The Agile Approach To Adaptive Research

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The Agile Approach to Adaptive Research

Author : Michael J. Rosenberg
Publisher : John Wiley & Sons
ISBN 13 : 0470599677
Total Pages : 296 pages
Book Rating : 4.4/5 (75 download)

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Book Synopsis The Agile Approach to Adaptive Research by : Michael J. Rosenberg

Download or read book The Agile Approach to Adaptive Research written by Michael J. Rosenberg and published by John Wiley & Sons. This book was released on 2010-02-18 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apply adaptive research to improve results in drug development The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research, using already-available tools and techniques, can enable the industry to streamline clinical trials and reach decision points faster and more efficiently. With a wealth of real-world cases and examples, author Michael Rosenberg gives readers a practical overview of drug development, the problems inherent in current practices, and the advantages of adaptive research technology and methods. He explains the concepts, principles, and specific techniques of adaptive research, and demonstrates why it is an essential evolutionary step toward improving drug research and development. Chapters explore such subjects as: The adaptive concept Design and operational adaptations Sample-size reestimation Agile clinical development Safety and dose finding Statistics in adaptive research, including frequentist and Bayesian approaches Data management technologies The future of clinical development By combining centuries-old intellectual foundations, recent technological advances, and modern management techniques, adaptive research preserves the integrity and validity of clinical research but dramatically improves efficiency.

Adaptive Software Development

Author : James A. Highsmith
Publisher : Dorset House Publishing Company, Incorporated
ISBN 13 : 9780932633408
Total Pages : 0 pages
Book Rating : 4.6/5 (334 download)

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Book Synopsis Adaptive Software Development by : James A. Highsmith

Download or read book Adaptive Software Development written by James A. Highsmith and published by Dorset House Publishing Company, Incorporated. This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: - support an adaptive culture or mindset, in which change and uncertainty are assumed to be the natural state--not a false expectation of order- introduce frameworks to guide the iterative process of managing change- institute collaboration, the interaction of people on three levels: interpersonal, cultural, and structural- add rigor and discipline to the RAD approach, making it scalable to the uncertainty and complexity of real-life undertakings

Adaptive Space: How GM and Other Companies are Positively Disrupting Themselves and Transforming into Agile Organizations

Author : Michael J. Arena
Publisher : McGraw Hill Professional
ISBN 13 : 1260118037
Total Pages : 289 pages
Book Rating : 4.2/5 (61 download)

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Book Synopsis Adaptive Space: How GM and Other Companies are Positively Disrupting Themselves and Transforming into Agile Organizations by : Michael J. Arena

Download or read book Adaptive Space: How GM and Other Companies are Positively Disrupting Themselves and Transforming into Agile Organizations written by Michael J. Arena and published by McGraw Hill Professional. This book was released on 2018-06-15 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lack of Agility is the kiss of death. Position your company to succeed in world of change.To edge out the competition in today’s disruptive environment, you need to ensure that your company is agile—that it can respond to change instantly and effectively. Because fast and furious change is the only thing you can count on in business today.Network expert Michael Arena helped enable GM’s legendary turnaround. In these pages, he explains how you can transform your own company through the concept of adaptive space. Based on hundreds of interviews and the author’s own groundbreaking study of dozens of organizations spanning a variety of industries, Adaptive Space shows how to position your company for today—and for the future—by enabling creativity, innovation, and novel ideas to flow freely among teams, across departments, and throughout the company. Using GM as the main case study—along with the stories of other highly adaptive organizations, like Apple, Amazon, Disney, and Gore—Arena provides a model you can follow to reinvent your company. It’s about inspiring employees to explore new ideas, empowering the most creative people and teams to spread their ideas across the organization, and operationalizing the entrepreneurial spirit so adaptability is set in stone. Hesitation is a killer in today’s business landscape. With Adaptive Space, you have everything you need to confront disruption with smart, confident actions and seize the valuable opportunities that come with change.

Managing Agile Projects

Author : Sanjiv Augustine
Publisher : Pearson
ISBN 13 :
Total Pages : 272 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Managing Agile Projects by : Sanjiv Augustine

Download or read book Managing Agile Projects written by Sanjiv Augustine and published by Pearson. This book was released on 2005 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Your Hands-On, "In-the-Trenches" Guide to Successfully Leading AgileProjectsAgile methods promise to infuse development with unprecedented flexibility, speed, and valueand these promises are attracting IT organizations worldwide. However, agile methods often fail to clearly define the manager s role, and many managers have been reluctant to buy in. Now, expert project manager Sanjiv Augustine introduces agility "from the manager s point of view, offering a proven management framework that addresses everything from team building to project control. Augustine bridges the disconnect between the assumptions and techniques of traditional and agile management, demonstrating why agility is better aligned with today s project realities, and how to simplify your transition. Using a detailed case study, he shows how agile methods can scale to succeed in even the largest projects: Defining a high-value role for the manager in agile project environmentsRefocusing on "outcomes--not rigid plans, processes, or controlsStructuring and building adaptive, self-organizing "organic teams"Forming a guiding vision that aligns your team behind a common purposeEmpowering your team with the information it needs to succeedManaging the flow of customer value from one creative stage to the nextLeveraging your team members strengths as "whole persons"Implementing full-life-cycle agility: from planning and coding to maintenance and knowledge transfer Customizing agile methods to your unique environmentBecoming an "adaptive leader" who can inspire and energize agile teams Whether you re a technical or business manager, "Managing Agile Projectsgives you all the tools you need to implement agility in "your environmentand reap its full benefits. "Managing Agile Projects is part of the Robert C. Martin series.(c) Copyright Pearson Education. All rights reserved.

Predictive Approaches in Drug Discovery and Development

Author : J. Andrew Williams
Publisher : John Wiley & Sons
ISBN 13 : 0470170832
Total Pages : 420 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Predictive Approaches in Drug Discovery and Development by : J. Andrew Williams

Download or read book Predictive Approaches in Drug Discovery and Development written by J. Andrew Williams and published by John Wiley & Sons. This book was released on 2012-04-10 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical Utility of Biomarkers in Drug Discovery and Development covers all aspects of biomarker research applied to drug discovery and development and contains state-of-the-art appraisals on the practical utility of genomic, biochemical, and protein biomarkers. Case histories and lessons from successful and unsuccessful applications of biomarkers are included along with key chapters on GLP validation, safety biomarkers and proteomics biomarkers. Regulatory agency perspectives and initiatives both in the US and internationally are also discussed.

Collaborative Computational Technologies for Biomedical Research

Author : Sean Ekins
Publisher : John Wiley & Sons
ISBN 13 : 1118026020
Total Pages : 462 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Collaborative Computational Technologies for Biomedical Research by : Sean Ekins

Download or read book Collaborative Computational Technologies for Biomedical Research written by Sean Ekins and published by John Wiley & Sons. This book was released on 2011-08-04 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods, Processes, and Tools for Collaboration "The time has come to fundamentally rethink how we handle the building of knowledge in biomedical sciences today. This book describes how the computational sciences have transformed into being a key knowledge broker, able to integrate and operate across divergent data types." Bryn Williams-Jones, Associate Research Fellow, Pfizer The pharmaceutical industry utilizes an extended network of partner organizations in order to discover and develop new drugs, however there is currently little guidance for managing information and resources across collaborations. Featuring contributions from the leading experts in a range of industries, Collaborative Computational Technologies for Biomedical Research provides information that will help organizations make critical decisions about managing partnerships, including: Serving as a user manual for collaborations Tackling real problems from both human collaborative and data and informatics perspectives Providing case histories of biomedical collaborations and technology-specific chapters that balance technological depth with accessibility for the non-specialist reader A must-read for anyone working in the pharmaceuticals industry or academia, this book marks a major step towards widespread collaboration facilitated by computational technologies.

Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio

Author : Mark Chang
Publisher : John Wiley & Sons
ISBN 13 : 0470438568
Total Pages : 284 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio by : Mark Chang

Download or read book Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio written by Mark Chang and published by John Wiley & Sons. This book was released on 2010-06-15 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: ExpDesign Studio facilitates more efficient clinical trial design This book introduces pharmaceutical statisticians, scientists, researchers, and others to ExpDesign Studio software for classical and adaptive designs of clinical trials. It includes the Professional Version 5.0 of ExpDesign Studio software that frees pharmaceutical professionals to focus on drug development and related challenges while the software handles the essential calculations and computations. After a hands-on introduction to the software and an overview of clinical trial designs encompassing numerous variations, Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio: Covers both classical and adaptive clinical trial designs, monitoring, and analyses Explains various classical and adaptive designs including groupsequential, sample-size reestimation, dropping-loser, biomarker-adaptive, and response-adaptive randomization designs Includes instructions for over 100 design methods that have been implemented in ExpDesign Studio and step-by-step demos as well as real-world examples Emphasizes applications, yet covers key mathematical formulations Introduces readers to additional toolkits in ExpDesign Studio that help in designing, monitoring, and analyzing trials, such as the adaptive monitor, graphical calculator, the probability calculator, the confidence interval calculator, and more Presents comprehensive technique notes for sample-size calculation methods, grouped by the number of arms, the trial endpoint, and the analysis basis Written with practitioners in mind, this is an ideal self-study guide for not only statisticians, but also scientists, researchers, and professionals in the pharmaceutical industry, contract research organizations (CROs), and regulatory bodies. It's also a go-to reference for biostatisticians, pharmacokinetic specialists, and principal investigators involved in clinical trials. ERRATUM Classical and Adaptive Clinical Trial Designs Using ExpDesign Studio By Mark Chang The license for the ExpDesign Studio software on the CD included with this book is good for one-year after installation of the software. Prior to the expiration of this period, the software will generate a reminder about renewal for the license. The user should contact CTriSoft International (the owners of ExpDesign Studio) at www.CTriSoft.net or by email at [email protected], about renewal for the license. This should have been made clear in the first printing of this book. We apologize for this error.

Software Engineering Research, Management and Applications 2009

Author : Roger Lee
Publisher : Springer Science & Business Media
ISBN 13 : 3642054404
Total Pages : 311 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Software Engineering Research, Management and Applications 2009 by : Roger Lee

Download or read book Software Engineering Research, Management and Applications 2009 written by Roger Lee and published by Springer Science & Business Media. This book was released on 2009-10-27 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 7th ACIS International Conference on Software Engineering Research, Management and Applications (SERA 2009) was held on Hainan Island, China from December 2 – 4. SERA ’09 featured excellent theoretical and practical contributions in the areas of formal methods and tools, requirements engineering, software process models, communication systems and networks, software quality and evaluation, software engineering, networks and mobile computing, parallel/distributed computing, software testing, reuse and metrics, database retrieval, computer security, software architectures and modeling. Our conference officers selected the best 17 papers from those papers accepted for presentation at the conference in order to publish them in this volume. The papers were chosen based on review scores submitted by members or the program committee, and underwent further rigorous rounds of review.

Collaborative Innovation in Drug Discovery

Author : Rathnam Chaguturu
Publisher : John Wiley & Sons
ISBN 13 : 0470917377
Total Pages : 768 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Collaborative Innovation in Drug Discovery by : Rathnam Chaguturu

Download or read book Collaborative Innovation in Drug Discovery written by Rathnam Chaguturu and published by John Wiley & Sons. This book was released on 2014-04-14 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: Can academia save the pharmaceutical industry? The pharmaceutical industry is at a crossroads. The urgent need for novel therapies cannot stem the skyrocketing costs and plummeting productivity plaguing R&D, and many key products are facing patent expiration. Dr. Rathnam Chaguturu presents a case for collaboration between the pharmaceutical industry and academia that could reverse the industry's decline. Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships provides insight into the potential synergy of basing R&D in academia while leaving drug companies to turn hits into marketable products. As Founder and CEO of iDDPartners, focused on pharmaceutical innovation, Founding president of the International Chemical Biology Society, and Senior Director-Discovery Sciences, SRI International, Dr. Chaguturu has assembled a panel of experts from around the world to weigh in on issues that affect the two driving forces in medical advancement. Gain global perspectives on the benefits and potential issues surrounding collaborative innovation Discover how industries can come together to prevent another "Pharma Cliff" Learn how nonprofits are becoming the driving force behind innovation Read case studies of specific academia-pharma partnerships for real-life examples of successful collaboration Explore government initiatives that help foster cooperation between industry and academia Dr. Chaguturu’s thirty-five years of experience in academia and industry, managing new lead discovery projects and forging collaborative partnerships with academia, disease foundations, nonprofits, and government agencies lend him an informative perspective into the issues facing pharmaceutical progress. In Collaborative Innovation in Drug Discovery: Strategies for Public and Private Partnerships, he and his expert team provide insight into the various nuances of the debate.

Business Intelligence and Agile Methodologies for Knowledge-Based Organizations: Cross-Disciplinary Applications

Author : Rahman El Sheikh, Asim Abdel
Publisher : IGI Global
ISBN 13 : 1613500513
Total Pages : 370 pages
Book Rating : 4.6/5 (135 download)

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Book Synopsis Business Intelligence and Agile Methodologies for Knowledge-Based Organizations: Cross-Disciplinary Applications by : Rahman El Sheikh, Asim Abdel

Download or read book Business Intelligence and Agile Methodologies for Knowledge-Based Organizations: Cross-Disciplinary Applications written by Rahman El Sheikh, Asim Abdel and published by IGI Global. This book was released on 2011-09-30 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Business intelligence applications are of vital importance as they help organizations manage, develop, and communicate intangible assets such as information and knowledge. Organizations that have undertaken business intelligence initiatives have benefited from increases in revenue, as well as significant cost savings.Business Intelligence and Agile Methodologies for Knowledge-Based Organizations: Cross-Disciplinary Applications highlights the marriage between business intelligence and knowledge management through the use of agile methodologies. Through its fifteen chapters, this book offers perspectives on the integration between process modeling, agile methodologies, business intelligence, knowledge management, and strategic management.

Computational Toxicology

Author : Sean Ekins
Publisher : John Wiley & Sons
ISBN 13 : 111928256X
Total Pages : 450 pages
Book Rating : 4.1/5 (192 download)

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Book Synopsis Computational Toxicology by : Sean Ekins

Download or read book Computational Toxicology written by Sean Ekins and published by John Wiley & Sons. This book was released on 2018-02-13 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dieses Buch ist ein wichtiges Referenzwerk für Toxikologen in vielen Bereichen und bietet eine umfassende Analyse molekular Modellansätze und Strategien der Risikobewertung von pharmazeutischen und Umweltchemikalien. - Zeigt, was mit rechnergestützter Toxikologie aktuell erreicht werden kann, und wirft einen Blick auf zukünftige Entwicklungen. - Gibt Antworten zu Themen wie Datenquellen, Datenpflege, Behandlung, Modellierung und Interpretation kritischer Endpunkte im Hinblick auf Gefahrenbewertungen im 21. Jahrhundert. - Bündelt herausragende Konzepte und das Wissen führender Autoren in einem einzigartigen Referenzwerk. - Untersucht detailliert QSAR-Modelle, Eigenschaften physiochemischer Arzneistoffe, strukturbasiertes Drug Targeting, die Bewertung chemischer Mischungen und Umweltmodelle. - Behandelt zusätzlich die Sicherheitsbewertung von Verbraucherprodukten und den Bereich chemische Abwehr und bietet Kapitel zu Open-Source-Toxikologie und Big Data.

Systems Biology in Drug Discovery and Development

Author : Daniel L. Young
Publisher : John Wiley & Sons
ISBN 13 : 0470261234
Total Pages : 398 pages
Book Rating : 4.4/5 (72 download)

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Book Synopsis Systems Biology in Drug Discovery and Development by : Daniel L. Young

Download or read book Systems Biology in Drug Discovery and Development written by Daniel L. Young and published by John Wiley & Sons. This book was released on 2011-10-18 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.

Pharmaceutical and Biomedical Project Management in a Changing Global Environment

Author : Scott D. Babler
Publisher : John Wiley & Sons
ISBN 13 : 1118058216
Total Pages : 283 pages
Book Rating : 4.1/5 (18 download)

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Book Synopsis Pharmaceutical and Biomedical Project Management in a Changing Global Environment by : Scott D. Babler

Download or read book Pharmaceutical and Biomedical Project Management in a Changing Global Environment written by Scott D. Babler and published by John Wiley & Sons. This book was released on 2011-01-06 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmaceutical and Biomedical Portfolio Management in a Changing Global Environment explores some of the critical forces at work today in the complex endeavour of pharmaceutical and medical product development. Written by experienced professionals, and including real-world approaches and best practice examples, this new title addresses three key areas – small molecules, large molecules, and medical devices - and provides hard-to-find, consolidated information relevant to and needed by pharmaceutical, biotech, and medical device company managers.

Agile Software Development Quality Assurance

Author : Stamelos, Ioannis G.
Publisher : IGI Global
ISBN 13 : 1599042185
Total Pages : 266 pages
Book Rating : 4.5/5 (99 download)

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Book Synopsis Agile Software Development Quality Assurance by : Stamelos, Ioannis G.

Download or read book Agile Software Development Quality Assurance written by Stamelos, Ioannis G. and published by IGI Global. This book was released on 2007-02-28 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book provides the research and instruction used to develop and implement software quickly, in small iteration cycles, and in close cooperation with the customer in an adaptive way, making it possible to react to changes set by the constant changing business environment. It presents four values explaining extreme programming (XP), the most widely adopted agile methodology"--Provided by publisher.

OECD Public Governance Reviews Tackling Policy Challenges Through Public Sector Innovation A Strategic Portfolio Approach

Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264768521
Total Pages : 223 pages
Book Rating : 4.2/5 (647 download)

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Book Synopsis OECD Public Governance Reviews Tackling Policy Challenges Through Public Sector Innovation A Strategic Portfolio Approach by : OECD

Download or read book OECD Public Governance Reviews Tackling Policy Challenges Through Public Sector Innovation A Strategic Portfolio Approach written by OECD and published by OECD Publishing. This book was released on 2022-11-23 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report discusses how steering innovation investment in public sector organisations through a portfolio approach can help governments respond to the multi-faceted challenges they face. Portfolio management is a well-known device in the financial sector, allowing for dynamic decision-making processes involving regular reviews of activity and ensuring a coherent distribution of resources among strategic options.

eHealth Research Theory and Development

Author : Hanneke Kip
Publisher : Taylor & Francis
ISBN 13 : 1040026044
Total Pages : 341 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis eHealth Research Theory and Development by : Hanneke Kip

Download or read book eHealth Research Theory and Development written by Hanneke Kip and published by Taylor & Francis. This book was released on 2024-05-01 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to provide a comprehensive overview of the multidisciplinary domain of eHealth – one of the most important recent developments in healthcare. It provides an overview of the possibilities of eHealth for different healthcare sectors, an outline of theoretical underpinnings and effectiveness, and key models, frameworks and methods for its development, implementation, and evaluation. This fully revised second edition brings together up-to-date knowledge on eHealth and includes several new chapters and sections on important topics such as implementation, human-centred design, healthcare systems, and evaluation methods. The first part of this book is focused on the underpinnings of eHealth, and consists of chapters on behaviour change, the possibilities of technology for healthcare systems, and the current state of affairs of eHealth for mental and public health. In the second part, chapters on development, implementation, and evaluation of eHealth are provided, presenting methods, theories and frameworks from disciplines such as human-centred design, engineering, psychology, business modelling, and implementation science. By drawing together expertise from different disciplines, the book offers a holistic approach to the use of technology to support health and wellbeing, giving readers an insight into how eHealth can offer multiple solutions for the major challenges with which our healthcare system is faced. Case studies, learning objectives, end of chapter summaries, and a list of key terms, make this accessible book very suitable for students, as well as researchers and healthcare professionals. Due to its multidisciplinary nature, it can be used by readers from a broad range of fields, such as psychology, health sciences, and human-centred design.

Agile Estimating and Planning

Author : Mike Cohn
Publisher : Pearson Education
ISBN 13 : 0132703106
Total Pages : 526 pages
Book Rating : 4.1/5 (327 download)

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Book Synopsis Agile Estimating and Planning by : Mike Cohn

Download or read book Agile Estimating and Planning written by Mike Cohn and published by Pearson Education. This book was released on 2005-11-01 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: Agile Estimating and Planning is the definitive, practical guide to estimating and planning agile projects. In this book, Agile Alliance cofounder Mike Cohn discusses the philosophy of agile estimating and planning and shows you exactly how to get the job done, with real-world examples and case studies. Concepts are clearly illustrated and readers are guided, step by step, toward how to answer the following questions: What will we build? How big will it be? When must it be done? How much can I really complete by then? You will first learn what makes a good plan-and then what makes it agile. Using the techniques in Agile Estimating and Planning, you can stay agile from start to finish, saving time, conserving resources, and accomplishing more. Highlights include: Why conventional prescriptive planning fails and why agile planning works How to estimate feature size using story points and ideal days–and when to use each How and when to re-estimate How to prioritize features using both financial and nonfinancial approaches How to split large features into smaller, more manageable ones How to plan iterations and predict your team's initial rate of progress How to schedule projects that have unusually high uncertainty or schedule-related risk How to estimate projects that will be worked on by multiple teams Agile Estimating and Planning supports any agile, semiagile, or iterative process, including Scrum, XP, Feature-Driven Development, Crystal, Adaptive Software Development, DSDM, Unified Process, and many more. It will be an indispensable resource for every development manager, team leader, and team member.