The Chemistry Of Contrast Agents In Medical Magnetic Resonance Imaging

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The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging

Author : Andre S. Merbach
Publisher : John Wiley & Sons
ISBN 13 : 1118503678
Total Pages : 514 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging by : Andre S. Merbach

Download or read book The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging written by Andre S. Merbach and published by John Wiley & Sons. This book was released on 2013-02-19 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Resonance Imaging (MRI) is one of the most important tools in clinical diagnostics and biomedical research. The number of MRI scanners operating around the world is estimated to be approximately 20,000, and the development of contrast agents, currently used in about a third of the 50 million clinical MRI examinations performed every year, has largely contributed to this significant achievement. This completely revised and extended second edition: Includes new chapters on targeted, responsive, PARACEST and nanoparticle MRI contrast agents. Covers the basic chemistries, MR physics and the most important techniques used by chemists in the characterization of MRI agents from every angle from synthesis to safety considerations. Is written for all of those involved in the development and application of contrast agents in MRI. Presented in colour, it provides readers with true representation and easy interpretation of the images. A word from the Authors: Twelve years after the first edition published, we are convinced that the chemistry of MRI agents has a bright future. By assembling all important information on the design principles and functioning of magnetic resonance imaging probes, this book intends to be a useful tool for both experts and newcomers in the field. We hope that it helps inspire further work in order to create more efficient and specific imaging probes that will allow materializing the dream of seeing even deeper and better inside the living organisms. Reviews of the First Edition: "...attempts, for the first time, to review the whole spectrum of involved chemical disciplines in this technique..."—Journal of the American Chemical Society "...well balanced in its scope and attention to detail...a valuable addition to the library of MR scientists..."—NMR in Biomedicine

Medical Imaging Contrast Agents: A Clinical Manual

Author : Sukru Mehmet Erturk
Publisher : Springer Nature
ISBN 13 : 3030792560
Total Pages : 303 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Medical Imaging Contrast Agents: A Clinical Manual by : Sukru Mehmet Erturk

Download or read book Medical Imaging Contrast Agents: A Clinical Manual written by Sukru Mehmet Erturk and published by Springer Nature. This book was released on 2021-08-24 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume highlights and broadens our understanding of the correct use and the possible contraindications of contrast agents applied in radiology. Written by experts in the field, it not only focuses on the chemistry, physiochemical properties and pharmacokinetics of both iodinated and gadolinium-containing contrast agents, but also on the relevant safety issues such as frequency of their short- and long-term side effects and ways to avoid them nephrotoxicity risk related to the iodinated contrast agents NSF (nephrogenic systemic fibrosis) accumulation of gadolinium in the brain use of contrast agents in pediatric patients and pregnancy It also includes essential data on the use of contrast agents, such as scanning protocols, in the context of various clinical conditions. This comprehensive manual addresses all professionals involved in radiological imaging and is an invaluable tool for radiologists and technologists, as well as for residents and clinicians.

Electron Paramagnetic Resonance Spectroscopy

Author : Patrick Bertrand
Publisher : Springer Nature
ISBN 13 : 3030396630
Total Pages : 433 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis Electron Paramagnetic Resonance Spectroscopy by : Patrick Bertrand

Download or read book Electron Paramagnetic Resonance Spectroscopy written by Patrick Bertrand and published by Springer Nature. This book was released on 2020-02-03 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although originally invented and employed by physicists, electron paramagnetic resonance (EPR) spectroscopy has proven to be a very efficient technique for studying a wide range of phenomena in many fields, such as chemistry, biochemistry, geology, archaeology, medicine, biotechnology, and environmental sciences. Acknowledging that not all studies require the same level of understanding of this technique, this book thus provides a practical treatise clearly oriented toward applications, which should be useful to students and researchers of various levels and disciplines. In this book, the principles of continuous wave EPR spectroscopy are progressively, but rigorously, introduced, with emphasis on interpretation of the collected spectra. Each chapter is followed by a section highlighting important points for applications, together with exercises solved at the end of the book. A glossary defines the main terms used in the book, and particular topics, whose knowledge is not required for understanding the main text, are developed in appendices for more inquisitive readers.

Contrast Agents I

Author : Werner Krause
Publisher : Springer Science & Business Media
ISBN 13 : 3540422471
Total Pages : 251 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis Contrast Agents I by : Werner Krause

Download or read book Contrast Agents I written by Werner Krause and published by Springer Science & Business Media. This book was released on 2002-01-22 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extracellular MRI and X-ray contrast agents are characterized by their phar- cokinetic behaviour.After intravascular injection their plasma-level time curve is characeterized by two phases. The agents are rapidly distributed between plasma and interstitial spaces followed by renal elimination with a terminal half-live of approximatly 1–2 hours. They are excreted via the kidneys in unchanged form by glomerular filtration. Extracellular water-soluble contrast agents to be applied for X-ray imaging were introduced into clinical practice in 1923. Since that time they have proved to be most valuable tools in diagnostics.They contain iodine as the element of choice with a sufficiently high atomic weight difference to organic tissue. As positive contrast agents their attenuation of radiation is higher compared with the attenuation of the surrounding tissue. By this contrast enhancement X-ray diagnostics could be improved dramatically. In 2,4,6-triiodobenzoic acid derivatives iodine is firmly bound. Nowadays diamides of the 2,4,6-triiodo-5-acylamino-isophthalic acid like iopromide (Ultravist, Fig. 1) are used as non-ionic (neutral) X-ray contrast agents in most cases [1].

The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging

Author : André E. Merbach
Publisher : Wiley
ISBN 13 : 9780471607786
Total Pages : 0 pages
Book Rating : 4.6/5 (77 download)

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Book Synopsis The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging by : André E. Merbach

Download or read book The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging written by André E. Merbach and published by Wiley. This book was released on 2001-04-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a huge increase in the use of MRI and contrast agents in medicine in recent years as evidenced by a big increase in the number of hospitals with MRI machines and the ever-increasing number of examinations using contrast agents. Contrast agents have revolutionized the use of Magnetic Resonance Imaging (MRI) in medical diagnostics, allowing doctors to distinguish between normal and abnormal tissues and ultimately improving prognosis for the patient. This monograph covers all aspects of production, use, operating mechanisms and theory of these diagnostic agents, used to produce high contrast images in MRI. It will therefore be unique resource for what is currently a very active domain of research both in universities and in industry. The Chemistry of Contrast Agents in Medical Magnetic Resonance Imaging is a comprehensive treatise: * written by the most active scientists in the field of contrast agents for medical MRI - from both university and industrial backgrounds * covering the topic from every angle from synthesis to safety considerations * invaluable to physicists, chemists, biologists as well as physicians * the first in-depth coverage of this topic

Biomedical Imaging

Author : Martin Braddock
Publisher : Royal Society of Chemistry
ISBN 13 : 1849732914
Total Pages : 553 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Biomedical Imaging by : Martin Braddock

Download or read book Biomedical Imaging written by Martin Braddock and published by Royal Society of Chemistry. This book was released on 2011-11-23 with total page 553 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this new book is for medicinal chemists on the chemical agents that have been used, or might be required in the future, and the methods of synthesis for inserting the reporter groups. Medicinal chemists need to know the critical issues involved in using such chemical agents with regard to the biological applications - for instance - what properties are needed chemically and why? The topics covered in the book are: PET, SPECT, contrast agents, radioimaging/radionuclide conjugates, receptor mapping, small animal imaging (eg. WBAR - whole body autoradiography); photoinduced labelling, as well as chapters on the physical techniques used including: NMR, mass spectrometry and Xray. A key reference for academics, postgraduates, researchers, industrialists and professionals working in or joining this field.

Cardiovascular Magnetic Resonance Imaging

Author : Raymond Y. Kwong
Publisher : Springer
ISBN 13 : 1493988417
Total Pages : 472 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Cardiovascular Magnetic Resonance Imaging by : Raymond Y. Kwong

Download or read book Cardiovascular Magnetic Resonance Imaging written by Raymond Y. Kwong and published by Springer. This book was released on 2019-01-31 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The significantly updated second edition of this important work provides an up-to-date and comprehensive overview of cardiovascular magnetic resonance imaging (CMR), a rapidly evolving tool for diagnosis and intervention of cardiovascular disease. New and updated chapters focus on recent applications of CMR such as electrophysiological ablative treatment of arrhythmias, targeted molecular MRI, and T1 mapping methods. The book presents a state-of-the-art compilation of expert contributions to the field, each examining normal and pathologic anatomy of the cardiovascular system as assessed by magnetic resonance imaging. Functional techniques such as myocardial perfusion imaging and assessment of flow velocity are emphasized, along with the exciting areas of artherosclerosis plaque imaging and targeted MRI. This cutting-edge volume represents a multi-disciplinary approach to the field, with contributions from experts in cardiology, radiology, physics, engineering, physiology and biochemistry, and offers new directions in noninvasive imaging. The Second Edition of Cardiovascular Magnetic Resonance Imaging is an essential resource for cardiologists and radiologists striving to lead the way into the future of this important field.

Fluorine Magnetic Resonance Imaging

Author : Ulrich Flogel
Publisher : CRC Press
ISBN 13 : 1315340933
Total Pages : 426 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Fluorine Magnetic Resonance Imaging by : Ulrich Flogel

Download or read book Fluorine Magnetic Resonance Imaging written by Ulrich Flogel and published by CRC Press. This book was released on 2016-10-26 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, fluorine (19F) magnetic resonance imaging (MRI) has garnered significant scientific interest in the biomedical research community owing to the unique properties of fluorinated materials and the 19F nucleus. Fluorine has an intrinsically sensitive nucleus for MRI. There is negligible endogenous 19F in the body and thus there is no background signal. Fluorine-containing compounds are ideal tracer labels for a wide variety of MRI applications. Moreover, the chemical shift and nuclear relaxation rate can be made responsive to physiology via creative molecular design. This book is an interdisciplinary compendium that details cutting-edge science and medical research in the emerging field of 19F MRI. Edited by Ulrich Flögel and Eric Ahrens, two prominent MRI researchers, this book will appeal to investigators involved in MRI, biomedicine, immunology, pharmacology, probe chemistry, and imaging physics.

Molecular Imaging I

Author : Wolfhard Semmler
Publisher : Springer Science & Business Media
ISBN 13 : 3540727183
Total Pages : 298 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Molecular Imaging I by : Wolfhard Semmler

Download or read book Molecular Imaging I written by Wolfhard Semmler and published by Springer Science & Business Media. This book was released on 2008-07-15 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this textbook of molecular imaging is to provide an up to date review of this rapidly growing field and to discuss basic methodological aspects necessary for the interpretation of experimental and clinical results. Emphasis is placed on the interplay of imaging technology and probe development, since the physical properties of the imaging approach need to be closely linked with the biologic application of the probe (i.e. nanoparticles and microbubbles). Various chemical strategies are discussed and related to the biologic applications. Reporter-gene imaging is being addressed not only in experimental protocols, but also first clinical applications are discussed. Finally, strategies of imaging to characterize apoptosis and angiogenesis are described and discussed in the context of possible clinical translation.

MRI

Author : Brian M. Dale
Publisher : John Wiley & Sons
ISBN 13 : 1119013038
Total Pages : 246 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis MRI by : Brian M. Dale

Download or read book MRI written by Brian M. Dale and published by John Wiley & Sons. This book was released on 2015-08-06 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fifth edition of the most accessible introduction to MRI principles and applications from renowned teachers in the field provides an understandable yet comprehensive update. Accessible introductory guide from renowned teachers in the field Provides a concise yet thorough introduction for MRI focusing on fundamental physics, pulse sequences, and clinical applications without presenting advanced math Takes a practical approach, including up-to-date protocols, and supports technical concepts with thorough explanations and illustrations Highlights sections that are directly relevant to radiology board exams Presents new information on the latest scan techniques and applications including 3 Tesla whole body scanners, safety issues, and the nephrotoxic effects of gadolinium-based contrast media

Visualizing Chemistry

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030916463X
Total Pages : 222 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Visualizing Chemistry by : National Research Council

Download or read book Visualizing Chemistry written by National Research Council and published by National Academies Press. This book was released on 2006-06-01 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists and engineers have long relied on the power of imaging techniques to help see objects invisible to the naked eye, and thus, to advance scientific knowledge. These experts are constantly pushing the limits of technology in pursuit of chemical imagingâ€"the ability to visualize molecular structures and chemical composition in time and space as actual events unfoldâ€"from the smallest dimension of a biological system to the widest expanse of a distant galaxy. Chemical imaging has a variety of applications for almost every facet of our daily lives, ranging from medical diagnosis and treatment to the study and design of material properties in new products. In addition to highlighting advances in chemical imaging that could have the greatest impact on critical problems in science and technology, Visualizing Chemistry reviews the current state of chemical imaging technology, identifies promising future developments and their applications, and suggests a research and educational agenda to enable breakthrough improvements.

PET/MRI in Oncology

Author : Andrei Iagaru
Publisher : Springer
ISBN 13 : 3319685171
Total Pages : 435 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis PET/MRI in Oncology by : Andrei Iagaru

Download or read book PET/MRI in Oncology written by Andrei Iagaru and published by Springer. This book was released on 2018-01-23 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, experts from premier institutions across the world with extensive experience in the field clearly and succinctly describe the current and anticipated uses of PET/MRI in oncology. The book also includes detailed presentations of the MRI and PET technologies as they apply to the combined PET/MRI scanners. The applications of PET/MRI in a wide range of oncological settings are well documented, highlighting characteristic findings, advantages of this dual-modality technique, and pitfalls. Whole-body PET/MRI applications and pediatric oncology are discussed separately. In addition, information is provided on PET technology designs and MR hardware for PET/MRI, MR pulse sequences and contrast agents, attenuation and motion correction, the reliability of standardized uptake value measurements, and safety considerations. The balanced presentation of clinical topics and technical aspects will ensure that the book is of wide appeal. It will serve as a reference for specialists in nuclear medicine and radiology and oncologists and will also be of interest for residents in these fields and technologists.

Magnetic Resonance Imaging

Author : Robert W. Brown
Publisher : John Wiley & Sons
ISBN 13 : 0471720852
Total Pages : 976 pages
Book Rating : 4.4/5 (717 download)

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Book Synopsis Magnetic Resonance Imaging by : Robert W. Brown

Download or read book Magnetic Resonance Imaging written by Robert W. Brown and published by John Wiley & Sons. This book was released on 2014-06-23 with total page 976 pages. Available in PDF, EPUB and Kindle. Book excerpt: New edition explores contemporary MRI principles and practices Thoroughly revised, updated and expanded, the second edition of Magnetic Resonance Imaging: Physical Principles and Sequence Design remains the preeminent text in its field. Using consistent nomenclature and mathematical notations throughout all the chapters, this new edition carefully explains the physical principles of magnetic resonance imaging design and implementation. In addition, detailed figures and MR images enable readers to better grasp core concepts, methods, and applications. Magnetic Resonance Imaging, Second Edition begins with an introduction to fundamental principles, with coverage of magnetization, relaxation, quantum mechanics, signal detection and acquisition, Fourier imaging, image reconstruction, contrast, signal, and noise. The second part of the text explores MRI methods and applications, including fast imaging, water-fat separation, steady state gradient echo imaging, echo planar imaging, diffusion-weighted imaging, and induced magnetism. Lastly, the text discusses important hardware issues and parallel imaging. Readers familiar with the first edition will find much new material, including: New chapter dedicated to parallel imaging New sections examining off-resonance excitation principles, contrast optimization in fast steady-state incoherent imaging, and efficient lower-dimension analogues for discrete Fourier transforms in echo planar imaging applications Enhanced sections pertaining to Fourier transforms, filter effects on image resolution, and Bloch equation solutions when both rf pulse and slice select gradient fields are present Valuable improvements throughout with respect to equations, formulas, and text New and updated problems to test further the readers' grasp of core concepts Three appendices at the end of the text offer review material for basic electromagnetism and statistics as well as a list of acquisition parameters for the images in the book. Acclaimed by both students and instructors, the second edition of Magnetic Resonance Imaging offers the most comprehensive and approachable introduction to the physics and the applications of magnetic resonance imaging.

Surface-modified Nanobiomaterials for Electrochemical and Biomedicine Applications

Author : Alain R. Puente-Santiago
Publisher : Springer Nature
ISBN 13 : 303055502X
Total Pages : 260 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Surface-modified Nanobiomaterials for Electrochemical and Biomedicine Applications by : Alain R. Puente-Santiago

Download or read book Surface-modified Nanobiomaterials for Electrochemical and Biomedicine Applications written by Alain R. Puente-Santiago and published by Springer Nature. This book was released on 2020-07-27 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

Chemical Exchange Saturation Transfer Imaging

Author : Michael T. McMahon
Publisher : CRC Press
ISBN 13 : 1315340755
Total Pages : 463 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Chemical Exchange Saturation Transfer Imaging by : Michael T. McMahon

Download or read book Chemical Exchange Saturation Transfer Imaging written by Michael T. McMahon and published by CRC Press. This book was released on 2017-01-12 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first textbook dedicated to CEST imaging and covers the fundamental principles of saturation transfer, key features of CEST agents that enable the production of imaging contrast, and practical aspects of preparing image-acquisition and post-processing schemes suited for in vivo applications. CEST is a powerful MRI contrast mechanism with unique features, and the rapid expansion it has seen over the past 15 years since its original discovery in 2000 has created a need for a graduate-level handbook describing all aspects of pre-clinical, translational, and clinical CEST imaging. The book provides an illustrated historical perspective by leaders at the five key sites who developed CEST imaging, from the initial saturation transfer NMR experiments performed in the 1960s in Stockholm, Sweden, described by Sture Forsén, to the work on integrating the basic principles of CEST into imaging by Robert Balaban, Dean Sherry, Silvio Aime, and Peter van Zijl in the United States and Italy. The editors, Drs. Michael T. McMahon, Assaf A. Gilad, Jeff W. M. Bulte, and Peter C. M. van Zijl, have been pioneers developing this field at the Johns Hopkins University School of Medicine and the Kennedy Krieger Institute including contributions to Nature Medicine, Nature Biotechnology, Nature Materials, and the Proceedings of the National Academy of Sciences. As recognition for their initial development of the field, Drs. van Zijl and Balaban were awarded the Laukien Prize in April 2016, established in 1999 to honor the memory of Professor Gunther Laukien, a co-founder of Bruker Biospin GmbH.

NMR and MRI of Gels

Author : Yves De Deene
Publisher : Royal Society of Chemistry
ISBN 13 : 1788019202
Total Pages : 426 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis NMR and MRI of Gels by : Yves De Deene

Download or read book NMR and MRI of Gels written by Yves De Deene and published by Royal Society of Chemistry. This book was released on 2020-07-07 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gels are used in a large variety of commercial and scientific products from drug delivery systems and food science to biomedical sensors. They also are invaluable in MRI physics research where they mimic biological tissue and in radiotherapy quality assurance where they are used to capture the three dimensional radiation dose distribution. This unique book discusses the state-of-the-art of NMR and MRI techniques in studying the physics and chemistry of gel systems, in their application as MRI phantoms and as three dimensional radiation dosimeters. The first part of the book will cover the fundamental physical concepts of gels and the NMR techniques to study gel systems. The second part is dedicated to the application of gels in the life sciences and in the medical practice to validate radiotherapy and new MRI techniques. Filling the gap in literature, this volume provides the scientific reader with an extensive overview of possible techniques and methods to study the interesting properties and applications of gels. For the MRI researcher and medical physicist, the book will be a valuable resource in using gel phantoms for validating contemporary MRI techniques and radiotherapy treatments.

Computational Molecular Magnetic Resonance Imaging for Neuro-oncology

Author : Michael O. Dada
Publisher : Springer Nature
ISBN 13 : 3030767280
Total Pages : 412 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Computational Molecular Magnetic Resonance Imaging for Neuro-oncology by : Michael O. Dada

Download or read book Computational Molecular Magnetic Resonance Imaging for Neuro-oncology written by Michael O. Dada and published by Springer Nature. This book was released on 2021-07-31 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the analytical methods and the computer programs presented in this book, all that may be needed to perform MRI tissue diagnosis is the availability of relaxometric data and simple computer program proficiency. These programs are easy to use, highly interactive and the data processing is fast and unambiguous. Laboratories (with or without sophisticated facilities) can perform computational magnetic resonance diagnosis with only T1 and T2 relaxation data. The results have motivated the use of data to produce data-driven predictions required for machine learning, artificial intelligence (AI) and deep learning for multidisciplinary and interdisciplinary research. Consequently, this book is intended to be very useful for students, scientists, engineers, the medical personnel and researchers who are interested in developing new concepts for deeper appreciation of computational magnetic resonance imaging for medical diagnosis, prognosis, therapy and management of tissue diseases.