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T Lymphocytes As Tools In Diagnostics And Immunotoxicology
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Book Synopsis T Lymphocytes as Tools in Diagnostics and Immunotoxicology by : Stefan F. Martin
Download or read book T Lymphocytes as Tools in Diagnostics and Immunotoxicology written by Stefan F. Martin and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods. The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest.
Book Synopsis Military Strategies for Sustainment of Nutrition and Immune Function in the Field by : Institute of Medicine
Download or read book Military Strategies for Sustainment of Nutrition and Immune Function in the Field written by Institute of Medicine and published by National Academies Press. This book was released on 1999-05-13 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every aspect of immune function and host defense is dependent upon a proper supply and balance of nutrients. Severe malnutrition can cause significant alteration in immune response, but even subclinical deficits may be associated with an impaired immune response, and an increased risk of infection. Infectious diseases have accounted for more off-duty days during major wars than combat wounds or nonbattle injuries. Combined stressors may reduce the normal ability of soldiers to resist pathogens, increase their susceptibility to biological warfare agents, and reduce the effectiveness of vaccines intended to protect them. There is also a concern with the inappropriate use of dietary supplements. This book, one of a series, examines the impact of various types of stressors and the role of specific dietary nutrients in maintaining immune function of military personnel in the field. It reviews the impact of compromised nutrition status on immune function; the interaction of health, exercise, and stress (both physical and psychological) in immune function; and the role of nutritional supplements and newer biotechnology methods reported to enhance immune function. The first part of the book contains the committee's workshop summary and evaluation of ongoing research by Army scientists on immune status in special forces troops, responses to the Army's questions, conclusions, and recommendations. The rest of the book contains papers contributed by workshop speakers, grouped under such broad topics as an introduction to what is known about immune function, the assessment of immune function, the effect of nutrition, and the relation between the many and varied stresses encountered by military personnel and their effect on health.
Download or read book Metal Allergy written by Jennifer K Chen and published by Springer. This book was released on 2018-04-13 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume opens by providing a comprehensive overview of the use and regulation of metals in our society, metal properties, and available testing methodologies. Common and uncommon metal allergens and sources of exposure are then reviewed in depth, detailing allergic responses and paying special consideration to select patient populations. In the general population, the prevalence of metal allergy is high. Environmental sources of metal exposure include jewelry, clothing, electronic devices, coins, leather, diet, and occupational exposure. Metal allergy may result in allergic contact dermatitis and systemic contact dermatitis, as well as several less common manifestations. Further, metal allergy has been associated with device failure and/or dermatitis following implantation of medical devices and dental implants. As metals are ubiquitous, this book will be indispensable for a wide range of clinicians and investigators. This handy reference will meet the needs of all health professionals and investigators who are interested in metal allergy and its diagnosis and management.
Book Synopsis Information Resources in Toxicology, Volume 1: Background, Resources, and Tools by : Steve Gilbert
Download or read book Information Resources in Toxicology, Volume 1: Background, Resources, and Tools written by Steve Gilbert and published by Academic Press. This book was released on 2020-05-16 with total page 1055 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools. Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology’s presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field. The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children’s environmental health. Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals Explores recent internet trends, web-based databases, and software tools in a section on the online environment Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field
Book Synopsis Principles and Methods of Immunotoxicology by : Jacques Descotes
Download or read book Principles and Methods of Immunotoxicology written by Jacques Descotes and published by Elsevier. This book was released on 2004-10-14 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a review of clinical adverse effects on the human immune system that may occur following drug treatments and chemcical exposures. Current and prospective models and assays that can be used to predict these adverse effects in animal toxicity studies or in human beings are described.
Book Synopsis Pulmonary Immunotoxicology by : Mitchell D. Cohen
Download or read book Pulmonary Immunotoxicology written by Mitchell D. Cohen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pulmonary Immunotoxicology is a comprehensive exploration of the effects of various inhaled materials upon the immune system of the respiratory tract. It will be useful to investigators in the field of pulmonary toxicology and immunotoxicology, and to those involved in administration and regulation of matters related to inhaled materials. It can also serve as a textbook for a course in pulmonary immunotoxicology at graduate or advanced undergraduate level. Pulmonary Immunotoxicology comprises four sections. The first provides basic background concepts essential for understanding pulmonary immunotoxicology, including discussions of the normal structure and function of the respiratory system, its basic immunology, and the manner by which inhaled particles and gases are removed from the air and deposited upon respiratory tract surfaces. The second section provides an overview of the major types of pathological consequences which can arise from immunomodulation within the respiratory tract, including hypersensitivity and asthma, inflammation and fibrosis, as well as immunosuppression and autoimmunity. The third section, which comprises the largest portion of the book, deals specifically with major classes of airborne agents that are known to alter the immune function of the respiratory tract. These are arranged into major classes: organic agents, metals, gases, particles, biologics, and complex mixtures. The fourth and final section of the book explores the area of risk assessment, including discussions of the basic concepts of risk assessment as they apply specifically to immunotoxicologic effects upon the lungs, and the use of biomarkers as indices of potential pulmonary immunotoxic responses to inhaled materials.
Book Synopsis The Thymus in Immunotoxicology by : Marion D. Kendall
Download or read book The Thymus in Immunotoxicology written by Marion D. Kendall and published by CRC Press. This book was released on 1991 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Thymus Update 4" details the sensitivity of the thymus to xenobiotics and their effects on thymocyte development and maturation. It highlights the importance of immunological testing of all envoronmental toxins, such as dioxin, tin compounds and caramel additives, and drugs, such as immunosuppressives, antiviral agents and antihypertensive agents. The effects of trauma are also considered. Part two covers a subject of topical importance: an update on procedures for vascular transplantation of the thymus.
Book Synopsis Principles of Toxicology by : Stephen M. Roberts
Download or read book Principles of Toxicology written by Stephen M. Roberts and published by John Wiley & Sons. This book was released on 2015-01-12 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fully updated and expanded edition of the bestselling guide on toxicology and its practical application • Covers the diverse chemical hazards encountered in the modern work and natural environment, and provides a practical understanding of these hazards • New chapters cover the emerging areas of toxicology such as omics, computational toxicology, and nanotoxicology • Provides clear explanations and practical understanding of the fundamentals necessary for an understanding of the effects of chemical hazards on human health and ecosystems • Includes case histories and examples from industry demonstrate the application of toxicological principles • Supplemented with numerous illustrations to clarify and summarize key points, annotated bibliographies, and a comprehensive glossary of toxicological terms
Book Synopsis Dermal and Ocular Toxicology by : David W. Hobson
Download or read book Dermal and Ocular Toxicology written by David W. Hobson and published by CRC Press. This book was released on 2020-11-26 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dermal and Ocular Toxicology: Fundamentals and Methods is a procedurally-oriented volume of detailed methods and practical examples discussing the dermal and ocular aspects of toxicology. The book is divided into a dermal section and an ocular section. Each section begins with a chapter on the anatomy and physiology of each organ system and then progresses to more specialized chapters discussing such topics as the toxicological pathology of each system, state-of-the-art in vitro and in vivo evaluatory procedures, statistical considerations for test design and data interpretation, and the utilization of test findings. Test methods are provided for acute dermal exposure effects, dermal hypersensitivity and photoallergy assessment, dermal and ocular 0.pharmacokinetics, skin flap and skin grafting techniques, and in vitro alternative methods. This book can be used as an instructional text or as a sourcebook for practicing toxicologists, pharmacologists, industrial hygienists, occupational health professionals, and graduate students.
Book Synopsis Investigative Immunotoxicology by : Helen Tryphonas
Download or read book Investigative Immunotoxicology written by Helen Tryphonas and published by CRC Press. This book was released on 2005-01-27 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Investigative Immunotoxicology provides a critical evaluation of proposed experimental animal models and approaches, and discusses the contribution that immunotoxicity can make to the overall assessment of chemical-induced adverse health effects on humans and the ecosystem. Following a review of general concepts in immunotoxicology, the book discus
Book Synopsis Encyclopedic Reference of Immunotoxicology by : Hans-Werner Vohr
Download or read book Encyclopedic Reference of Immunotoxicology written by Hans-Werner Vohr and published by Springer. This book was released on 2005-06-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work provides rapid access to focused information on topics of Immunotoxicology not only for scientists and those dealing with laboratory aspects but also for lecturers and advanced students. Over 200 contributing authors – including many of the world’s top specialists – have contributed full essays on all relevant topics, supplemented by keyword definitions of related terms. Full essays are structured uniformly to provide reader-friendly information on all aspects of Immunotoxicology, including methods of testing and analysis, characteristics of substances, the regulatory environment and the relevance of these to humans. The single A–Z format of both types of entry makes this reference book very easy to use. The Encyclopedic Reference of Immunotoxicology is intended to be a comprehensive work of reference which will provide easy access to relevant information in the fast-growing field of Immunotoxicology.
Book Synopsis Toxicology of Marine Mammals by : Joseph G. Vos
Download or read book Toxicology of Marine Mammals written by Joseph G. Vos and published by CRC Press. This book was released on 2002-12-05 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: The activities of modern society have unleashed a range of toxic chemicals into the global environment. Many of these toxicants are now being detected in increasing quantities in the tissues of marine mammals, most notably in top predators who acquire relatively large amounts of toxic chemicals by ingesting contaminated prey. Toxicology of M
Book Synopsis Molecular Immunotoxicology by : Emanuela Corsini
Download or read book Molecular Immunotoxicology written by Emanuela Corsini and published by John Wiley & Sons. This book was released on 2014-11-24 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human immune system is constantly exposed to chemical contaminants, whether from food, water or air. Some chemicals directly elicit an immune response, while others indirectly activate or deactivate components within the immune system. Thus when tracking or predicting the effect of a chemical on the immune system, many different pathways and modes of action need to be considered. Following an introduction to the various pathways and toxicity mechanisms from a systemic perspective, the main part of this comprehensive reference surveys individual molecular mechanisms of important immunotoxicants, from PAHs to biopharmaceuticals, and from receptor-mediated toxicity to nanoparticle toxicity, using analyses based on molecular effects rather than on animal models. Taken together, the knowledge presented here provides an up-to-date overview of this hot topic that can be directly applied to the prediction and characterization of immunotoxic effects in drugs, chemicals, and environmental contaminants.
Book Synopsis Immunotoxicity Testing by : Jamie C. DeWitt
Download or read book Immunotoxicity Testing written by Jamie C. DeWitt and published by Humana. This book was released on 2019-06-22 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated volume utilizes the expertise of scientists currently engaged in immunotoxicity testing to provide the reader with lab-ready procedures and the background information needed to identify effective testing approaches. Dedicated to identifying and describing exogenous agents that can modify immune function, uncovering modes and mechanisms of action for such agents, and translating data from the laboratory and from the clinic to better predict health risks as well as benefits to those who are exposed to immunomodulatory agents, immunotoxicity testing continues to be a vital field of study, and this collection highlights both the “tried and true” methods as well as alternative protocols that have been more recently developed. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immunotoxicity Testing: Methods and Protocols, Second Edition serves as a valuable contribution to the continued evolution and the application of immunotoxicity testing.
Book Synopsis Immunotoxicology Strategies for Pharmaceutical Safety Assessment by : Danuta J. Herzyk
Download or read book Immunotoxicology Strategies for Pharmaceutical Safety Assessment written by Danuta J. Herzyk and published by John Wiley & Sons. This book was released on 2008-11-21 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important reference which provides an overview of the current and recently introduced methodologies for testing the immunotoxic risks in drug candidates Helps readers understand the significance of the methods and approaches to immunotoxicology testing Aids drug scientists in industry and regulatory areas to consolidate approaches to immunotox testing Offers a definitive assessment of nonclinical models to study the toxic impacts (bio)pharmaceuticals can have on the immune system Includes chapter authors from across the pharma industry, bringing a real-world and applied perspective to immunotox testing
Book Synopsis Clinical Immunotoxicology by : David S Newcombe
Download or read book Clinical Immunotoxicology written by David S Newcombe and published by CRC Press. This book was released on 1992-06-30 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is a comprehensive source of information on the toxic effects of environmental, industrial, and pharmacological agents on the human immune system. Focusing entirely on human immunotoxicology, without relying on animal models, the book explains the basic principles of immunotoxicology defines the mechanisms by which immunotoxins act, describes the clinical expression of immunotoxic disorders in the lung, skin, and other target organs, offers practical guidelines for early detection and control of host defense dysfunctions, and explores strategies for assessing the short- and long-term health effects of new and old chemicals and biologicals. The book includes extensive discussions on the role of low-dose, chronic immunosuppression in cancer, as well as on specific environmental and occupational immunotoxins and immunotoxic drugs used in hematology, anesthesiology, oncology and transplantation surgery.
Author :United States. Public Health Service. Office of the Surgeon General Publisher : ISBN 13 : Total Pages :728 pages Book Rating :4.:/5 (318 download)
Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
