Targeted Therapies In Cancer

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Targeted Therapies in Oncology, Second Edition

Author : Giuseppe Giaccone
Publisher : CRC Press
ISBN 13 : 1842145452
Total Pages : 500 pages
Book Rating : 4.8/5 (421 download)

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Book Synopsis Targeted Therapies in Oncology, Second Edition by : Giuseppe Giaccone

Download or read book Targeted Therapies in Oncology, Second Edition written by Giuseppe Giaccone and published by CRC Press. This book was released on 2013-10-21 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the last edition of this book, major advances have been made in our understanding of key pathways that control tumor progression. This has led to the development of new anticancer agents that have the ability to block the activity of proteins involved in neoplastic cell development and proliferation. Targeted Therapies in Oncology, Second Edition provides a concise timely panorama of existing targeted therapies and progress into future anticancer treatments. These therapies notably include: Targeted agents of immune checkpoints Signal-transduction inhibitors Antiangiogenic agents Vascular-disrupting agents Apoptosis modulators Stem cell inhibitors Tumor profiling for drug development The book emphasizes the biology behind this new class of drugs as well as the clinical achievements obtained. The contributors to this volume stand at the cutting edge of cancer research and treatment around the world.

Targeted Therapies in Breast Cancer

Author : Gw Sledge
Publisher : Clinical Pub
ISBN 13 : 9781846920660
Total Pages : 0 pages
Book Rating : 4.9/5 (26 download)

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Book Synopsis Targeted Therapies in Breast Cancer by : Gw Sledge

Download or read book Targeted Therapies in Breast Cancer written by Gw Sledge and published by Clinical Pub. This book was released on 2012-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

A Beginner's Guide to Targeted Cancer Treatments

Author : Elaine Vickers
Publisher : John Wiley & Sons
ISBN 13 : 1119126835
Total Pages : 360 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis A Beginner's Guide to Targeted Cancer Treatments by : Elaine Vickers

Download or read book A Beginner's Guide to Targeted Cancer Treatments written by Elaine Vickers and published by John Wiley & Sons. This book was released on 2018-05-08 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The accessible guide to the principles behind new, more targeted drug treatments for cancer Written for anyone who encounters cancer patients, cancer data or cancer terminology, but have no more than a passing knowledge of cell biology. A Beginner's Guide to Targeted Cancer Treatments provides an understanding of how cancer works and the many new treatments available. Using over 100 original illustrations, this accessible handbook covers the biology and mechanisms behind a huge range of targeted drug treatments, including many new immunotherapies. Dr Vickers translates a complex and often overwhelming topic into something digestible and easily understood. She also explains what cancer is, how it behaves and how our understanding of cancer has changed in recent years. Each chapter takes the reader through how new cancer drugs work and their benefits and limitations. With the help of this book, readers will be able to better understand more complex, in-depth articles in journals and books and develop their knowledge. This vital resource: Offers the latest insights into cancer biology Provides a broad understanding of how targeted cancer treatments work Describes many of the new immunotherapy approaches to cancer treatment, such as checkpoint inhibitors and CAR-modified T cells Helps readers feel confident discussing treatment options with colleagues and patients Provides an overview of which treatments are relevant to each of the most common solid tumours and haematological cancers, and the rationale behind them Demystifies the jargon – terms such as the EMT, cancer stem cells, monoclonal antibodies, kinase inhibitors, angiogenesis inhibitors etc. Explains the resistance mechanisms to many new treatments, including issues such as the way cancer cells diversify and evolve and the complex environment in which they live

Advances in Cancer Treatment

Author : Iago Dillion Lima Cavalcanti
Publisher : Springer Nature
ISBN 13 : 3030683346
Total Pages : 109 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Advances in Cancer Treatment by : Iago Dillion Lima Cavalcanti

Download or read book Advances in Cancer Treatment written by Iago Dillion Lima Cavalcanti and published by Springer Nature. This book was released on 2021-02-24 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work covers the pathophysiology of cancer, exploring the difficulty of optimal treatment due to the complexity and diversity of cancer types. The search for distinctive molecular biology characteristics of tumor cells is especially relevant in the identification of overexpressed receptors and proteins that can be used as a target for cancer treatment. We highlight the main therapeutic modalities, particularly conventional systemic chemotherapy, addressing its mechanisms of action, therapeutic classes and even the toxic effects. We also describe the main tumor markers, their importance in the diagnosis and treatment of cancer, and the specificity of tumor cells. The first chapters serve as an introduction to the central topic of this book, targeted therapy. Key aspects of target therapy, such as classes of drugs, immunotherapy, monoclonal antibodies, checkpoint inhibitors, cancer vaccines and tyrosine kinase inhibitors are presented, and, for each one, the benefits, as well as the adverse effects are reported. Chapter 6 compares conventional systemic chemotherapy and targeted therapy, identifies the risks and benefits and also the eligibility criteria for patient care. The possibility of targeted therapy replacing conventional chemotherapy is discussed while reviewing studies that demonstrate the benefits of combining both types of treatment. Finally, the introduction of pharmaceutical nanotechnology to improve antineoplastic agents is addressed in the last chapter and sets the direction for future research in cancer treatment. This is a valuable resource for many health professionals including physicians, pharmacists, nurses, researchers and students interested in the field of oncology.

Targeted Therapies for Lung Cancer

Author : Ravi Salgia
Publisher : Springer
ISBN 13 : 3030178323
Total Pages : 238 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Targeted Therapies for Lung Cancer by : Ravi Salgia

Download or read book Targeted Therapies for Lung Cancer written by Ravi Salgia and published by Springer. This book was released on 2019-06-26 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

Handbook of Targeted Cancer Therapy

Author : Daniel D. Karp
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1469894580
Total Pages : 288 pages
Book Rating : 4.4/5 (698 download)

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Book Synopsis Handbook of Targeted Cancer Therapy by : Daniel D. Karp

Download or read book Handbook of Targeted Cancer Therapy written by Daniel D. Karp and published by Lippincott Williams & Wilkins. This book was released on 2014-09-09 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Make optimal use of the latest personalized therapeutic strategies with Handbook of Targeted Cancer Therapy! This concise, practical oncology reference examines more than 140 targeted therapy agents for which clinical trial data are available, and explains when and how you can use them to most effectively combat cancer. Approach clinical challenges from any direction with separate sections on Targets by Organ Site, Carcinogenesis from the Perspective of Targeted Therapy, Molecular Targets and Pathways, and Targeted Therapy Agents. Find information easily thanks to a color-coded format and an intuitive organization. Access the complete contents online and on mobile devices, with regular updates to include newly approved treatments. Important state of the art cancer information for caregivers, researchers, other health care professionals, and even patients

Molecularly Targeted Therapy for Childhood Cancer

Author : Peter J. Houghton
Publisher : Springer Science & Business Media
ISBN 13 : 038769062X
Total Pages : 536 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Molecularly Targeted Therapy for Childhood Cancer by : Peter J. Houghton

Download or read book Molecularly Targeted Therapy for Childhood Cancer written by Peter J. Houghton and published by Springer Science & Business Media. This book was released on 2010-09-10 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular ‘drivers’ can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.

Targeted Radionuclide Therapy

Author : Tod W. Speer
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451153260
Total Pages : 564 pages
Book Rating : 4.4/5 (511 download)

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Book Synopsis Targeted Radionuclide Therapy by : Tod W. Speer

Download or read book Targeted Radionuclide Therapy written by Tod W. Speer and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Successes and Limitations of Targeted Cancer Therapy

Author : S. Peters
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318025429
Total Pages : 124 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Successes and Limitations of Targeted Cancer Therapy by : S. Peters

Download or read book Successes and Limitations of Targeted Cancer Therapy written by S. Peters and published by Karger Medical and Scientific Publishers. This book was released on 2014-02-19 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: The treatment of patients with advanced malignancies has undergone remarkable change in the last few years. While in the past decisions about systemic therapy were largely based on the performance status of a patient, oncologists today also take into account the pathological and molecular characteristics of the patient’s tumor. Targeting specific molecular pathways important for tumorigenesis has become the preferred way of treatment for many types of malignancies. With these advances come new challenges including the optimization of therapy, recognizing and dealing with side effects and, importantly, the development of resistance. This book provides an up-to-date overview of the advances and limitations of targeted therapy for several tumor entities including breast cancer, colon cancer, gastrointestinal stromal tumors, lung cancer, melanoma, ovarian cancer and renal cell carcinoma. Written by over a dozen internationally renowned scientists, the book is suitable for advanced students, postdoctoral researchers, scientists and clinicians who wish to update their knowledge of the latest approaches to targeted cancer therapies.

Targeted Cancer Treatment in Silico

Author : Natalia L. Komarova
Publisher : Springer Science & Business Media
ISBN 13 : 1461483018
Total Pages : 235 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Targeted Cancer Treatment in Silico by : Natalia L. Komarova

Download or read book Targeted Cancer Treatment in Silico written by Natalia L. Komarova and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments' effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations. The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.

Targeted Therapies in Cancer

Author : Manfred Dietel
Publisher : Springer
ISBN 13 : 9783642432439
Total Pages : 0 pages
Book Rating : 4.4/5 (324 download)

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Book Synopsis Targeted Therapies in Cancer by : Manfred Dietel

Download or read book Targeted Therapies in Cancer written by Manfred Dietel and published by Springer. This book was released on 2014-11-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: From its introduction, oncological chemotherapy has been encumbered by poor selectivity because antiproliferative drugs are often toxic not only to tumor cells but also to important populations of the body’s non-neoplastic cells. Modern targeted therapies interact with defined molecules present on cancer cells, adding increased selectivity to their toxic effects. This book presents an integrated critical view on the theories, mechanisms, problems and pitfalls of the targeted therapy approach.

Targeted Therapies for Solid Tumors

Author : Antonio Russo
Publisher : Humana Press
ISBN 13 : 1493920472
Total Pages : 269 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Targeted Therapies for Solid Tumors by : Antonio Russo

Download or read book Targeted Therapies for Solid Tumors written by Antonio Russo and published by Humana Press. This book was released on 2015-03-11 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers a comprehensive and state-of-the-art overview about the range of applications of targeted therapies for solid tumors. The sections of the book have been structured to review the oncogene addicted tumors, the pharmacology and clinical development of new molecularly targeted agents, the use of biomarkers as prognostic, predictive and surrogate endpoints, and the evaluation of tumor response and specific malignancies treated with targeted agents. The book also covers some of the newest developments in cancer therapy that are not adequately covered by any current available literature. Written by recognized experts in the field, Targeted Therapies for Solid Tumors: A Handbook for Moving Toward New Frontiers in Cancer Treatment provides a unique and valuable resource in the field of molecular oncology, both for those currently in training, and for those already in clinical or research practice.

Handbook of Targeted Cancer Therapy and Immunotherapy

Author : Daniel D. Karp
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1975179269
Total Pages : 1277 pages
Book Rating : 4.9/5 (751 download)

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Book Synopsis Handbook of Targeted Cancer Therapy and Immunotherapy by : Daniel D. Karp

Download or read book Handbook of Targeted Cancer Therapy and Immunotherapy written by Daniel D. Karp and published by Lippincott Williams & Wilkins. This book was released on 2022-03-28 with total page 1277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Designed for quick, everyday reference, Handbook of Targeted Cancer Therapy and Immunotherapy, 3rd Edition, includes clinical trial results of more than 250 state-of-the-art targeted therapy and immunotherapy agents, providing a practical, intuitive, colorful overview of this rapidly advancing field. Comprehensive yet concise, this easy-access resource by Drs. Daniel D. Karp, Gerald S. Falchook, and JoAnn D. Lim, helps you navigate through the newest research reports and apply the most recent discoveries as they pertain to specific tumor types, actionable molecular targets, and clinical performance of investigational targeted agents and combinations of agents. This handbook presents information distilled by dozens of translational research clinicians and other healthcare experts with hundreds of years of cumulative experience in the revolutionary area of genomically based precision oncology.

Resistance to Targeted Therapies in Multiple Myeloma

Author : Silvia CW Ling
Publisher : Springer Nature
ISBN 13 : 3030734404
Total Pages : 154 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Resistance to Targeted Therapies in Multiple Myeloma by : Silvia CW Ling

Download or read book Resistance to Targeted Therapies in Multiple Myeloma written by Silvia CW Ling and published by Springer Nature. This book was released on 2021-07-23 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Myeloma remains an incurable malignancy. As the disease progresses, it invariably becomes resistant to treatment and almost all patients develop refractory disease. There are multiple different types of targeted therapies and many of them are used in combination at different stages of disease. Targeted therapies that are approved to be used include Proteasome Inhibitors, Immunomodulatory Drugs and Monoclonal Antibodies. Second and third generations of these drugs are developed to overcome resistance and they have unique mechanism of actions. Targeted therapies that are undergoing clinical trials include CAR-T cells, bi-specific antibodies, vaccines, ubiquitin ligase inhibitors and BCL-2 inhibitors. This book will help to develop an understanding of targeted therapies in Multiple Myeloma. Its goal is to provide a unique review of the mechanism of action and resistance of the many targeted therapies in Multiple Myeloma by leaders of the field. The book will be useful for students in medical science, clinicians, health professionals, scientists, pharmaceutical professionals, drug developers, and policy makers. This book will provide an insightful knowledge of the biology of Multiple Myeloma, the mechanism of action and resistance of targeted therapies, application of biomarkers and genomics and possible strategies in overcoming resistance and future development.

Targeted Therapies in Oncology

Author : Giuseppe Giaccone
Publisher : CRC Press
ISBN 13 : 1420020587
Total Pages : 426 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Targeted Therapies in Oncology by : Giuseppe Giaccone

Download or read book Targeted Therapies in Oncology written by Giuseppe Giaccone and published by CRC Press. This book was released on 2007-09-25 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Targeted therapy is one of the most burgeoning areas of development in cancer research. Increasing knowledge in tumor formation and growth at the molecular level has generated a broad array of therapeutic options, including signal transduction inhibition, anti-angiogenic and anti-vascular agents, cell cycle inhibitors, telomerase and telomere inter

Dermatologic Principles and Practice in Oncology

Author : Mario E. Lacouture
Publisher : John Wiley & Sons
ISBN 13 : 1118590600
Total Pages : 764 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis Dermatologic Principles and Practice in Oncology by : Mario E. Lacouture

Download or read book Dermatologic Principles and Practice in Oncology written by Mario E. Lacouture and published by John Wiley & Sons. This book was released on 2013-11-26 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book focusing specifically on frequent and frequently disabling side effects involving the skin, hair and nails in cancer patients According to the World Health Organization, there are approximately thirty million people living with a diagnosis of cancer – the majority of whom will receive surgery, systemic therapy, and/or radiation, and who will suffer from dermatologic adverse events. Dermatologists and oncologists are only beginning to grapple with these events, which pose serious quality-of-life issues with so many patients, and will become more prevalent as survival rates improve, thanks in part to new cancer treatments and drug regimens. Concentrating on a topic that has only been briefly touched upon by other texts, this book offers a focused perspective on the clinical presentation, underlying pathophysiologic mechanisms, and management of skin, hair, and nail conditions for oncologists, dermatologists, and allied practitioners. Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients: • Covers in detail the dermatologic adverse events of oncologic therapies, clinical presentations, and treatment recommendations • Enables dermatologists and other practitioners to significantly improve the care of patients with cancer • Addresses the dermatologic adverse events of cancer therapies used globally, of which a large number are found in developing countries • Emphasizes prophylactic measures – based on treatments used and type of cancer – to prevent the appearance of adverse events • Provides built-in discussions on patient education for practical counseling during therapies • Offers rapid-reference sections on topical dermatology drugs The first book to present dermatologic conditions in cancer patients and survivors in a uniform and in-depth manner, Dermatologic Principles and Practice in Oncology is ideal for oncologists, oncology nurses, and dermatologists who wish to take better care of those with adverse skin, hair, and nail conditions.

Handbook of Cancer Treatment-Related Symptoms and Toxicities

Author : Vamsidhar Velcheti
Publisher : Elsevier Health Sciences
ISBN 13 : 032367299X
Total Pages : 355 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Handbook of Cancer Treatment-Related Symptoms and Toxicities by : Vamsidhar Velcheti

Download or read book Handbook of Cancer Treatment-Related Symptoms and Toxicities written by Vamsidhar Velcheti and published by Elsevier Health Sciences. This book was released on 2021-01-28 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early recognition and management of adverse effects of cancer treatments are essential for optimal care of patients with cancer, and drastically different approaches are required for different physiologic reactions. Handbook of Cancer Treatment-Related Symptoms and Toxicities is a focused, one-stop resource that enables clinicians to quickly find up-to-date, reliable information needed at the point of care. The high-yield approach prioritizes the most common toxicities associated with cancer treatment, and concise, templated chapters offer fast access to information needed in day-to-day practice. Presents a user-friendly overview of cancer treatment-related symptoms and toxicities management in a practical, easy-to-use format, allowing you to quickly find information in one convenient, concise resource. Covers systemic and radiation therapies, including chemotherapy, immunotherapy, targeted therapies, and radiation therapy, detailing symptoms of each toxicity to confirm your diagnosis. Overviews pharmacologic and non-pharmacologic approaches to symptom management. Offers recommendations for mitigating toxicities in high-risk patients. Discusses key topics such as management of infusion reactions, when the need for biopsy is warranted, and the unique challenges posed by novel immunotherapies.