Synthetic Studies Towards 55 Benzannulated Spiroketals Isolated From Traditional Chinese Medicines

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Synthetic Studies Towards 5,5-Benzannulated Spiroketals Isolated from Traditional Chinese Medicines

Author : Daniel Chorley
Publisher :
ISBN 13 :
Total Pages : 361 pages
Book Rating : 4.:/5 (935 download)

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Book Synopsis Synthetic Studies Towards 5,5-Benzannulated Spiroketals Isolated from Traditional Chinese Medicines by : Daniel Chorley

Download or read book Synthetic Studies Towards 5,5-Benzannulated Spiroketals Isolated from Traditional Chinese Medicines written by Daniel Chorley and published by . This book was released on 2015 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes synthetic endeavours towards two families of 5,5-benzannulated spiroketals isolated from plants used in traditional Chinese medicine: the danshenspiroketallactones and the pinnatifinosides. The first part of this thesis describes the successful synthesis of danshenspiroketallactone (14) and epi-danshenspiroketallactone (15). Danshenspiroketallactone (14) was isolated in 1985 by Rao et al. from Chinese Sage (Salvia miltiorrhiza), a plant used in traditional Chinese medicine to treat cardiovascular disease. In 1988 epi-danshenspiroketallactone (15) was isolated from S. miltiorrhiza by Snyder et al. These natural products possess a 5,5-spiroketallactone moiety fused to a naphthalene ring and are epimeric at the spiroketal centre. Key features of the total synthesis described herein are a directed ortho-metalation/lactonisation procedure used to unite the aromatic and aliphatic fragments of the molecule and form the lactone ring, and an oxidative radical cyclisation by intramolecular hydrogen abstraction used to complete the spiroketal. The second part of this thesis presents synthetic attempts towards pinnatifinosides C (18) and D (19), two members of the pinnatifinosides family of 5,5-spiroketal flavone containing natural products isolated by Zhang et al. in 2001 from Chinese Hawthorn (Crataegus pinnatifida). Two benzannulated spiroketal model compounds possessing the core of the pinnatifinosides were synthesised using a key Sonogashira cross-coupling reaction and gold-catalysed spiroketalisation. While the final spiroketalisation step of the attempted total synthesis of pinnatifinosides C (18) and D (19) using methods developed during the initial model studies proved unsuccessful, these investigations have established a sound platform that will enable further synthetic efforts towards pinnatifinosides C (18) and D (19), and other related compounds.

Iron Catalysis

Author : Bernd Plietker
Publisher : Springer Science & Business Media
ISBN 13 : 3642146694
Total Pages : 227 pages
Book Rating : 4.6/5 (421 download)

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Book Synopsis Iron Catalysis by : Bernd Plietker

Download or read book Iron Catalysis written by Bernd Plietker and published by Springer Science & Business Media. This book was released on 2011-01-05 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Juan I. Padrón and Víctor S. Martín: Catalysis by means of Fe-based Lewis acids; Hiroshi Nakazawa*, Masumi Itazaki: Fe–H Complexes in Catalysis; Kristin Schröder, Kathrin Junge, Bianca Bitterlich, and Matthias Beller: Fe-catalyzed Oxidation Reactions of Olefins, Alkanes and Alcohols: Involvement of Oxo- and Peroxo Complexes; Chi-Ming Che, Cong-Ying Zhou, Ella Lai-Ming Wong: Catalysis by Fe=X Complexes (X=NR, CR2); René Peters, Daniel F. Fischer and Sascha Jautze: Ferrocene and Half Sandwich Complexes as Catalysts with Iron Participation; Markus Jegelka, Bernd Plietker: Catalysis by Means of Complex Ferrates.

Iron Catalysis in Organic Chemistry

Author : Bernd Plietker
Publisher : John Wiley & Sons
ISBN 13 : 3527623280
Total Pages : 295 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Iron Catalysis in Organic Chemistry by : Bernd Plietker

Download or read book Iron Catalysis in Organic Chemistry written by Bernd Plietker and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first comprehensive book to cover this exciting field also deals with the biological aspects, such as enzymes with iron. Following an introduction, this handy reference and handbook goes on to deal with reductions, oxidations of C, H- and C=C bonds, oxidative allylic oxygenation and amination, the oxidation of heteroatoms, cross coupling reactions, aromatic and nucleophilic substitutions, addition to carbonyl compounds, and cyclisations as well as ring opening reactions. The chapters are clearly classified according to the reaction type, allowing readers to quickly locate the desired information.

Remote C-H Bond Functionalizations

Author : Debabrata Maiti
Publisher : John Wiley & Sons
ISBN 13 : 3527346678
Total Pages : 450 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Remote C-H Bond Functionalizations by : Debabrata Maiti

Download or read book Remote C-H Bond Functionalizations written by Debabrata Maiti and published by John Wiley & Sons. This book was released on 2021-04-26 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to contemporary advancements in the field of distal C-H functionalizations An important and dynamic topic within the modern field of organic synthesis, selective functionalization of C-H bonds can be used in a variety of applications across the pharmaceutical and agrochemical industries. Remote C-H Bond Functionalizations presents an inclusive account of the most recent developments and potential applications of performing variegated functionalizations selectively at the distal positions of organic compounds. Featuring contributions by an international team of experts, this authoritative volume provides deep insight into distal functionalizations, including detailed discussion of mechanisms, the engineering of templates, and the design of strategies. The text covers a diverse range of topics including C-H functionalization of palladium/norbornene catalysis, ruthenium-catalyzed remote functionalization, the non-directed distal C(sp2)-H, functionalization, transition metal catalyzed distal para-selective C-H functionalization, and much more. Reviewing contemporary advancements in the field while laying the foundation for future research, this important resource: Provides the most recent research and thorough coverage of the subject available in a single volume Offers practical information on C-H functionalizations in various industries Includes an up-to-date introduction to distal C-H functionalizations Remote C-H Bond Functionalizations is a must-read for every synthetic chemist, including chemists working with organometallics, organic chemists and researchers, and industrial chemists.

Small Molecule Drug Discovery

Author : Andrea Trabocchi
Publisher : Elsevier
ISBN 13 : 0128183500
Total Pages : 358 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Small Molecule Drug Discovery by : Andrea Trabocchi

Download or read book Small Molecule Drug Discovery written by Andrea Trabocchi and published by Elsevier. This book was released on 2019-11-23 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Small Molecule Drug Discovery: Methods, Molecules and Applications presents the methods used to identify bioactive small molecules, synthetic strategies and techniques to produce novel chemical entities and small molecule libraries, chemoinformatics to characterize and enumerate chemical libraries, and screening methods, including biophysical techniques, virtual screening and phenotypic screening. The second part of the book gives an overview of privileged cyclic small molecules and major classes of natural product-derived small molecules, including carbohydrate-derived compounds, peptides and peptidomimetics, and alkaloid-inspired compounds. The last section comprises an exciting collection of selected case studies on drug discovery enabled by small molecules in the fields of cancer research, CNS diseases and infectious diseases. The discovery of novel molecular entities capable of specific interactions represents a significant challenge in early drug discovery. Small molecules are low molecular weight organic compounds that include natural products and metabolites, as well as drugs and other xenobiotics. When the biological target is well defined and understood, the rational design of small molecule ligands is possible. Alternatively, small molecule libraries are being used for unbiased assays for complex diseases where a target is unknown or multiple factors contribute to a disease pathology. - Outlines modern concepts and synthetic strategies underlying the building of small molecules and their chemical libraries useful for drug discovery - Provides modern biophysical methods to screening small molecule libraries, including high-throughput screening, small molecule microarrays, phenotypic screening and chemical genetics - Presents the most advanced chemoinformatics tools to characterize the structural features of small molecule libraries in terms of chemical diversity and complexity, also including the application of virtual screening approaches - Gives an overview of structural features and classification of natural product-derived small molecules, including carbohydrate derivatives, peptides and peptidomimetics, and alkaloid-inspired small molecules

Diversity Oriented Synthesis

Author : Andrea Basso
Publisher : Frontiers Media SA
ISBN 13 : 2889457885
Total Pages : 150 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Diversity Oriented Synthesis by : Andrea Basso

Download or read book Diversity Oriented Synthesis written by Andrea Basso and published by Frontiers Media SA. This book was released on 2019-03-22 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Has the concept of Diversity Oriented Synthesis remained unchanged over these two decades, or do we observe improvements or deviations from the original guidelines drawn by the pioneers? The aim of this Research Topic is to collect contributions on the state-of-the-art and progress of Diversity Oriented Synthesis, and to foresee its shape in the next decade.

Helicene Chemistry

Author : Chuan-Feng Chen
Publisher : Springer
ISBN 13 : 3662531682
Total Pages : 276 pages
Book Rating : 4.6/5 (625 download)

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Book Synopsis Helicene Chemistry by : Chuan-Feng Chen

Download or read book Helicene Chemistry written by Chuan-Feng Chen and published by Springer. This book was released on 2016-11-04 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systematically reviews recent advances in the synthetic methods and applications of helicenes. The first part of this book introduces the nomenclature and structural features of helicenes. The second part reviews several classic and useful methods as well as recently-developed approaches for the preparation and functionalization of helicenes, including photocyclization and Diels-Alder reactions, which are two important breakthroughs in the syntheses of helicenes. In the last part, the applications of helicenes in asymmetric syntheses, molecular machines, molecular recognition, self-assembly and other fields are discussed. This book provides a useful reference source for researchers and graduate students working not only in the area of helicene chemistry, but also in other research areas including materials science, supramolecular chemistry, coordination chemistry, and physical organic chemistry. Chuan-Feng Chen is a Professor at the Institute of Chemistry, Chinese Academy of Sciences, China.

Natural Product Biosynthesis

Author : Christopher T. Walsh
Publisher : Royal Society of Chemistry
ISBN 13 : 1788010760
Total Pages : 787 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis Natural Product Biosynthesis by : Christopher T. Walsh

Download or read book Natural Product Biosynthesis written by Christopher T. Walsh and published by Royal Society of Chemistry. This book was released on 2017-04-28 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Author : Bimal Banik
Publisher : Elsevier
ISBN 13 : 0443161674
Total Pages : 699 pages
Book Rating : 4.4/5 (431 download)

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Book Synopsis Green Approaches in Medicinal Chemistry for Sustainable Drug Design by : Bimal Banik

Download or read book Green Approaches in Medicinal Chemistry for Sustainable Drug Design written by Bimal Banik and published by Elsevier. This book was released on 2024-05-31 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive experimentation and high failure rates are a well-recognized downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry 2e reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry, Second Edition encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This second volume of the second edition includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods. - Highlights the need for adoption of sustainable and green chemistry pathways in drug development - Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these - Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability

Medically Important Plant Biomes: Source of Secondary Metabolites

Author : Dilfuza Egamberdieva
Publisher : Springer Nature
ISBN 13 : 9811395667
Total Pages : 355 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Medically Important Plant Biomes: Source of Secondary Metabolites by : Dilfuza Egamberdieva

Download or read book Medically Important Plant Biomes: Source of Secondary Metabolites written by Dilfuza Egamberdieva and published by Springer Nature. This book was released on 2019-11-17 with total page 355 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides insights into various aspects of medicinal plant-associated microbes, known to be a unique source of biological active compounds, including their biotechnological uses and their potential in pharmaceutical, agricultural and industrial applications. Featuring review papers and original research by leading experts in the field, it discusses medicinal plants and their interactions with the environment; medicinal plants as a source of biologically active compounds; medicinal plant-associated microbes (diversity and metabolites); their pharmaceutical, agricultural and industrial applications as well as their potential applications as plant growth stimulators and biocontrol agents. As such the book offers a valuable, up-to-date overview of the current research on medicinal plants, their ecology, biochemistry and associated biomes.

Catalytic Hydroarylation of Carbon-Carbon Multiple Bonds

Author : Lutz Ackermann
Publisher : John Wiley & Sons
ISBN 13 : 3527697659
Total Pages : 566 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Catalytic Hydroarylation of Carbon-Carbon Multiple Bonds by : Lutz Ackermann

Download or read book Catalytic Hydroarylation of Carbon-Carbon Multiple Bonds written by Lutz Ackermann and published by John Wiley & Sons. This book was released on 2017-10-13 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a gap in the literature, this book comprehensively reviews catalytic C-H addition reactions of (hetero)aromatic hydrocarbons across carbon-carbon multiple bonds. In so doing, it summarizes both the scope as well as the limitations of different catalyst systems and building blocks, while highlighting their application to the synthesis of pharmaceuticals as well as commodity chemicals. Focusing on the latest developments, the team of authors comprising leaders in the field covers such topics as the hydroarylation of olefins, alkyne hydroarylation in the presence of transition metal catalysts, reaction of alkynes with arylboronic acids, and allene hydroarylation, as well as the synthesis of functionalized arenes and heteroaromatics. A must-have for synthetic chemists in academia and industry dealing with catalysis, organometallic chemistry, the synthesis of natural products, fine chemicals, pharmaceuticals, products of the chemical industry and organic materials.

Cycloaddition Reactions in Organic Synthesis

Author : W. Carruthers
Publisher : Elsevier
ISBN 13 : 008091232X
Total Pages : 382 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Cycloaddition Reactions in Organic Synthesis by : W. Carruthers

Download or read book Cycloaddition Reactions in Organic Synthesis written by W. Carruthers and published by Elsevier. This book was released on 2013-10-22 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demonstrates the wide scope of cycloaddition reactions, including the Diels-Alder reaction, the ene reaction, 1,3-dipolar cycloadditions and [2+2] cycloadditions in organic synthesis. The author, a leading exponent of the subject, illustrates the ways in which they can be employed in the synthesis of a wide range of carbocyclic and heterocyclic compounds, including a variety of natural products of various types. Special attention is given to intramolecular reactions, which often provide a rapid and efficient route to polycyclic compounds, and to the stereochemistry of the reactions, including recent and developing work on enantioselective synthesis.

Ruthenium in Organic Synthesis

Author : Shun-Ichi Murahashi
Publisher : John Wiley & Sons
ISBN 13 : 3527605797
Total Pages : 398 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Ruthenium in Organic Synthesis by : Shun-Ichi Murahashi

Download or read book Ruthenium in Organic Synthesis written by Shun-Ichi Murahashi and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this comprehensive book, one of the leading experts, Shun-Ichi Murahashi, presents all the important facets of modern synthetic chemistry using Ruthenium, ranging from hydrogenation to metathesis. In 14 contributions, written by an international authorship, readers will find all the information they need about this fascinating and extraordinary chemistry. The result is a high quality information source and a indispensable reading for everyone working in organometallic chemistry. From the contents: Introduction (S.-I. Murahashi) Hydrogenation and Transfer Hydrogenation (M. Kitamura and R. Noyori) Oxidations (S.-I. Murahashi and N. Komiya) Carbon-Carbon Bond Formations via Ruthenacycle Intermediates (K. Itoh) Carbon-Carbon Bond Formation via pi-Allylruthenium Intermediates (T. Mitsudo) Olefin Metathesis (R. H. Grubbs) Cyclopropanation (H. Nishiyama) Nucleophilic Addition to Alkynes and Reactions via Vinylidene Intermediates (P. Dixneuf) Reactions via C-H Activation (N. Chatani) Lewis Acid Reactions (E. P. Kundig) Reactions with CO and CO2 (T. Mitsudo) Isomerization of Organic Substrates Catalyzed by Ruthenium Complexes (H. Suzuki) Radical Reactions (H. Nagashima) Bond Cleavage Reactions (S. Komiya)

Bioinspiration and Biomimicry in Chemistry

Author : Gerhard Swiegers
Publisher : John Wiley & Sons
ISBN 13 : 1118310071
Total Pages : 532 pages
Book Rating : 4.1/5 (183 download)

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Book Synopsis Bioinspiration and Biomimicry in Chemistry by : Gerhard Swiegers

Download or read book Bioinspiration and Biomimicry in Chemistry written by Gerhard Swiegers and published by John Wiley & Sons. This book was released on 2012-09-17 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Can we emulate nature's technology in chemistry? Through billions of years of evolution, Nature has generated some remarkable systems and substances that have made life on earth what it is today. Increasingly, scientists are seeking to mimic Nature's systems and processes in the lab in order to harness the power of Nature for the benefit of society. Bioinspiration and Biomimicry in Chemistry explores the chemistry of Nature and how we can replicate what Nature does in abiological settings. Specifically, the book focuses on wholly artificial, man-made systems that employ or are inspired by principles of Nature, but which do not use materials of biological origin. Beginning with a general overview of the concept of bioinspiration and biomimicry in chemistry, the book tackles such topics as: Bioinspired molecular machines Bioinspired catalysis Biomimetic amphiphiles and vesicles Biomimetic principles in macromolecular science Biomimetic cavities and bioinspired receptors Biomimicry in organic synthesis Written by a team of leading international experts, the contributed chapters collectively lay the groundwork for a new generation of environmentally friendly and sustainable materials, pharmaceuticals, and technologies. Readers will discover the latest advances in our ability to replicate natural systems and materials as well as the many impediments that remain, proving how much we still need to learn about how Nature works. Bioinspiration and Biomimicry in Chemistry is recommended for students and researchers in all realms of chemistry. Addressing how scientists are working to reverse engineer Nature in all areas of chemical research, the book is designed to stimulate new discussion and research in this exciting and promising field.

Industrially Important Fungi for Sustainable Development

Author : Ahmed M. Abdel-Azeem
Publisher : Springer Nature
ISBN 13 : 3030675610
Total Pages : 609 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Industrially Important Fungi for Sustainable Development by : Ahmed M. Abdel-Azeem

Download or read book Industrially Important Fungi for Sustainable Development written by Ahmed M. Abdel-Azeem and published by Springer Nature. This book was released on 2021-06-18 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fungi are an understudied, biotechnologically valuable group of organisms. Due to their immense range of habitats, and the consequent need to compete against a diverse array of other fungi, bacteria, and animals, fungi have developed numerous survival mechanisms. However, besides their major basic positive role in the cycling of minerals, organic matter and mobilizing insoluble nutrients, fungi have other beneficial impacts: they are considered good sources of food and active agents for a number of industrial processes involving fermentation mechanisms as in the bread, wine and beer industry. A number of fungi also produce biologically important metabolites such as enzymes, vitamins, antibiotics and several products of important pharmaceutical use; still others are involved in the production of single cell proteins. The economic value of these marked positive activities has been estimated as approximating to trillions of US dollars. The unique attributes of fungi thus herald great promise for their application in biotechnology and industry. Since ancient Egyptians mentioned in their medical prescriptions how they can use green molds in curing wounds as the obvious historical uses of penicillin, fungi can be grown with relative ease, making production at scale viable. The search for fungal biodiversity, and the construction of a living fungi collection, both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel products. Fungi have provided the world with penicillin, lovastatin, and other globally significant medicines, and they remain an untapped resource with enormous industrial potential. Volume 1 of Industrially Important Fungi for Sustainable Development provides an overview to understanding fungal diversity from diverse habitats and their industrial application for future sustainability. It encompasses current advanced knowledge of fungal communities and their potential biotechnological applications in industry and allied sectors. The book will be useful to scientists, researchers, and students of microbiology, biotechnology, agriculture, molecular biology, and environmental biology.

Food Security and Safety

Author : Olubukola Oluranti Babalola
Publisher : Springer Nature
ISBN 13 : 303050672X
Total Pages : 926 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Food Security and Safety by : Olubukola Oluranti Babalola

Download or read book Food Security and Safety written by Olubukola Oluranti Babalola and published by Springer Nature. This book was released on 2021-09-01 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on food security and safety issues in Africa, a continent presently challenged with malnutrition and food insecurity. The continuous increase in the human population of Africa will lead to higher food demands, and climate change has already affected food production in most parts of Africa, resulting in drought, reduced crop yields, and loss of livestock and income. For Africa to be food-secure, safe and nutritious food has to be available, well-distributed, and sufficient to meet people’s food requirements. Contributors to Food Security and Safety: African Perspectives offer solutions to the lack of adequate safe and nutritious food in sub-Saharan Africa, as well as highlight the positive efforts being made to address this lack through a holistic approach. The book discusses the various methods used to enhance food security, such as food fortification, fermentation, genetic modification, and plant breeding for improved yield and resistance to diseases. Authors emphasize the importance of hygiene and food safety in food preparation and preservation, and address how the constraints of climate change could be overcome using smart crops. As a comprehensive reference text, Food Security and Safety: African Perspectives seeks to address challenges specific to the African continent while enhancing the global knowledge base around food security, food safety, and food production in an era of rapid climate change.

C-Furanosides

Author : Peter Goekjian
Publisher : Academic Press
ISBN 13 : 012803789X
Total Pages : 796 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis C-Furanosides by : Peter Goekjian

Download or read book C-Furanosides written by Peter Goekjian and published by Academic Press. This book was released on 2017-11-30 with total page 796 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon analogs of carbohydrates, dubbed C-glycosides, have remained an important and interesting class of mimetics, be it in natural product synthesis, for pharmacological applications, as conformational probes, or for biological studies. C-Furanosides: Synthesis and Stereochemistry provides a much-needed overview of synthetic and stereochemical principles for C-furanosides: analogs of a 5-membered ring carbohydrate glycoside (furanoside), in which the anomeric oxygen has been replaced with a carbon. While our understanding of conformational behavior and of stereoselective synthesis in 6-membered ring compounds is quite good, our ability to predict the conformation of 5-membered ring compounds, or to predict the stereochemical outcome of a given reaction, remains anecdotal. Through a comprehensive review of literature approaches to the different C-furanoside stereoisomers, as well as an interpretation of the outcome in terms of a reasonable number of stereochemical models, C-Furanosides: Synthesis and Stereochemistry enables the reader to determine the best approach to a particular C-glycoside compound, and also hopes to provide a certain level of rationalization and predictability for the synthesis of new systems. - Provides a comprehensive review of the growing literature in C-furanosides - Enables readers to choose the most convenient approach to access a defined target in natural products synthesis or pharmacology and make reasonable predictions for the stereochemical outcome in unpublished cases - Explores the various rational models for stereochemical analysis of furanoside reactivity, with a clear distinction made between physical chemical mechanisms and stereochemical models