Technologies For Detection Of Dna Damage And Mutations

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Technologies for Detection of DNA Damage and Mutations

Author : G.P. Pfeifer
Publisher : Springer Science & Business Media
ISBN 13 : 1489903011
Total Pages : 443 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Technologies for Detection of DNA Damage and Mutations by : G.P. Pfeifer

Download or read book Technologies for Detection of DNA Damage and Mutations written by G.P. Pfeifer and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Man-made carcinogens, natural genotoxic agents in the environment, as well as ionizing and ultraviolet radiation can damage DNA and are a constant threat to genome integrity. Throughout the evolution oflife, complex DNA repair systems have developed in all living organisms to cope with this damage. Unrepaired DNA lesions can promote genetic alterations (mutations) that may be linked to an altered phenotype, and, if growth-controlling genes are involved, these mutations can lead to cell transformation and the development of malignant tumors. Proto oncogenes and tumor suppressor genes may be critical targets for DNA damaging agents. In a number of animal model systems, correlations between exposure to a carcinogen, tumor develop ment, and genetic changes in tumor DNA have been established. To understand mutagenesis processes in more detail at the molecular level, we need to know the type and frequency of DNA adducts within cells, their distribution along genes and specific DNA sequences, as well as the rates at which they are repaired. We also need to know what types of mutations are produced and which gene positions are most prone to mutagenesis. This book provides a collection of techniques that are useful in mutagenesis research. The book is divided into three parts. In Part I, methods for DNA damage and repair analysis are provided.

Mutation Detection

Author : R. G. H. Cotton
Publisher : IRL Press
ISBN 13 : 0191565695
Total Pages : 266 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Mutation Detection by : R. G. H. Cotton

Download or read book Mutation Detection written by R. G. H. Cotton and published by IRL Press. This book was released on 1998-02-05 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mutation detection is increasingly undertaken in a wide spectrum of research areas: in medicine it is fundamental in isolating disease genes and diagnbosis, and is especially important in cancer research; in biology, commercially important genes can be identified by the mutations they contain. But mutation detection is time-consuming and expensive. This volume offers the latest tried and tested protocols for a range of detection methods, from the labs of the leading researchers in the field.

Fast Detection of DNA Damage

Author : Vladimir V. Didenko
Publisher : Humana
ISBN 13 : 9781493984114
Total Pages : 216 pages
Book Rating : 4.9/5 (841 download)

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Book Synopsis Fast Detection of DNA Damage by : Vladimir V. Didenko

Download or read book Fast Detection of DNA Damage written by Vladimir V. Didenko and published by Humana. This book was released on 2018-06-11 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a comprehensive collection of quick assays for the detection of nuclear and mitochondrial DNA damage and its effects in live and fixed cells and tissues, and in bacterial genomes. Although, such rapid techniques are in demand in the “research trenches” they are not covered well in the literature. This volume is the first such compendium of the time-saving techniques for detection of DNA damage and its direct physiological outcomes including apoptosis, necrosis and phagocytic clearance. The volume demonstrates all levels of detection, starting from the molecular level up to the level of the entire live organism. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Fast Detection of DNA Damage: Methods and Protocols aims to provide easily reproducible techniques requiring only few steps to perform.

DNA Damage Detection In Situ, Ex Vivo, and In Vivo

Author : Vladimir V. Didenko
Publisher : Humana Press
ISBN 13 : 9781603274081
Total Pages : 0 pages
Book Rating : 4.2/5 (74 download)

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Book Synopsis DNA Damage Detection In Situ, Ex Vivo, and In Vivo by : Vladimir V. Didenko

Download or read book DNA Damage Detection In Situ, Ex Vivo, and In Vivo written by Vladimir V. Didenko and published by Humana Press. This book was released on 2010-11-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in organic chemistry, fluorescent microscopy, and materials science have created an entirely new range of techniques and probes for imaging DNA damage in molecular and cellular biology. In DNA Damage Detection In Situ, Ex Vivo, and In Vivo: Methods and Protocols, expert researchers explore the latest advances in the area, covering both recent and established techniques to detect and quantify DNA damage at scales ranging from subcellular to the level of a whole live organism. Chapters present all major assays used in molecular and cellular biology for the labeling of DNA damage in situ, ex vivo, and in vivo. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Comprehensive and current, DNA Damage Detection In Situ, Ex Vivo, and In Vivo: Methods and Protocols is an essential handbook for novice and experienced researchers in a variety of fields, including molecular and cellular biology, experimental and clinical pathology, toxicology, radiobiology, oncology, embryology, experimental pharmacology, drug design, and environmental science.

In Situ Detection of DNA Damage

Author : Vladimir V. Didenko
Publisher : Springer Science & Business Media
ISBN 13 : 1592591795
Total Pages : 314 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis In Situ Detection of DNA Damage by : Vladimir V. Didenko

Download or read book In Situ Detection of DNA Damage written by Vladimir V. Didenko and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detection and analysis of DNA damage is of critical importance in a variety of biological disciplines studying apoptosis, cell cycle and cell di- sion, carcinogenesis, tumor growth, embryogenesis and aging, neu- degenerative and heart diseases, anticancer drug development, environmental and radiobiological research, and others. Individual cells within the same tissue or in cell culture may vary in the extent of their DNA damage and, consequently, can display different re- tions to it. These differences between individual cells in the same cell popu- tion are detected using in situ approaches. In situ is a Latin term meaning “on site” or “in place.” It is used to denote the processes occurring or detected in their place of origin. In mole- lar and cell biology this usually refers to undisrupted mounted cells or tissue sections. In that meaning “in situ” is used as part of the terms “in situ PCR,” “in situ transcription,” “in situ hybridization,” “in situ end labeling,” and “in situ ligation.” Sometimes the “in situ” term is applied at the subcellular level to cells disrupted in the process of analysis, for example, in the detection of specific sequences in chromosomes using fluorescent in situ hybridization (FISH). Historically, the term was used primarily in methods dealing with nucleic acids.

2019 Innovations in Power and Advanced Computing Technologies (i-PACT)

Author :
Publisher :
ISBN 13 : 9781538681909
Total Pages : pages
Book Rating : 4.6/5 (819 download)

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Book Synopsis 2019 Innovations in Power and Advanced Computing Technologies (i-PACT) by :

Download or read book 2019 Innovations in Power and Advanced Computing Technologies (i-PACT) written by and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Methods to Assess DNA Damage and Repair

Author : Robert G. Tardiff
Publisher :
ISBN 13 :
Total Pages : 300 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Methods to Assess DNA Damage and Repair by : Robert G. Tardiff

Download or read book Methods to Assess DNA Damage and Repair written by Robert G. Tardiff and published by . This book was released on 1994-08-16 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrates data obtained from a variety of disciplines to evaluate the current state of knowledge regarding defense mechanisms and applies this information to estimate health risks to humans exposed to substances that alter genetic material. Recognized experts document, to a large extent, which carcinogens can cause injury to human beings and their surroundings, providing guidance for the structured acquisition of key information to reduce cancer risks throughout the environment.

Chimeric Proteins for Detection and Quantitation of DNA Mutations, DNA Sequence Variations, DNA Damage and DNA Mismatches

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (873 download)

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Book Synopsis Chimeric Proteins for Detection and Quantitation of DNA Mutations, DNA Sequence Variations, DNA Damage and DNA Mismatches by :

Download or read book Chimeric Proteins for Detection and Quantitation of DNA Mutations, DNA Sequence Variations, DNA Damage and DNA Mismatches written by and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Chimeric proteins having both DNA mutation binding activity and nuclease activity are synthesized by recombinant technology. The proteins are of the general formula A-L-B and B-L-A where A is a peptide having DNA mutation binding activity, L is a linker and B is a peptide having nuclease activity. The chimeric proteins are useful for detection and identification of DNA sequence variations including DNA mutations (including DNA damage and mismatches) by binding to the DNA mutation and cutting the DNA once the DNA mutation is detected.

Health Effects of Exposure to Low Levels of Ionizing Radiation

Author : National Research Council
Publisher : National Academies
ISBN 13 : 0309039959
Total Pages : 436 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Health Effects of Exposure to Low Levels of Ionizing Radiation by : National Research Council

Download or read book Health Effects of Exposure to Low Levels of Ionizing Radiation written by National Research Council and published by National Academies. This book was released on 1990-02-01 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.

DNA Repair Mechanisms

Author : ICN Pharmaceuticals, inc
Publisher :
ISBN 13 :
Total Pages : 840 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis DNA Repair Mechanisms by : ICN Pharmaceuticals, inc

Download or read book DNA Repair Mechanisms written by ICN Pharmaceuticals, inc and published by . This book was released on 1978 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Repair Mechanisms is an account of the proceedings at a major international conference on DNA Repair Mechanisms held at Keystone, Colorado on February 1978. The conference discusses through plenary sessions the overall standpoint of DNA repair. The papers presented and other important documents, such as short summaries by the workshop session conveners, comprise this book. The compilation describes the opposing views, those that agree and dispute about certain topic areas. This book, divided into 15 parts, is arranged according to the proceedings in the conference. The plenary sessions are ...

DNA Damage Recognition

Author : Wolfram Siede
Publisher : CRC Press
ISBN 13 : 0849352681
Total Pages : 871 pages
Book Rating : 4.8/5 (493 download)

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Book Synopsis DNA Damage Recognition by : Wolfram Siede

Download or read book DNA Damage Recognition written by Wolfram Siede and published by CRC Press. This book was released on 2005-09-19 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stands as the most comprehensive guide to the subject-covering every essential topic related to DNA damage identification and repair. Covering a wide array of topics from bacteria to human cells, this book summarizes recent developments in DNA damage repair and recognition while providing timely reviews on the molecular mechanisms employe

Protein Phosphorylation in Human Health

Author : Cai Huang
Publisher : BoD – Books on Demand
ISBN 13 : 9535107372
Total Pages : 482 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Protein Phosphorylation in Human Health by : Cai Huang

Download or read book Protein Phosphorylation in Human Health written by Cai Huang and published by BoD – Books on Demand. This book was released on 2012-09-06 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: 15 chapters on protein phosphorylation and human health written by expert scientists. Covers most important research hot points, such as Akt, AMPK and mTOR. Bridges the basic protein phosphorylation pathways with human health and diseases. Detailed and comprehensive text with excellent figure illustration.

Systems Biology of Cancer

Author : Sam Thiagalingam
Publisher : Cambridge University Press
ISBN 13 : 0521493390
Total Pages : 597 pages
Book Rating : 4.5/5 (214 download)

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Book Synopsis Systems Biology of Cancer by : Sam Thiagalingam

Download or read book Systems Biology of Cancer written by Sam Thiagalingam and published by Cambridge University Press. This book was released on 2015-04-09 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Assessing Genetic Risks

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309047986
Total Pages : 353 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Assessing Genetic Risks by : Institute of Medicine

Download or read book Assessing Genetic Risks written by Institute of Medicine and published by National Academies Press. This book was released on 1994-01-01 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Raising hopes for disease treatment and prevention, but also the specter of discrimination and "designer genes," genetic testing is potentially one of the most socially explosive developments of our time. This book presents a current assessment of this rapidly evolving field, offering principles for actions and research and recommendations on key issues in genetic testing and screening. Advantages of early genetic knowledge are balanced with issues associated with such knowledge: availability of treatment, privacy and discrimination, personal decision-making, public health objectives, cost, and more. Among the important issues covered: Quality control in genetic testing. Appropriate roles for public agencies, private health practitioners, and laboratories. Value-neutral education and counseling for persons considering testing. Use of test results in insurance, employment, and other settings.

Technologies for Detecting Heritable Mutations in Human Beings

Author :
Publisher :
ISBN 13 :
Total Pages : 32 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis Technologies for Detecting Heritable Mutations in Human Beings by :

Download or read book Technologies for Detecting Heritable Mutations in Human Beings written by and published by . This book was released on 1986 with total page 32 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genome-Wide Identification and 3D Modeling of Proteins Involved in DNA Damage Recognition and Repair (Final Report).

Author : Ruben Abagyan
Publisher :
ISBN 13 :
Total Pages : 14 pages
Book Rating : 4.:/5 (316 download)

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Book Synopsis Genome-Wide Identification and 3D Modeling of Proteins Involved in DNA Damage Recognition and Repair (Final Report). by : Ruben Abagyan

Download or read book Genome-Wide Identification and 3D Modeling of Proteins Involved in DNA Damage Recognition and Repair (Final Report). written by Ruben Abagyan and published by . This book was released on 2005 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Damage Recognition and Repair (DDR & R) proteins play a critical role in cellular responses to low-dose radiation and are associated with cancer. We have performed a systematic, genome-wide computational analysis of genomic data for human genes involved in the DDR & R process. The significant achievements of this project include: 1) Construction of the computational pipeline for searching DDR & R genes, building and validation of 3D models of proteins involved in DDR & R; 2) Functional and structural annotation of the 3D models and generation of comprehensive lists of suggested knock-out mutations; and the development of a method to predict the effects of mutations. Large scale testing of technology to identify novel small binding pockets in protein structures leading to new DDRR inhibitor strategies3) Improvements of macromolecular docking technology (see the CAPRI 1-3 and 4-5 results) 4) Development of a new algorithm for improved analysis of high-density oligonucleotide arrays for gene expression profiling;5) Construction and maintenance of the DNA Damage Recognition and Repair Database;6) Producing 15 research papers (12 published and 3 in preparation).

Molecular Epidemiology

Author : Paul A. Schulte
Publisher : Academic Press
ISBN 13 : 0323138578
Total Pages : 609 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Molecular Epidemiology by : Paul A. Schulte

Download or read book Molecular Epidemiology written by Paul A. Schulte and published by Academic Press. This book was released on 2012-12-02 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will serve as a primer for both laboratory and field scientists who are shaping the emerging field of molecular epidemiology. Molecular epidemiology utilizes the same paradigm as traditional epidemiology but uses biological markers to identify exposure, disease or susceptibility. Schulte and Perera present the epidemiologic methods pertinent to biological markers. The book is also designed to enumerate the considerations necessary for valid field research and provide a resource on the salient and subtle features of biological indicators.