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The Benzodiazepines
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Download or read book Benzodiazepines written by H. Schütz and published by Springer. This book was released on 2011-11-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: To comment at length on the importance of the benzodiazepines seems superfluous within the scope of this preface. No other class of active substances has experienced an even approximately compa rable advance in the past two decades. It is therefore not surprising that the formerly dominant barbiturates and bromocarbamides have had to give way in many fields to the benzodiazepines, which now rank first (Proudfoot and Park [1828]). Closely linked with the great therapeutic importance of the benzodia zepines are analytical problems. Detection and the determination of blood levels can be necessary under therapeutic aspects, for instance in working out optimally effective levels in the treatment of epileptic conditions ("drug monitoring"), but also in connection with questions at issue in toxicology and traffic medicine. A toxicological analysis can be subdivided into the following steps: Detection (identification including screening) Determination (e. g. blood, plasma or serum levels) Interpretation of the analytical results. This book is intended as a contribution to each of these chapters: The part "Analytical Data" (pp.I-122) gives a comprehensive collec tion of data, e.g. general and chromatographic data (TLC, GLC) as well as spectra (UV, IR, MS) of 19 commercial preparations, 23 important metabolites and 18 hydrolysis derivatives. Information about biotransformation and the possible formation of aminobenzo phenone derivatives is also given. The most important analytical methods are presented in an extensive review on pp.123-204 in order to make it possible to select the optimum method on the basis of the essential data.
Book Synopsis The Benzodiazepines Crisis by : John Peppin
Download or read book The Benzodiazepines Crisis written by John Peppin and published by Oxford University Press. This book was released on 2020-10-01 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed decades ago to treat a legitimate medical need, benzodiazepines promisingly displaced less-effective and less-safe drugs, though prescribing has since exceeded their intended use and outpaced the available data. The current situation is characterized by excessive prescribing and extended utilization beyond good therapeutic practice. Evidence indicates that prolonged use of benzodiazepines causes a wide range of adverse reactions, and withdrawal can be particularly challenging. Misused, abused, diverted, and counterfeited, benzodiazepines have serious potential for substance use disorder, and are among the leading causes of drug-related overdose deaths. The Benzodiazepines Crisis sounds the alarm against the overuse of benzodiazepines, presenting an updated, evidence-based overview of this class of drugs and their negative consequences. Bringing together years of research, clinical expertise, and scientific evidence, this book aims to address a perceived lag between evidence and action in order to call for rational and dramatically reduced usage of benzodiazepines.
Book Synopsis The Benzo Book by : Jack Hobson-Dupont
Download or read book The Benzo Book written by Jack Hobson-Dupont and published by Lulu.com. This book was released on 2006-06-01 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: FROM THE BACK COVER: Are you--or is someone you care about--taking tranquilizers or sleeping pills? You could be at risk of addiction without even knowing it. Benzos are the most commonly prescribed tranquilizers and sleeping pills, in use by millions of people. Doctors prescribe these drugs routinely without ever warning patients that regular use may cause a dangerous dependency. For many people, Benzos are much harder to quit than heroin, cocaine, crack and other illegal substances, even when taken under a physician's supervision. Benzo Withdrawal may last for months, even years. Get the facts about the drugs in your medicine cabinet--facts the pharmaceutical companies, and even the FDA, don't want you to know. The Benzo Book recounts the author's experience as an unwitting addict, with full details about minimizing withdrawal symptoms, and exposes the sociological, medical and economic factors which cause this widespread--yet largely unknown--problem.
Book Synopsis Benzodiazepines II by : Harald Schütz
Download or read book Benzodiazepines II written by Harald Schütz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 621 pages. Available in PDF, EPUB and Kindle. Book excerpt: " ... this is an excellent compilation of data which should be on the bookshelves of all analysts interested in the benzodiazepines. It is to be hoped that, with the introduction of so many new ben zodiazepines, the author will quickly add these in a second edi tion" (A. C. Moffat in: Trends in Analytical Chemistry, 1983). This review, deputizing for many others, reflects the friendly reception enjoyed by the first volume of Benzodiazepines, which was published in 1982 and apparently closed a gap in the ben zodiazepine literature. In the meantime, Benzodiazepines has established itself as a standard book, as evidenced by numerous letters and quotations. Suggestions were also soon made for a new edition in view of the unusually rapid development in the field of the benzodiazepines. It became quickly obvious, however, that it would not be sufficient to publish a revised second edition, but that a completely new second volume would be required for which, however, the successful previous format could be largely retained. The following considerations seem worth mentioning in connection with the preparation of Volume II: - To ensure continuity with Volume I as far as possible, the list of references was consecutively numbered (references 1 to 3779 in Volume I, references 3780 to 11338 in Volume II). Whereas in Vol. I the substances appear in the sequential order of their historical development they are listed in alphabetical order in Vol. II.
Book Synopsis Modern Anesthetics by : Jürgen Schüttler
Download or read book Modern Anesthetics written by Jürgen Schüttler and published by Springer Science & Business Media. This book was released on 2008-01-08 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some important constraints of anesthesia must be taken into consideration when the pharmacological properties of modern anesthetics are discussed. The most imp- tant of these could be that the target effect be achieved preferably within seconds, at most within a few minutes. Similarly, offset of drug action should be achieved within minutes rather hours. The target effects, such as unconsciousness, are pot- tially life-threatening, as are the side effects of modern anesthetics, such as respi- tory and cardiovascular depression. Finally, the patient’s purposeful responses are not available to guide drug dosage, because, either the patient is unconscious, or more problematically, the patient is aware but unable to communicate pain because of neuromuscular blockade. These constraints were already recognised 35 years ago, when in 1972 Volume XXX entitled “Modern Inhalation Anesthetics” appeared in this Handbook Series. The present volume is meant as a follow up and extension of that volume. At the beginning of the 1970’s anesthesia was commonly delivered by inhalation, with only very few exceptions. The clinical understanding of that time considered anesthesia as a unique state achieved by any of the inhalation anesthetics, in- pendent of their specific molecular structure. “The very mechanism of anesthetic action at the biophase” was discussed within the theoretical framework of the “u- tary theory of narcosis”.
Download or read book The Benzodiazepines written by J. Marks and published by . This book was released on 1978-05-31 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmacological Treatment of Mental Disorders in Primary Health Care by : World Health Organization
Download or read book Pharmacological Treatment of Mental Disorders in Primary Health Care written by World Health Organization and published by World Health Organization. This book was released on 2009 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: This manual attempts to provide simple, adequate and evidence-based information to health care professionals in primary health care especially in low- and middle-income countries to be able to provide pharmacological treatment to persons with mental disorders. The manual contains basic principles of prescribing followed by chapters on medicines used in psychotic disorders; depressive disorders; bipolar disorders; generalized anxiety and sleep disorders; obsessive compulsive disorders and panic attacks; and alcohol and opioid dependence. The annexes provide information on evidence retrieval, assessment and synthesis and the peer view process.
Book Synopsis Hepatotoxicity by : Hyman J. Zimmerman
Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
Download or read book Calming the Brain written by Adam Doble and published by CRC Press. This book was released on 2020-09-08 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the entire field of research in the area of minor tranquillizers and its application to current clinical practice in the treatment of anxiety and insomnia. These drugs are principally the benzodiazepines and related drugs with a similar mechanism of action, such as zolpidem and zopiclone. The molecular mechanism of action of benzodiazepines is described, focussing on the interaction of these drugs with the different isoform of the GABAA^O >receptor, and the consequences of this for brain function. Recent advances in this knowledge have provided a framework for defining the physiochemical nature of the interaction between such drugs and their receptor protein, and thus pave the way for the design of new anxiolytic and hypnotic drugs. The animal models available for evaluating the potential of such new therapeutic agents in the treatment of anxiety and insomnia are discussed. Furthermore, understanding of the physiological regulation of the GABAA receptor may provide insights into the aetiopathology of these diseases. The clinical use of benzodiazepines and related drugs in the treatment of anxiety, insomnia, epilepsy and as anaesthetics are explored. The advantages and limitations of such treatments are discussed, and the impact of drugs evaluated. A chapter is devoted to the issue of independence, the clinical pertinence of tolerence and dependence, and evaluates treatment options that may minimise the risk of dependence.
Download or read book The Benzodiazepines written by J. Marks and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: The story of the benzodiazepines is a fascinating one: the synthesis of a long series of inert compounds and the abandonment of the project: months later, the renewal of the project and the discovery that this compound R05-0690 (Librium ®) was a sedative and muscle relaxant in laboratory animals: the recognition that its postulated structure was wrong and that it was in fact a member of an entirely new chemical class: the excitement caused by the discovery of the powerful taming effect of the drug in wild animals: the even greater excitement in medical circles when its dramatic anxiety relieving effects were cstablished in humans: the subsequent enormous world wide usc of drugs of the benzodiazepine group. I have reason to know the story well for during that period I worked in various capacities in research, marketing and manage ment in the British subsidiary of F. Hoffmann-Ia Roche. It was during this period that I became interested in whether dependence on benzodiazepines could occur and if so to what extent, but felt that this could be examined best from outside the concern. Having now retired from Roche back to academic medicine I have taken the opportunity to examine and analyse the evidence.
Author :Salvatore J. Salamone Publisher :Springer Science & Business Media ISBN 13 :1592591094 Total Pages :157 pages Book Rating :4.5/5 (925 download)
Book Synopsis Benzodiazepines and GHB by : Salvatore J. Salamone
Download or read book Benzodiazepines and GHB written by Salvatore J. Salamone and published by Springer Science & Business Media. This book was released on 2001-09-14 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prominent experts explain the pharmacology and metabolism of benzodiazepines (LDB) and g-hydroxybutyric acid (GHB) and offer powerful and effective methodologies that will enable better detection of these drugs in various body fluids, as well as in hair. The techniques include highly sensitive immunoassay detection of LDBs, the detection of Rohypnol® and other LDBs by mass spectrometry, and the ultrasensitive detection of GHB. State-of-the-art and highly practical, Benzodiazepines and GHB: Detection and Pharmacology offers toxicologists, forensic scientists, and clinical chemists today's most effective methods for detecting these widely abused drugs that are sometimes found associated with criminal acts.
Book Synopsis The Ashton Manual (Revised) by : Prof Ashton
Download or read book The Ashton Manual (Revised) written by Prof Ashton and published by Blurb. This book was released on 2024-04-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication presents insights into the impacts of benzodiazepines on both the mind and body, elucidating the mechanisms through which these effects manifest. It offers comprehensive guidance on safely discontinuing usage following extended periods, furnishing tailored tapering plans for various benzodiazepines. The text delves into withdrawal symptoms, both immediate and prolonged, elucidating their underlying causes and strategies for managing them. Ultimately, the overarching message underscores the potential for successful withdrawal among most long-term benzodiazepine users, leading to enhanced well-being and contentment.
Book Synopsis The Benzodiazepines Crisis by : John Peppin
Download or read book The Benzodiazepines Crisis written by John Peppin and published by Oxford University Press, USA. This book was released on 2021 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Misused, abused, diverted, and counterfeited, benzodiazepines have serious potential for substance use disorder, and are among the leading causes of drug-related overdose deaths. Evidence indicates that prolonged use of benzodiazepines causes a wide range of adverse reactions, and withdrawal can be particularly challenging. Nevertheless, these negative aspects have yet to be thoroughly addressed within the medical community and remain virtually unknown to patients. This book offers an in-depth discussion of the downsides of this overused class of drugs and calls for their rational and dramatically reduced usage.
Download or read book Death Grip written by Matt Samet and published by St. Martin's Press. This book was released on 2013-02-12 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Death Grip chronicles a top climber's near-fatal struggle with anxiety and depression, and his nightmarish journey through the dangerous world of prescription drugs. Matt Samet lived to climb, and craved the challenge, risk, and exhilaration of conquering sheer rock faces around the United States and internationally. But Samet's depression, compounded by the extreme diet and fitness practices of climbers, led him to seek professional help. He entered the murky, inescapable world of psychiatric medicine, where he developed a dangerous addiction to prescribed medications—primarily "benzos," or benzodiazepines—that landed him in institutions and nearly killed him. With dramatic storytelling, persuasive research data, and searing honesty, Matt Samet reveals the hidden epidemic of benzo addiction, which some have suggested can be harder to quit than heroin. Millions of adults and teenagers are prescribed these drugs, but few understand how addictive they are—and how dangerous long-term usage can be, even when prescribed by doctors. After a difficult struggle with addiction, Samet slowly makes his way to a life in recovery through perseverance and a deep love of rock climbing. Conveying both the exhilaration of climbing in the wilderness and the utter madness of addiction, Death Grip is a powerful and revelatory memoir.
Book Synopsis The Benzodiazepines: Current Standards for Medical Practice by : D.E. Smith
Download or read book The Benzodiazepines: Current Standards for Medical Practice written by D.E. Smith and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Seminars in Addiction Psychiatry by : Ed Day
Download or read book Seminars in Addiction Psychiatry written by Ed Day and published by Cambridge University Press. This book was released on 2021-11-04 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive coverage of the theory, practical understanding and management of the psychiatric aspects of drug and alcohol use and dependence.
Book Synopsis Advances in Patient Safety by : Kerm Henriksen
Download or read book Advances in Patient Safety written by Kerm Henriksen and published by . This book was released on 2005 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: v. 1. Research findings -- v. 2. Concepts and methodology -- v. 3. Implementation issues -- v. 4. Programs, tools and products.
