book in the dissection room. The method of dissection is similar to dissection proce dures used in many medical schools throughout the world, and variations of the technique have been published by several authors including Ivar Broman in the "Manniskohjarnan" (The Human Brain) published by Gleerups F6rlag, Lund, 1926, and Laszlo Komaromy in "Dissection of the Brain," published by Akademiai Kiado, Budapest, 1947. The great popularity of the CT scanner justifies an extra laboratory session for the comparison of nearly horizontal brain sections with matching CT scans.

Cerebellar Disorders

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Author :
Publisher : Cambridge University Press
ISBN 13 : 1139487264
Total Pages : 313 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Cerebellar Disorders by : Mario Ubaldo Manto

Download or read book Cerebellar Disorders written by Mario Ubaldo Manto and published by Cambridge University Press. This book was released on 2010-03-25 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last three decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and the biology of mental processes, behavioral symptoms and emotion. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias, and the growing number of diseases presents a source of difficulty for clinicians during daily practice. This practical guide summarizes and evaluates current knowledge in the field of cerebellar disorders. Encompassing details of both common and uncommon cerebellar ataxias, including vascular, immune, neoplastic, infectious, traumatic, toxic and inherited disorders, this book will assist clinicians in the diagnosis and management of the full spectrum of cerebellar ataxias encountered in daily practice. Essential reading for clinicians, including general practitioners, neurologists, pediatricians, radiologists, psychiatrists and neuropsychologists, this will also prove a valuable tool for students, trainees and researchers.

Measuring Cerebellar Function

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Author :
Publisher : Humana
ISBN 13 : 9781071620250
Total Pages : 351 pages
Book Rating : 4.6/5 (22 download)

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Book Synopsis Measuring Cerebellar Function by : Roy V. Sillitoe

Download or read book Measuring Cerebellar Function written by Roy V. Sillitoe and published by Humana. This book was released on 2022-01-06 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume considers the current techniques used by experts to study and measure cerebellar function. The chapters in this book cover topics such as stem cell-based techniques; conditional genetics approaches in model systems; neuronal recordings conducted in vitro and in vivo; and an ever-growing list of behavioral paradigms. This book also provides readers with a guide for how to use tools such as iPSCs and how to address questions using a range of approaches in animal model systems including mouse, rat, zebrafish, and non-human primate. In the Neuromethods series style, the chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Measuring Cerebellar Function is a valuable resource for cerebellar enthusiasts and other scientists interested in learning more about the cerebellum and the technological advances that are currently being employed to unlock brain function and understand animal behavior.