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Synthetic Studies Toward A Total Synthesis Of Anisatin
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Book Synopsis Synthetic Studies Toward a Total Synthesis of Anisatin by : Melvin Joseph Yu
Download or read book Synthetic Studies Toward a Total Synthesis of Anisatin written by Melvin Joseph Yu and published by . This book was released on 1985 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward the Total Synthesis of Alstomicine by : Yang Su Tran
Download or read book Synthetic Studies Toward the Total Synthesis of Alstomicine written by Yang Su Tran and published by . This book was released on 2006 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards the Total Synthesis of Altohyrtin A by : Stuart Edward Bradley
Download or read book Synthetic Studies Towards the Total Synthesis of Altohyrtin A written by Stuart Edward Bradley and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies on a Total Synthesis of Anisatin by : David Louis Lindner
Download or read book Studies on a Total Synthesis of Anisatin written by David Louis Lindner and published by . This book was released on 1985 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward the Total Synthesis of Sirodesmin A by : Daniel James Conatser
Download or read book Synthetic Studies Toward the Total Synthesis of Sirodesmin A written by Daniel James Conatser and published by . This book was released on 1982 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Part I. Synthetic Studies Towards Dynemicin A by : Taeyoung Yoon
Download or read book Part I. Synthetic Studies Towards Dynemicin A written by Taeyoung Yoon and published by . This book was released on 1994 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards the Total Synthesis of Lancifodilactone G. by : Sanil Sreekumar
Download or read book Synthetic Studies Towards the Total Synthesis of Lancifodilactone G. written by Sanil Sreekumar and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis presents our studies towards the first total synthesis of the novel anti- HIV agent lancifodilactone G, which has a highly unusual aliphatic enol. The first chapter provides a survey of architecturally diverse nortriterpenoids that were isolated from the Schisandraceae family. A proposed biosynthetic pathway for lancifodilactone G and closely related natural products provides a rationale for the formation of the consecutive 7/8/5 fused carbo cycles that are unique to Schisandra nortriterpenoids. Chapter 1 goes on to outline the reported strategies to access the core of lancifodilactone G and concludes with a retrosynthetic analysis proposed by the Evans group, which includes a biosynthetically inspired single-pot polycyclisation reaction. Chapter 2 describes the highly stereocontrolled synthesis of the eastern fragment (F-G rings) using transition metal-mediated Pauson-Khand reaction. This chapter also reviews the metal-mediated diastereoselective Pauson-Khand reaction directed by the stereogenic centre at C2, with the ample illustration to total synthesis. Attempted strategies for the assembly of the bicyclic cyclopentanone motif via a dienyl Pauson-Khand reaction of silicon- and oxygen- tethered diene-enes are presented. The failure of these strategies at different stages of the synthesis resulted in the exploration of a classical Pauson-Khand approach, which successfully furnished the eastern fragment. Finally, a second-generation synthesis is described which provided the fully functionalised eastern fragment with improved efficiency and overall yield. Chapter 3 discusses the successful synthesis of the western fragment (B-C rings) using a diastereoselective [4+3] cycloaddition strategy. Attempted strategies for the synthesis of the key 2,3-disubstituted furan derivative are presented, which was achieved via a hetero Pauson- Khand reaction. This chapter includes a brief account of the classical [4+3] cycloaddition reactions of furans using an in situ generated oxyallyl cation and also employing vinyl carbenoids in the metal-catalysed version. The review also highlights the application of the [4+ 3] cycloaddition reaction in the expeditious assembly of functionalised 7-membered rings that occur in a number of important biologically active natural products. The third chapter goes on to describe the application of these cycloaddition reactions in the synthesis of the fully functionalised western fragment of Lancifodilactone G. Chapter 4 describes a model study aimed at expediting the synthesis of the western fragment using a rhodium-catalysed allylic substitution reaction. A brief mechanistic discussion on unique aspects of the allylic alkylation reaction is illustrated. Chapter 4 concludes by outlining the coupling strategy for eastern and western fragments and the end game studies for the completion of the synthesis of lancifodilactone G.
Book Synopsis Synthetic Studies Towards Aruncin B by : Aubert Ribaucourt
Download or read book Synthetic Studies Towards Aruncin B written by Aubert Ribaucourt and published by . This book was released on 2017 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward the Total Synthesis (±)-ajmaline and the Development Of, Investigation Into, and Application of a Phosphine-catalyzed [4+1] Annulation by : Brian Richard Blank
Download or read book Synthetic Studies Toward the Total Synthesis (±)-ajmaline and the Development Of, Investigation Into, and Application of a Phosphine-catalyzed [4+1] Annulation written by Brian Richard Blank and published by . This book was released on 2014 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several synthetic routes toward the synthesis of the indole alkaloid (±)-ajmaline have been explored. The retrosynthetic plan was devised around two key transformations, one being a tandem aza-Michael-Michael reaction, and the other a phosphine-catalyzed [4+2] annulation. While these approaches have not allowed for the completion of ajmaline, they have provided a great deal of insight into the chemistry of many intermediates. For example, it was discovered that following installation of the D-ring, functionalization of the tricyclic scaffold to deliver a precursor for the aza-Michael-Michael sequence was a futile undertaking. As such, the necessary functionality had to be installed prior to the [4+2] annulation. For this purpose, ethyl 3-allyl-1H-indole-2-carboxylate was prepared by way of a stepwise Japp-Klingemann reaction, and a subsequent Fischer indolization. Successful conversion of this compound into the N-sulfonyl imine required the employment of 2,6-lutidine to impede isomerization of the allyl moiety. This imine was converted into the tetrahydropyridine through a phosphine-catalyzed [4+2] annulation with ethyl 2-methyl-2,3-butadienoate. Cross-metathesis with methyl acrylate provided the first precursor to the desired aza-Michael-Michael reaction sequence. Unfortunately, only mono-Michael addition was observed when this substrate was employed in the reaction, providing a tetracyclic structure instead of the desired pentacyclic scaffold. As a result, we are currently pursuing tricyclic derivatives that feature either alternative Michael donors or an increased strength of the second Michael acceptor. A phosphine-catalyzed [4+1] annulative rearrangement has been developed to prepare 3-pyrrolines from allenylic carbamates through phosphonium diene intermediates. This methodology was employed to synthesize an array of 1,3-disubstituted- and 1,2,3-trisubstituted-3-pyrrolines, including the often difficult to prepare 2-alkyl variants. A mechanistic investigation employing allenylic acetates and mononucleophiles unexpectedly unveiled that a phosphine-catalyzed [4+1] reaction previously reported by Tong might not occur through a phosphonium diene as was proposed, but rather involves multiple mechanisms working in concert to construct cyclopentene products. Consequentially, our phosphine-catalyzed rearrangement is most likely the first reaction that unequivocally forms a phosphonium diene intermediate along the reaction pathway. Concise formal syntheses of pyrrolizidine alkaloids (±)-trachelanthamidine and (±)-supinidine were completed, demonstrating the synthetic utility of this newly developed reaction.
Book Synopsis Synthetic Studies Towards the Total Synthesis of Tuberostemonine by : Lilian Ai Cheng Low
Download or read book Synthetic Studies Towards the Total Synthesis of Tuberostemonine written by Lilian Ai Cheng Low and published by . This book was released on 1998 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Total Synthesis of (+- )-ceratopicanol, and Synthetic Studies Towards New Methods for Making Amides by : Steven Richard Magnuson
Download or read book Total Synthesis of (+- )-ceratopicanol, and Synthetic Studies Towards New Methods for Making Amides written by Steven Richard Magnuson and published by . This book was released on 1996 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Directed Towards the Total Synthesis of Penitrem D. by : Peter V. Zawada
Download or read book Synthetic Studies Directed Towards the Total Synthesis of Penitrem D. written by Peter V. Zawada and published by . This book was released on 2006 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Part I. Synthetic Studies on Xestospongin A, C and Their Analogs Part II. Synthetic Efforts Towards a Total Synthesis of Communesin B (a.k.a Nomofungin) by : Peng Zhao
Download or read book Part I. Synthetic Studies on Xestospongin A, C and Their Analogs Part II. Synthetic Efforts Towards a Total Synthesis of Communesin B (a.k.a Nomofungin) written by Peng Zhao and published by . This book was released on 2005 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Toward the Ideal Synthesis by : Timothy Michael Dore
Download or read book Toward the Ideal Synthesis written by Timothy Michael Dore and published by . This book was released on 1998 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Towards the Total Synthesis of Norzoanthamine by : Fatima R. Rivas
Download or read book Synthetic Studies Towards the Total Synthesis of Norzoanthamine written by Fatima R. Rivas and published by . This book was released on 2006 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: The work presented herein is the conclusion of synthetic studies toward the total synthesis of norzoanthamine. This dissertation on the norzoanthamine synthetic studies will be divided into 3 sections: (1) an introduction describing the norzoanthamine family along with their biological significance and previous studies; (2) a stereoselective synthesis of the ABC ring system, and the crucial development of the fully functionalized C ring; (3) a biomimetic approach towards norzoanthamine; which will discuss studies to create the C ring from a polyene system through a Diels-Alder reaction, studies to synthesize the A ring through a sigmatropic rearrangement, studies to generate the BC ring through an intramolecular Diels-Alder reaction from carvone as a chiral pool, development of isocarvone, and studies of 2-acylamino 1,3 dienes as a viable synthon to form the BC ring through a [4+2] cycloaddition reaction.
Book Synopsis Studies Toward The Total Synthesis of Manzamine A by : Brian B. Filippini
Download or read book Studies Toward The Total Synthesis of Manzamine A written by Brian B. Filippini and published by . This book was released on 1995 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward the Enantioselective Total Synthesis of Manzamine A by : Matthew David Kowalski
Download or read book Studies Toward the Enantioselective Total Synthesis of Manzamine A written by Matthew David Kowalski and published by . This book was released on 2008 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: